New Delhi metallo-β-lactamase 1 catalyzes avibactam and aztreonam hydrolysis

Antimicrobial Agents and Chemotherapy

Volumn 61, Issue 12, 2017, Pages

  Lohans, Christopher T ^a   Brem, Jürgen ^a   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antibiotic resistance; Avibactam; Aztreonam; Beta lactamases; Metalloenzymes; Monobactams

Indexed keywords

AVIBACTAM; AZTREONAM; CAPTOPRIL; CEPHALOSPORIN DERIVATIVE; EDETIC ACID; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; AZABICYCLO DERIVATIVE; BETA LACTAMASE; BETA-LACTAMASE NDM-1;

CATALYSIS; CONTROLLED STUDY; DRUG HYDROLYSIS; FLUORINE NUCLEAR MAGNETIC RESONANCE; HUMAN; LETTER; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; SUBSTRATE CONCENTRATION; ULTRAVIOLET SPECTROPHOTOMETRY; DRUG EFFECT; GENETICS; GRAM NEGATIVE BACTERIUM; HYDROLYSIS; METABOLISM; MICROBIAL SENSITIVITY TEST;

ANTI-BACTERIAL AGENTS; AZABICYCLO COMPOUNDS; AZTREONAM; BETA-LACTAMASES; GRAM-NEGATIVE BACTERIA; HUMANS; HYDROLYSIS; MICROBIAL SENSITIVITY TESTS;

EID: 85034739279     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01224-17     Document Type: Letter

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