-
2
-
-
0032548830
-
Crystal structure of the tyrosine phosphatase SHP-2
-
Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE. Crystal structure of the tyrosine phosphatase SHP-2. Cell 1998;92:441–50.
-
(1998)
Cell
, vol.92
, pp. 441-450
-
-
Hof, P.1
Pluskey, S.2
Dhe-Paganon, S.3
Eck, M.J.4
Shoelson, S.E.5
-
3
-
-
85006707443
-
Role of PTPN11 (SHP2) in cancer
-
Neel BGand-Tonks NK, editors. New York: Springer ScienceþBusiness Media;
-
Chan G, Neel BG. Role of PTPN11 (SHP2) in cancer. In: Neel BGand-Tonks NK, editors. Protein tyrosine phosphatases in cancer. New York: Springer ScienceþBusiness Media; 2016. pp.115–43.
-
(2016)
Protein Tyrosine Phosphatases in Cancer
, pp. 115-143
-
-
Chan, G.1
Neel, B.G.2
-
4
-
-
84907345106
-
Structure, function, and pathogenesis of SHP2 in developmental disorders and tumorigenesis
-
Huang WQ, Lin Q, Zhuang X, Cai LL, Ruan RS, Lu ZX, et al. Structure, function, and pathogenesis of SHP2 in developmental disorders and tumorigenesis. Curr Cancer Drug Targets 2014;14:567–88.
-
(2014)
Curr Cancer Drug Targets
, vol.14
, pp. 567-588
-
-
Huang, W.Q.1
Lin, Q.2
Zhuang, X.3
Cai, L.L.4
Ruan, R.S.5
Lu, Z.X.6
-
5
-
-
84948674328
-
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
-
Bunda S, Burrell K, Heir P, Zeng L, Alamsahebpour A, Kano Y, et al. Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis. Nat Commun 2015;6:8859.
-
(2015)
Nat Commun
, vol.6
, pp. 8859
-
-
Bunda, S.1
Burrell, K.2
Heir, P.3
Zeng, L.4
Alamsahebpour, A.5
Kano, Y.6
-
7
-
-
33846854905
-
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase
-
Chan RJ, Feng GS. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood 2007;3:862–7.
-
(2007)
Blood
, vol.3
, pp. 862-867
-
-
Chan, R.J.1
Feng, G.S.2
-
8
-
-
85016130633
-
Leukaemo-genic effects of Ptpn11 activating mutations in the stem cell microenvironment
-
Dong L, Yu WM, Zheng H, Loh ML, Bunting ST, Pauly M, et al. Leukaemo-genic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature 2016;539:304–8.
-
(2016)
Nature
, vol.539
, pp. 304-308
-
-
Dong, L.1
Yu, W.M.2
Zheng, H.3
Loh, M.L.4
Bunting, S.T.5
Pauly, M.6
-
9
-
-
44049086087
-
SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis
-
Zhou X, Coad J, Ducatman B, Agazie YM. SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis. Histopath 2008;53:389–402.
-
(2008)
Histopath
, vol.53
, pp. 389-402
-
-
Zhou, X.1
Coad, J.2
Ducatman, B.3
Agazie, Y.M.4
-
10
-
-
84859571797
-
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
-
Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, et al. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med 2012; 18:529–37.
-
(2012)
Nat Med
, vol.18
, pp. 529-537
-
-
Aceto, N.1
Sausgruber, N.2
Brinkhaus, H.3
Gaidatzis, D.4
Martiny-Baron, G.5
Mazzarol, G.6
-
11
-
-
84952774308
-
SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer
-
Matalkah F, Martin E, Zhao H, Agazie YM. SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer. Breast Cancer Res 2016;18:2.
-
(2016)
Breast Cancer Res
, vol.18
, pp. 2
-
-
Matalkah, F.1
Martin, E.2
Zhao, H.3
Agazie, Y.M.4
-
12
-
-
84960803308
-
Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition
-
Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, et al. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene 2016;35:1271–82.
-
(2016)
Oncogene
, vol.35
, pp. 1271-1282
-
-
Zhang, K.1
Zhao, H.2
Ji, Z.3
Zhang, C.4
Zhou, P.5
Wang, L.6
-
13
-
-
84995740074
-
SHP2 phosphatase as a novel therapeutic target for melanoma treatment
-
Zhang RY, Yu ZH, Zeng L, Zhang S, Bai Y, Miao J, et al. SHP2 phosphatase as a novel therapeutic target for melanoma treatment. Oncotarget 2016; 7:73817–29.
-
(2016)
Oncotarget
, vol.7
, pp. 73817-73829
-
-
Zhang, R.Y.1
Yu, Z.H.2
Zeng, L.3
Zhang, S.4
Bai, Y.5
Miao, J.6
-
14
-
-
84942833027
-
PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs
-
Prahallad A, Heynen GJ, Germano G, Willems SM, Evers B, Vecchione L, et al. PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs. Cell Rep 2015;12:1978–85.
-
(2015)
Cell Rep
, vol.12
, pp. 1978-1985
-
-
Prahallad, A.1
Heynen, G.J.2
Germano, G.3
Willems, S.M.4
Evers, B.5
Vecchione, L.6
-
15
-
-
84906080682
-
Therapeutic potential of targeting the oncogenic SHP2 phosphatase
-
Zeng LF, Zhang RY, Yu ZH, Li S, Wu L, Gunawan AM, et al. Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem 2014;57:6594–609.
-
(2014)
J Med Chem
, vol.57
, pp. 6594-6609
-
-
Zeng, L.F.1
Zhang, R.Y.2
Yu, Z.H.3
Li, S.4
Wu, L.5
Gunawan, A.M.6
-
16
-
-
77949853380
-
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)
-
Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, et al. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J Med Chem 2010;53:2482–93.
-
(2010)
J Med Chem
, vol.53
, pp. 2482-2493
-
-
Zhang, X.1
He, Y.2
Liu, S.3
Yu, Z.4
Jiang, Z.X.5
Yang, Z.6
-
17
-
-
84866866031
-
Role of SHP2 phosphatase in KIT induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT
-
Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, et al. Role of SHP2 phosphatase in KIT induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood 2012;120: 2669–78.
-
(2012)
Blood
, vol.120
, pp. 2669-2678
-
-
Mali, R.S.1
Ma, P.2
Zeng, L.F.3
Martin, H.4
Ramdas, B.5
He, Y.6
-
18
-
-
84928489506
-
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo
-
Grosskopf S, Eckert C, Arkona C, Radetzki S, Bohm K, Heinemann U, et al. Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo. Chem-MedChem 2015;10:815–26.
-
(2015)
Chem-MedChem
, vol.10
, pp. 815-826
-
-
Grosskopf, S.1
Eckert, C.2
Arkona, C.3
Radetzki, S.4
Bohm, K.5
Heinemann, U.6
-
19
-
-
84978416165
-
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
-
Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature 2016;535:148–52.
-
(2016)
Nature
, vol.535
, pp. 148-152
-
-
Chen, Y.N.1
LaMarche, M.J.2
Chan, H.M.3
Fekkes, P.4
Garcia-Fortanet, J.5
Acker, M.G.6
-
21
-
-
0035834386
-
A phosphatase associated with metastasis of colorectal cancer
-
Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, et al. A phosphatase associated with metastasis of colorectal cancer. Science 2001;294:1343–6.
-
(2001)
Science
, vol.294
, pp. 1343-1346
-
-
Saha, S.1
Bardelli, A.2
Buckhaults, P.3
Velculescu, V.E.4
Rago, C.5
St Croix, B.6
-
22
-
-
0344629830
-
PRL-3 expression in metastatic cancers
-
Bardelli A, Saha S, Sager JA, Romans KE, Markowitz SD, Lengauer C, et al. PRL-3 expression in metastatic cancers. Clin Cancer Res 2003;15:5607–15.
-
(2003)
Clin Cancer Res
, vol.15
, pp. 5607-5615
-
-
Bardelli, A.1
Saha, S.2
Sager, J.A.3
Romans, K.E.4
Markowitz, S.D.5
Lengauer, C.6
-
23
-
-
84963764162
-
Phosphatase PTP4A3 promotes triple-negative breast cancer growth and predicts poor patient survival
-
den Hollander P, Rawls K, Tsimelzon A, Shephard J, Mazumdar A, Fuqua SA, et al. Phosphatase PTP4A3 promotes triple-negative breast cancer growth and predicts poor patient survival. Cancer Res 2016;76:1942–53.
-
(2016)
Cancer Res
, vol.76
, pp. 1942-1953
-
-
Den Hollander, P.1
Rawls, K.2
Tsimelzon, A.3
Shephard, J.4
Mazumdar, A.5
Fuqua, S.A.6
-
24
-
-
84971671969
-
Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancers
-
Gari HH, Gearheart CM, Fosmire S, DeGala GD, Fan Z, Torkko KC, et al. Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancers. Oncotarget 2016;7:15757–71.
-
(2016)
Oncotarget
, vol.7
, pp. 15757-15771
-
-
Gari, H.H.1
Gearheart, C.M.2
Fosmire, S.3
DeGala, G.D.4
Fan, Z.5
Torkko, K.C.6
-
25
-
-
33749592145
-
Overexpression of phosphatase of regenerating liver-3 in breast cancer: Association with a poor clinical outcome
-
Wang L, Peng L, Dong B, Kong L, Meng L, Yan L, et al. Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome. Ann Oncol 2006;17:1517–22.
-
(2006)
Ann Oncol
, vol.17
, pp. 1517-1522
-
-
Wang, L.1
Peng, L.2
Dong, B.3
Kong, L.4
Meng, L.5
Yan, L.6
-
26
-
-
85001728274
-
Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia
-
Kobayashi M, Bai Y, Chen S, Gao R, Yao C, Cai W, et al. Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia. Leukemia 2017;31:751–4.
-
(2017)
Leukemia
, vol.31
, pp. 751-754
-
-
Kobayashi, M.1
Bai, Y.2
Chen, S.3
Gao, R.4
Yao, C.5
Cai, W.6
-
27
-
-
34248155345
-
PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition
-
Wang H, Quah SY, Dong JM, Manser E, Tang JP, Zeng Q. PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. Cancer Res 2007;67:2922–6.
-
(2007)
Cancer Res
, vol.67
, pp. 2922-2926
-
-
Wang, H.1
Quah, S.Y.2
Dong, J.M.3
Manser, E.4
Tang, J.P.5
Zeng, Q.6
-
28
-
-
84895913865
-
The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis
-
Hardy S, Uetani N, Wong N, Kostantin E, Labbe DP, Begin LR, et al. The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. Oncogene 2015;34: 986–95.
-
(2015)
Oncogene
, vol.34
, pp. 986-995
-
-
Hardy, S.1
Uetani, N.2
Wong, N.3
Kostantin, E.4
Labbe, D.P.5
Begin, L.R.6
-
29
-
-
84915818520
-
Membrane protein CNNM4-dependent Mg2þ efflux suppresses tumor progression
-
Funato Y, Yamazaki D, Mizukami S, Du L, Kikuchi K, Miki H. Membrane protein CNNM4-dependent Mg2þ efflux suppresses tumor progression. J Clin Invest 2014;124:5398–410.
-
(2014)
J Clin Invest
, vol.124
, pp. 5398-5410
-
-
Funato, Y.1
Yamazaki, D.2
Mizukami, S.3
Du, L.4
Kikuchi, K.5
Miki, H.6
-
30
-
-
84999751761
-
Phospho-cysteine in the PRL-CNNM pathway mediates magnesium homeostasis
-
Gulerez I, Funato Y, Wu H, Yang M, Kozlov G, Miki H, et al. Phospho-cysteine in the PRL-CNNM pathway mediates magnesium homeostasis. EMBO Rep 2016;17:1890–900.
-
(2016)
EMBO Rep
, vol.17
, pp. 1890-1900
-
-
Gulerez, I.1
Funato, Y.2
Wu, H.3
Yang, M.4
Kozlov, G.5
Miki, H.6
-
31
-
-
85010699655
-
Structural basis of the oncogenic interaction of phosphatase PRL-1 with the magnesium transporter CNNM2
-
Gimenez-Mascarell P, Oyenarte I, Hardy S, Breiderhoff T, Stuiver M, Kostantin E, et al. Structural basis of the oncogenic interaction of phosphatase PRL-1 with the magnesium transporter CNNM2. J Biol Chem 2017;292:786–801.
-
(2017)
J Biol Chem
, vol.292
, pp. 786-801
-
-
Gimenez-Mascarell, P.1
Oyenarte, I.2
Hardy, S.3
Breiderhoff, T.4
Stuiver, M.5
Kostantin, E.6
-
32
-
-
84875506390
-
Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer
-
Zimmerman MW, Homanics GE, Lazo JS. Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. PLoS One 2013;8:e58300.
-
(2013)
PLoS One
, vol.8
, pp. e58300
-
-
Zimmerman, M.W.1
Homanics, G.E.2
Lazo, J.S.3
-
33
-
-
84988835871
-
Role of Phosphatase of Regenerating Liver 1 (PRL-1) in spermatogenesis
-
Bai Y, Zhou HM, Zhang L, Dong Y, Zeng Q, Shou W, et al. Role of Phosphatase of Regenerating Liver 1 (PRL-1) in spermatogenesis. Sci Rep 2016;6:34211.
-
(2016)
Sci Rep
, vol.6
, pp. 34211
-
-
Bai, Y.1
Zhou, H.M.2
Zhang, L.3
Dong, Y.4
Zeng, Q.5
Shou, W.6
-
34
-
-
84866346272
-
Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein
-
Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, et al. Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. J Biol Chem 2012; 287:32172–9.
-
(2012)
J Biol Chem
, vol.287
, pp. 32172-32179
-
-
Dong, Y.1
Zhang, L.2
Zhang, S.3
Bai, Y.4
Chen, H.5
Sun, X.6
-
35
-
-
84893673469
-
Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis
-
Dong Y, Zhang L, Bai Y, Zhou HM, Campbell AM, Chen H, et al. Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis. J Biol Chem 2014;289:3799–810.
-
(2014)
J Biol Chem
, vol.289
, pp. 3799-3810
-
-
Dong, Y.1
Zhang, L.2
Bai, Y.3
Zhou, H.M.4
Campbell, A.M.5
Chen, H.6
-
36
-
-
84902603173
-
PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal
-
Kobayashi M, Bai Y, Dong Y, Chen S, Gao R, Zhang L, et al. PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal. Stem Cells 2014;32:1956–7.
-
(2014)
Stem Cells
, vol.32
, pp. 1956-1957
-
-
Kobayashi, M.1
Bai, Y.2
Dong, Y.3
Chen, S.4
Gao, R.5
Zhang, L.6
-
37
-
-
79953038262
-
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
-
Hollander MC,Blumenthal GM,Dennis PA.PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 2011;11:289–301.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 289-301
-
-
Hollander, M.C.1
Blumenthal, G.M.2
Dennis, P.A.3
-
38
-
-
39449127662
-
A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage
-
Daouti S, Li WH, Qian H, Huang KS, Holmgren J, Levin W, et al. A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. Cancer Res 2008;68:1162–9.
-
(2008)
Cancer Res
, vol.68
, pp. 1162-1169
-
-
Daouti, S.1
Li, W.H.2
Qian, H.3
Huang, K.S.4
Holmgren, J.5
Levin, W.6
-
39
-
-
84969253461
-
Inhibition of PRL-2CNNM3 protein complex formation decreases breast cancer proliferation and tumor growth
-
Kostantin E, Hardy S, Valinsky WC, Kompatscher A, de Baaij JH, Zolotarov Y, et al. Inhibition of PRL-2CNNM3 protein complex formation decreases breast cancer proliferation and tumor growth. J Biol Chem 2016;291: 10716–25.
-
(2016)
J Biol Chem
, vol.291
, pp. 10716-10725
-
-
Kostantin, E.1
Hardy, S.2
Valinsky, W.C.3
Kompatscher, A.4
De Baaij, J.H.5
Zolotarov, Y.6
-
40
-
-
84979031648
-
Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor
-
Salamoun JM, McQueeney KE, Patil K, Geib SJ, Sharlow ER, Lazo JS, et al. Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor. Org Biomol Chem 2016;14:6398–402.
-
(2016)
Org Biomol Chem
, vol.14
, pp. 6398-6402
-
-
Salamoun, J.M.1
McQueeney, K.E.2
Patil, K.3
Geib, S.J.4
Sharlow, E.R.5
Lazo, J.S.6
-
41
-
-
84911478385
-
Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver
-
Hoeger B, Diether M, Ballester PJ, Kohn M. Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver. Eur J Med Chem 2014;88: 89–100.
-
(2014)
Eur J Med Chem
, vol.88
, pp. 89-100
-
-
Hoeger, B.1
Diether, M.2
Ballester, P.J.3
Kohn, M.4
-
42
-
-
84982182373
-
Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase
-
Bai Y, Yu ZH, Liu S, Zhang L, Zhang RY, Zeng LF, et al. Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase. Cancer Res 2016;76:4805–15.
-
(2016)
Cancer Res
, vol.76
, pp. 4805-4815
-
-
Bai, Y.1
Yu, Z.H.2
Liu, S.3
Zhang, L.4
Zhang, R.Y.5
Zeng, L.F.6
-
43
-
-
85099691247
-
PRL3-zumab, a first-in-class humanized antibody for cancer therapy
-
Thura M, Al-Aidaroos AQ, Yong WP, Kono K, Gupta A, Lin YB, et al. PRL3-zumab, a first-in-class humanized antibody for cancer therapy. JCI Insight 2016;1:e87607.
-
(2016)
JCI Insight
, vol.1
, pp. e87607
-
-
Thura, M.1
Al-Aidaroos, A.Q.2
Yong, W.P.3
Kono, K.4
Gupta, A.5
Lin, Y.B.6
|