Antimicrobial stewardship in inpatient settings in the Asia pacific region: A systematic review and meta-analysis

Clinical Infectious Diseases

Volumn 64, Issue , 2017, Pages S119-S126

  Honda, Hitoshi ^a   Ohmagari, Norio ^b   Tokuda, Yasuharu ^c   Mattar, Caline ^d   Warren, David K ^d  

^a TOKYO METROPOLITAN TAMA MEDICAL CENTER   (Japan)

^b Bureau of Advanced Medicine and Hemato Oncology   (United States)

^c KYUSHU HOSPITAL   (Japan)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotic control; Antimicrobial stewardship; Asia Pacific; Far East; Meta analysis

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ASIA; CLINICAL DECISION SUPPORT SYSTEM; CLINICAL OUTCOME; CLOSTRIDIUM DIFFICILE INFECTION; COMPARATIVE STUDY; DRUG COST; HEALTH CARE COST; HEALTHCARE ASSOCIATED INFECTION; HOSPITAL PATIENT; HUMAN; INCIDENCE; META ANALYSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; OUTCOME ASSESSMENT; PRESCRIPTION; PRIORITY JOURNAL; PROGRAM EFFECTIVENESS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REVIEW; SOUTHEAST ASIA; SYSTEMATIC REVIEW; ANTIMICROBIAL STEWARDSHIP; CROSS INFECTION; ECONOMICS; HOSPITAL; LEGISLATION AND JURISPRUDENCE; MICROBIOLOGY; MORTALITY; MULTIDRUG RESISTANCE; STATISTICS AND NUMERICAL DATA;

ANTI-INFECTIVE AGENTS; ANTIMICROBIAL STEWARDSHIP; ASIA; CROSS INFECTION; DRUG PRESCRIPTIONS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HOSPITALS; HUMANS; INPATIENTS;

EID: 85033442360     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cix017     Document Type: Review

References (66)

1. Schuts EC, Hulscher ME, Mouton JW, et al. Current evidence on hospital antimicrobial stewardship objectives: a systematic review and meta-analysis. Lancet Infect Dis 2016; 16:847-56
2. Davey P, Brown E, Charani E, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev 2013; CD003543
3. Holmes AH, Moore LS, Sundsfjord A, et al. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet 2016; 387:176-87
4. Barlam TF, Cosgrove SE, Abbo LM, et al. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 2016; 62:e51-77
5. National Institute for Health and Care Excellence. Antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. 2015. Available at: https://www.nice.org.uk/guidance/ng15/resources/antimicrobial-stewardship-systems-and-processes-for-effective-antimicrobial-medicine-use-1837273110469. Accessed 20 August 2016
6. Pollack LA, Plachouras D, GruhlerH, et al. Transatlantic Taskforce on Antimicrobial Resistance (TATFAR) Summary the modified Delphi process for common structure and process indicators for hospital antimicrobial stewardship programs. 2015. Available at: http://www.cdc.gov/drugresistance/pdf/summary- of-tatfar-recommendation-1.pdf. Accessed 19 August 2016
7. World Health Organization, South-East Asia Regional Office. Jaipur declaration on antimicrobial resistance. 2011. Available at: http://www.searo.who.int/entity/ world-health-day/media/2011/whd-11-amr-jaipur-declaration-.pdf. Accessed 24 August 2016
8. World Health Orgnaization. Asia Pacific countries vow to tackle antimicrobial resistance together. 2016. Available at: http://www.searo.who.int/mediacentre/ releases/2016/1622/en/. Accessed 19 August 2016
9. Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). 2015. Available at: http://www.prisma-statement.org/ Default.aspx. Accessed 19 August 2016
10. Wagner B, Filice GA, Drekonja D, et al. Antimicrobial stewardship programs in inpatient hospital settings: a systematic review. Infect Control Hosp Epidemiol 2014; 35:1209-28
11. The World Bank. East Asia Pacific. Available at: http://www.worldbank.org/en/ region/eap. Accessed 19 August 2016
12. Altman DG, Bland JM. How to obtain the confidence interval from a P value. BMJ 2011; 343:d2090
13. Higgins JPT, Green S, eds. Cochrane handbook of systematic reviews of interventions, version 5.1.0. Cochrane Collaboration, 2011. Available at: http://handbook. cochrane.org. Accessed 13 August 2016
14. Cochrane Effective Practice and Organisation of Care Group. Available at: http:// epoc.cochrane.org/sites/epoc.cochrane.org/files/uploads/Suggested%20risk%20 of%20bias%20criteria%20for%20EPOC%20reviews.pdf. Accessed 13 August 2016
15. Karanika S, Paudel S, Grigoras C, Kalbasi A, Mylonakis E. Systematic review and meta-analysis of clinical and economic outcomes from the implementation of hospital-based antimicrobial stewardship programs. Antimicrob Agents Chemother 2016; 60:4840-52
16. Cheng VCC, To KKW, Li IWS, et al. Antimicrobial stewardship program directed at broad-spectrum intravenous antibiotics prescription in a tertiary hospital. Eur J Clin Microbiol Infect Dis 2009; 28:1447-56
17. Rattanaumpawan P, Sutha P, Thamlikitkul V. Effectiveness of drug use evaluation and antibiotic authorization on patients' clinical outcomes, antibiotic consumption, and antibiotic expenditures. Am J Infect Control 2010; 38:38-43
18. Shen J, Sun Q, Zhou X, et al. Pharmacist interventions on antibiotic use in inpatients with respiratory tract infections in a Chinese hospital. Int J Clin Pharm 2011; 33:929-33
19. Liew YX, Lee W, Loh JC, et al. Impact of an antimicrobial stewardship programme on patient safety in Singapore general hospital. Int J Antimicrob Agents 2012; 40:55-60
20. Niwa T, Shinoda Y, Suzuki A, et al. Outcome measurement of extensive implementation of antimicrobial stewardship in patients receiving intravenous antibiotics in a Japanese university hospital. Int J Clin Pract 2012; 66:999-1008
21. Teo J, Kwa AL, Loh J, Chlebicki MP, Lee W. The effect of a whole-system approach in an antimicrobial stewardship programme at the Singapore general hospital. Eur J Clin Microbiol Infect Dis 2012; 31:947-55
22. Yeo CL, Chan DS, Earnest A, et al. Prospective audit and feedback on antibiotic prescription in an adult hematology-oncology unit in Singapore. Eur J Clin Microbiol Infect Dis 2012; 31:583-90
23. Baysari MT, Oliver K, Egan B, et al. Audit and feedback of antibiotic use: utilising electronic prescription data. Appl Clin Inform 2013; 4:583-95
24. Cairns KA, Jenney AW, Abbott IJ, et al. Prescribing trends before and after implementation of an antimicrobial stewardship program. Med J Aust 2013; 198:262-6
25. Fukuda T, Watanabe H, Ido S, Shiragami M. Contribution of antimicrobial stewardship programs to reduction of antimicrobial therapy costs in community hospital with 429 beds-before-after comparative two-year trial in Japan. J Pharm Policy Pract 2014; 7:10. doi:10.1186/2052-3211-7-10
26. Lew KY, Ng TM, Tan M, et al. Safety and clinical outcomes of carbapenem de-escalation as part of an antimicrobial stewardship programme in an ESBL-endemic setting. J Antimicrob Chemother 2015; 70:1219-25
27. Apisarnthanarak A, Lapcharoen P, Vanichkul P, Srisaeng-Ngoen T, Mundy LM. Design and analysis of a pharmacist-enhanced antimicrobial stewardship program in Thailand. Am J Infect Control 2015; 43:956-9
28. Chen CH, Lin LC, Chang YJ, Liu CE, Soon MS. Long-term effectiveness of infection and antibiotic control programs on the transmission of carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex in central Taiwan. Med Mal Infect 2015; 45:264-72
29. Liew YX, Lee W, Tay D, et al. Prospective audit and feedback in antimicrobial stewardship: is there value in early reviewing within 48 h of antibiotic prescription? Int J Antimicrob Agents 2015; 45:168-73
30. Cai Y, Shek PY, Teo I, et al. A multidisciplinary antimicrobial stewardship programme safely decreases the duration of broad-spectrum antibiotic prescription in Singaporean adult renal patients. Int J Antimicrob Agents 2016; 47:91-6
31. Cheon S, Kim MJ, Yun SJ, Moon JY, Kim YS. Controlling endemic multidrug-resistant Acinetobacter baumannii in intensive care units using antimicrobial stewardship and infection control. Korean J Intern Med 2016; 31:367-74
32. Tagashira Y, Horiuchi M, Tokuda Y, Heist BS, Higuchi M, Honda H. Antimicrobial stewardship for carbapenem use at a Japanese tertiary care center: An interrupted time series analysis on the impact of infectious disease consultation, prospective audit, and feedback. Am J Infect Control 2016; 44:708-10
33. Chang MT, Wu TH, Wang CY, Jang TN, Huang CY. The impact of an intensive antimicrobial control program in a Taiwanese medical center. Pharm World Sci 2006; 28:257-64
34. Buising KL, Thursky KA, Robertson MB, et al. Electronic antibiotic stewardship-reduced consumption of broad-spectrum antibiotics using a computerized antimicrobial approval system in a hospital setting. J Antimicrob Chemother 2008; 62:608-16
35. Kim JY, Sohn JW, Park DW, Yoon YK, Kim YM, Kim MJ. Control of extended-spectrum {beta}-lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict third-generation cephalosporin use. J Antimicrob Chemother 2008; 62:416-21
36. Chan YY, Lin TY, Huang CT, et al. Implementation and outcomes of a hospital-wide computerised antimicrobial stewardship programme in a large medical centre in Taiwan. Int J Antimicrob Agents 2011; 38:486-92
37. Ikeda Y, Mamiya T, Nishiyama H, et al. A permission system for carbapenem use reduced incidence of drug-resistant bacteria and cost of antimicrobials at a general hospital in Japan. Nagoya J Med Sci 2012; 74:93-104
38. Kim YC, Kim MH, Song JE, et al. Trend of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in an institution with a high rate of MRSA after the reinforcement of antibiotic stewardship and hand hygiene. Am J Infect Control 2013; 41:e39-43
39. Li JS, Zhang XG, Wang HQ, Wang Y, Wang JM, Shao QD. The meaningful use of EMR in Chinese hospitals: a case study on curbing antibiotic abuse. J Med Syst 2013; 37:9937
40. Yoon YK, Yang KS, Lee SE, Kim HJ, Sohn JW, Kim MJ. Effects of group 1 versus group 2 carbapenems on the susceptibility of Acinetobacter baumannii to carbapenems: a before and after intervention study of carbapenem-use stewardship. PLoS One 2014; 9:e99101
41. Apisarnthanarak A, Danchaivijitr S, Khawcharoenporn T, et al; Thammasart University Antibiotic Management Team. Effectiveness of education and an antibiotic-control program in a tertiary care hospital in Thailand. Clin Infect Dis 2006; 42:768-75
42. Ikai H, Morimoto T, Shimbo T, Imanaka Y, Koike K. Impact of postgraduate education on physician practice for community-acquired pneumonia. J Eval Clin Pract 2012; 18:389-95
43. Miyawaki K, Miwa Y, Tomono K, Kurokawa N. Impact of antimicrobial stewardship by infection control team in a Japanese teaching hospital. Yakugaku Zasshi 2010; 130:1105-11
44. Shi Q, Ding F, Sang R, Liu Y, Yuan H, Yu M. Drug use evaluation of cefepime in the first affiliated hospital of Bengbu medical college: a retrospective and prospective analysis. BMC Infect Dis 2013; 13:160
45. Lin YS, Lin IF, Yen YF, et al. Impact of an antimicrobial stewardship program with multidisciplinary cooperation in a community public teaching hospital in Taiwan. Am J Infect Control 2013; 41:1069-72
46. Chaves NJ, Ingram RJ, MacIsaac CM, Buising KL. Sticking to minimum standards: implementing antibiotic stewardship in intensive care. Intern Med J 2014; 44:1180-7
47. Song YJ, Kim M, Huh S, et al. Impact of an antimicrobial stewardship program on unnecessary double anaerobic coverage prescription. Infect Chemother 2015; 47:111-6
48. Ng CK, Wu TC, Chan WM, et al. Clinical and economic impact of an antibiotics stewardship programme in a regional hospital in Hong Kong. Qual Saf Health Care 2008; 17:387-92
49. Hadi U, Keuter M, van Asten H, van den Broek P; Study Group Antimicrobial Resistance in Indonesia: Prevalence and Prevention (AMRIN). Optimizing antibiotic usage in adults admitted with fever by a multifaceted intervention in an Indonesian governmental hospital. Trop Med Int Health 2008; 13:888-99
50. Zou X, Fang Z, Min R, et al. Is nationwide special campaign on antibiotic stewardship program effective on ameliorating irrational antibiotic use in China? Study on the antibiotic use of specialized hospitals in China in 2011-2012. J Huazhong Univ Sci Technol Med Sci 2014; 34:456-63
51. Zou YM, Ma Y, Liu JH, et al. Trends and correlation of antibacterial usage and bacterial resistance: time series analysis for antibacterial stewardship in a Chinese teaching hospital (2009-2013). Eur J Clin Microbiol Infect Dis 2015; 34:795-803
52. Guo W, He Q, Wang Z, et al. Influence of antimicrobial consumption on gram-negative bacteria in inpatients receiving antimicrobial resistance therapy from 2008-2013 at a tertiary hospital in Shanghai, China. Am J Infect Control 2015; 43:358-64
53. Apisarnthanarak A, Pinitchai U, Thongphubeth K, et al. Effectiveness of an educational program to reduce ventilator-associated pneumonia in a tertiary care center in Thailand: a 4-year study. Clin Infect Dis 2007; 45:704-11
54. Tan A, Seah A, Chua G, Lim TK, Phua J. Impact of a palliative care initiative on end-of-life care in the general wards: a before-and-after study. Palliat Med 2014; 28:34-41
55. Maeda M, Takuma T, Seki H, et al. Effect of interventions by an antimicrobial stewardship team on clinical course and economic outcome in patients with bloodstream infection. J Infect Chemother 2016; 22:90-5
56. Sime FB, Roberts MS, Tiong IS, et al. Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial. J Antimicrob Chemother 2015; 70:2369-75
57. Masuda N, Maiguma T, Komoto A, et al. Impact of pharmacist intervention on preventing nephrotoxicity from vancomycin. Int J Clin Pharmacol Ther 2015; 53:284-91
58. Davies J, Gordon CL, Tong SY, Baird RW, Davis JS. Impact of results of a rapid Staphylococcus aureus diagnostic test on prescribing of antibiotics for patients with clustered gram-positive cocci in blood cultures. J Clin Microbiol 2012; 50:2056-8
59. Taniguchi T, Tsuha S, Shiiki S, Narita M. Gram-stain-based antimicrobial selection reduces cost and overuse compared with Japanese guidelines. BMC Infect Dis 2015; 15:458
60. Sintchenko V, Iredell JR, Gilbert GL, Coiera E. Handheld computer-based decision support reduces patient length of stay and antibiotic prescribing in critical care. J Am Med Inform Assoc 2005; 12:398-402
61. Yong MK, Buising KL, Cheng AC, Thursky KA. Improved susceptibility of gram-negative bacteria in an intensive care unit following implementation of a computerized antibiotic decision support system. J Antimicrob Chemother 2010; 65:1062-9
62. Howard P, Pulcini C, Nathwani D. First global antimicrobial stewardship survey: interim analysis of non-UK European data. Eur J Hosp Pharm 2013; 20:A186
63. Ling ML, Apisarnthanarak A, Madriaga G. The burden of healthcare-associated infections in Southeast Asia: a systematic literature review and meta-analysis. Clin Infect Dis 2015; 60:1690-9
64. Laxminarayan R, Matsoso P, Pant S, et al. Access to effective antimicrobials: a worldwide challenge. Lancet 2016; 387:168-75
65. World Health Organization. Global action plan on antimicrobial resistance. Available at: http://www.who.int/drugresistance/global-action-plan/en/. Accessed 15 August 2016
66. Dar OA, Hasan R, Schlundt J, et al. Exploring the evidence base for national and regional policy interventions to combat resistance. Lancet 2016; 387:285-95