Dose-response effects of aerobic exercise on body composition among colon cancer survivors: A randomised controlled trial

British Journal of Cancer

Volumn 117, Issue 11, 2017, Pages 1614-1620

  Brown, Justin C ^a   Zemel, Babette S ^b,c   Troxel, Andrea B ^d   Rickels, Michael R ^c   Damjanov, Nevena ^c   Ky, Bonnie ^c   Rhim, Andrew D ^e   Rustgi, Anil K ^c   Courneya, Kerry S ^f   Schmitz, Kathryn H ^g  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f UNIVERSITY OF ALBERTA   (Canada)

^g PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

obesity; physical activity; prevention; recurrence; visceral adipose tissue; waist circumference

Indexed keywords

ADULT; AEROBIC EXERCISE; ARTICLE; BODY COMPOSITION; BONE DENSITY; CANCER RECURRENCE; CANCER SURVIVOR; CLINICAL ARTICLE; CLINICAL OUTCOME; COLON CANCER; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE INTENSITY; FAT MASS; FEMALE; HUMAN; INTRAPERITONEAL FAT; LEAN BODY WEIGHT; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SUBCUTANEOUS FAT; WAIST CIRCUMFERENCE; AGED; COLON TUMOR; EXERCISE; INTRAABDOMINAL FAT; METABOLISM; MIDDLE AGED; MORTALITY; PREVENTION AND CONTROL; TUMOR RECURRENCE;

ADULT; AGED; BODY COMPOSITION; CANCER SURVIVORS; COLONIC NEOPLASMS; EXERCISE; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL;

EID: 85034843491     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2017.339     Document Type: Article

References (37)

1. Ahima RS, Flier JS (2000) Adipose tissue as an endocrine organ. Trends Endocrinol Metab 11(8): 327-332.
2. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O'Brien WL, Bassett Jr DR, Schmitz KH, Emplaincourt PO, Jacobs Jr DR, Leon AS (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32(9 Suppl): S498-S504.
3. Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, Shiraishi R, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K (2007) Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro. Am J Physiol Gastrointest Liver Physiol 292(3): G923-G929.
4. André T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J (2004) Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350(23): 2343-2351.
5. Belavý D, Möhlig M, Pfeiffer A, Felsenberg D, Armbrecht G (2014) Preferential deposition of visceral adipose tissue occurs due to physical inactivity. Int J Obes 38(11): 1478-1480.
6. Bredella MA, Gill CM, Keating LK, Torriani M, Anderson EJ, Punyanitya M, Wilson KE, Kelly TL, Miller KK (2013) Assessment of abdominal fat compartments using DXA in premenopausal women from anorexia nervosa to morbid obesity. Obesity 21(12): 2458-2464.
7. Brito EC, Lyssenko V, Renström F, Berglund G, Nilsson PM, Groop L, Franks PW (2009) Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes. Diabetes 58(6): 1411-1418.
8. Brown JC, Troxel AB, Ky B, Damjanov N, Zemel BS, Rickels MR, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH (2016) A randomized phase II dose-response exercise trial among colon cancer survivors: purpose, study design, methods, and recruitment results. Contemp Clin Trials 47: 366-375.
9. Brown JC, Troxel AB, Ky B, Damjanov N, Zemel BS, Rickels MR, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH (2017) Dose-response effects of aerobic exercise among colon cancer survivors: a randomized phase II trial. Clin Colorectal Cancer; e-pub ahead of print 17 June 2017; doi:10.1016/j.clcc.2017.06.001.
10. Del Corno M, D'Archivio M, Conti L, Scazzocchio B, Vari R, Donninelli G, Varano B, Giammarioli S, De Meo S, Silecchia G, Pennestri F, Persiani R, Masella R, Gessani S (2016) Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and omega6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells. Oncotarget 7(39): 63093-63105.
11. Donninelli G, Del Corno M, Pierdominici M, Scazzocchio B, Vari R, Varano B, Pacella I, Piconese S, Barnaba V, D'Archivio M, Masella R, Conti L, Gessani S (2017) Distinct blood and visceral adipose tissue regulatory T cell and innate lymphocyte profiles characterize obesity and colorectal cancer. Front Immunol 8: 643.
12. Fitzmaurice GM, Laird NM, Ware JH (2012) Applied Longitudinal Analysis Vol. 998, John Wiley & Sons: Hoboken, NJ, USA.
13. Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M, Lee EY, Weiss HL, O'Connor KL, Gao T, Evers BM (2011) mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71(9): 3246-3256.
14. Haydon AM, Macinnis RJ, English DR, Giles GG (2006) Effect of physical activity and body size on survival after diagnosis with colorectal cancer. Gut 55(1): 62-67.
15. Johnson NA, Sachinwalla T, Walton DW, Smith K, Armstrong A, Thompson MW, George J (2009) Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 50(4): 1105-1112.
16. Katzmarzyk PT, Mire E, Bouchard C (2012) Abdominal obesity and mortality: The Pennington Center Longitudinal Study. Nutr Diabetes 2(8): e42.
17. Kay SJ, Fiatarone Singh MA (2006) The influence of physical activity on abdominal fat: a systematic review of the literature. Obes Rev 7(2): 183-200.
18. Kilpelainen TO, Lakka TA, Laaksonen DE, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M (2008) SNPs in PPARG associate with type 2 diabetes and interact with physical activity. Med Sci Sports Exerc 40(1): 25-33.
19. Kuk JL, Katzmarzyk PT, Nichaman MZ, Church TS, Blair SN, Ross R (2006) Visceral fat is an independent predictor of all-cause mortality in men. Obesity 14(2): 336-341.
20. Lee S, Kuk JL, Davidson LE, Hudson R, Kilpatrick K, Graham TE, Ross R (2005) Exercise without weight loss is an effective strategy for obesity reduction in obese individuals with and without type 2 diabetes. J Appl Physiol 99(3): 1220-1225.
21. Liesenfeld DB, Grapov D, Fahrmann JF, Salou M, Scherer D, Toth R, Habermann N, Böhm J, Schrotz-King P, Gigic B (2015) Metabolomics and transcriptomics identify pathway differences between visceral and subcutaneous adipose tissue in colorectal cancer patients: the ColoCare study. Am J Clin Nutr 102(2): 433-443.
22. McCurdy CE, Klemm DJ (2013) Adipose tissue insulin sensitivity and macrophage recruitment: does PI3K pick the pathway? Adipocyte 2(3): 135-142.
23. Meyerhardt JA, Catalano PJ, Haller DG, Mayer RJ, Macdonald JS, Benson 3rd AB, Fuchs CS (2003) Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol 21(3): 433-440.
24. Meyerhardt JA, Heseltine D, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Thomas J, Nelson H, Whittom R, Hantel A, Schilsky RL, Fuchs CS (2006) Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol 24(22): 3535-3541.
25. Micklesfield LK, Goedecke JH, Punyanitya M, Wilson KE, Kelly TL (2012) Dual-energy X-ray performs as well as clinical computed tomography for the measurement of visceral fat. Obesity 20(5): 1109-1114.
26. Paffenbarger R, Wing A, Hyde R (1978) Paffenbarger physical activity questionnaire. Am J Epidemiol 108: 161-175.
27. Park J, Euhus DM, Scherer PE (2011) Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev 32(4): 550-570.
28. Park J, Morley TS, Kim M, Clegg DJ, Scherer PE (2014) Obesity and cancer [mdash] mechanisms underlying tumour progression and recurrence. Nat Rev Endocrinol 10(8): 455-465.
29. Powers C, Fan B, Shepherd J (2014) Importance of image review for accurate reporting of hologic DXA visceral adipose tissue. J Clin Densitom 17(3): 399.
30. Sargent DJ, Wieand HS, Haller DG, Gray R, Benedetti JK, Buyse M, Labianca R, Seitz JF, O'Callaghan CJ, Francini G (2005) Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20, 898 patients on 18 randomized trials. J Clin Oncol 23(34): 8664-8670.
31. Sarraf P, Mueller E, Jones D, King FJ, DeAngelo DJ, Partridge JB, Holden SA, Chen LB, Singer S, Fletcher C (1998) Differentiation and reversal of malignant changes in colon cancer through PPARg. Nat Med 4(9): 1046-1052.
32. Schmid D, Leitzmann M (2014) Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol 25(7): 1293-1311.
33. Sebio A, Gerger A, Matsusaka S, Yang D, Zhang W, Stremitzer S, Stintizing S, Sunakawa Y, Yamauchi S, Ning Y (2015) Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer. Pharmacogenet Genomics 25(1): 30.
34. Siegel R, Desantis C, Jemal A (2014) Colorectal cancer statistics, 2014. CA Cancer J Clin 64(2): 104-117.
35. Slentz CA, Houmard JA, Kraus WE (2009) Exercise, abdominal obesity, skeletal muscle, and metabolic risk: evidence for a dose response. Obesity (Silver Spring) 17(Suppl 3(S3)): S27-S33.
36. Xiao J, Mazurak VC, Olobatuyi TA, Caan BJ, Prado CM (2016) Visceral adiposity and cancer survival: a review of imaging studies. Eur J Cancer Care (Engl); e-pub ahead of print 6 December 2017; doi:10.1111/ecc.12611.
37. Zhang Y-J, Dai Q, Sun D-F, Xiong H, Tian X-Q, Gao F-H, Xu M-H, Chen G-Q, Han Z-G, Fang J-Y (2009) mTOR signaling pathway is a target for the treatment of colorectal cancer. Ann Surg Oncol 16(9): 2617-2628.