Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia

Clinical Science

Volumn 131, Issue 23, 2017, Pages 2777-2789

  Stanhewicz, Anna E ^a   Jandu, Sandeep ^b   Santhanam, Lakshmi ^b   Alexander, Lacy M ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLESTEROL; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; HEMOGLOBIN A1C; NITRIC OXIDE; NORADRENALIN;

ARTICLE; BLOOD VESSEL REACTIVITY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COHORT ANALYSIS; CONDUCTANCE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MICROVASCULATURE; PREECLAMPSIA; PRIORITY JOURNAL; PUERPERIUM; SKIN BLOOD FLOW; SYSTOLIC BLOOD PRESSURE; VASCULAR DISEASE; VASOCONSTRICTION; VASODILATATION; ADULT; BIOPSY; DRUG EFFECTS; ELECTRODERMAL RESPONSE; METABOLISM; MICRODIALYSIS; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; SIGNAL TRANSDUCTION; SKIN; VASCULAR ENDOTHELIUM; YOUNG ADULT;

ACETYLCHOLINE; ADULT; BIOPSY; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FEMALE; GALVANIC SKIN RESPONSE; HUMANS; MICRODIALYSIS; MICROVESSELS; NITRIC OXIDE; NOREPINEPHRINE; PRE-ECLAMPSIA; PREGNANCY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; SIGNAL TRANSDUCTION; SKIN; VASOCONSTRICTION; VASODILATION; YOUNG ADULT;

EID: 85035779055     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20171292     Document Type: Article

References (61)

1. Mosca, L., Benjamin, E.J., Berra, K., Bezanson, J.L., Dolor, R.J., Lloyd-Jones, D.M. et al. (2011) Effectiveness-based guidelines for the prevention of cardiovascular disease in women-2011 update: a guideline from the American heart association. Circulation 123, 1243-1262, Epub 2011/02/18
2. Drost, J.T., Arpaci, G., Ottervanger, J.P., de Boer, M.J., van Eyck, J., van der Schouw, Y.T. et al. (2012) Cardiovascular risk factors in women 10 years post early preeclampsia: the Preeclampsia Risk EValuation in FEMales study (PREVFEM). Eur. J. Prev. Cardiol. 19, 1138-1144, Epub 2011/08/24
3. Yinon, Y., Kingdom, J.C., Odutayo, A., Moineddin, R., Drewlo, S., Lai, V. et al. (2010) Vascular dysfunction in women with a history of preeclampsia and intrauterine growth restriction: insights into future vascular risk. Circulation 122, 1846-1853, Epub 2010/10/20
4. Uzan, J., Carbonnel, M., Piconne, O., Asmar, R. and Ayoubi, J.M. (2011) Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc. Health Risk Manage. 7, 467-474, Epub 2011/08/09
5. Bellamy, L., Casas, J.P., Hingorani, A.D. and Williams, D.J. (2007) Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. Br. Med. J. 335, 974, Epub 2007/11/03
6. Mongraw-Chaffin, M.L., Cirillo, P.M. and Cohn, B.A. (2010) Preeclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort. Hypertension 56, 166-171, Epub 2010/06/03
7. Ahmed, R., Dunford, J., Mehran, R., Robson, S. and Kunadian, V. (2014) Pre-eclampsia and future cardiovascular risk among women: a review. J. Am. Coll. Cardiol. 63, 1815-1822, Epub 2014/03/13
8. Haukkamaa, L., Salminen, M., Laivuori, H., Leinonen, H., Hiilesmaa, V. and Kaaja, R. (2004) Risk for subsequent coronary artery disease after preeclampsia. Am. J. Cardiol. 93, 805-808, Epub 2004/03/17
9. Ghossein-Doha, C., van Neer, J., Wissink, B., Breetveld, N.M., de Windt, L.J., van Dijk, A.P. et al. (2017) Pre-eclampsia: an important risk factor for asymptomatic heart failure. Ultrasound Obst. Gynecol. 49, 143-149, Epub 2016/11/03
10. Jonsdottir, L.S., Arngrimsson, R., Geirsson, R.T., Sigvaldason, H. and Sigfusson, N. (1995) Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstet. Gynecol. Scand. 74, 772-776, Epub 1995/11/01
11. Arnadottir, G.A., Geirsson, R.T., Arngrimsson, R., Jonsdottir, L.S. and Olafsson, O. (2005) Cardiovascular death in women who had hypertension in pregnancy: a case-control study. BJOG 112, 286-292, Epub 2005/02/17
12. Alvarez-Alvarez, B., Martell-Claros, N., Abad-Cardiel, M. and Garcia-Donaire, J.A. (2017) Hypertensive disorders during pregnancy: cardiovascular long-term outcomes. Hipertension y Riesgo Vascular 34, 85-92, Epub 2016/07/11
13. Chambers, J.C., Fusi, L., Malik, I.S., Haskard, D.O., De Swiet, M. and Kooner, J.S. (2001) Association of maternal endothelial dysfunction with preeclampsia. JAMA 285, 1607-1612, Epub 2001/04/13
14. Hausvater, A., Giannone, T., Sandoval, Y.H., Doonan, R.J., Antonopoulos, C.N., Matsoukis, I.L. et al. (2012) The association between preeclampsia and arterial stiffness. J. Hypertens. 30, 17-33, Epub 2011/12/03
15. Evans, C.S., Gooch, L., Flotta, D., Lykins, D., Powers, R.W., Landsittel, D. et al. (2011) Cardiovascular system during the postpartum state in women with a history of preeclampsia. Hypertension 58, 57-62, Epub 2011/05/25
16. Orabona, R., Sciatti, E., Vizzardi, E., Bonadei, I., Valcamonico, A., Metra, M. et al. (2017) Endothelial dysfunction and vascular stiffness in women with previous pregnancy complicated by early or late pre-eclampsia. Ultrasound Obst. Gynecol. 49, 116-123, Epub 2016/02/27
17. Hamad, R.R., Eriksson, M.J., Silveira, A., Hamsten, A. and Bremme, K. (2007) Decreased flow-mediated dilation is present 1 year after a pre-eclamptic pregnancy. J. Hypertens. 25, 2301-2307, Epub 2007/10/09
18. Scholten, R.R., Spaanderman, M.E., Green, D.J., Hopman, M.T. and Thijssen, D.H. (2014) Retrograde shear rate in formerly preeclamptic and healthy women before and after exercise training: relationship with endothelial function. Am. J. Physiol. Heart and Circulatory Physiol. 307, H418-H425, Epub 2014/06/08
19. White, W.M., Mielke, M.M., Araoz, P.A., Lahr, B.D., Bailey, K.R., Jayachandran, M. et al. (2016) A history of preeclampsia is associated with a risk for coronary artery calcification 3 decades later. Am. J. Obstet. Gynecol. 214, 519e1-519e8, Epub 2016/02/14
20. Stanhewicz, A.E., Jandu, S., Santhanam, L. and Alexander, L.M. (2017) Increased angiotensin II sensitivity contributes to microvascular dysfunction in women who have had preeclampsia. Hypertension 70, 382-389, Epub 2017/06/28
21. Saxena, A.R., Karumanchi, S.A., Brown, N.J., Royle, C.M., McElrath, T.F. and Seely, E.W. (2010) Increased sensitivity to angiotensin II is present postpartum in women with a history of hypertensive pregnancy. Hypertension 55, 1239-1245, Epub 2010/03/24
22. Verdonk, K., Saleh, L., Lankhorst, S., Smilde, J.E., van Ingen, M.M., Garrelds, I.M. et al. (2015) Association studies suggest a key role for endothelin-1 in the pathogenesis of preeclampsia and the accompanying renin-angiotensin-aldosterone system suppression. Hypertension 65, 1316-1323, Epub 2015/04/15
23. Aggarwal, P.K., Chandel, N., Jain, V. and Jha, V. (2012) The relationship between circulating endothelin-1, soluble fms-like tyrosine kinase-1 and soluble endoglin in preeclampsia. J. Hum. Hypertens. 26, 236-241, Epub 2011/04/01
24. Brewer, J., Liu, R., Lu, Y., Scott, J., Wallace, K., Wallukat, G. et al. (2013) Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy. Hypertension 62, 886-892, Epub 2013/09/18
25. George, E.M., Palei, A.C. and Granger, J.P. (2012) Endothelin as a final common pathway in the pathophysiology of preeclampsia: therapeutic implications. Curr. Opin. Nephrol. Hypertens. 21, 157-162, Epub 2012/01/20
26. Mazzuca, M.Q., Li, W., Reslan, O.M., Yu, P., Mata, K.M. and Khalil, R.A. (2014) Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. Hypertension 64, 632-643, Epub 2014/06/11
27. Walther, G., Obert, P., Dutheil, F., Chapier, R., Lesourd, B., Naughton, G. et al. (2015) Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction: cross-sectional study. Arterioscler. Thromb. Vasc. Biol. 35, 1022-1029, Epub 2015/02/07
28. Holowatz, L.A., Thompson-Torgerson, C.S. and Kenney, W.L. (2008) The human cutaneous circulation as a model of generalized microvascular function. J. Appl. Physiol. 105, 370-372, Epub 2007/10/13
29. Kenney, W.L., Cannon, J.G. and Alexander, L.M. (2013) Cutaneous microvascular dysfunction correlates with serum LDL and sLOX-1 receptor concentrations. Microvasc. Res. 85, 112-117, Epub 2012/11/10
30. Khan, F., Patterson, D., Belch, J.J., Hirata, K. and Lang, C.C. (2008) Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography. Clin. Sci. (Lond.) 115, 295-300, Epub 2008/03/15
31. Coulon, P., Constans, J. and Gosse, P. (2012) Impairment of skin blood flow during post-occlusive reactive hyperhemy assessed by laser Doppler flowmetry correlates with renal resistive index. J. Hum. Hypertens. 26, 56-63, Epub 2011/01/21
32. Debbabi, H., Bonnin, P., Ducluzeau, P.H., Leftheriotis, G. and Levy, B.I. (2010) Noninvasive assessment of endothelial function in the skin microcirculation. Am. J. Hypertens. 23, 541-546, Epub 2010/02/20
33. ACOG practice bulletin (2002) Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int. J. Gynaecol. Obst. 77, 67-75, Epub 2002/07/04
34. Bruning, R.S., Santhanam, L., Stanhewicz, A.E., Smith, C.J., Berkowitz, D.E., Kenney, W.L. et al. (2012) Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin. J. Appl. Physiol. 112, 2019-2026, Epub 2012/04/14
35. Wenner, M.M., Taylor, H.S. and Stachenfeld, N.S. (2013) Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors. Am. J. Physiol. Endocrinol. Metab. 305, E818-E825, Epub 2013/08/08
36. Wenner, M.M., Taylor, H.S. and Stachenfeld, N.S. (2011) Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome. J. Physiol. 589, 4671-4679, Epub 2011/08/10
37. Johnson, J.M., O'Leary, D.S., Taylor, W.F. and Kosiba, W. (1986) Effect of local warming on forearm reactive hyperaemia. Clin. Physiol. 6, 337-346, Epub 1986/08/01
38. Smith, C.J., Santhanam, L., Bruning, R.S., Stanhewicz, A., Berkowitz, D.E. and Holowatz, L.A. (2011) Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans. Hypertension 58, 935-942, Epub 2011/09/21
39. Minson, C.T., Berry, L.T. and Joyner, M.J. (2001) Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J. Appl. Physiol. (1985) 91, 1619-1626, Epub 2001/09/25
40. Minson, C.T. (2010) Thermal provocation to evaluate microvascular reactivity in human skin. J. Appl. Physiol. 109, 1239-1246, Epub 2010/05/29
41. Greaney, J.L., Stanhewicz, A.E., Kenney, W.L. and Alexander, L.M. (2014) Lack of limb or sex differences in the cutaneous vascular responses to exogenous norepinephrine. J. Appl. Physiol. (1985) 117, 1417-1423, Epub 2014/10/25
42. DuPont, J.J., Greaney, J.L., Wenner, M.M., Lennon-Edwards, S.L., Sanders, P.W., Farquhar, W.B. et al. (2013) High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J. Hypertens. 31, 530-536, Epub 2012/12/25
43. Wenner, M.M., Sebzda, K.N., Kuczmarski, A.V., Pohlig, R.T. and Edwards, D.G. (2017) ETB receptor contribution to vascular dysfunction in postmenopausal women. Am. J. Physiol. Regulatory, Integrative Comparative Physiol. 313, R51-R57, Epub 2017/04/26
44. Wenner, M.M., Wilson, T.E., Davis, S.L. and Stachenfeld, N.S. (2011) Pharmacological curve fitting to analyze cutaneous adrenergic responses. J. Appl. Physiol. (1985) 111, 1703-1709, Epub 2011/08/27
45. Roberts, L., LaMarca, B.B., Fournier, L., Bain, J., Cockrell, K. and Granger, J.P. (2006) Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusion. Hypertension 47, 615-618, Epub 2006/01/05
46. Alexander, B.T., Rinewalt, A.N., Cockrell, K.L., Massey, M.B., Bennett, W.A. and Granger, J.P. (2001) Endothelin type a receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure. Hypertension 37, 485-489, Epub 2001/03/07
47. LaMarca, B., Speed, J., Fournier, L., Babcock, S.A., Berry, H., Cockrell, K. et al. (2008) Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: effect of tumor necrosis factor-alpha blockade. Hypertension 52, 1161-1167, Epub 2008/11/05
48. Bernardi, F.C., Vuolo, F., Petronilho, F., Michels, M., Ritter, C. and Dal-Pizzol, F. (2015) Plasma nitric oxide, endothelin-1, arginase and superoxide dismutase in the plasma and placentae from preeclamptic patients. An. Acad. Bras. Cienc. 87, 713-719, Epub 2015/05/21
49. Fuchs, D., Dupon, P.P., Schaap, L.A. and Draijer, R. (2017) The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis. Cardiovasc. Diabetol. 16, 11, Epub 2017/01/21
50. Ergul, A., Shoemaker, K., Puett, D. and Tackett, R.L. (1998) Gender differences in the expression of endothelin receptors in human saphenous veins in vitro. J. Pharmacol. Exp. Ther. 285, 511-517, Epub 1998/05/15
51. Kitada, K., Ohkita, M. and Matsumura, Y. (2012) Pathological Importance of the Endothelin-1/ET(B) Receptor System on Vascular Diseases. Cardiology Res. Practice 2012, 731970, Epub 2012/08/18
52. Kellogg, Jr, D.L., Liu, Y. and Pergola, P.E. (2001) Selected contribution: Gender differences in the endothelin-B receptor contribution to basal cutaneous vascular tone in humans. J. Appl. Physiol. (1985) 91, 2407-2411, discussion 389-90. Epub 2001/10/20
53. Lee, D.K. and Nevo, O. (2016) Microvascular endothelial cells from preeclamptic women exhibit altered expression of angiogenic and vasopressor factors. Am. J. Physiol. Heart Circ. Physiol. 310, H1834-H1841, Epub 2016/05/21
54. Tam Tam, K.B., George, E., Cockrell, K., Arany, M., Speed, J., Martin, Jr., J.N. et al. (2011) Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance. Am. J. Obstet. Gynecol. 204, 330e1-334e1, Epub 2011/04/05
55. LaMarca, B., Parrish, M., Ray, L.F., Murphy, S.R., Roberts, L., Glover, P. et al. (2009) Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1. Hypertension 54, 905-909, Epub 2009/08/26
56. Murphy, S.R., LaMarca, B.B., Cockrell, K. and Granger, J.P. (2010) Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats. Hypertension 55, 394-398, Epub 2009/12/23
57. Laffin, L.J. and Bakris, G.L. (2015) Endothelin antagonism and hypertension: an evolving target. Semin. Nephrol. 35, 168-175, Epub 2015/05/13
58. Gohar, E.Y., Giachini, F.R., Pollock, D.M. and Tostes, R.C. (2016) Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases. Life Sci. 159, 20-29, Epub 2016/03/05
59. Orabona, R., Sciatti, E., Vizzardi, E., Bonadei, I., Prefumo, F., Valcamonico, A. et al. (2017) Maternal endothelial function and vascular stiffness after HELLP syndrome: a case-control study. Ultrasound Obst. Gynecol. 50, 596-602, Epub 2016/12/23
60. Weissgerber, T.L., Milic, N.M., Milin-Lazovic, J.S. and Garovic, V.D. (2016) Impaired flow-mediated dilation before, during, and after preeclampsia: a systematic review and meta-analysis. Hypertension 67, 415-423, Epub 2015/12/30
61. Henriques, A.C., Carvalho, F.H., Feitosa, H.N., Macena, R.H., Mota, R.M. and Alencar, J.C. (2014) Endothelial dysfunction after pregnancy-induced hypertension. Int. J. Gynaecol. Obst. 124, 230-234, Epub 2013/12/12