Microvascular endothelial cells from preeclamptic women exhibit altered expression of angiogenic and vasopressor factors

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 310, Issue 11, 2016, Pages H1834-H1841

  Lee, Dennis K ^a   Nevo, Ori ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Angiotensin; Blood pressure; Cardiovascular diseases; Endothelin; Hypertension

Indexed keywords

ANGIOGENIC FACTOR; ANGIOTENSIN 1 RECEPTOR; APELIN RECEPTOR; ENDOGLIN; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; HYPERTENSIVE FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PLACENTAL GROWTH FACTOR; PROSTACYCLIN SYNTHASE; THROMBOXANE SYNTHASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; ANGIOTENSIN RECEPTOR; KDR PROTEIN, HUMAN; VASCULOTROPIN A;

ADULT; ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CAPILLARY ENDOTHELIAL CELL; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; MAGNETIC SEPARATION; PHENOTYPE; PREECLAMPSIA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; WESTERN BLOTTING; ENDOTHELIUM CELL; GENETICS; METABOLISM; PHYSIOLOGY; PREGNANCY; SIGNAL TRANSDUCTION;

ADULT; ENDOGLIN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION; HUMANS; MAP KINASE SIGNALING SYSTEM; PRE-ECLAMPSIA; PREGNANCY; RECEPTORS, ANGIOTENSIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84983775962     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00083.2016     Document Type: Article

References (47)

1. Abdel-Samad D, Bkaily G, Magder S, Jacques D. ETA and ETB receptors contribute to neuropeptide Y-induced secretion of endothelin-1 in right but not left human ventricular endocardial endothelial cells. Neuropeptides 55: 145–153, 2016.
2. American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol 122: 1122–1131, 2013.
3. Amraoui F, Spijkers L, Hassani Lahsinoui H, Vogt L, van der Post J, Peters S, Afink G, Ris-Stalpers C, van den Born BJ. SFlt-1 elevates blood pressure by augmenting endothelin-1-mediated vasoconstriction in mice. PLoS One 9: e91897, 2014.
4. Avedanian L, Riopel J, Bkaily G, Nader M, D’Orleans-Juste P, Jacques D. ETA receptors are present in human aortic vascular endothe-lial cells and modulate intracellular calcium. Can J Physiol Pharmacol 88: 817–829, 2010.
5. Carmeliet P. Angiogenesis in health and disease. Nat Med 9: 653–660, 2003.
6. Cha ST, Talavera D, Demir E, Nath AK, Sierra-Honigmann MR. A method of isolation and culture of microvascular endothelial cells from mouse skin. Microvasc Res 70: 198–204, 2005.
7. Chaiworapongsa T, Chaemsaithong P, Yeo L, Romero R. Pre-eclamp-sia part 1: current understanding of its pathophysiology. Nat Rev Nephrol 10: 466–480, 2014.
8. Chavarria ME, Lara-Gonzalez L, Gonzalez-Gleason A, Garcia-Paleta Y, Vital-Reyes VS, Reyes A. Prostacyclin/thromboxane early changes in pregnancies that are complicated by preeclampsia. Am J Obstet Gynecol 188: 986–992, 2003.
9. Cindrova-Davies T, Sanders DA, Burton GJ, Charnock-Jones DS. Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling. Cardiovasc Res 89: 671–679, 2011.
10. Dalzell JR, Rocchiccioli JP, Weir RA, Jackson CE, Padmanabhan N, Gardner RS, Petrie MC, McMurray JJ. The emerging potential of the apelin-APJ system in heart failure. J Card Fail 21: 489–498, 2015.
11. Dekker GA, Kraayenbrink AA, Zeeman GG, van Kamp GJ. Increased plasma levels of the novel vasoconstrictor peptide endothelin in severe pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 40: 215–220, 1991.
12. George EM, Granger JP. Endothelin: key mediator of hypertension in preeclampsia. Am J Hypertens 24: 964–969, 2011.
13. Gogg S, Smith U, Jansson PA. Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1. Diabetes 58: 2238–2245, 2009.
14. Herse F, LaMarca B. Angiotensin II type 1 receptor autoantibody (AT1-AA)-mediated pregnancy hypertension. Am J Reprod Immunol 69: 413–418, 2013.
15. Hewett PW. Vascular endothelial cells from human micro-and macroves-sels: isolation, characterisation and culture. Methods Mol Biol 467: 95–111, 2009.
16. Hewett PW, Murray JC. Immunomagnetic purification of human mi-crovessel endothelial cells using Dynabeads coated with monoclonal antibodies to PECAM-1. Eur J Cell Biol 62: 451–454, 1993.
17. Hood JD, Meininger CJ, Ziche M, Granger HJ. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol Heart Circ Physiol 274: H1054–H1058, 1998.
18. Inuzuka H, Nishizawa H, Inagaki A, Suzuki M, Ota S, Miyamura H, Miyazaki J, Sekiya T, Kurahashi H, Udagawa Y. Decreased expression of apelin in placentas from severe pre-eclampsia patients. Hypertens Pregnancy 32: 410–421, 2013.
19. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morpho-logic and immunologic criteria. J Clin Invest 52: 2745–2756, 1973.
20. Lang I, Pabst MA, Hiden U, Blaschitz A, Dohr G, Hahn T, Desoye G. Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells. Eur J Cell Biol 82: 163–173, 2003.
21. Langenkamp E, Molema G. Microvascular endothelial cell heterogene-ity: general concepts and pharmacological consequences for anti-angio-genic therapy of cancer. Cell Tissue Res 335: 205–222, 2009.
22. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA. Soluble en-doglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355: 992–1005, 2006.
23. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350: 672–683, 2004.
24. Liu S, Premont RT, Kontos CD, Huang J, Rockey DC. Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-pro-tein betagamma subunit signaling to protein jinase B/Akt. J Biol Chem 278: 49929–49935, 2003.
25. Liu X, Deng F, Yu Z, Xie Y, Hu C, Chen L. Inhibition of endothelin A receptor protects brain microvascular endothelial cells against hypoxiain-duced injury. Int J Mol Med 34: 313–320, 2014.
26. Mastrogiannis DS, O’Brien WF, Krammer J, Benoit R. Potential role of endothelin-1 in normal and hypertensive pregnancies. Am J Obstet Gynecol 165: 1711–1716, 1991.
27. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Liber-mann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and pro-teinuria in preeclampsia. J Clin Invest 111: 649–658, 2003.
28. Mazzuca MQ, Dang Y, Khalil RA. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca(2)]i in mesenteric mi-crovessels of pregnant rats. Br J Pharmacol 169: 1335–1351, 2013.
29. Mazzuca MQ, Li W, Reslan OM, Yu P, Mata KM, Khalil RA. Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. Hypertension 64: 632–643, 2014.
30. Nevo O, Lee DK, Caniggia I. Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta. PLoS One 8: e81176, 2013.
31. Nevo O, Soleymanlou N, Wu Y, Xu J, Kingdom J, Many A, Zamudio S, Caniggia I. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol 291: R1085–R1093, 2006.
32. Orecchia A, Lacal PM, Schietroma C, Morea V, Zambruno G, Failla CM. Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the alpha 5 beta 1 integrin. J Cell Sci 116: 3479–3489, 2003.
33. Osol G, Celia G, Gokina N, Barron C, Chien E, Mandala M, Luksha L, Kublickiene K. Placental growth factor is a potent vasodilator of rat and human resistance arteries. Am J Physiol Heart Circ Physiol 294: H1381–H1387, 2008.
34. Petraglia F, Imperatore A, Challis JR. Neuroendocrine mechanisms in pregnancy and parturition. Endocr Rev 31: 783–816, 2010.
35. Przewlocka-Kosmala M, Kotwica T, Mysiak A, Kosmala W. Reduced circulating apelin in essential hypertension and its association with cardiac dysfunction. J Hypertens 29: 971–979, 2011.
36. Rajakumar A, Michael HM, Rajakumar PA, Shibata E, Hubel CA, Karumanchi SA, Thadhani R, Wolf M, Harger G, Markovic N. Extra-placental expression of vascular endothelial growth factor recep-tor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. Pla-centa 26: 563–573, 2005.
37. Rautureau Y, Schiffrin EL. Endothelin in hypertension: an update. Curr Opin Nephrol Hypertens 21: 128–136, 2012.
38. Romundstad PR, Magnussen EB, Smith GD, Vatten LJ. Hypertension in pregnancy and later cardiovascular risk: common antecedents? Circu-lation 122: 579–584, 2010.
39. Sanchez A, Martinez P, Munoz M, Benedito S, Garcia-Sacristan A, Hernandez M, Prieto D. Endothelin-1 contributes to endothelial dysfunc-tion and enhanced vasoconstriction through augmented superoxide pro-duction in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol 171: 5682–5695, 2014.
40. Scott A, Mellor H. VEGF receptor trafficking in angiogenesis. Biochem Soc Trans 37: 1184–1188, 2009.
41. Sek AC, Xie Z, Terai K, Long LM, Nelson C, Dudek AZ, Druey KM. Endothelial expression of endothelin receptor A in the systemic capillary leak syndrome. PLoS One 10: e0133266, 2015.
42. Shao R, Guo X. Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis. Biochem Biophys Res Commun 321: 788–794, 2004.
43. Simons M. An inside view: VEGF receptor trafficking and signaling. Physiology (Bethesda) 27: 213–222, 2012.
44. Sobrevia L, Abarzua F, Nien JK, Salomon C, Westermeier F, Puebla C, Cifuentes F, Guzman-Gutierrez E, Leiva A, Casanello P. Review: Differential placental macrovascular and microvascular endothelial dys-function in gestational diabetes. Placenta 32, Suppl 2: S159–S164, 2011.
45. Soleymanlou N, Jurisica I, Nevo O, Ietta F, Zhang X, Zamudio S, Post M, Caniggia I. Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab 90: 4299–4308, 2005.
46. Wassmer SC, Moxon CA, Taylor T, Grau GE, Molyneux ME, Craig AG. Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF. Cell Micro-biol 13: 198–209, 2011.
47. Wheeler-Jones C, Abu-Ghazaleh R, Cospedal R, Houliston RA, Mar-tin J, Zachary I. Vascular endothelial growth factor stimulates prostacy-clin production and activation of cytosolic phospholipase A2 in endothe-lial cells via p42/p44 mitogen-activated protein kinase. FEBS Lett 420: 28–32, 1997.