Effects of saponin from trigonella foenum-graecum seeds on dyslipidemia

Iranian Journal of Medical Sciences

Volumn 42, Issue 6, 2017, Pages 577-585

  Chen, Zhi ^a,b   Lei, Yan Li ^b   Wang, Wen Ping ^b,c,d   Lei, Ya Ya ^b   Liu, Yan Hua ^b,c,d   Hei, Jing ^b   Hu, Jin ^b   Sui, Hong ^b,c,d  

^a SHIMANE UNIVERSITY   (Japan)

^b NINGXIA MEDICAL UNIVERSITY   (China)

^c Modernization of Hui Medicine   (China)

^d BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Cholesterol; Dyslipidemias; Fenugreek; Saponins

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ATORVASTATIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; LIPID; SAPONIN; SCAVENGER RECEPTOR BI; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BIOCHEMICAL ANALYSIS; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DATA ANALYSIS SOFTWARE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DYSLIPIDEMIA; FENUGREEK; GENE EXPRESSION; HISTOPATHOLOGY; IN VIVO STUDY; LIPID BLOOD LEVEL; LIPID DIET; LIVER TISSUE; MALE; NIEMANN-PICK DISEASE CELL LINE; NONHUMAN; PLANT SEED; PROTEIN EXPRESSION; RAT;

EID: 85035057006     PISSN: 02530716     EISSN: 17353688     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Mehrafarin A, Rezazadeh Sh, Naghdi Badi H, Noormohammadi Gh, Zand E, Qaderi A. A Review on Biology, Cultivation and Biotechnology of Fenugreek (Trigonella foenum-graecum L.) as a Valuable Medicinal Plant and Multipurpose. Journal of Medicinal Plants. 2011;10:6-24. doi: 10.4172/2157-7110.1000181.
2. Sushma N, Devasena T. Aqueous extract of Trigonella foenum graecum (fenugreek) prevents cypermethrin-induced hepatotoxicity and nephrotoxicity. Hum Exp Toxicol. 2010;29:311-9. doi: 10.1177/0960327110361502. PubMed PMID: 20147568.
3. Haeri MR, Limaki HK, White CJ, White KN. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine. 2012;19:571-4. doi: 10.1016/j.phymed.2012.01.004. PubMed PMID: 22397995.
4. Hamza N, Berke B, Cheze C, Le Garrec R, Umar A, Agli AN, et al. Preventive and curative effect of Trigonella foenum-graecum L. seeds in C57BL/6J models of type 2 diabetes induced by high-fat diet. J Ethnopharmacol. 2012;142:516-22. doi: 10.1016/j.jep.2012.05.028. PubMed PMID: 22633967.
5. Muraki E, Matsuoka C, Oikawa R, Sato S, Chiba H, Tsunoda N, et al. Fenugreek attenuates lipid accumulation in normal rats. J Jpn Nutr Food Sci. 2011;64:99-106. doi: 10.4327/jsnfs.64.99.
6. Kumar P, Bhandari U, Jamadagni S. Fenugreek seed extract inhibit fat accumulation and ameliorates dyslipidemia in high fat diet-induced obese rats. Biomed Res Int. 2014;2014:606021. doi: 10.1155/2014/606021. PubMed PMID: 24868532; PubMed Central PMCID: PMC4020548.
7. Vijayakumar MV, Pandey V, Mishra GC, Bhat MK. Hypolipidemic effect of fenugreek seeds is mediated through inhibition of fat accumulation and upregulation of LDL receptor. Obesity (Silver Spring). 2010;18:667-74. doi: 10.1038/oby.2009.337. PubMed PMID: 19851306.
8. Uemura T, Goto T, Kang MS, Mizoguchi N, Hirai S, Lee JY, et al. Diosgenin, the main aglycon of fenugreek, inhibits LXRalpha activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr. 2011;141:17-23. doi: 10.3945/jn.110.125591. PubMed PMID: 21106928.
9. Brown JM, Yu L. Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8). Immunol Endocr Metab Agents Med Chem. 2009;9:18-29. doi: 10.2174/187152209788009797. PubMed PMID: 20174593; PubMed Central PMCID: PMC2824437.
10. Xu Y, Liu Q, Xu Y, Liu C, Wang X, He X, et al. Rutaecarpine suppresses atherosclerosis in ApoE-/-mice through upregulating ABCA1 and SR-BI within RCT. J Lipid Res. 2014;55:1634-47. doi: 10.1194/jlr.M044198. PubMed PMID: 24908654; PubMed Central PMCID: PMC4109758.
11. Sporstol M, Mousavi SA, Eskild W, Roos N, Berg T. ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. BMC Mol Biol. 2007;8:5. doi: 10.1186/1471-2199-8-5. PubMed PMID: 17241464; PubMed Central PMCID: PMC1790708.
12. Canovas A, Quintanilla R, Gallardo D, Diaz I, Noguera JL, Ramirez O, et al. Functional and association studies on the pig HMGCR gene, a cholesterol-synthesis limiting enzyme. Animal. 2010;4:224-33. doi: 10.1017/S1751731109991145. PubMed PMID: 22443876.
13. Li T, Matozel M, Boehme S, Kong B, Nilsson LM, Guo G, et al. Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology. 2011;53:996-1006. doi: 10.1002/ hep.24107. PubMed PMID: 21319191; PubMed Central PMCID: PMC3079544.
14. Hei J, Chen Z, Lei Y, Wang W, Sui H. Investigation of Extraction and Purification Process for Total Saponins in Trigonellae Semen. Chinese Journal of Experimental Traditional Medical Formulae. 2014;20:11-3.
15. Carr TP, Andresen CJ, Rudel LL. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem. 1993;26:39-42. PubMed PMID: 8448837.
16. Yuan JS, Reed A, Chen F, Stewart CN, Jr. Statistical analysis of real-time PCR data. BMC Bioinformatics. 2006;7:85. doi: 10.1186/1471-2105-7-85. PubMed PMID: 16504059; PubMed Central PMCID: PMC1395339.
17. Fuller S, Stephens JM. Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: mechanisms of actions and potential effects on metabolic syndrome. Adv Nutr. 2015;6:189-97. doi: 10.3945/ an.114.007807. PubMed PMID: 25770257; PubMed Central PMCID: PMC4352177.
18. Verma N, Usman K, Patel N, Jain A, Dhakre S, Swaroop A, et al. A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro) in patients with type 2 diabetes. Food Nutr Res. 2016;60:32382. doi: 10.3402/fnr.v60.32382. PubMed PMID: 27733237; PubMed Central PMCID: PMC5061863.
19. Puri D, Prabhu KM, Dev G, Agarwal S, Murthy PS. Mechanism of Antidiabetic Action of Compound GII Purified from Fenugreek (Trigonella foenum graecum) Seeds. Indian J Clin Biochem. 2011;26:335-46. doi: 10.1007/s12291-011-0150-2. PubMed PMID: 23024468; PubMed Central PMCID: PMC3210251.
20. Haritha C, Reddy AG, Reddy YR, Anilkumar B. Pharmacodynamic interaction of fenugreek, insulin and glimepiride on sero-biochemical parameters in diabetic Sprague-Dawley rats. Vet World. 2015;8:656-63. doi: 10.14202/vetworld.2015.656-663. PubMed PMID: 27047152; PubMed Central PMCID: PMC4774730.
21. Mohammadi A, Gholamhosseinian A, Fallah H. Trigonella foenum-graecum water extract improves insulin sensitivity and stimulates PPAR and gamma gene expression in high fructose-fed insulin-resistant rats. Adv Biomed Res. 2016;5:54. doi: 10.4103/2277-9175.178799. PubMed PMID: 27110551; PubMed Central PMCID: PMC4817393.
22. Kumar P, Kale RK, McLean P, Baquer NZ. Antidiabetic and neuroprotective effects of Trigonella foenum-graecum seed powder in diabetic rat brain. Prague Med Rep. 2012;113:33-43. doi: 10.14712/23362936.2015.35. PubMed PMID: 22373803.
23. Kumar P, Kale RK, Baquer NZ. Antihyperglycemic and protective effects of Trigonella foenum graecum seed powder on biochemical alterations in alloxan diabetic rats. Eur Rev Med Pharmacol Sci. 2012;16 Suppl 3:18-27. PubMed PMID: 22957414.
24. Ramulu P, Giridharan NV, Udayasekhararao P. Hypolipidemic effect of soluble dietary fiber (galactomannan) isolated from fenugreek seeds in WNIN (GR-Ob) obese rats. J Med Plant Res. 2011;5:4804-13.
25. Belguith-Hadriche O, Bouaziz M, Jamoussi K, El Feki A, Sayadi S, Makni-Ayedi F. Lipid-lowering and antioxidant effects of an ethyl acetate extract of fenugreek seeds in high-cholesterol-fed rats. J Agric Food Chem. 2010;58:2116-22. doi: 10.1021/jf903186w. PubMed PMID: 20108903.
26. Kalailingam P, Kannaian B, Tamilmani E, Kaliaperumal R. Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats. Phytomedicine. 2014;21:1154-61. doi: 10.1016/j.phymed.2014.04.005. PubMed PMID: 24889525.
27. Son IS, Kim JH, Sohn HY, Son KH, Kim JS, Kwon CS. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats. Biosci Biotechnol Biochem. 2007;71:3063-71. doi: 10.1271/bbb.70472. PubMed PMID: 18071250.
28. Prajapati VD, Jani GK, Moradiya NG, Randeria NP, Nagar BJ, Naikwadi NN, et al. Galactomannan: a versatile biodegradable seed polysaccharide. Int J Biol Macromol. 2013;60:83-92. doi: 10.1016/j. ijbiomac.2013.05.017. PubMed PMID: 23707734.
29. Tang W, Jia L, Ma Y, Xie P, Haywood J, Dawson PA, et al. Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver. Biochim Biophys Acta. 2011;1811:549-55. doi: 10.1016/j.bbalip.2011.05.013. PubMed PMID: 21683156; PubMed Central PMCID: PMC3140631.
30. Hao S, Xu R, Li D, Zhu Z, Wang T, Liu K. Attenuation of Streptozotocin-Induced Lipid Profile Anomalies in the Heart, Brain, and mRNA Expression of HMG-CoA Reductase by Diosgenin in Rats. Cell Biochem Biophys. 2015;72:741-9. doi: 10.1007/s12013-015-0525-8. PubMed PMID: 25631375.