The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: A randomized controlled trial

PLoS ONE

Volumn 12, Issue 10, 2017, Pages

  Schädler, Dirk ^a   Pausch, Christine ^b   Heise, Daniel ^c   Meier Hellmann, Andreas ^d   Brederlau, Jörg ^e   Weiler, Norbert ^a   Marx, Gernot ^f   Putensen, Christian ^g   Spies, Claudia ^h   Jörres, Achim ⁱ   Quintel, Michael ^c   Engel, Christoph ^b   Kellum, John A ^j   Kuhlmann, Martin K ^k  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d HELIOS KLINIKUM ERFURT   (Germany)

^e Helios Hospital Berlin Buch   (Germany)

^f UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^g UNIVERSITY OF BONN   (Germany)

^h CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

ⁱ UNIVERSITY OF WITTEN HERDECKE   (Germany)

^j UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^k VIVANTES KLINIKUM IM FRIEDRICHSHAIN   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR; VASCULOTROPIN; CYTOKINE;

ACUTE LUNG INJURY; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ALL CAUSE MORTALITY; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; FEMALE; HEMADSORPTION; HEMOPERFUSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; OPEN STUDY; OUTCOME ASSESSMENT; OXYGENATION; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RENAL REPLACEMENT THERAPY; SEPSIS; SEPTIC SHOCK; THERAPY EFFECT; TREATMENT DURATION; BLOOD; CLINICAL TRIAL; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; PROCEDURES;

AGED; CYTOKINES; FEMALE; HEMOPERFUSION; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; SEPSIS;

EID: 85033373477     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0187015     Document Type: Article

References (35)

1. Bone RC, Fisher CJ Jr., Clemmer TP, Slotman GJ, Metz CA, Balk RA. Sepsis syndrome: a valid clinical entity. Crit Care Med. 1989; 17(5):389–93. PMID: 2651003.
2. Gentile LF, Cuenca AG, Efron PA, Ang D, Bihorac A, McKinley BA, et al. Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg. 2012; 72(6):1491–501. PMID: 22695412
3. Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, et al. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med. 2007; 167(15):1655–63. https://doi.org/10.1001/archinte.167.15.1655 PMID: 17698689.
4. De Vriese AS, Colardyn FA, Philippe JJ, Vanholder RC, De Sutter JH, Lameire NH. Cytokine removal during continuous hemofiltration in septic patients. J Am Soc Nephrol. 1999; 10(4):846–53. PMID: 10203370.
5. Payen D, Mateo J, Cavaillon JM, Fraisse F, Floriot C, Vicaut E, et al. Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit Care Med. 2009; 37(3):803–10. https://doi.org/10.1097/CCM.0b013e3181962316 PMID: 19237881.
6. Joannes-Boyau O, Honore PM, Perez P, Bagshaw SM, Grand H, Canivet JL, et al. High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial. Intensive Care Med. 2013; 39(9):1535–46. https://doi.org/10.1007/s00134-013-2967-z PMID: 23740278.
7. Zhou F, Peng Z, Murugan R, Kellum JA. Blood purification and mortality in sepsis: a meta-analysis of randomized trials. Crit Care Med. 2013; 41(9):2209–20. PMID: 23860248
8. Nakamura T, Ebihara I, Shoji H, Ushiyama C, Suzuki S, Koide H. Treatment with polymyxin B-immobilized fiber reduces platelet activation in septic shock patients: decrease in plasma levels of soluble P-selectin, platelet factor 4 and beta-thromboglobulin. Inflamm Res. 1999; 48(4):171–5. https://doi.org/10.1007/s000110050442 PMID: 10344466.
9. Nakamura T, Kawagoe Y, Suzuki T, Shoji H, Ueda Y, Koide H. Polymyxin B-immobilized fiber hemoperfusion with the PMX-05R column in elderly patients suffering from septic shock. Am J Med Sci. 2007; 334(4):244–7. PMID: 18030179.
10. Nemoto H, Nakamoto H, Okada H, Sugahara S, Moriwaki K, Arai M, et al. Newly developed immobilized polymyxin B fibers improve the survival of patients with sepsis. Blood Purif. 2001; 19(4):361–8. PMID: 11574732.
11. Shoji H. Extracorporeal endotoxin removal for the treatment of sepsis: endotoxin adsorption cartridge (Toraymyxin). Ther Apher Dial. 2003; 7(1):108–14. PMID: 12921125.
12. Suzuki H, Nemoto H, Nakamoto H, Okada H, Sugahara S, Kanno Y, et al. Continuous hemodiafiltration with polymyxin-B immobilized fiber is effective in patients with sepsis syndrome and acute renal failure. Ther Apher. 2002; 6(3):234–40. PMID: 12109950.
13. Cruz DN, Antonelli M, Fumagalli R, Foltran F, Brienza N, Donati A, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA. 2009; 301 (23):2445–52. https://doi.org/10.1001/jama.2009.856 PMID: 19531784.
14. Payen DM, Guilhot J, Launey Y, Lukaszewicz AC, Kaaki M, Veber B, et al. Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial. Intensive Care Med. 2015; 41(6):975–84. https://doi.org/10.1007/s00134-015-3751-z PMID: 25862039
15. Kellum JA, Song M, Venkataraman R. Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-kappaB DNA binding, and improves short-term survival in lethal endotoxemia. Crit Care Med. 2004; 32(3):801–5. PMID: 15090965.
16. Namas RA, Namas R, Lagoa C, Barclay D, Mi Q, Zamora R, et al. Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies. Mol Med. 2012; 18:1366–74. PMID: 22751621
17. Peng ZY, Carter MJ, Kellum JA. Effects of hemoadsorption on cytokine removal and short-term survival in septic rats. Crit Care Med. 2008; 36(5):1573–7. https://doi.org/10.1097/CCM.0b013e318170b9a7PMID: 18434884.
18. Peng ZY, Wang HZ, Carter MJ, Dileo MV, Bishop JV, Zhou FH, et al. Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis. Kidney Int. 2012; 81(4):363–9. https://doi.org/10.1038/ki.2011.320 PMID: 21918497
19. Kellum JA, Venkataraman R, Powner D, Elder M, Hergenroeder G, Carter M. Feasibility study of cytokine removal by hemoadsorption in brain-dead humans. Crit Care Med. 2008; 36(1):268–72. https://doi.org/10.1097/01.CCM.0000291646.34815.BB PMID: 18090355.
20. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992; 20(6):864–74. PMID: 1597042.
21. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000; 342(18):1301–8. Epub 2000/05/04. https://doi.org/10.1056/NEJM200005043421801 PMID: 10793162.
22. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995; 23(10):1638–52. PMID: 7587228.
23. R Developpment Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2014.
24. Ghani RA, Zainudin S, Ctkong N, Rahman AF, Wafa SR, Mohamad M, et al. Serum IL-6 and IL-1-ra with sequential organ failure assessment scores in septic patients receiving high-volume haemofiltration and continuous venovenous haemofiltration. Nephrology (Carlton). 2006; 11(5):386–93. https://doi.org/10.1111/j.1440-1797.2006.00600.x PMID: 17014550.
25. Morgera S, Haase M, Kuss T, Vargas-Hein O, Zuckermann-Becker H, Melzer C, et al. Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure. Crit Care Med. 2006; 34(8):2099–104. https://doi.org/10.1097/01.CCM.0000229147.50592.F9 PMID: 16763508.
26. Huang Z, Wang SR, Su W, Liu JY. Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column. Ther Apher Dial. 2010; 14(6):596–602. https://doi.org/10.1111/j.1744-9987.2010.00825.x PMID: 21118369.
27. Honore PM, Matson JR. Extracorporeal removal for sepsis: Acting at the tissue level—the beginning of a new era for this treatment modality in septic shock. Crit Care Med. 2004; 32(3):896–7. PMID: 15090989.
28. Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, et al. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab’)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med. 2004; 32(11):2173–82. PMID: 15640628.
29. Haase M, Silvester W, Uchino S, Goldsmith D, Davenport P, Tipping P, et al. A pilot study of high-adsorption hemofiltration in human septic shock. Int J Artif Organs. 2007; 30(2):108–17. PMID: 17377905.
30. Kobe Y, Oda S, Matsuda K, Nakamura M, Hirasawa H. Direct hemoperfusion with a cytokine-adsorbing device for the treatment of persistent or severe hypercytokinemia: a pilot study. Blood Purif. 2007; 25 (5–6):446–53. https://doi.org/10.1159/000111568 PMID: 18037813
31. Nakada TA, Oda S, Matsuda K, Sadahiro T, Nakamura M, Abe R, et al. Continuous hemodiafiltration with PMMA Hemofilter in the treatment of patients with septic shock. Mol Med. 2008; 14(5–6):257–63. PMID: 18327291
32. Shiga H, Hirasawa H, Nishida O, Oda S, Nakamura M, Mashiko K, et al. Continuous hemodiafiltration with a cytokine-adsorbing hemofilter in patients with septic shock: a preliminary report. Blood Purif. 2014; 38(3–4):211–8. https://doi.org/10.1159/000369377 PMID: 25531978.
33. Vincent JL, Laterre PF, Cohen J, Burchardi H, Bruining H, Lerma FA, et al. A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock. 2005; 23(5):400–5. PMID: 15834304.
34. Reinhart K, Meier-Hellmann A, Beale R, Forst H, Boehm D, Willatts S, et al. Open randomized phase II trial of an extracorporeal endotoxin adsorber in suspected Gram-negative sepsis. Crit Care Med. 2004; 32(8):1662–8. Epub 2004/08/03. PMID: 15286541.
35. Casey LC, Balk RA, Bone RC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med. 1993; 119(8):771–8. PMID: 8379598.