High-stringency evaluation of the automated BD phoenix CPO detect and rapidec carba NP tests for detection and classification of carbapenemases

Journal of Clinical Microbiology

Volumn 55, Issue 12, 2017, Pages 3437-3443

  Thomson, Gina ^a,b   Turner, David ^c   Brasso, William ^c   Kircher, Susan ^c   Guillet, Thierry ^c,d   Thomson, Kenneth ^b  

^a UNIVERSITY OF LOUISVILLE HOSPITAL   (United States)

^b University of Louisville School of Medicine   (United States)

^c BD Diagnostic Systems   (United States)

^d Thierry Guillet   (Spain)

Author keywords

Carbapenemase; CPO; CPO detect; KPC; NDM; Rapidec carba NP; VIM

Indexed keywords

AVIBACTAM PLUS CEFTAZIDIME; BETA LACTAMASE; BETA LACTAMASE AMPC; BROAD SPECTRUM BETA LACTAMASE; CARBAPENEM; CARBAPENEMASE; EXTENDED SPECTRUM BETA LACTAMASE; IMI PROTEIN; IMIPENEM; IMP PROTEIN; KLEBSIELLA PNEUMONIAE CARBAPENEMASE; MUTANT PROTEIN; NDM PROTEIN; NMC A PROTEIN; OXA 181 PROTEIN; OXA 23 PROTEIN; OXA 232 PROTEIN; OXA 40 PROTEIN; OXA 48 PROTEIN; OXA 58 PROTEIN; OXA 72 PROTEIN; PORIN; SME PROTEIN; SPM PROTEIN; UNCLASSIFIED DRUG; VIM PROTEIN; BACTERIAL PROTEIN;

ACINETOBACTER BAUMANNII; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; AUTOMATION; BACTERIUM ISOLATE; CLASSIFICATION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ENTEROBACTERIACEAE; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SENSITIVITY AND SPECIFICITY; COMPARATIVE STUDY; DIAGNOSTIC TEST; ENZYMOLOGY; EVALUATION STUDY; MICROBIOLOGICAL EXAMINATION; PROCEDURES;

ACINETOBACTER BAUMANNII; BACTERIAL PROTEINS; BACTERIOLOGICAL TECHNIQUES; BETA-LACTAMASES; DIAGNOSTIC TESTS, ROUTINE; ENTEROBACTERIACEAE; PSEUDOMONAS AERUGINOSA; SENSITIVITY AND SPECIFICITY;

EID: 85036626066     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01215-17     Document Type: Article

References (28)

1. Thomson KS. 2017. The immaculate carbapenemase study. J Clin Microbiol 55: 1608-1611. https://doi.org/10.1128/JCM.00430-17.
2. Watanabe M, Iyobe S, Inoue M, Mitsuhashi S. 1991. Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 35: 147-151. https://doi.org/10.1128/AAC.35.1.147.
3. Manenzhe RI, Zar HJ, Nicol MP, Kaba M. 2015. The spread of carbapenemase-producing bacteria in Africa: A systematic review. J Antimicrob Chemother 70: 23-40. https://doi.org/10.1093/jac/dku356.
4. Tzouvelekis LS, Markogiannakis A, Piperaki E, Souli M, Daikos GL. 2014. Treating infections caused by carbapenemase-producing Enterobacteriaceae. Clin Microbiol Infect 20: 862-872. https://doi.org/10.1111/1469-0691.12697.
5. Karlowsky JA, Lob SH, Kazmierczak KM, Badal RE, Young K, Motyl MR, Sahm DF. 2017. In vitro activity of imipenem against carbapenemasepositive Enterobacteriaceae isolates collected by the SMART global surveillance program from 2008 to 2014. J Clin Microbiol 55: 1638-1649. https://doi.org/10.1128/JCM.02316-16.
6. Elemam A, Rahimian J, Mandell W. 2009. Infection with panresistant Klebsiella pneumoniae: A report of 2 cases and a brief review of the literature. Clin Infect Dis 49: 271-274. https://doi.org/10.1086/600042.
7. Endimiani A, Patel G, Hujer KM, Swaminathan M, Perez F, Rice LB, Jacobs MR, Bonomo RA. 2010. In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin. Antimicrob Agents Chemother 54: 526-529. https://doi.org/10.1128/AAC.01235-09.
8. Elemam A, Rahimian J, Doymaz M. 2010. In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae. J Clin Microbiol 48: 3558-3562. https://doi.org/10.1128/JCM.01106-10.
9. Lee GC, Burgess DS. 2012. Treatment of Klebsiella pneumoniae carbapenemase (KPC) infections: A review of published case series and case reports. Ann Clin Microbiol Antimicrob 11: 32. https://doi.org/10.1186/1476-0711-11-32.
10. Ariza-Heredia EJ, Patel R, Blumberg EA, Walker RC, Lewis R, Evans J, Sankar A, Willliams MD, Rogers J, Milano C, Razonable RR. 2012. Outcomes of transplantation using organs from a donor infected with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. Transpl Infect Dis 14: 229-236. https://doi.org/10.1111/j.1399-3062.2012.00742.x.
11. Aitken SL, Tarrand JJ, Deshpande LM, Tverdek FP, Jones AL, Shelburne SA, Prince RA, Bhatti MM, Rolston KVI, Jones RN, Castanheira M, Chemaly RF. 2016. High rates of nonsusceptibility to ceftazidime-avibactam and identification of New Delhi metallo-beta-lactamase production in Enterobacteriaceae bloodstream infections at a major cancer center. Clin Infect Dis 63: 954-958. https://doi.org/10.1093/cid/ciw398.
12. Shields RK, Potoski BA, Haidar G, Hao B, Doi Y, Chen L, Press EG, Kreiswirth BN, Clancy CJ, Nguyen MH. 2016. Clinical outcomes, drug toxicity, and emergence of ceftazidime-avibactam resistance among patients treated for carbapenem-resistant Enterobacteriaceae infections. Clin Infect Dis 63: 1615-1618. https://doi.org/10.1093/cid/ciw636.
13. Haidar G, Clancy CJ, Shields RK, Hao B, Cheng S, Nguyen MH. 2017. Mutations in blaKPC-3 that confer ceftazidime-avibactam resistance encode novel KPC-3 variants that function as extended-spectrum betalactamases. Antimicrob Agents Chemother 61: E02534-16. https://doi.org/10.1128/AAC.02534-16.
14. Thomson GK, Snyder JW, McElheny CL, Thomson KS, Doi Y. 2016. Coproduction of KPC-18 and VIM-1 carbapenemases by Enterobacter cloacae: Implications for newer beta-lactam-beta-lactamase inhibitor combinations. J Clin Microbiol 54: 791-794. https://doi.org/10.1128/JCM.02739-15.
15. Poirel L, Nordmann P. 2015. Rapidec Carba NP test for rapid detection of carbapenemase producers. J Clin Microbiol 53: 3003-3008. https://doi.org/10.1128/JCM.00977-15.
16. Garg A, Garg J, Upadhyay GC, Agarwal A, Bhattacharjee A. 2015. Evaluation of the Rapidec Carba NP test kit for detection of carbapenemaseproducing Gram-negative Bacteria. Antimicrob Agents Chemother 59: 7870-7872. https://doi.org/10.1128/AAC.01783-15.
17. Kabir MH, Meunier D, Hopkins KL, Giske CG, Woodford N. 2016. A two-centre evaluation of RAPIDEC(R) CARBA NP for carbapenemase detection in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. J Antimicrob Chemother 71: 1213-1216. https://doi.org/10.1093/jac/dkv468.
18. Lifshitz Z, Adler A, Carmeli Y. 2016. Comparative study of a novel biochemical assay, the Rapidec Carba NP test, for detecting carbapenemase-producing Enterobacteriaceae. J Clin Microbiol 54: 453-456. https://doi.org/10.1128/JCM.02626-15.
19. Noel A, Huang TD, Berhin C, Hoebeke M, Bouchahrouf W, Yunus S, Bogaerts P, Glupczynski Y. 2017. Comparative evaluation of four phenotypic tests for detection of carbapenemase-producing Gram-negative bacteria. J Clin Microbiol 55: 510-518. https://doi.org/10.1128/JCM.01853-16.
20. Robledo IE, Aquino EE, Sante MI, Santana JL, Otero DM, Leon CF, Vazquez GJ. 2010. Detection of KPC in Acinetobacter spp. in Puerto Rico. Antimicrob Agents Chemother 54: 1354-1135. https://doi.org/10.1128/AAC.00899-09.
21. Poirel L, Potron A, Nordmann P. 2012. OXA-48-like carbapenemases: The phantom menace. J Antimicrob Chemother 67: 1597-1606. https://doi.org/10.1093/jac/dks121.
22. Doyle D, Peirano G, Lascols C, Lloyd T, Church DL, Pitout JD. 2012. Laboratory detection of Enterobacteriaceae that produce carbapenemases. J Clin Microbiol 50: 3877-3880. https://doi.org/10.1128/JCM.02117-12.
23. Girlich D, Poirel L, Nordmann P. 2012. Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae. J Clin Microbiol 50: 477-479. https://doi.org/10.1128/JCM.05247-11.
24. Moland ES, Kim SY, Hong SG, Thomson KS. 2008. Newer beta-lactamases: Clinical and laboratory implications, part II. Clin Microbiol Newsl 30: 79-84. https://doi.org/10.1016/j.clinmicnews.2008.05.001.
25. Weisenberg SA, Morgan DJ, Espinal-Witter R, Larone DH. 2009. Clinical outcomes of patients with Klebsiella pneumoniae carbapenemaseproducing K. pneumoniae after treatment with imipenem or meropenem. Diagn Microbiol Infect Dis 64: 233-235. https://doi.org/10.1016/j.diagmicrobio.2009.02.004.
26. Girlich D, Poirel L, Nordmann P. 2008. Do CTX-M beta-lactamases hydrolyse ertapenem? J Antimicrob Chemother 62: 1155-1156. https://doi.org/10.1093/jac/dkn317.
27. Lartigue MF, Poirel L, Poyart C, Reglier-Poupet H, Nordmann P. 2007. Ertapenem resistance of Escherichia coli. Emerg Infect Dis 13: 315-317. https://doi.org/10.3201/eid1302.060747.
28. Girlich D, Poirel L, Nordmann P. 2009. CTX-M expression and selection of ertapenem resistance in Klebsiella pneumoniae and Escherichia coli. Antimicrob Agents Chemother 53: 832-834. https://doi.org/10.1128/AAC.01007-08.