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Volumn 7, Issue 1, 2017, Pages

Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - An 11-Year Prospective Study

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; FATTY LIVER; FEMALE; HUMAN; INSULIN RESISTANCE; LIVER; MALE; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; PATHOLOGY; PROSPECTIVE STUDY; RISK FACTOR;

EID: 85033448661     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-14706-0     Document Type: Article
Times cited : (19)

References (48)
  • 1
    • 84962661546 scopus 로고    scopus 로고
    • EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease.
    • European Association for the Study of Diabetes, European Association for the Study of Diabetes & European Association for the Study of Obesity
    • European Association for the Study of Diabetes, European Association for the Study of Diabetes & European Association for the Study of Obesity. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J. Hepatol. 64, 1388-1402 (2016).
    • (2016) J. Hepatol. , vol.64 , pp. 1388-1402
  • 2
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow-up study
    • Teli, M. R., James, O. F., Burt, A. D., Bennett, M. K. & Day, C. P. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 22, 1714-1719 (1995).
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 3
    • 84882906611 scopus 로고    scopus 로고
    • A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
    • Pais, R. et al. A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver. J. Hepatol. 59, 550-556 (2013).
    • (2013) J. Hepatol. , vol.59 , pp. 550-556
    • Pais, R.1
  • 4
    • 77953971188 scopus 로고    scopus 로고
    • Disease progression of non-alcoholic fatty liver disease: A prospective study with paired liver biopsies at 3 years
    • Wong, V. W. et al. Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut 59, 969-974 (2010).
    • (2010) Gut , vol.59 , pp. 969-974
    • Wong, V.W.1
  • 5
    • 84927796763 scopus 로고    scopus 로고
    • Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management
    • McPherson, S. et al. Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management. J. Hepatol. 62, 1148-1155 (2015).
    • (2015) J. Hepatol. , vol.62 , pp. 1148-1155
    • McPherson, S.1
  • 6
    • 84924938800 scopus 로고    scopus 로고
    • Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: A systematic review and meta-analysis of paired-biopsy studies
    • quiz e39-40
    • Singh, S. et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin. Gastroenterol. Hepatol. 13, 643-54.e1-9; quiz e39-40 (2015).
    • (2015) Clin. Gastroenterol. Hepatol. , vol.13 , pp. 54e19-643e19
    • Singh, S.1
  • 7
    • 0033960898 scopus 로고    scopus 로고
    • Oxygen: Modulator of metabolic zonation and disease of the liver
    • Jungermann, K. & Kietzmann, T. Oxygen: modulator of metabolic zonation and disease of the liver. Hepatology 31, 255-260 (2000).
    • (2000) Hepatology , vol.31 , pp. 255-260
    • Jungermann, K.1    Kietzmann, T.2
  • 8
    • 84856390541 scopus 로고    scopus 로고
    • Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases
    • Nath, B. & Szabo, G. Hypoxia and hypoxia inducible factors: diverse roles in liver diseases. Hepatology 55, 622-633 (2012).
    • (2012) Hepatology , vol.55 , pp. 622-633
    • Nath, B.1    Szabo, G.2
  • 10
    • 0348134685 scopus 로고    scopus 로고
    • Fibrogenic impact of high serum glucose in chronic hepatitis C
    • Ratziu, V. et al. Fibrogenic impact of high serum glucose in chronic hepatitis C. J. Hepatol. 39, 1049-1055 (2003).
    • (2003) J. Hepatol. , vol.39 , pp. 1049-1055
    • Ratziu, V.1
  • 11
    • 85014407677 scopus 로고    scopus 로고
    • PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease
    • Simons, N. et al. PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease. Gastroenterology 152, 912-913 (2017).
    • (2017) Gastroenterology , vol.152 , pp. 912-913
    • Simons, N.1
  • 12
    • 84898058711 scopus 로고    scopus 로고
    • Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
    • Kozlitina, J. et al. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 46, 352-356 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 352-356
    • Kozlitina, J.1
  • 13
    • 84964334172 scopus 로고    scopus 로고
    • The MBOAT7-TMC4 Variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of european descent
    • Mancina, R. M. et al. The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent. Gastroenterology 150, 1219-1230.e6 (2016).
    • (2016) Gastroenterology , vol.150 , pp. 1219e6-1230e6
    • Mancina, R.M.1
  • 14
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo, S. et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40, 1461-1465 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 1461-1465
    • Romeo, S.1
  • 15
    • 84918504185 scopus 로고    scopus 로고
    • Incidence of non-alcoholic fatty liver disease in Hong Kong: A population study with paired proton-magnetic resonance spectroscopy
    • Wong, V. W. et al. Incidence of non-alcoholic fatty liver disease in Hong Kong: a population study with paired proton-magnetic resonance spectroscopy. J. Hepatol. 62, 182-189 (2015).
    • (2015) J. Hepatol. , vol.62 , pp. 182-189
    • Wong, V.W.1
  • 16
    • 84872016294 scopus 로고    scopus 로고
    • Longitudinal effects of MRI-measured hepatic steatosis on biomarkers of glucose homeostasis and hepatic apoptosis in obese youth
    • Kim, G. et al. Longitudinal effects of MRI-measured hepatic steatosis on biomarkers of glucose homeostasis and hepatic apoptosis in obese youth. Diabetes Care 36, 130-136 (2013).
    • (2013) Diabetes Care , vol.36 , pp. 130-136
    • Kim, G.1
  • 17
    • 84931572246 scopus 로고    scopus 로고
    • EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis
    • European Association for Study of Liver & Asociacion Latinoamericana para el Estudio del Higado
    • European Association for Study of Liver & Asociacion Latinoamericana para el Estudio del Higado. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J. Hepatol. 63, 237-264 (2015).
    • (2015) J. Hepatol. , vol.63 , pp. 237-264
  • 18
    • 84979656488 scopus 로고    scopus 로고
    • Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease
    • Boursier, J. et al. Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease. J. Hepatol. 65, 570-578 (2016).
    • (2016) J. Hepatol. , vol.65 , pp. 570-578
    • Boursier, J.1
  • 19
    • 34748901835 scopus 로고    scopus 로고
    • Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity
    • Makkonen, J. et al. Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity. Int. J. Obes. (Lond) 31, 1617-1625 (2007).
    • (2007) Int. J. Obes. (Lond) , vol.31 , pp. 1617-1625
    • Makkonen, J.1
  • 21
    • 0342314436 scopus 로고    scopus 로고
    • Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
    • Ryysy, L. et al. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49, 749-758 (2000).
    • (2000) Diabetes , vol.49 , pp. 749-758
    • Ryysy, L.1
  • 22
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • Seppala-Lindroos, A. et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J. Clin. Endocrinol. Metab. 87, 3023-3028 (2002).
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3023-3028
    • Seppala-Lindroos, A.1
  • 23
    • 0342615049 scopus 로고    scopus 로고
    • Insulin therapy improves endothelial function in type 2 diabetes
    • Vehkavaara, S. et al. Insulin therapy improves endothelial function in type 2 diabetes. Arterioscler. Thromb. Vasc. Biol. 20, 545-550 (2000).
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 545-550
    • Vehkavaara, S.1
  • 24
    • 31444446947 scopus 로고    scopus 로고
    • Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects
    • Westerbacka, J. et al. Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects. Diabetologia 49, 132-140 (2006).
    • (2006) Diabetologia , vol.49 , pp. 132-140
    • Westerbacka, J.1
  • 25
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews, D. R. et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419 (1985).
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1
  • 26
    • 34247384560 scopus 로고    scopus 로고
    • The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
    • Angulo, P. et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 45, 846-854 (2007).
    • (2007) Hepatology , vol.45 , pp. 846-854
    • Angulo, P.1
  • 27
    • 84859705556 scopus 로고    scopus 로고
    • Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up
    • Zelber-Sagi, S. et al. Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up. J. Hepatol. 56, 1145-1151 (2012).
    • (2012) J. Hepatol. , vol.56 , pp. 1145-1151
    • Zelber-Sagi, S.1
  • 28
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies
    • Adams, L. A., Sanderson, S., Lindor, K. D. & Angulo, P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J. Hepatol. 42, 132-138 (2005).
    • (2005) J. Hepatol. , vol.42 , pp. 132-138
    • Adams, L.A.1    Sanderson, S.2    Lindor, K.D.3    Angulo, P.4
  • 29
    • 76349119700 scopus 로고    scopus 로고
    • Predicting fibrosis worsening in obese patients with NASH through parenchymal fibronectin, HOMA-IR, and hypertension
    • Sorrentino, P. et al. Predicting fibrosis worsening in obese patients with NASH through parenchymal fibronectin, HOMA-IR, and hypertension. Am. J. Gastroenterol. 105, 336-344 (2010).
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 336-344
    • Sorrentino, P.1
  • 30
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt, M. et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 44, 865-873 (2006).
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1
  • 31
    • 84874117479 scopus 로고    scopus 로고
    • High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China
    • Li, H. et al. High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China. J. Hepatol. 58, 557-563 (2013).
    • (2013) J. Hepatol. , vol.58 , pp. 557-563
    • Li, H.1
  • 32
    • 84878175866 scopus 로고    scopus 로고
    • Association between metabolic syndrome and the development of non-alcoholic fatty liver disease
    • Wang, Y. et al. Association between metabolic syndrome and the development of non-alcoholic fatty liver disease. Exp. Ther. Med. 6, 77-84 (2013).
    • (2013) Exp. Ther. Med. , vol.6 , pp. 77-84
    • Wang, Y.1
  • 33
    • 84863148823 scopus 로고    scopus 로고
    • Natural course of nonalcoholic fatty liver disease in southern China: A prospective cohort study
    • Zhou, Y. J., Li, Y. Y., Nie, Y. Q., Huang, C. M. & Cao, C. Y. Natural course of nonalcoholic fatty liver disease in southern China: a prospective cohort study. J. Dig. Dis. 13, 153-160 (2012).
    • (2012) J. Dig. Dis. , vol.13 , pp. 153-160
    • Zhou, Y.J.1    Li, Y.Y.2    Nie, Y.Q.3    Huang, C.M.4    Cao, C.Y.5
  • 34
    • 84864287523 scopus 로고    scopus 로고
    • Serum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean men
    • Kim, C. W., Chang, Y., Sung, E., Shin, H. & Ryu, S. Serum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean men. Metabolism 61, 1182-1188 (2012).
    • (2012) Metabolism , vol.61 , pp. 1182-1188
    • Kim, C.W.1    Chang, Y.2    Sung, E.3    Shin, H.4    Ryu, S.5
  • 35
    • 79957462315 scopus 로고    scopus 로고
    • Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    • Sookoian, S. & Pirola, C. J. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 53, 1883-1894 (2011).
    • (2011) Hepatology , vol.53 , pp. 1883-1894
    • Sookoian, S.1    Pirola, C.J.2
  • 36
    • 84903708160 scopus 로고    scopus 로고
    • TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
    • Liu, Y. L. et al. TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease. Nat. Commun. 5, 4309 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 4309
    • Liu, Y.L.1
  • 37
    • 67349174005 scopus 로고    scopus 로고
    • A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
    • Kotronen, A. et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 52, 1056-1060 (2009).
    • (2009) Diabetologia , vol.52 , pp. 1056-1060
    • Kotronen, A.1
  • 38
    • 85017448528 scopus 로고    scopus 로고
    • Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
    • Luukkonen, P. K. et al. Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. J. Hepatol. (2017).
    • (2017) J. Hepatol.
    • Luukkonen, P.K.1
  • 39
    • 85004009110 scopus 로고    scopus 로고
    • The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans
    • Luukkonen, P. K. et al. The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans. J. Hepatol. 65, 1263-1265 (2016).
    • (2016) J. Hepatol. , vol.65 , pp. 1263-1265
    • Luukkonen, P.K.1
  • 41
    • 24144448806 scopus 로고    scopus 로고
    • T1, T2 relaxation and magnetization transfer in tissue at 3T
    • Greg J. Stanisz, et al. T1, T2 relaxation and magnetization transfer in tissue at 3T. Magnetic Resonance in Medicine 54(3), 507-512 (2005).
    • (2005) Magnetic Resonance in Medicine , vol.54 , Issue.3 , pp. 507-512
    • Stanisz, G.J.1
  • 43
    • 0029300637 scopus 로고
    • Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis
    • Renata Longo, et al. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. Journal of Magnetic Resonance Imaging 5(3), 281-285 (1995).
    • (1995) Journal of Magnetic Resonance Imaging , vol.5 , Issue.3 , pp. 281-285
    • Longo, R.1
  • 44
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population
    • Szczepaniak, L. S. et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am. J. Physiol. Endocrinol. Metab. 288, E462-8 (2005).
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288 , pp. E8-E462
    • Szczepaniak, L.S.1
  • 45
    • 0033007207 scopus 로고    scopus 로고
    • Measurement of intracellular triglyceride stores by H spectroscopy: Validation in vivo
    • Szczepaniak, et al. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am.J.Physiol., 276, E977-89 (1999).
    • (1999) Am.J.Physiol. , vol.276 , pp. E89-E977
    • Szczepaniak1
  • 46
    • 0028347149 scopus 로고
    • Quantification of liver fat using magnetic resonance spectroscopy
    • Thomsen, C. et al. Quantification of liver fat using magnetic resonance spectroscopy. Magn. Reson. Imaging 12, 487-495 (1994).
    • (1994) Magn. Reson. Imaging , vol.12 , pp. 487-495
    • Thomsen, C.1
  • 47
    • 84870819164 scopus 로고    scopus 로고
    • Liver stiffness measurement using XL probe in patients with nonalcoholic fatty liver disease
    • Wong, V. W. et al. Liver stiffness measurement using XL probe in patients with nonalcoholic fatty liver disease. Am. J. Gastroenterol. 107, 1862-1871 (2012).
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 1862-1871
    • Wong, V.W.1
  • 48
    • 0023710206 scopus 로고
    • Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach
    • DeLong, E. R., DeLong, D. M. & Clarke-Pearson, D. L. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44, 837-845 (1988).
    • (1988) Biometrics , vol.44 , pp. 837-845
    • DeLong, E.R.1    DeLong, D.M.2    Clarke-Pearson, D.L.3


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