Construction of glycerol synthesis pathway in Klebsiella pneumoniae for bioconversion of glucose into 1,3-propanediol

Biotechnology and Bioprocess Engineering

Volumn 22, Issue 5, 2017, Pages 549-555

  Zong, Hong ^a   Liu, Xiaohong ^b   Chen, Wenqiang ^b   Zhuge, Bin ^a   Sun, Jin ^c  

^a JIANGNAN UNIVERSITY   (China)

^b SHAANXI UNIVERSITY OF TECHNOLOGY   (China)

^c Zhejiang Zhengwei Food Co   (China)

Author keywords

1,3 propanediol; glycerol 3 phosphatase; glycerol 3 phosphate dehydrogenase; Klebsiella pneumoniae

Indexed keywords

BACTERIA; CARBON; ENCODING (SYMBOLS); FERMENTATION; GENE ENCODING; GENES; GLUCOSE; PHOSPHATASES; SIGNAL ENCODING; YEAST;

1 ,3 PROPANEDIOL; CANDIDA GLYCERINOGENES; CARBON COMPOUNDS; KLEBSIELLA PNEUMONIAE; METABOLIC PATHWAYS; POLYMER MATERIALS; SYNTHESIS PATHWAYS; SYNTHETIC PATHWAYS;

GLYCEROL;

1,3 PROPANEDIOL; 1,3 PROPANEDIOL OXIDOREDUCTASE; GLUCOSE; GLYCEROL; GLYCEROL 3 PHOSPHATASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CANDIDA GLYCERINOGENES; CARBON SOURCE; DEHYDROGENATION; ENZYME ACTIVITY; FERMENTATION; KLEBSIELLA PNEUMONIAE; NONHUMAN; SACCHAROMYCES CEREVISIAE; WILD TYPE;

EID: 85035136994     PISSN: 12268372     EISSN: 19763816     Source Type: Journal    
DOI: 10.1007/s12257-016-0375-2     Document Type: Article

References (23)

1. Nakamura, C. E. and G. M. Whited (2003) Metabolic engineering for the microbial production of 1,3-propanediol. Curr. Opin. Biotech. 14: 454–459.
2. Oh, B. R., J. W. Seo, S. Y. Heo, L. H. Luo, W. K. Hong, D. H. Park, and C. H. Kim (2013) Efficient production of 1,3-propanediol from glycerol upon constitutive expression of the 1,3-propanediol oxidoreductase gene in engineered Klebsiella pneumoniae with the elimination of by-product formation. Bioproc. Biosyst. Eng. 36: 757–763.
3. Seo, J. W., M. Y. Seo, B. R. Oh, S. Y. Heo, J. O. Baek, D. Rairakhwada, L. H. Luo, W. K. Hong, and C. H. Kim (2010) Identification and utilization of a 1,3-propanediol oxidoreductase isoenzyme for the production of 1,3-propanediol from glycerol in Klebsiella pneumoniae. Appl. Microbiol. Biotechnol. 85: 659–666.
4. Zhu, J. G., S. Li, X. J. Ji, H. Huang, and N. Hu (2009) Enhanced 1,3-propanediol production in recombinant Klebsiella pneumoniae carrying the gene yqhD encoding 1,3-propanediol oxidoreductase isoenzyme. World J. Microb. Biot. 25: 1217–1223.
5. Zhao, Y. N., G. Chen, and S. J. Yao (2006) Microbial production of 1,3-propanediol from glycerol by encapsulated Klebsiella pneumoniae. Biochem. Eng. J. 32: 93–99.
6. Hartlep, M., W. Hussmann, N. Prayitno, I. Meynial-Salles, and A. P. Zeng (2002) Study of two-stage processes for the microbial production of 1,3-propanediol from glucose. Appl. Microbiol. Biotechnol. 60: 60–66.
7. Nakamura, C. E., A. A. Gatenby, A. K. H. Hsu, R.D. La Reau, S. L. Haynie, M. Diaz-torres, D. E. Trimbur, G. M. Whited, V. Nagarajan, M. S. Payne, S. K. Picataggio, and R. V. Nair (2000) Method for the production of 1,3-propanediol by recombinant microorganisms. US Patent 6,013,494.
8. Ma, Z., Z. M. Rao, W. Shen, H. Y. Fang, and J. Zhuge (2007) Construction of recombinant Saccharomyces cerevisiae producing 1,3-propanediol by one step method. Acta Microbiolog. Sin. 47: 598–603.
9. Liang, Q., H. Zhang, S. Li, and Q. Qi (2011) Construction of stress-induced metabolic pathway from glucose to 1,3-propanediol in Escherichia coli. Appl. Microbiol. Biotechnol. 89: 57–62.
10. Fang, H. Y., C. Zhang, B. Zhuge, and J. Zhuge (2009) Construction of novel recombinant strains capable of producing 1,3-propanediol. Chin. J. Appl. Environ. Biol. 15: 708–712.
11. Saxena, R. K., P. Anand, S. Saran, and J. Isar (2009) Microbial production of 1,3-propanediol: Recent developments and emerging opportunities. Biotech. Adv. 27: 895–913.
12. Albertyn, J., A. V. Tonder, and B. A. Prior (1992) Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae. FEBS. Lett. 308: 130–132.
13. Norbeck, J., A. K. Pâhlman, N. Akhta, A. Blomberg, and L. Adler (1996) Purification and Characterization of Two Isoenzymes of DL-Glycerol-3-phosphatase from Saccharomyces cerevisiae. J. Biol. Chem. 271: 13875–13881.
14. Ji, X. J., H. Huang, J. G. Zhu, L. J. Ren, Z. K. Nie, J. Du, and S. Li (2010) Engineering Klebsiella oxytoca for efficient 2,3-butanediol production through insertional inactivation of acetaldehyde dehydrogenase gene. Appl. Microbiol. Biotechnol. 85: 1751–1758.
15. +-dependent glycerol-3-phosphate dehydrogenase gene from Candida glycerinogenes, an industrial glycerol producer. FEMS. Yeast. Res. 8: 725–734.
16. Khan, N. H., T. S. Kang, D. A. Grahame, M. C. Haakensen, K. Ratanapariyanuch, M. J. Reaney, D. R. Korber, and T. Tanaka (2013) Isolation and characterization of novel 1,3-propanediolproducing Lactobacillus planes PM1 from bioethanol thin stillage. Appl. Microbiol. Biotechnol. 97: 417–428.
17. Zhang, X., Y. Li, B. Zhuge, X. Tang, W. Shen, Z. M. Rao, H. Y. Fang, and J. Zhuge (2006) Construction of a novel recombinant Escherichia coli strain capable of producing 1,3-propanediol and optimization of fermentation parameters by statistical design. World J. Microb. Biot. 22: 945–952.
18. Zhuge, B., C. Zhang, H. Y. Fang, J. Zhuge, and K. Permaul (2010) Expression of 1,3-propanediol oxidoreductase and its isoenzyme in Klebsiella pneumoniae for bioconversion of glycerol into 1,3-propanediol. Appl. Microbiol. Biotechnol. 87: 2177–2184.
19. Xie, T., H. Y. Fang, B. Zhuge, and J. Zhuge (2009) Promotional mechanism of high glycerol productivity in the aerobic batch fermentation of Candida glycerinogenes after feeding several amino acids. Appl. Biochem. Microbiol. 45: 303–308.
20. Zhang, Y., Y. Li, C. Du, M. Liu, and Z. Cao (2006) Inactivation of aldehyde dehydrogenase: A key factor for engineering 1,3-propanediol production by Klebsiella pneumoniae. Metab. Eng. 8: 578–586.
21. Streekstra, H., de Mattos, M. J. Teixeira, O. M. Neijssel, and D. W. Tempest (1987) Overflow metabolism during anaerobic growth of Klebsiella aerogenes NCTC 418 on glycerol and dihydroxyacetone in chemostat culture. Arch. Microbiol. 147: 268–275.
22. Menzel, K., A. P. Zeng, and W. D. Deckwer (1997) High concentration and productivity of 1,3-propanediol from continuous fermentation of glycerol by Klebsiella pneumoniae. Enz. Microb. Tech. 20: 82–86.
23. Zhang, Y. P., C. Y. Du, Z. M. Rao, and Z. Cao (2005) Regulation of vitamin C and vitamin E on the biosynthesis of 1,3-propanediol by Klebsiella pneumoniae. Chin. J. Proc. Eng. 5: 197–200.