메뉴 건너뛰기




Volumn 8, Issue 1, 2017, Pages

DNA methylation at enhancers identifies distinct breast cancer lineages

(32)  Fleischer, Thomas a   Tekpli, Xavier a,b   Mathelier, Anthony a,c   Wang, Shixiong c   Nebdal, Daniel a   Dhakal, Hari P d   Sahlberg, Kristine Kleivi a,e   Schlichting, Ellen d   Sauer, Torill b   Geisler, Jürgen b   Hofvind, Solveig h,i   Bathen, Tone F j   Engebraaten, Olav d,g   Garred, Øystein d   Geitvik, Gry Aarum a   Langerød, Anita a   Kåresen, Rolf d,g   Mælandsmo, Gunhild Mari d,k   Russnes, Hege G a,d   Sørlie, Therese a   more..


Author keywords

[No Author keywords available]

Indexed keywords

DNA; ESTROGEN RECEPTOR ALPHA; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTOME; ESTROGEN RECEPTOR ALPHA, HUMAN; FOXA1 PROTEIN, HUMAN; GATA3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 85033801233     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00510-x     Document Type: Article
Times cited : (93)

References (62)
  • 1
    • 84878587983 scopus 로고    scopus 로고
    • Assessment of DNA methylation status in early stages of breast cancer development
    • van Hoesel, A. Q. et al. Assessment of DNA methylation status in early stages of breast cancer development. Br. J. Cancer 108, 2033-2038 (2013).
    • (2013) Br. J. Cancer , vol.108 , pp. 2033-2038
    • Van Hoesel, A.Q.1
  • 3
    • 78650877915 scopus 로고    scopus 로고
    • DNA methylation epigenotypes in breast cancer molecular subtypes
    • Bediaga, N. G. et al. DNA methylation epigenotypes in breast cancer molecular subtypes. Breast Cancer Res. 12, R77 (2010).
    • (2010) Breast Cancer Res. , vol.12 , pp. R77
    • Bediaga, N.G.1
  • 4
    • 80053356357 scopus 로고    scopus 로고
    • Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence
    • Fackler, M. J. et al. Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence. Cancer Res. 71, 6195-6207 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 6195-6207
    • Fackler, M.J.1
  • 5
    • 84924571057 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis
    • Fleischer, T. et al. Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis. Genome. Biol. 15, 435 (2014).
    • (2014) Genome. Biol. , vol.15 , pp. 435
    • Fleischer, T.1
  • 6
    • 77958540564 scopus 로고    scopus 로고
    • Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
    • Holm, K. et al. Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns. Breast Cancer Res. 12, R36 (2010).
    • (2010) Breast Cancer Res. , vol.12 , pp. R36
    • Holm, K.1
  • 7
    • 78951487862 scopus 로고    scopus 로고
    • DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables
    • Kamalakaran, S. et al. DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Mol. Oncol. 5, 77-92 (2011).
    • (2011) Mol. Oncol. , vol.5 , pp. 77-92
    • Kamalakaran, S.1
  • 8
    • 78951491753 scopus 로고    scopus 로고
    • Methylation profiling with a panel of cancer related genes: Association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer
    • Ronneberg, J. A. et al. Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer. Mol. Oncol. 5, 61-76 (2011).
    • (2011) Mol. Oncol. , vol.5 , pp. 61-76
    • Ronneberg, J.A.1
  • 9
    • 79551655285 scopus 로고    scopus 로고
    • Functional and mechanistic diversity of distal transcription enhancers
    • Bulger, M. & Groudine, M. Functional and mechanistic diversity of distal transcription enhancers. Cell 144, 327-339 (2011).
    • (2011) Cell , vol.144 , pp. 327-339
    • Bulger, M.1    Groudine, M.2
  • 10
    • 84899450857 scopus 로고    scopus 로고
    • Transcriptional enhancers: From properties to genome-wide predictions
    • Shlyueva, D., Stampfel, G. & Stark, A. Transcriptional enhancers: from properties to genome-wide predictions. Nat. Rev. Genet. 15, 272-286 (2014).
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 272-286
    • Shlyueva, D.1    Stampfel, G.2    Stark, A.3
  • 11
    • 48749124117 scopus 로고    scopus 로고
    • ChIPping away at gene regulation
    • Massie, C. E. & Mills, I. G. ChIPping away at gene regulation. EMBO Rep. 9, 337-343 (2008).
    • (2008) EMBO Rep. , vol.9 , pp. 337-343
    • Massie, C.E.1    Mills, I.G.2
  • 12
    • 84865249952 scopus 로고    scopus 로고
    • Transcription factors: From enhancer binding to developmental control
    • Spitz, F. & Furlong, E. E. Transcription factors: from enhancer binding to developmental control. Nat. Rev. Genet. 13, 613-626 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 613-626
    • Spitz, F.1    Furlong, E.E.2
  • 13
    • 70449103609 scopus 로고    scopus 로고
    • An oestrogen-receptor-alpha-bound human chromatin interactome
    • Fullwood, M. J. et al. An oestrogen-receptor-alpha-bound human chromatin interactome. Nature 462, 58-64 (2009).
    • (2009) Nature , vol.462 , pp. 58-64
    • Fullwood, M.J.1
  • 14
    • 84881171344 scopus 로고    scopus 로고
    • Enhancer transcripts mark active estrogen receptor binding sites
    • Hah, N., Murakami, S., Nagari, A., Danko, C. G. & Kraus, W. L. Enhancer transcripts mark active estrogen receptor binding sites. Genome Res. 23, 1210-1223 (2013).
    • (2013) Genome Res. , vol.23 , pp. 1210-1223
    • Hah, N.1    Murakami, S.2    Nagari, A.3    Danko, C.G.4    Kraus, W.L.5
  • 15
    • 78651250284 scopus 로고    scopus 로고
    • FOXA1 is a key determinant of estrogen receptor function and endocrine response
    • Hurtado, A., Holmes, K. A., Ross-Innes, C. S., Schmidt, D. & Carroll, J. S. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat. Genet. 43, 27-33 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 27-33
    • Hurtado, A.1    Holmes, K.A.2    Ross-Innes, C.S.3    Schmidt, D.4    Carroll, J.S.5
  • 16
    • 84871995408 scopus 로고    scopus 로고
    • GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility
    • Theodorou, V., Stark, R., Menon, S. & Carroll, J. S. GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility. Genome Res. 23, 12-22 (2013).
    • (2013) Genome Res. , vol.23 , pp. 12-22
    • Theodorou, V.1    Stark, R.2    Menon, S.3    Carroll, J.S.4
  • 17
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister, R. et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462, 315-322 (2009).
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1
  • 18
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman, J. G. & Baylin, S. B. Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349, 2042-2054 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 19
    • 84928335700 scopus 로고    scopus 로고
    • Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer
    • Aure, M. R. et al. Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer. Genome Med. 7, 21 (2015).
    • (2015) Genome Med. , vol.7 , pp. 21
    • Aure, M.R.1
  • 20
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 21
    • 84907196865 scopus 로고    scopus 로고
    • Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer
    • Taberlay, P. C., Statham, A. L., Kelly, T. K., Clark, S. J. & Jones, P. A. Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer. Genome Res. 24, 1421-1432 (2014).
    • (2014) Genome Res. , vol.24 , pp. 1421-1432
    • Taberlay, P.C.1    Statham, A.L.2    Kelly, T.K.3    Clark, S.J.4    Jones, P.A.5
  • 22
    • 84888015137 scopus 로고    scopus 로고
    • Super-enhancers in the control of cell identity and disease
    • Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934-947 (2013).
    • (2013) Cell , vol.155 , pp. 934-947
    • Hnisz, D.1
  • 23
    • 84976872373 scopus 로고    scopus 로고
    • DbSUPER: A database of super-enhancers in mouse and human genome
    • Khan, A. & Zhang, X. dbSUPER: a database of super-enhancers in mouse and human genome. Nucleic Acids Res. 44, D164-D171 (2016).
    • (2016) Nucleic Acids Res. , vol.44 , pp. D164-D171
    • Khan, A.1    Zhang, X.2
  • 24
    • 84887650018 scopus 로고    scopus 로고
    • Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes
    • Beck, D. et al. Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes. Blood 122, E12-E22 (2013).
    • (2013) Blood , vol.122 , pp. E12-E22
    • Beck, D.1
  • 25
    • 78649689206 scopus 로고    scopus 로고
    • Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation
    • Starck, J. et al. Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation. Blood 116, 4795-4805 (2010).
    • (2010) Blood , vol.116 , pp. 4795-4805
    • Starck, J.1
  • 26
    • 69549138554 scopus 로고    scopus 로고
    • Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage
    • Kruse, E. A. et al. Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc. Natl Acad. Sci. USA 106, 13814-13819 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 13814-13819
    • Kruse, E.A.1
  • 27
    • 45549102935 scopus 로고    scopus 로고
    • The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
    • Loughran, S. J. et al. The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat. Immunol. 9, 810-819 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 810-819
    • Loughran, S.J.1
  • 28
    • 84865777819 scopus 로고    scopus 로고
    • ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
    • Landt, S. G. et al. ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Res. 22, 1813-1831 (2012).
    • (2012) Genome Res. , vol.22 , pp. 1813-1831
    • Landt, S.G.1
  • 29
    • 0034982567 scopus 로고    scopus 로고
    • Transcription factors that regulate growth and differentiation of myeloid cells
    • Nagamura-Inoue, T., Tamura, T. & Ozato, K. Transcription factors that regulate growth and differentiation of myeloid cells. Int. Rev. Immunol. 20, 83-105 (2001).
    • (2001) Int. Rev. Immunol. , vol.20 , pp. 83-105
    • Nagamura-Inoue, T.1    Tamura, T.2    Ozato, K.3
  • 30
    • 84944446432 scopus 로고    scopus 로고
    • Integrative analysis of public ChIP-seq experiments reveals a complex multi-cell regulatory landscape
    • Griffon, A. et al. Integrative analysis of public ChIP-seq experiments reveals a complex multi-cell regulatory landscape. Nucleic Acids Res. 43, e27 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , pp. e27
    • Griffon, A.1
  • 31
    • 84856008906 scopus 로고    scopus 로고
    • Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
    • Ross-Innes, C. S. et al. Differential oestrogen receptor binding is associated with clinical outcome in breast cancer. Nature 481, 389-393 (2012).
    • (2012) Nature , vol.481 , pp. 389-393
    • Ross-Innes, C.S.1
  • 32
    • 84961357451 scopus 로고    scopus 로고
    • DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
    • Teschendorff, A. E. et al. DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer. Nat. Commun. 7, 10478 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 10478
    • Teschendorff, A.E.1
  • 33
    • 84988883201 scopus 로고    scopus 로고
    • Global run-on sequencing (GRO-Seq)
    • Gardini, A. Global run-on sequencing (GRO-Seq). Methods Mol. Biol. 1468, 111-120 (2017).
    • (2017) Methods Mol. Biol. , vol.1468 , pp. 111-120
    • Gardini, A.1
  • 34
    • 84884412556 scopus 로고    scopus 로고
    • Defining cell-type specificity at the transcriptional level in human disease
    • Ju, W. et al. Defining cell-type specificity at the transcriptional level in human disease. Genome Res. 23, 1862-1873 (2013).
    • (2013) Genome Res. , vol.23 , pp. 1862-1873
    • Ju, W.1
  • 35
    • 85010962092 scopus 로고    scopus 로고
    • Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studies
    • Zheng, X., Zhang, N., Wu, H. J. & Wu, H. Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studies. Genome Biol. 18, 17 (2017).
    • (2017) Genome Biol. , vol.18 , pp. 17
    • Zheng, X.1    Zhang, N.2    Wu, H.J.3    Wu, H.4
  • 36
    • 84968863271 scopus 로고    scopus 로고
    • Mechanisms and disease associations of haplotype-dependent allele-specific DNA methylation
    • Do, C. et al. Mechanisms and disease associations of haplotype-dependent allele-specific DNA methylation. Am. J. Hum. Genet. 98, 934-955 (2016).
    • (2016) Am. J. Hum. Genet. , vol.98 , pp. 934-955
    • Do, C.1
  • 37
    • 84941365580 scopus 로고    scopus 로고
    • Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells
    • de Goede, O. M. et al. Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells. Clin. Epigenet. 7, 95 (2015).
    • (2015) Clin. Epigenet. , vol.7 , pp. 95
    • De Goede, O.M.1
  • 38
    • 84968431728 scopus 로고    scopus 로고
    • Aging-associated DNA methylation changes in middle-aged individuals: The Young Finns study
    • Kananen, L. et al. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 17, 103 (2016).
    • (2016) BMC Genomics. , vol.17 , pp. 103
    • Kananen, L.1
  • 39
    • 84937026981 scopus 로고    scopus 로고
    • DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer
    • Stone, A. et al. DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer. Nat. Commun. 6, 7758 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 7758
    • Stone, A.1
  • 40
    • 84899145981 scopus 로고    scopus 로고
    • Effect of estrogen receptor alpha binding on functional DNA methylation in breast cancer
    • Ung, M., Ma, X., Johnson, K. C., Christensen, B. C. & Cheng, C. Effect of estrogen receptor alpha binding on functional DNA methylation in breast cancer. Epigenetics 9, 523-532 (2014).
    • (2014) Epigenetics , vol.9 , pp. 523-532
    • Ung, M.1    Ma, X.2    Johnson, K.C.3    Christensen, B.C.4    Cheng, C.5
  • 41
    • 84866844032 scopus 로고    scopus 로고
    • Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns
    • Sproul, D. et al. Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns. Genome Biol. 13, R84 (2012).
    • (2012) Genome Biol. , vol.13 , pp. R84
    • Sproul, D.1
  • 42
    • 38149040758 scopus 로고    scopus 로고
    • CpG island hypermethylation of tumor-suppressor genes in H pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk
    • Kaise, M. et al. CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk. Helicobacter 13, 35-41 (2008).
    • (2008) Helicobacter , vol.13 , pp. 35-41
    • Kaise, M.1
  • 43
    • 33845325205 scopus 로고    scopus 로고
    • Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers
    • Nakajima, T. et al. Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol. Biomarkers Prev. 15, 2317-2321 (2006).
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 2317-2321
    • Nakajima, T.1
  • 44
    • 34047190317 scopus 로고    scopus 로고
    • Epigenetic field for cancerization
    • Ushijima, T. Epigenetic field for cancerization. J. Biochem. Mol. Biol. 40, 142-150 (2007).
    • (2007) J. Biochem. Mol. Biol. , vol.40 , pp. 142-150
    • Ushijima, T.1
  • 45
    • 84952637711 scopus 로고    scopus 로고
    • Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells
    • Quigley, D. A. & Kristensen, V. Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells. Mol. Oncol. 9, 2054-2062 (2015).
    • (2015) Mol. Oncol. , vol.9 , pp. 2054-2062
    • Quigley, D.A.1    Kristensen, V.2
  • 46
    • 84949844816 scopus 로고    scopus 로고
    • Clinical relevance of host immunity in breast cancer: From TILs to the clinic
    • Savas, P. et al. Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Nat. Rev. Clin. Oncol. 13, 228-241 (2016).
    • (2016) Nat. Rev. Clin. Oncol. , vol.13 , pp. 228-241
    • Savas, P.1
  • 47
    • 34547555607 scopus 로고    scopus 로고
    • Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer
    • Naume, B. et al. Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer. Mol. Oncol. 1, 160-171 (2007).
    • (2007) Mol. Oncol. , vol.1 , pp. 160-171
    • Naume, B.1
  • 48
    • 79952049614 scopus 로고    scopus 로고
    • MiRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors
    • Enerly, E. et al. miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors. PLoS ONE 6, e16915 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e16915
    • Enerly, E.1
  • 49
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas N.
    • Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature 490, 61-70 (2012).
    • (2012) Nature , vol.490 , pp. 61-70
  • 50
    • 84862266444 scopus 로고    scopus 로고
    • Complete pipeline for infinium((r)) human methylation 450k beadchip data processing using subset quantile normalization for accurate DNA methylation estimation
    • Touleimat, N. & Tost, J. Complete pipeline for Infinium((R)) Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation. Epigenomics 4, 325-341 (2012).
    • (2012) Epigenomics , vol.4 , pp. 325-341
    • Touleimat, N.1    Tost, J.2
  • 51
    • 85033775861 scopus 로고    scopus 로고
    • R-Core-Team. R: A language and environment for statistical computing (eds R Foundation for Statistical Computing) (2015)
    • R-Core-Team. R: A language and environment for statistical computing (eds R Foundation for Statistical Computing) (2015).
  • 54
    • 69649109364 scopus 로고    scopus 로고
    • Circos: An information aesthetic for comparative genomics
    • Krzywinski, M. et al. Circos: an information aesthetic for comparative genomics. Genome Res. 19, 1639-1645 (2009).
    • (2009) Genome Res. , vol.19 , pp. 1639-1645
    • Krzywinski, M.1
  • 55
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 56
    • 85019986787 scopus 로고    scopus 로고
    • Intervene: A tool for intersection and visualization of multiple gene or genomic region sets
    • Khan, A. & Mathelier, A. Intervene: a tool for intersection and visualization of multiple gene or genomic region sets. BMC Bioinform. 18, 287 (2017).
    • (2017) BMC Bioinform. , vol.18 , pp. 287
    • Khan, A.1    Mathelier, A.2
  • 57
    • 84862908850 scopus 로고    scopus 로고
    • Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
    • Li, G. et al. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell 148, 84-98 (2012).
    • (2012) Cell , vol.148 , pp. 84-98
    • Li, G.1
  • 58
    • 84866127830 scopus 로고    scopus 로고
    • Identifying ChIP-seq enrichment using MACS
    • Feng, J. X., Liu, T., Qin, B., Zhang, Y. & Liu, X. S. Identifying ChIP-seq enrichment using MACS. Nat. Protoc. 7, 1728-1740 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 1728-1740
    • Feng, J.X.1    Liu, T.2    Qin, B.3    Zhang, Y.4    Liu, X.S.5
  • 59
    • 79959198166 scopus 로고    scopus 로고
    • Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA
    • Wang, D. et al. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature 474, 390-394 (2011).
    • (2011) Nature , vol.474 , pp. 390-394
    • Wang, D.1
  • 60
    • 67649834440 scopus 로고    scopus 로고
    • ChIP-seq: Using high-throughput sequencing to discover protein-DNA interactions
    • Schmidt, D. et al. ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. Methods 48, 240-248 (2009).
    • (2009) Methods , vol.48 , pp. 240-248
    • Schmidt, D.1
  • 61
    • 84867492822 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact
    • Dhakal, H. P. et al. Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact. Histol. Histopathol. 27, 1315-1325 (2012).
    • (2012) Histol. Histopathol. , vol.27 , pp. 1315-1325
    • Dhakal, H.P.1
  • 62
    • 84857707318 scopus 로고    scopus 로고
    • ChromHMM: Automating chromatin-state discovery and characterization
    • Ernst, J. & Kellis, M. ChromHMM: automating chromatin-state discovery and characterization. Nat. Methods 9, 215-216 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 215-216
    • Ernst, J.1    Kellis, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.