Combination of biomarkers for the discrimination between bacterial and viral lower respiratory tract infections

Journal of Infection

Volumn 65, Issue 6, 2012, Pages 490-495

  ten Oever, Jaap ^a   Tromp, Mirjam ^a   Bleeker Rovers, Chantal P ^a   Joosten, Leo A B ^a   Netea, Mihai G ^a   Pickkers, Peter ^a   van de Veerdonk, Frank L ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Biomarkers; C reactive protein; Emergency department; Lower respiratory tract infection; Sepsis

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 18; INTERLEUKIN 6; LIPOPOLYSACCHARIDE BINDING PROTEIN; PROCALCITONIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1;

ADOLESCENT; ADULT; AGED; ARTICLE; BACTEREMIA; BACTERIAL LOWER RESPIRATORY TRACT INFECTION; BACTERIUM ISOLATION; CLINICAL ASSESSMENT; CLINICAL FEATURE; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; LENGTH OF STAY; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; PREDICTION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; VIRAL LOWER RESPIRATORY TRACT INFECTION; VIRUS ISOLATION;

ADULT; AGED; AREA UNDER CURVE; BACTEREMIA; BACTERIAL INFECTIONS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; DIAGNOSIS, DIFFERENTIAL; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RESPIRATORY TRACT INFECTIONS; STATISTICS, NONPARAMETRIC; VIRUS DISEASES;

EID: 84869097545     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2012.08.004     Document Type: Article

References (31)

1. Martin G.S., Mannino D.M., Eaton S., Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348(16):1546-1554.
2. Kumar A., Roberts D., Wood K.E., Light B., Parrillo J.E., Sharma S., et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006, 34(6):1589-1596.
3. Houck P.M., Bratzler D.W., Nsa W., Ma A., Bartlett J.G. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med 2004, 164(6):637-644.
4. World Health Organization WHO global strategy for containment of antimicrobial resistance 2001, Anti-Infective Drug Resistance Surveillance and Containment Team, World Health Organization, Geneva.
5. Cals J.W., Butler C.C., Hopstaken R.M., Hood K., Dinant G.J. Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial. BMJ 2009, 338. b1374.
6. Schuetz P., Christ-Crain M., Thomann R., Falconnier C., Wolbers M., Widmer I., et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA 2009, 302(10):1059-1066.
7. Oshita H., Sakurai J., Kamitsuna M. Semi-quantitative procalcitonin test for the diagnosis of bacterial infection: clinical use and experience in Japan. J Microbiol Immunol Infect 2010, 43(3):222-227. 10.1016/S1684-1182(10)60035-7.
8. Simon L., Gauvin F., Amre D.K., Saint-Louis P., Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 2004, 39(2):206-217.
9. van de Berg P.J., Heutinck K.M., Raabe R., Minnee R.C., Young S.L., van Donselaar-van der Pant K.A., et al. Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature. J Infect Dis 2010, 202(5):690-699.
10. Ahmad R., Sindhu S.T., Toma E., Morisset R., Ahmad A. Elevated levels of circulating interleukin-18 in human immunodeficiency virus-infected individuals: role of peripheral blood mononuclear cells and implications for AIDS pathogenesis. J Virol 2002, 76(24):12448-12456.
11. Mustafa A.S., Elbishbishi E.A., Agarwal R., Chaturvedi U.C. Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever. FEMS Immunol Med Microbiol 2001, 30(3):229-233.
12. van de Veerdonk F.L., Wever P.C., Hermans M.H., Fijnheer R., Joosten L.A., van der Meer J.W., et al. IL-18 serum concentration is markedly elevated in acute EBV infection and can serve as a marker for disease severity. J Infect Dis 2012, 206(2):197-201.
13. Jiyong J., Tiancha H., Wei C., Huahao S. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med 2009, 35(4):587-595.
14. Schumann R.R., Leong S.R., Flaggs G.W., Gray P.W., Wright S.D., Mathison J.C., et al. Structure and function of lipopolysaccharide binding protein. Science 1990, 249(4975):1429-1431.
15. Ubenauf K.M., Krueger M., Henneke P., Berner R. Lipopolysaccharide binding protein is a potential marker for invasive bacterial infections in children. Pediatr Infect Dis J 2007, 26(2):159-162. 10.1097/01.inf.0000253064.88722.6d.
16. Ip M., Rainer T.H., Lee N., Chan C., Chau S.S., Leung W., et al. Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections. Diagn Microbiol Infect Dis 2007, 59(2):131-136. 10.1016/j.diagmicrobio.2007.04.019.
17. Nuutila J., Hohenthal U., Laitinen I., Kotilainen P., Rajamaki A., Nikoskelainen J., et al. Quantitative analysis of complement receptors, CR1 (CD35) and CR3 (CD11b), on neutrophils improves distinction between bacterial and viral infections in febrile patients: comparison with standard clinical laboratory data. J Immunol Methods 2006, 315(1-2):191-201. 10.1016/j.jim.2006.07.021.
18. Kofoed K., Andersen O., Kronborg G., Tvede M., Petersen J., Eugen-Olsen J., et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care 2007, 11(2):R38.
19. Don M., Valent F., Korppi M., Canciani M. Differentiation of bacterial and viral community-acquired pneumonia in children. Pediatr Int 2009, 51(1):91-96.
20. Tromp M., Lansdorp B., Bleeker-Rovers C.P., Gunnewiek J.M., Kullberg B.J., Pickkers P. Serial and panel analyses of biomarkers do not improve the prediction of bacteremia compared to one procalcitonin measurement. J Infect 2012, 65(4):292-301.
21. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 2003, 31(4):1250-1256.
22. Hanley J.A., McNeil B.J. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983, 148(3):839-843.
23. Stolz D., Christ-Crain M., Gencay M.M., Bingisser R., Huber P.R., Muller B., et al. Diagnostic value of signs, symptoms and laboratory values in lower respiratory tract infection. Swiss Med Wkly 2006, 136(27-28):434-440.
24. Dellinger R.P., Levy M.M., Carlet J.M., Bion J., Parker M.M., Jaeschke R., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock. Crit Care Med 2008, 36(1):296-327.
25. Boucher H.W., Talbot G.H., Bradley J.S., Edwards J.E., Gilbert D., Rice L.B., et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009, 48(1):1-12.
26. Kruger S., Ewig S., Papassotiriou J., Kunde J., Marre R., von Baum H., et al. Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP: results from the German competence network CAPNETZ. Respir Res 2009, 10:65.
27. Masia M., Gutierrez F., Llorca B., Navarro J.C., Mirete C., Padilla S., et al. Serum concentrations of lipopolysaccharide-binding protein as a biochemical marker to differentiate microbial etiology in patients with community-acquired pneumonia. Clin Chem 2004, 50(9):1661-1664.
28. Jennings L.C., Anderson T.P., Beynon K.A., Chua A., Laing R.T., Werno A.M., et al. Incidence and characteristics of viral community-acquired pneumonia in adults. Thorax 2008, 63(1):42-48.
29. Toikka P., Irjala K., Juven T., Virkki R., Mertsola J., Leinonen M., et al. Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children. Pediatr Infect Dis J 2000, 19(7):598-602.
30. Korppi M. Non-specific host response markers in the differentiation between pneumococcal and viral pneumonia: what is the most accurate combination?. Pediatr Int 2004, 46(5):545-550.
31. Keijmel S.P., Krijger E., Delsing C.E., Sprong T., Nabuurs-Franssen M.H., Bleeker-Rovers C.P. Clinical presentation of patients with acute Q fever to the hospital. Clin Microbiol Infect 2012, 18(s3):525.