Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): Study protocol for a randomised controlled trial

Trials

Volumn 17, Issue 1, 2016, Pages

  Krag, Mette ^a   Perner, Anders ^a   Wetterslev, Jørn ^a   Wise, Matt P ^b   Borthwick, Mark ^c   Bendel, Stepani ^d   Pelosi, Paolo ^e   Keus, Frederik ^f   Guttormsen, Anne Berit ^g   Schefold, Joerg C ^h   Møller, Morten Hylander ^a  

^a University of Copenhagen   (Denmark)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^c OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF GENOA   (Italy)

^f UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^g HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^h UNIVERSITY OF BERN   (Switzerland)

Author keywords

Adverse event; Critically ill; Gastrointestinal bleeding; Intensive care unit; Placebo; Randomised clinical trial; Stress ulcer prophylaxis

Indexed keywords

PANTOPRAZOLE; PLACEBO; PROTON PUMP INHIBITOR; ANTIULCER AGENT;

ACUTE LIVER FAILURE; AGRANULOCYTOSIS; ANGIONEUROTIC EDEMA; ARTICLE; CLINICAL EFFECTIVENESS; CLOSTRIDIUM DIFFICILE INFECTION; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; DRUG EFFECT; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; GASTROINTESTINAL HEMORRHAGE; HEALTH CARE COST; HEART MUSCLE ISCHEMIA; HUMAN; INTERSTITIAL NEPHRITIS; MORTALITY; OUTCOME ASSESSMENT; PANCYTOPENIA; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RISK FACTOR; STEVENS JOHNSON SYNDROME; STOMACH PROTECTION; STRESS ULCER; TOXIC EPIDERMAL NECROLYSIS; CLINICAL PROTOCOL; CONTROLLED STUDY; COST BENEFIT ANALYSIS; CRITICAL ILLNESS; CROSS INFECTION; DRUG ADMINISTRATION; DRUG COST; ECONOMICS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; EUROPE; HOSPITAL COST; METHODOLOGY; MYOCARDIAL ISCHEMIA; PEPTIC ULCER; PEPTIC ULCER HEMORRHAGE; TIME FACTOR; TREATMENT OUTCOME;

ANTI-ULCER AGENTS; CLINICAL PROTOCOLS; COST-BENEFIT ANALYSIS; CRITICAL ILLNESS; CROSS INFECTION; DRUG ADMINISTRATION SCHEDULE; DRUG COSTS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; EUROPE; HOSPITAL COSTS; HUMANS; MYOCARDIAL ISCHEMIA; PEPTIC ULCER; PEPTIC ULCER HEMORRHAGE; PNEUMONIA; PROTON PUMP INHIBITORS; RESEARCH DESIGN; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84963759675     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/s13063-016-1331-3     Document Type: Article

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