Comparative analysis of morphological and molecular motifs in bronchiolitis obliterans and alveolar fibroelastosis after lung and stem cell transplantation

Journal of Pathology: Clinical Research

Volumn 3, Issue 1, 2017, Pages 17-28

  Jonigk, Danny ^a,b   Rath, Berenice ^a   Borchert, Paul ^a   Braubach, Peter ^a   Maegel, Lavinia ^a   Izykowski, Nicole ^a   Warnecke, Gregor ^a,b   Sommer, Wiebke ^a,b   Kreipe, Hans ^a   Blach, Robert ^a   Anklamm, Adrian ^a   Haverich, Axel ^a,b   Eder, Matthias ^a   Stadler, Michael ^a   Welte, Tobias ^a,b   Gottlieb, Jens ^a,b   Kuehnel, Mark ^a,b   Laenger, Florian ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)   (Germany)

Author keywords

allograft; bronchiolitis obliterans physiopathology; hematopoietic stem cell transplantation adverse effects; idiopathic pulmonary fibrosis pathology; lung transplantation adverse effects; primary graft dysfunction physiopathology; pulmonary fibrosis pathology

Indexed keywords

FIBRIN;

ALVEOLAR FIBROELASTOSIS; ARTICLE; BRONCHIOLITIS OBLITERANS; CHRONIC LUNG ALLOGRAFT DYSFUNCTION; COMPARATIVE STUDY; CONTROLLED STUDY; DETERIORATION; FEMALE; FIBRINOLYSIS; FIBROGENESIS; GENE EXPRESSION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LASER MICRODISSECTION; LUNG DISEASE; LUNG FUNCTION TEST; LUNG GRAFT REJECTION; LUNG STRUCTURE; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PATHOLOGICAL ANATOMY; POLYMERASE CHAIN REACTION; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

EID: 85034787364     PISSN: None     EISSN: 20564538     Source Type: Journal    
DOI: 10.1002/cjp2.60     Document Type: Article

References (51)

1. Vos R, Verleden SE, Verleden GM. Chronic lung allograft dysfunction: evolving practice. Curr Opin Organ Transpl 2015; 20: 483–491.
2. Verleden SE, Vasilescu DM, McDonough JE, et al. Linking clinical phenotypes of chronic lung allograft dysfunction to changes in lung structure. Eur Respir J 2015; 46: 1430–1439.
3. Suwara MI, Vanaudenaerde BM, Verleden SE, et al. Mechanistic differences between phenotypes of chronic lung allograft dysfunction after lung transplantation. Transpl Int 2014; 27: 857–867.
4. Verleden GM, Raghu G, Meyer KC. A new classification system for chronic lung allograft dysfunction. J Heart Lung Transplant 2014; 33: 127–133.
5. Fuller J, Paraskeva M, Thompson B. A spirometric journey following lung transplantation. Respirol Case Reports 2014; 2: 120–122.
6. Suhling H, Dettmer S, Greer M, et al. Phenotyping chronic lung allograft dysfunction using body plethysmography and computed tomography. Am J Transplant. 2016; 16: 3163–3170.
7. Jonigk D, Izykowski N, Rische J, et al. Molecular profiling in lung biopsies of human pulmonary allografts to predict chronic lung allograft dysfunction. Am J Pathol 2015; 185: 3178–3188.
8. Jonigk D, Merk M, Hussein K, et al. Obliterative airway remodeling: molecular evidence for shared pathways in transplanted and native lungs. Am J Pathol 2011; 178: 599–608.
9. Ishii T, Bandoh S, Kanaji N, et al. Air-leak Syndrome by Pleuroparenchymal Fibroelastosis after Bone Marrow Transplantation. Intern Med 2016; 55: 105–111.
10. Panoskaltsis-Mortari A, Griese M, Madtes DK, et al. An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Care Med 2011; 183: 1262–1279.
11. Bergeron A, Godet C, Chevret S, et al. Bronchiolitis obliterans syndrome after allogeneic hematopoietic SCT: phenotypes and prognosis. Bone Marrow Transplant 2013; 48: 819–824.
12. Sato Y, Takeuchi M, Takata K, et al. Clinicopathologic analysis of IgG4-related skin disease. Mod Pathol 2013; 26: 523–532.
13. Ofek E, Sato M, Saito T, et al. Restrictive allograft syndrome post lung transplantation is characterized by pleuroparenchymal fibroelastosis. Mod Pathol 2013; 26: 350–356.
14. Alici IO, Yekeler E, Yazicioglu A, et al. A case of acute fibrinous and organizing pneumonia during early postoperative period after lung transplantation. Transpl Proc 2015; 47: 836–840.
15. Sato M, Hwang DM, Ohmori-Matsuda K, et al. Revisiting the pathologic finding of diffuse alveolar damage after lung transplantation. J Hear Lung Transpl 2012; 31: 354–363.
16. Costa AN, Carraro RM, Nascimento ECT, et al. Acute fibrinoid organizing pneumonia in lung transplant: the most feared allograft dysfunction. Transplantation 2016; 100: e11–e12.
17. Matsui T, Maeda T, Kida T, et al. Pleuroparenchymal fibroelastosis after allogenic hematopoietic stem cell transplantation: important histological component of late-onset noninfectious pulmonary complication accompanied with recurrent pneumothorax. Int J Hematol 2016; 104: 525–530.
18. Yu J. Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation. Korean J Pediatr 2015; 58: 459–465.
19. Uhlving HH, Andersen CB, Christensen IJ, et al. Biopsy-verified bronchiolitis obliterans and other noninfectious lung pathologies after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transpl 2015; 21: 531–538.
20. von der Thüsen JH, Hansell DM, Tominaga M, et al. Pleuroparenchymal fibroelastosis in patients with pulmonary disease secondary to bone marrow transplantation. Mod Pathol 2011; 24: 1633–1639.
21. Izykowski N, Kuehnel M, Hussein K, et al. Organizing pneumonia in mice and men. J Transl Med 2016; 14: 169.
22. Evers A, Atanasova S, Fuchs-Moll G, et al. Adaptive and innate immune responses in a rat orthotopic lung transplant model of chronic lung allograft dysfunction. Transpl Int 2015; 28: 95–107.
23. Jonigk D, Theophile K, Hussein K, et al. Obliterative airway remodelling in transplanted and non-transplanted lungs. Virchows Arch 2010; 457: 369–380.
24. Bröcker V, Länger F, Fellous TG, et al. Fibroblasts of recipient origin contribute to bronchiolitis obliterans in human lung transplants. Am J Respir Crit Care Med 2006; 173: 1276–1282.
25. Atanasova S, Hirschburger M, Jonigk D, et al. A relevant experimental model for human bronchiolitis obliterans syndrome. J Hear Lung Transpl 2013; 32: 1131–1139.
26. Kellner M, Wehling J, Warnecke G, et al. Correlating 3D morphology with molecular pathology: fibrotic remodelling in human lung biopsies. Thorax 2015; 70: 1197–1198.
27. Kellner M, Heidrich M, Beigel R, et al. Imaging of the mouse lung with scanning laser optical tomography (SLOT). J Appl Physiol 2012; 113: 975–983.
28. Jonigk D, Modde F, Bockmeyer CL. Optimized RNA extraction from non-deparaffinized, laser-microdissected material. Methods Mol Biol 2011; 755: 67–75.
29. Jonigk D, Al-Omari M, Maegel L, et al. Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase. Proc Natl Acad Sci U S A 2013; 110: 15007–15012.
30. Theophile K, Jonigk D, Kreipe H. Amplification of mRNA from laser-microdissected single or clustered cells in formalin-fixed and paraffin-embedded tissues for application in quantitative real-time PCR. Diagn Mol Pathol 2008; 17: 101–106.
31. Jonigk D, Lehmann U, Stuht S, et al. Recipient-derived neoangiogenesis of arterioles and lymphatics in quilty lesions of cardiac allografts. Transplantation 2007; 84: 1335–1342.
32. Shino MY, Weigt SS, Li N, et al. CXCR3 ligands are associated with the continuum of diffuse alveolar damage to chronic lung allograft dysfunction. Am J Respir Crit Care Med 2013; 188: 1117–1125.
33. Takeuchi Y, Miyagawa-Hayashino A, Chen F, et al. Pleuroparenchymal fibroelastosis and non-specific interstitial pneumonia: frequent pulmonary sequelae of haematopoietic stem cell transplantation. Histopathology 2015; 66: 536–544.
34. Konen E, Weisbrod GL, Pakhale S, et al. Fibrosis of the upper lobes: a newly identified late-onset complication after lung transplantation?. AJR Am J Roentgenol 2003; 181: 1539–1543.
35. Pakhale SS, Hadjiliadis D, Howell DN, et al. Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantation. J Hear Lung Transpl 2005; 24: 1260–1268.
36. Parish JM, Muhm JR, Leslie KO. Upper lobe pulmonary fibrosis associated with high-dose chemotherapy containing BCNU for bone marrow transplantation. Mayo Clin Proc 2003; 78: 630–634.
37. Frankel SK, Cool CD, Lynch DA, et al. Idiopathic pleuroparenchymal fibroelastosis: description of a novel clinicopathologic entity. Chest 2004; 126: 2007–2013.
38. Pegorier S, Campbell GA, Kay AB, et al. Bone morphogenetic protein (BMP)−4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF). Respir Res 2010; 11: 85.
39. Molloy EL, Adams A, Moore JB, et al. BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells. Growth Factors 2008; 26: 12–22.
40. Suzuki T, Arumugam P, Sakagami T, et al. Pulmonary macrophage transplantation therapy. Nature 2014; 514: 450–454.
41. Muñoz-Félix JM, González-Núñez M, López-Novoa JM. ALK1-Smad1/5 signaling pathway in fibrosis development: friend or foe? Cytokine Growth Factor Rev 2013; 24: 523–537.
42. Buijs JT, Rentsch CA, van der Horst G, et al. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am J Pathol 2007; 171: 1047–1057.
43. Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003; 9: 964–968.
44. Heijink IH, Rozeveld D, van der Heide S, et al. Metalloproteinase profiling in lung transplant recipients with good outcome and bronchiolitis obliterans syndrome. Transplantation 2015; 99: 1946–1952.
45. Taghavi S, Krenn K, Jaksch P, et al. Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans. Am J Transplant 2005; 5: 1548–1552.
46. Hirota T, Yoshida Y, Kitasato Y, et al. Histological evolution of pleuroparenchymal fibroelastosis. Histopathology 2015; 66: 545–554.
47. Long JL, Tranquillo RT. Elastic fiber production in cardiovascular tissue-equivalents. Matrix Biol 2003; 22: 339–350.
48. Ji X, Wang L, Wu B, et al. Associations of MMP1, MMP2 and MMP3 genes polymorphism with coal workers’ pneumoconiosis in Chinese Han population. Int J Environ Res Public Health 2015; 12: 13901–13912.
49. Mashimo Y, Sakurai-Yageta M, Watanabe M, et al. Induction of the matrix metalloproteinase 13 gene in bronchial epithelial cells by interferon and identification of its novel functional polymorphism. Inflammation 2016; 39: 949–962.
50. Miles LA, Parmer RJ. Angry macrophages patrol for fibrin. Blood 2016; 127: 1079–1080.
51. Kokosi MA, Nicholson AG, Hansell DM, et al. Rare idiopathic interstitial pneumonias: LIP and PPFE and rare histologic patterns of interstitial pneumonias: AFOP and BPIP. Respirology 2016; 21: 600–614.