Association of C-reactive protein with bacterial and respiratory syncytial virus-associated pneumonia among children aged <5 years in the PERCH study

Clinical Infectious Diseases

Volumn 64, Issue , 2017, Pages S378-S386

  Higdon, Melissa M ^a   Le, Tham ^a,b   O'Brien, Katherine L ^a   Murdoch, David R ^c,d   Prosperi, Christine ^a   Baggett, Henry C ^e,f   Brooks, W Abdullah ^a,g   Feikin, Daniel R ^a,h   Hammitt, Laura L ^a,i   Howie, Stephen R C ^c,j,k   Kotloff, Karen L ^l   Levine, Orin S ^a,m   Scott, J Anthony G ^i,j   Thea, Donald M ⁿ   Awori, Juliet O ⁱ   Baillie, Vicky L ^o   Cascio, Stephanie ^a   Chuananon, Somchai ^p   DeLuca, Andrea N ^a   Driscoll, Amanda J ^a   Ebruke, Bernard E ^j   Endtz, Hubert P ^g,q,r   Kaewpan, Anek ^e   Kahn, Geoff ^a   Karani, Angela ⁱ   Karron, Ruth A ^a   Moore, David P ^o,s   Park, Daniel E ^a,t   Rahman, Mohammed Ziaur ^g   Salaudeen, Rasheed ^j,u   Seidenberg, Phil ^n,v   Somwe, Somwe Wa ^w   Sylla, Mamadou ^x   Tapia, Milagritos D ^l   Zeger, Scott L ^a   Knoll, Maria Deloria ^a   Madhi, Shabir A ^o   Fancourt, Nicholas ^a   Fu, Wei ^a   Kagucia, E Wangeci ^a   Li, Mengying ^a   Wu, Zhenke ^a   Watson, Nora L ^y   Crawley, Jane ^z   Zaman, Khalequ ^g   Goswami, Doli ^g   Hossain, Lokman ^g   Jahan, Yasmin ^g   Ashraf, Hasan ^g   Antonio, Martin ^j   McLellan, Jessica ^j   Machuka, Eunice ^j   Shamsul, Arifin ^j   Zaman, Syed M A ^j   Mackenzie, Grant ^j   Morpeth, Susan C ⁱ   Kamau, Alice ⁱ   Kazungu, Sidi ⁱ   Ominde, Micah Silaba ⁱ   Sow, Samba O ^l,x   Tamboura, Boubou ^l,x   Onwuchekwa, Uma ^l,x   Kourouma, Nana ^l,x   Toure, Aliou ^l,x   Adrian, Peter V ^o   Kuwanda, Locadiah ^o   Mudau, Azwifarwi ^o   Groome, Michelle J ^o   Mahomed, Nasreen ^o   Thamthitiwat, Somsak ^e   Maloney, Susan A ^e   Bunthi, Charatdao ^e   Rhodes, Julia ^e   Sawatwong, Pongpun ^e   Akarasewi, Pasakorn ^e   Mwananyanda, Lawrence ^n,aa   Chipeta, James ^n,aa   Mwansa, James ^n,aa   Kwenda, Geoffrey ^n,aa   Anderson, Trevor P ^d   Mitchell, Joanne ^d   more..

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d CANTERBURY HEALTH LABORATORIES   (New Zealand)

^e Centers for Disease Control CDC Thailand Field Station   (Thailand)

^f CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^g INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

^h NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES   (United States)

ⁱ KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^j LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^k UNIVERSITY OF AUCKLAND   (New Zealand)

^l UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^m BILL AND MELINDA GATES FOUNDATION   (United States)

ⁿ BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^o UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^p Nakhon Phanom Provincial Hospital   (Thailand)

^q ERASMUS MEDICAL CENTER   (Netherlands)

^r Fondation Merieux   (France)

^s UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^t GEORGE WASHINGTON UNIVERSITY   (United States)

^u LAGOS UNIVERSITY TEACHING HOSPITAL   (Nigeria)

^v UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^w UNIVERSITY OF ZAMBIA   (Zambia)

^x Centre Pour le Développement des Vaccins CVD Mali   (Mali)

^y EMMES CORPORATION   (United States)

^z UNIVERSITY OF OXFORD   (United Kingdom)

^aa UNIVERSITY TEACHING HOSPITAL   (Zambia)

more..

Author keywords

Bacteria; Biomarker; C reactive protein; Pneumonia; RSV

Indexed keywords

C REACTIVE PROTEIN; BIOLOGICAL MARKER;

ARTICLE; BACTERIAL PNEUMONIA; CASE CONTROL STUDY; CHILD; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; INFANT; MAJOR CLINICAL STUDY; MALE; PLEURA FLUID; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY SYNCYTIAL VIRUS INFECTION; SENSITIVITY AND SPECIFICITY; SPUTUM CULTURE; THORAX RADIOGRAPHY; VIRUS PNEUMONIA; BACTERIUM; BLOOD; CLINICAL TRIAL; COMMUNITY ACQUIRED INFECTION; EVALUATION STUDY; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MULTICENTER STUDY; NASOPHARYNX; NEWBORN; OROPHARYNX; RECEIVER OPERATING CHARACTERISTIC; VIROLOGY;

BACTERIA; BIOMARKERS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; NASOPHARYNX; OROPHARYNX; PNEUMONIA, BACTERIAL; PNEUMONIA, VIRAL; POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 85038085859     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cix150     Document Type: Article

References (42)

1. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003; 111:1805-12.
2. Tillett WS, Francis T. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med 1930; 52:561-71.
3. Morley JJ, Kushner I. Serum C-reactive protein levels in disease. Ann N Y Acad Sci 1982; 389:406-18.
4. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340:448-54.
5. Korppi M, Kroger L. C-reactive protein in viral and bacterial respiratory infection in children. Scand J Infect Dis 1993; 25:207-13.
6. Virkki R, Juven T, Rikalainen H, Svedstrom E, Mertsola J, Ruuskanen O. Differentiation of bacterial and viral pneumonia in children. Thorax 2002; 57:438-41.
7. Lala SG, Madhi SA, Pettifor JM. The discriminative value of C-reactive protein levels in distinguishing between community-acquired bacteraemic and respiratory virus-associated lower respiratory tract infections in HIV-1-infected and -uninfected children. Ann Trop Paediatr 2002; 22:271-9.
8. Elemraid MA, Rushton SP, Thomas MF, Spencer DA, Gennery AR, Clark JE. Utility of inflammatory markers in predicting the aetiology of pneumonia in children. Diagn Microbiol Infect Dis 2014; 79:458-62.
9. Ip M, Rainer TH, Lee N, et al. Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections. Diagn Microbiol Infect Dis 2007; 59:131-6.
10. Korppi M, Heiskanen-Kosma T, Jalonen E, et al. Aetiology of community-acquired pneumonia in children treated in hospital. Eur J Pediatr 1993; 152:24-30.
11. Toikka P, Irjala K, Juven T, et al. Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children. Pediatr Infect Dis J 2000; 19:598-602.
12. ten Oever J, Tromp M, Bleeker-Rovers CP, et al. Combination of biomarkers for the discrimination between bacterial and viral lower respiratory tract infections. J Infect 2012; 65:490-5.
13. Kruger S, Ewig S, Papassotiriou J, et al; CAPNETZ Study Group. Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP: results from the German competence network CAPNETZ. Respir Res 2009; 10:65.
14. Pfister R, Kochanek M, Leygeber T, et al. Procalcitonin for diagnosis of bacterial pneumonia in critically ill patients during 2009 H1N1 influenza pandemic: a prospective cohort study, systematic review and individual patient data meta-analysis. Crit Care 2014; 18:R44.
15. Rainer TH, Chan CP, Leung MF, et al. Diagnostic utility of CRP to neopterin ratio in patients with acute respiratory tract infections. J Infect 2009; 58:123-30.
16. Korppi M, Heiskanen-Kosma T, Leinonen M. White blood cells, C-reactive protein and erythrocyte sedimentation rate in pneumococcal pneumonia in children. Eur Respir J 1997; 10:1125-9.
17. Nohynek H, Valkeila E, Leinonen M, Eskola J. Erythrocyte sedimentation rate, white blood cell count and serum C-reactive protein in assessing etiologic diagnosis of acute lower respiratory infections in children. Pediatr Infect Dis J 1995; 14:484-90.
18. Heiskanen-Kosma T, Korppi M. Serum C-reactive protein cannot differentiate bacterial and viral aetiology of community-acquired pneumonia in children in primary healthcare settings. Scand J Infect Dis 2000; 32:399-402.
19. Turner RB, Lande AE, Chase P, Hilton N, Weinberg D. Pneumonia in pediatric outpatients: cause and clinical manifestations. J Pediatr 1987; 111:194-200.
20. Levine OS, O'Brien KL, Deloria-Knoll M, et al. The Pneumonia Etiology Research for Child Health Project: a 21st century childhood pneumonia etiology study. Clin Infect Dis 2012; 54(suppl 2):S93-101.
21. Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010; 375:1545-55.
22. Deloria-Knoll M, Feikin DR, Scott JA, et al; Pneumonia Methods Working Group. Identification and selection of cases and controls in the Pneumonia Etiology Research for Child Health project. Clin Infect Dis 2012; 54(suppl 2):S117-23.
23. World Health Organization. Pocket book of hospital care for children. Geneva, Switzerland: WHO, 2005.
24. Falade AG, Mulholland EK, Adegbola RA, Greenwood BM. Bacterial isolates from blood and lung aspirate cultures in Gambian children with lobar pneumonia. Ann Trop Paediatr 1997; 17:315-9.
25. Driscoll AJ, Karron RA, Morpeth SC, et al. Standardization of laboratory methods for the PERCH study. Clin Infect Dis 2017; 64(suppl 3):S245-52.
26. Cherian T, Mulholland EK, Carlin JB, et al. Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies. Bull World Health Organ 2005; 83:353-9.
27. Fancourt N, Deloria Knoll M, Barger-Kamate B, et al. Standardized interpretation of chest radiographs in cases of pediatric pneumonia from the PERCH study. Clin Infect Dis 2017; 64(suppl 3):S253-61.
28. Baggett H, Watson N, Deloria Knoll M, et al. Density of upper respiratory colonization with Streptococcus pneumoniae and its role in the diagnosis of pneumococcal pneumonia among children aged <5 years in the PERCH study. Clin Infect Dis 2017; 64(suppl 3):S317-27.
29. Deloria Knoll M, Morpeth SC, Watson NL, et al. Evaluation of pneumococcal load in blood by polymerase chain reaction for the diagnosis of pneumococcal pneumonia in young children in the PERCH study. Clin Infect Dis 2017; 64(suppl 3):S357-67.
30. Park DE, Baggett HC, Howie SRC, et al. Colonization density of the upper respiratory tract as a predictor of pneumonia: Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii. Clin Infect Dis 2017; 64(suppl 3): S328-36.
31. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982; 143:29-36.
32. Youden WJ. Index for rating diagnostic tests. Cancer 1950; 3:32-5.
33. Leeflang MMG, Moons KGM, Reitsma JB, Zwinderman AH. Bias in sensitivity and specificity caused by data-driven selection of optimal cutoff values: mechanisms, magnitude, and solutions. Clin Chem 2008; 54:729-37.
34. Ruuskanen O, Putto A, Sarkkinen H, Meurman O, Irjala K. C-reactive protein in respiratory virus infections. J Pediatr 1985; 107:97-100.
35. Shimizu Y, Abiko C, Ikeda T, Mizuta K, Matsuzaki Y. Influenza C virus and human metapneumovirus infections in hospitalized children with lower respiratory tract illness. Pediatr Infect Dis J 2015; 34:1273-5.
36. Kawasaki Y, Hosoya M, Katayose M, Suzuki H. Correlation between serum interleukin 6 and C-reactive protein concentrations in patients with adenoviral respiratory infection. Pediatr Infect Dis J 2002; 21:370-4.
37. Chan PC, Wang CY, Wu PS, et al. Detection of human metapneumovirus in hospitalized children with acute respiratory tract infection using real-time RT-PCR in a hospital in northern Taiwan. J Formos Med Assoc 2007; 106:16-24.
38. Lee JY, Hwang SJ, Shim JW, et al. Clinical significance of serum procalcitonin in patients with community-acquired lobar pneumonia. Korean J Lab Med 2010; 30:406-13.
39. Nunes AA, Camargos PA, Costa PR, Campos MT. Antigen detection for the diagnosis of pneumonia. Pediatr Pulmonol 2004; 38:135-9.
40. Celik T, Guler E, Berksoy EA, Sorguc Y, Arslan N. Mean platelet volume in children with acute gastroenteritis caused by Entamoeba histolytica. Turkiye Parazitol Derg 2015; 39:205-8.
41. Ribeiro MA. Levels of C-reactive protein in serum samples from healthy children and adults in Sao Paulo, Brazil. Braz J Med Biol Res 1997; 30:1055-9.
42. Ning J, Shao X, Ma Y, Lv D. Valuable hematological indicators for the diagnosis and severity assessment of Chinese children with community-acquired pneumonia: prealbumin. Medicine (Baltimore) 2016; 95:e5452.