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Volumn 6, Issue 1, 2008, Pages

Marine biotoxins in shellfish - okadaic acid and analogues - Scientific Opinion of the Panel on Contaminants in the Food chain
[No Author Info available]

Author keywords

acute reference dose; bivalve molluscs; DTX1; DTX2; DTX3; human health; mammalian biotests; Marine biotoxins; methods of analysis; Okadaic acid; portion size; risk assessment; shellfish

Indexed keywords


EID: 85032993007     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2008.589     Document Type: Article
Times cited : (52)

References (94)
  • 1
    • 33845514866 scopus 로고    scopus 로고
    • Relative toxicity of dinophysistoxin-2 (DTX2) compared with okadaic acid, based on acute intraperitoneal toxicity in mice
    • Aune T, Larsen, S, Aasen, J.A.B, Rehmann, N., Satake, M., Hess, P., 2007. Relative toxicity of dinophysistoxin-2 (DTX2) compared with okadaic acid, based on acute intraperitoneal toxicity in mice. Toxicon 49, 1–7.
    • (2007) Toxicon , vol.49 , pp. 1-7
    • Aune, T.1    Larsen, S.2    Aasen, J.A.B.3    Rehmann, N.4    Satake, M.5    Hess, P.6
  • 3
    • 0003208437 scopus 로고    scopus 로고
    • Risk assessment of toxins associated with DSP, PSP and ASP in seafood
    • Proceedings of the Xth International IUPAC Symposium on Mycotoxins and Phycotoxins., Brasil 2000 (Eds., W.J. de Koe, R.A. Samson, H.P. van Egmond, M. Sabino
    • Aune, T., 2001. Risk assessment of toxins associated with DSP, PSP and ASP in seafood. In: Mycotoxins and Phycotoxins in perspective at the turn of the Millennium. Proceedings of the Xth International IUPAC Symposium on Mycotoxins and Phycotoxins., Brasil 2000 (Eds. W.J. de Koe, R.A. Samson, H.P. van Egmond and M. Sabino)., pp. 515–526.
    • (2001) Mycotoxins and Phycotoxins in perspective at the turn of the Millennium , pp. 515-526
    • Aune, T.1
  • 5
    • 0023691731 scopus 로고
    • Inhibitory effect of a marine sponge toxin, okadaic acid, on protein phosphatases
    • Bialojan, C. and Takai, A., 1988. Inhibitory effect of a marine sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256, 283–290.
    • (1988) Biochem. J , vol.256 , pp. 283-290
    • Bialojan, C.1    Takai, A.2
  • 6
    • 33750614129 scopus 로고    scopus 로고
    • Comparative Study of Domoic Acid and Okadaic Acid Induced - Chromosomal Abnormalities in the CACO-2 Cell Line
    • Carvalho, P.-S., Catia, R., Moukha, S., Matias, W.G. and Creppy, E.E., 2006. Comparative Study of Domoic Acid and Okadaic Acid Induced - Chromosomal Abnormalities in the CACO-2 Cell Line. Int. J. Environ. Res. Publich Health. 3(1), 4–10.
    • (2006) Int. J. Environ. Res. Publich Health , vol.3 , Issue.1 , pp. 4-10
    • Carvalho, P.-S.1    Catia, R.2    Moukha, S.3    Matias, W.G.4    Creppy, E.E.5
  • 9
    • 0024397415 scopus 로고
    • The structure and regulation of protein phosphatases
    • Cohen, P., 1989. The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58, 453–508.
    • (1989) Annu. Rev. Biochem , vol.58 , pp. 453-508
    • Cohen, P.1
  • 10
    • 0025181418 scopus 로고
    • Okadaic acid: a new probe for the study of cellular regulation
    • Cohen, P., Charles, F., Holmes, B. and Tsukitani, Y., 1990. Okadaic acid: a new probe for the study of cellular regulation. TIBS 15, 98–102.
    • (1990) TIBS , vol.15 , pp. 98-102
    • Cohen, P.1    Charles, F.2    Holmes, B.3    Tsukitani, Y.4
  • 11
    • 0033787088 scopus 로고    scopus 로고
    • Ecological analysis of digestive cancer mortality related to contamination by diarrhetic shellfish poisoning toxins along the coasts of France
    • Cordier, S., Monfort, C., Miossec, L., Richardson, S. and Belin, C., 2000. Ecological analysis of digestive cancer mortality related to contamination by diarrhetic shellfish poisoning toxins along the coasts of France. Environ Res 84, 145–50.
    • (2000) Environ Res , vol.84 , pp. 145-150
    • Cordier, S.1    Monfort, C.2    Miossec, L.3    Richardson, S.4    Belin, C.5
  • 13
    • 0036824254 scopus 로고    scopus 로고
    • An outbreak of diarrhoeic shellfish poisoning in Antwerp, Belgium
    • De Schrijver, K., Maes, I., De Man, L. and Michelet, J., 2002. An outbreak of diarrhoeic shellfish poisoning in Antwerp, Belgium. Eurosurveillance 7, 139–141.
    • (2002) Eurosurveillance , vol.7 , pp. 139-141
    • De Schrijver, K.1    Maes, I.2    De Man, L.3    Michelet, J.4
  • 14
    • 34249868477 scopus 로고    scopus 로고
    • PCT Gazette, 18 May 2000, PCT/BG99/03756, International Publication Number WO 00/28325.
    • Døskeland S.O., Serres M.H., Fladmark, K.E.; 2000. Assay for phosphatase-targeting toxins. PCT Gazette, 18 May 2000, Patent Application PCT/BG99/03756, International Publication Number: WO 00/28325. Available at URL: v3.espacenet.com/textdoc?DB=BPODOC&IDX=XO0028325&F=1&RPN=NP1129352&DOC=Cca34af1985008c1813bf7b07931d8a84f&QPN=NP1129352.
    • (2000) Assay for phosphatase-targeting toxins
    • Døskeland, S.O.1    Serres, M.H.2    Fladmark, K.E.3
  • 15
    • 0024208869 scopus 로고
    • Toxic mussels and okadaic acid induce rapid hypersecretion in the rat small intestine
    • Edebo, L., Lange, S., Li, X.P. and Allenmark, S., 1988. Toxic mussels and okadaic acid induce rapid hypersecretion in the rat small intestine. APMIS 96, 1029–1035.
    • (1988) APMIS , vol.96 , pp. 1029-1035
    • Edebo, L.1    Lange, S.2    Li, X.P.3    Allenmark, S.4
  • 16
    • 44749086017 scopus 로고    scopus 로고
    • Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment
    • EFSA (European Food Safety Authority), 2006. Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment. EFSA Journal 438, 1–54.
    • (2006) EFSA Journal , vol.438 , pp. 1-54
  • 17
    • 84889256114 scopus 로고    scopus 로고
    • Brussels
    • rd May 2001, Brussels.
    • (2001) rd May 2001
  • 18
    • 33744916869 scopus 로고    scopus 로고
    • Food and Agriculture Organization, Rome, Italy, p
    • FAO (Food and Agriculture Organization of the United Nations), 2004. Marine biotoxins. FAO Food and Nutrition Paper 80. Food and Agriculture Organization, Rome, Italy, p. 53.
    • (2004) Marine biotoxins. FAO Food and Nutrition Paper 80 , pp. 53
  • 20
    • 0000647460 scopus 로고
    • Mammalian Bioassays
    • Hallegraeff, G. M., and et.al., Part B],, UNESCO
    • Fernandez, M. L. and Cembella, A. D., 1995. Mammalian Bioassays. Hallegraeff, G. M. and et.al. Manual on Harmful Marine Microalgae. [10, Part B], 213–228. UNESCO.
    • (1995) Manual on Harmful Marine Microalgae , vol.10 , pp. 213-228
    • Fernandez, M.L.1    Cembella, A.D.2
  • 21
    • 72749105991 scopus 로고    scopus 로고
    • Bioensayos con mamíferos y ensayos bioquímicos y celulares para la detección de ficotoxinas
    • Sar, E. A., Ferrario, M. E., Reguera, B., Eds.) pp, Instituto Español de Oceanografía, Pontevedra, Spain
    • Fernández, M. L., Míguez, A., Cacho, E., Martínez, A., Diógene, J. and Yasumoto, T., 2002. Bioensayos con mamíferos y ensayos bioquímicos y celulares para la detección de ficotoxinas, In Floraciones algales nocivas en el cono sur americano. (Sar, E. A., Ferrario, M. E. and Reguera, B., Eds.) pp 77–120, Instituto Español de Oceanografía, Pontevedra, Spain.
    • (2002) Floraciones algales nocivas en el cono sur americano , pp. 77-120
    • Fernández, M.L.1    Míguez, A.2    Cacho, E.3    Martínez, A.4    Diógene, J.5    Yasumoto, T.6
  • 22
    • 0030581766 scopus 로고    scopus 로고
    • Okadaic acid treatment induces DNA adduct formation in BHK21 C13 fibroblasts and HESV keratinocytes
    • Fessard, V., Grosse, Y., Pfohl, L.A. and Puiseux, D.S., 1996. Okadaic acid treatment induces DNA adduct formation in BHK21 C13 fibroblasts and HESV keratinocytes. Mutation Research 361, 133–141.
    • (1996) Mutation Research , vol.361 , pp. 133-141
    • Fessard, V.1    Grosse, Y.2    Pfohl, L.A.3    Puiseux, D.S.4
  • 24
    • 0027272945 scopus 로고
    • Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds
    • Fujiki, H. and Suganuma, M., 1993. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds. Advances in Cancer Research, 61, 143–194.
    • (1993) Advances in Cancer Research , vol.61 , pp. 143-194
    • Fujiki, H.1    Suganuma, M.2
  • 26
    • 34250815661 scopus 로고    scopus 로고
    • Development of an Ultra Performance Liquid Chromatography – Mass Spectrometry method for the detection of lipophilic marine toxins
    • Fux E., McMillan D., Bire R. and Hess P., 2007. Development of an Ultra Performance Liquid Chromatography – Mass Spectrometry method for the detection of lipophilic marine toxins. J. Chromatogr. 1157, 273–280.
    • (2007) J. Chromatogr , vol.1157 , pp. 273-280
    • Fux, E.1    McMillan, D.2    Bire, R.3    Hess, P.4
  • 27
    • 30644460648 scopus 로고    scopus 로고
    • Metabolic transformation of Dinophysistoxin-3 into Dinophysistoxin-1 causes human intoxication by consumption of O-Acyl-Derivatives dinophysistoxins contaminated shellfish
    • Garcia, C., Truan, D., Lagos, M., Santelices, J.P., Diaz, J.C. and Lagos, N., 2005. Metabolic transformation of Dinophysistoxin-3 into Dinophysistoxin-1 causes human intoxication by consumption of O-Acyl-Derivatives dinophysistoxins contaminated shellfish. J. Toxicol. Sci. 30, 287–296.
    • (2005) J. Toxicol. Sci , vol.30 , pp. 287-296
    • Garcia, C.1    Truan, D.2    Lagos, M.3    Santelices, J.P.4    Diaz, J.C.5    Lagos, N.6
  • 30
    • 0023028440 scopus 로고
    • Enteropathogenicity of diarrhetic shellfish toxins in intestinal models
    • Hamano, Y., Kinoshita, Y. and Yasumoto, T., 1986. Enteropathogenicity of diarrhetic shellfish toxins in intestinal models. J. Food Hyg. Soc. Japan 27, 375–379.
    • (1986) J. Food Hyg. Soc. Japan , vol.27 , pp. 375-379
    • Hamano, Y.1    Kinoshita, Y.2    Yasumoto, T.3
  • 31
    • 0024592297 scopus 로고
    • Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism
    • Haystead, T.A., Sim, A.T.R., Carling, D., Honnor, R.C., Tsukitani, Y., Cohen, P. and Hardie, D.G., 1989. Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337, 78–81.
    • (1989) Nature , vol.337 , pp. 78-81
    • Haystead, T.A.1    Sim, A.T.R.2    Carling, D.3    Honnor, R.C.4    Tsukitani, Y.5    Cohen, P.6    Hardie, D.G.7
  • 34
    • 84904098870 scopus 로고
    • Protocol for the design, conduct and interpretation of method-performance studies (Technical Report)
    • Horwitz, W., 1995. Protocol for the design, conduct and interpretation of method-performance studies (Technical Report), Pure & Applied Chem. 67, 331–343.
    • (1995) Pure & Applied Chem , vol.67 , pp. 331-343
    • Horwitz, W.1
  • 39
    • 0036027413 scopus 로고    scopus 로고
    • Investigation of the distribution and excreation of okadaic acid in mice using immunostaining method
    • Ito, E., Yasumoto, T., Takai, A., Imanishi, S. and Harada, K., 2002. Investigation of the distribution and excreation of okadaic acid in mice using immunostaining method. Toxicon 40, 159–165.
    • (2002) Toxicon , vol.40 , pp. 159-165
    • Ito, E.1    Yasumoto, T.2    Takai, A.3    Imanishi, S.4    Harada, K.5
  • 40
    • 1842418882 scopus 로고    scopus 로고
    • Further guidance on derivation of the ARfD. Pesticide residues in food – 2002
    • FAO, Rome
    • JMPR (The Joint Food and Agriculture Organization of the United Nations/ World Health Organization Meeting on Pesticide Residues), 2002. Further guidance on derivation of the ARfD. Pesticide residues in food – 2002. Report of the JMPR 2002, FAO Plant Production and Protection Paper, 172, FAO, Rome, pp. 4–8.
    • (2002) Report of the JMPR 2002, FAO Plant Production and Protection Paper , vol.172 , pp. 4-8
  • 41
    • 0003155482 scopus 로고
    • The occurrence of Prorocentrum species and coincidental gastrointestinal illness of mussel consumers
    • Amsterdam, Elsevier
    • Kat, M., 1979. The occurrence of Prorocentrum species and coincidental gastrointestinal illness of mussel consumers. Anderson, D. M., White, A. W., and Baden, D. G. Toxic Dinoflagellates. 73–77. Amsterdam, Elsevier.
    • (1979) Toxic Dinoflagellates , pp. 73-77
    • Kat, M.1    Anderson, D.M.2    White, A.W.3    Baden, D.G.4
  • 42
    • 0021074507 scopus 로고
    • Diarrhetic mussel poisoning in the Netherlands related to the dinoflagellate Dinophysis acuminata
    • Kat, M., 1983. Diarrhetic mussel poisoning in the Netherlands related to the dinoflagellate Dinophysis acuminata. Antonie Van Leeuwenhoek 49, 417–27.
    • (1983) Antonie Van Leeuwenhoek , vol.49 , pp. 417-427
    • Kat, M.1
  • 46
    • 84954889676 scopus 로고
    • Fluorimetric determination of diarrhetic shellfish toxins by high-performance liquid chromatography
    • Lee, J.S., Yanagi, T., Kenna, R. and Yasumoto, T., 1987. Fluorimetric determination of diarrhetic shellfish toxins by high-performance liquid chromatography. Agric. Biol. Chem. 51, 877–881.
    • (1987) Agric. Biol. Chem , vol.51 , pp. 877-881
    • Lee, J.S.1    Yanagi, T.2    Kenna, R.3    Yasumoto, T.4
  • 47
    • 33244492464 scopus 로고    scopus 로고
    • Genotoxicity of the marine toxin okadaic acid in human Caco-2 cells and in mice gut cells
    • Le Hégarat, L., Jacquin, A.G., Bazin, E. and Fessard, V., 2006. Genotoxicity of the marine toxin okadaic acid in human Caco-2 cells and in mice gut cells. Environ. Toxicol. 21(1), 55–64.
    • (2006) Environ. Toxicol , vol.21 , Issue.1 , pp. 55-64
    • Le Hégarat, L.1    Jacquin, A.G.2    Bazin, E.3    Fessard, V.4
  • 48
    • 25844453511 scopus 로고    scopus 로고
    • Okadaic acid: Chromosomal non-disjunction analysis in human lymphocytes and study of aneugenic pathway in CHO-K1 cells
    • Le Hégarat, L., Orsiere, T., Botta, A. and Fessard, V., 2005. Okadaic acid: Chromosomal non-disjunction analysis in human lymphocytes and study of aneugenic pathway in CHO-K1 cells. Mutat. Res., 578, 53–63.
    • (2005) Mutat. Res , vol.578 , pp. 53-63
    • Le Hégarat, L.1    Orsiere, T.2    Botta, A.3    Fessard, V.4
  • 49
    • 0038054697 scopus 로고    scopus 로고
    • Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells
    • Le Hégarat, L., Peuch, L., Fessard, V., Poul, J.M. and Dragacci, S., 2003. Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells. Mutagenesis 18, 293–298.
    • (2003) Mutagenesis , vol.18 , pp. 293-298
    • Le Hégarat, L.1    Peuch, L.2    Fessard, V.3    Poul, J.M.4    Dragacci, S.5
  • 50
    • 7044227473 scopus 로고    scopus 로고
    • Lack of DNA damage induction by okadaic acid, a marine toxin, in the CHO-Hprt and the in vitro UDS assays
    • Le Hégarat, L., Nesslany, F., Mourot, A., Marzin, D. and Fessard, V., 2004. Lack of DNA damage induction by okadaic acid, a marine toxin, in the CHO-Hprt and the in vitro UDS assays. Mutat Res 564, 139–147.
    • (2004) Mutat Res , vol.564 , pp. 139-147
    • Le Hégarat, L.1    Nesslany, F.2    Mourot, A.3    Marzin, D.4    Fessard, V.5
  • 52
    • 33846818968 scopus 로고    scopus 로고
    • Harmful algal blooms, red tide and human health: diarretic shellfish poisoning and colorectal cancer
    • Lopez-Rodas, V., Maneiro, E., Martinez, J., Navarro, M. and Costas, E., 2006. Harmful algal blooms, red tide and human health: diarretic shellfish poisoning and colorectal cancer. An. R. Acad. Nac. Farm. 72, 391–408.
    • (2006) An. R. Acad. Nac. Farm , vol.72 , pp. 391-408
    • Lopez-Rodas, V.1    Maneiro, E.2    Martinez, J.3    Navarro, M.4    Costas, E.5
  • 53
    • 0036301117 scopus 로고    scopus 로고
    • Recovery of cellular E-cadherin precedes replenishment of estrogen receptor and estrogen-dependent proliferation of breast cancer cells rescued from a death stimulus
    • Malaguti, C. and Rossini, G.P., 2002. Recovery of cellular E-cadherin precedes replenishment of estrogen receptor and estrogen-dependent proliferation of breast cancer cells rescued from a death stimulus. J. Cell. Physiol. 192, 171–181.
    • (2002) J. Cell. Physiol , vol.192 , pp. 171-181
    • Malaguti, C.1    Rossini, G.P.2
  • 55
    • 0029670001 scopus 로고    scopus 로고
    • Transplacental passage of [3~]-okadaic acid in pregnant mice measured by radioactivity and high-performance liquid chromatography
    • Matias, W.G. and Creppy, E.E., 1996a. Transplacental passage of [3~]-okadaic acid in pregnant mice measured by radioactivity and high-performance liquid chromatography. Human Exp. Toxicol. 15(3), 226–230.
    • (1996) Human Exp. Toxicol , vol.15 , Issue.3 , pp. 226-230
    • Matias, W.G.1    Creppy, E.E.2
  • 56
    • 0029958289 scopus 로고    scopus 로고
    • Evidence for enterohepatic circulation of okadaic acid in mice
    • Matias, W.G. and Creppy, E.E., 1996b. Evidence for enterohepatic circulation of okadaic acid in mice. Toxic Substance Mechanism 15, 405–414.
    • (1996) Toxic Substance Mechanism , vol.15 , pp. 405-414
    • Matias, W.G.1    Creppy, E.E.2
  • 57
    • 0033055052 scopus 로고    scopus 로고
    • Variations in the distribution of okadaic acid in organs and biological fluids of mice related to diarrhoeic syndrome
    • Matias, W.G., Traore, A. and Creppy, E.E., 1999. Variations in the distribution of okadaic acid in organs and biological fluids of mice related to diarrhoeic syndrome. Human Exp. Toxicol. 18, 345–350.
    • (1999) Human Exp. Toxicol , vol.18 , pp. 345-350
    • Matias, W.G.1    Traore, A.2    Creppy, E.E.3
  • 58
    • 33847718250 scopus 로고    scopus 로고
    • Freeze-drying for the stabilisation of shellfish toxins in mussel tissue (Mytilus edulis) reference materials
    • McCarron, P. Emteborg, H. and Hess, P., 2007. Freeze-drying for the stabilisation of shellfish toxins in mussel tissue (Mytilus edulis) reference materials. Anal. Bioanal. Chem. 387(7), 2475–2486.
    • (2007) Anal. Bioanal. Chem , vol.387 , Issue.7 , pp. 2475-2486
    • McCarron, P.1    Emteborg, H.2    Hess, P.3
  • 60
    • 85008014335 scopus 로고
    • Isolation and structural elucidation of the causative toxin of the diarrhoetic shellfish poisoning
    • Murata, M., Shimatani, M., Sugitani, H., Oshima, Y., and Yasumoto, T., 1982. Isolation and structural elucidation of the causative toxin of the diarrhoetic shellfish poisoning. Bull. Jpn. Soc. Sci. Fish 48, 549–552.
    • (1982) Bull. Jpn. Soc. Sci. Fish , vol.48 , pp. 549-552
    • Murata, M.1    Shimatani, M.2    Sugitani, H.3    Oshima, Y.4    Yasumoto, T.5
  • 62
    • 0034625313 scopus 로고    scopus 로고
    • Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members
    • Nollet, F., Kools, P. and van Roy, F., 2000. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. J. Mol. Biol. 299, 551–572.
    • (2000) J. Mol. Biol , vol.299 , pp. 551-572
    • Nollet, F.1    Kools, P.2    van Roy, F.3
  • 63
    • 0031394513 scopus 로고    scopus 로고
    • Toxicologic evaluation of yessotoxin
    • Ogino, H., Kumagai, M., and Yasumoto, T., 1997. Toxicologic evaluation of yessotoxin. Nat Toxins 5(6), 255–259.
    • (1997) Nat Toxins , vol.5 , Issue.6 , pp. 255-259
    • Ogino, H.1    Kumagai, M.2    Yasumoto, T.3
  • 65
    • 33846512435 scopus 로고    scopus 로고
    • Azaspiracid-1 alters the E-cadherin pool in epithelial cells
    • Ronzitti, G., Hess, P., Rehmann, N. and Rossini, G.P., 2007. Azaspiracid-1 alters the E-cadherin pool in epithelial cells. Toxicol. Sci., 95, 427–435.
    • (2007) Toxicol. Sci , vol.95 , pp. 427-435
    • Ronzitti, G.1    Hess, P.2    Rehmann, N.3    Rossini, G.P.4
  • 66
    • 1642438579 scopus 로고    scopus 로고
    • Neoplastic activity of DSP toxins: The effects of okadaic acid and related compounds on cell proliferation: Tumor promotion or induction of apoptosis?
    • Botana, L.M., (Ed.)., New York, U.S.A
    • Rossini, G.P., 2000. Neoplastic activity of DSP toxins: The effects of okadaic acid and related compounds on cell proliferation: Tumor promotion or induction of apoptosis? In: Botana, L.M. (Ed.). Seafood and Freshwater Toxins Marcel Dekker, New York, U.S.A, pp. 257–288.
    • (2000) Seafood and Freshwater Toxins Marcel Dekker , pp. 257-288
    • Rossini, G.P.1
  • 67
    • 13144269571 scopus 로고    scopus 로고
    • Diarrhetic shellfish poisoning in the UK
    • Scoging, A. and Bahl, M., 1998. Diarrhetic shellfish poisoning in the UK. Lancet 352, 117.
    • (1998) Lancet , vol.352 , pp. 117
    • Scoging, A.1    Bahl, M.2
  • 68
    • 0033991763 scopus 로고    scopus 로고
    • An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases
    • Serres, M.H., Fladmark, K.E. and Doskeland, S.O., 2000. An ultrasensitive competitive binding assay for the detection of toxins affecting protein phosphatases. Toxicon 38, 347–360.
    • (2000) Toxicon , vol.38 , pp. 347-360
    • Serres, M.H.1    Fladmark, K.E.2    Doskeland, S.O.3
  • 69
    • 0028075869 scopus 로고
    • Highly sensitive assay of okadaic acid using protein phosphatase and paranitrophenyl phosphate
    • Simon, J. F. and Vernoux, J. P., 1994. “Highly sensitive assay of okadaic acid using protein phosphatase and paranitrophenyl phosphate.” Natural Toxins 2, 293–301.
    • (1994) Natural Toxins , vol.2 , pp. 293-301
    • Simon, J.F.1    Vernoux, J.P.2
  • 70
    • 27644598276 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry for analysis of lipophilic shellfish toxins described in EU Commission Decision 2002/225/EC
    • &
    • Stobo, L., Lacaze, J-P., Scott, A., Gallacher, S., Smith, E. & Quilliam, M.A., 2005. Liquid chromatography-mass spectrometry for analysis of lipophilic shellfish toxins described in EU Commission Decision 2002/225/EC. J. AOAC Int. 88, 1371–1382.
    • (2005) J. AOAC Int , vol.88 , pp. 1371-1382
    • Stobo, L.1    Lacaze, J.-P.2    Scott, A.3    Gallacher, S.4    Smith, E.5    Quilliam, M.A.6
  • 72
    • 0026649373 scopus 로고
    • An alternative theory of tissue specificity by tumour promotion of okadaic acid in glandular stomach of SD rats
    • Suginuma, M., Tatematsu, M., Yatsunami, J., Yoshizawa, S., Okabe, S., Uemura, D. and Fujiki, H., 1992. An alternative theory of tissue specificity by tumour promotion of okadaic acid in glandular stomach of SD rats. Carcinogenesis, 13, 1841–1845.
    • (1992) Carcinogenesis , vol.13 , pp. 1841-1845
    • Suginuma, M.1    Tatematsu, M.2    Yatsunami, J.3    Yoshizawa, S.4    Okabe, S.5    Uemura, D.6    Fujiki, H.7
  • 73
    • 0032889739 scopus 로고    scopus 로고
    • Direct evidence of transformation of dinophysistoxin-1 to 7-O-acyl-dinophysistoxin-1 (dinophysistoxin-3) in the scallop Patinopecten yessoensis
    • Suzuki, T., Ota, H. and Yamasaki, M., 1999. Direct evidence of transformation of dinophysistoxin-1 to 7-O-acyl-dinophysistoxin-1 (dinophysistoxin-3) in the scallop Patinopecten yessoensis. Toxicon, 37, 187–198.
    • (1999) Toxicon , vol.37 , pp. 187-198
    • Suzuki, T.1    Ota, H.2    Yamasaki, M.3
  • 74
    • 0025877838 scopus 로고
    • Inhibitory effect of okadaic acid on the p-nitrophenyl phospate phosphatase activity of protein phosphatases
    • Takai, A. and G. Mieskes, 1991. Inhibitory effect of okadaic acid on the p-nitrophenyl phospate phosphatase activity of protein phosphatases. Biochem. J. 275, 233–239.
    • (1991) Biochem. J , vol.275 , pp. 233-239
    • Takai, A.1    Mieskes, G.2
  • 75
    • 0026628626 scopus 로고
    • Inhibitory effect of okadaic acid derivatives on protein phosphatases
    • Takai, A., Murata, M., Torigoe, K., Isobe, M., Mieskes, G. and Yasumoto, T., 1992. Inhibitory effect of okadaic acid derivatives on protein phosphatases. Biochem. J. 284, 539–544.
    • (1992) Biochem. J , vol.284 , pp. 539-544
    • Takai, A.1    Murata, M.2    Torigoe, K.3    Isobe, M.4    Mieskes, G.5    Yasumoto, T.6
  • 76
    • 0022972488 scopus 로고
    • Histopathological studies on experimental marine toxin poisoning. 1. Ultrastructural changes in the small intestine and liver of suckling mice induced by dinophysistoxin-1 and pectenotoxin-1
    • Terao, K., Ito, E., Yanagi, T. and Yasumoto, T., 1986. Histopathological studies on experimental marine toxin poisoning. 1. Ultrastructural changes in the small intestine and liver of suckling mice induced by dinophysistoxin-1 and pectenotoxin-1. Toxicon 24, 1141–1151.
    • (1986) Toxicon , vol.24 , pp. 1141-1151
    • Terao, K.1    Ito, E.2    Yanagi, T.3    Yasumoto, T.4
  • 77
    • 0027376953 scopus 로고
    • Okadaic acid, a protein phosphatase inhibitor, induces sister-chromatid exchanges depending on the presence of bromodeoxyuridine
    • Tohda, H., Nagao, M., Sugimura, T. and Oikawa, A., 1993 Okadaic acid, a protein phosphatase inhibitor, induces sister-chromatid exchanges depending on the presence of bromodeoxyuridine. Mutat. Res. 289(2), 275–280.
    • (1993) Mutat. Res , vol.289 , Issue.2 , pp. 275-280
    • Tohda, H.1    Nagao, M.2    Sugimura, T.3    Oikawa, A.4
  • 78
    • 24344502293 scopus 로고    scopus 로고
    • Diarrhetic shellfish poisoning by okadaic acid esters from Brown crabs (Cancer pagurus) in Norway
    • Torgersen, T., Aasen, J., and Aune, T., 2005. Diarrhetic shellfish poisoning by okadaic acid esters from Brown crabs (Cancer pagurus) in Norway. Toxicon 46(5), 572–578.
    • (2005) Toxicon , vol.46 , Issue.5 , pp. 572-578
    • Torgersen, T.1    Aasen, J.2    Aune, T.3
  • 79
    • 0031032318 scopus 로고    scopus 로고
    • The toxin of diarrhetic shellfish poisoning, okadaic acid, increases intestinal epithelial paracellular permeability
    • Tripuraneni, J., Koutsoris, A., Pestic, L., De Lanerolle, P. and Hect, G., 1997. The toxin of diarrhetic shellfish poisoning, okadaic acid, increases intestinal epithelial paracellular permeability. Gastroenterology 112, 100–108.
    • (1997) Gastroenterology , vol.112 , pp. 100-108
    • Tripuraneni, J.1    Koutsoris, A.2    Pestic, L.3    De Lanerolle, P.4    Hect, G.5
  • 80
  • 81
    • 0030200158 scopus 로고    scopus 로고
    • A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels
    • Tubaro, A., Florio, C., Luxich, E., Sosa, S., Della Loggia, R. and Yasumoto, T., 1996. A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels. Toxicon 34, 743–752.
    • (1996) Toxicon , vol.34 , pp. 743-752
    • Tubaro, A.1    Florio, C.2    Luxich, E.3    Sosa, S.4    Della Loggia, R.5    Yasumoto, T.6
  • 83
    • 0036027996 scopus 로고    scopus 로고
    • Esterification of DSP toxins by Portuguese bivalves from the Northwest coast determined by LC-MS-a widespread phenomenon
    • Vale, P. and Sampayo, M.A., 2002a. Esterification of DSP toxins by Portuguese bivalves from the Northwest coast determined by LC-MS-a widespread phenomenon. Toxicon 40, 33–42.
    • (2002) Toxicon , vol.40 , pp. 33-42
    • Vale, P.1    Sampayo, M.A.2
  • 84
    • 0035998333 scopus 로고    scopus 로고
    • First confirmation of human diarrhoeic poisonings by okadaic acid esters after ingestion of razor clams (Solen marginatus) and green crabs (Carcinus maenas) in Aveiro lagoon, Portugal and detection of okadaic acid esters in phytoplankton
    • Vale, P. and Sampayo, M., 2002b. First confirmation of human diarrhoeic poisonings by okadaic acid esters after ingestion of razor clams (Solen marginatus) and green crabs (Carcinus maenas) in Aveiro lagoon, Portugal and detection of okadaic acid esters in phytoplankton. Toxicon 40(7), 989–996.
    • (2002) Toxicon , vol.40 , Issue.7 , pp. 989-996
    • Vale, P.1    Sampayo, M.2
  • 85
    • 0344654905 scopus 로고    scopus 로고
    • Esters of okadaic acid and dinophysistoxin-2 in Portuguese bivalves related to human poisonings
    • Vale, P. and Sampayo, M.A., 1999. Esters of okadaic acid and dinophysistoxin-2 in Portuguese bivalves related to human poisonings. Toxicon 37, 1109–1121.
    • (1999) Toxicon , vol.37 , pp. 1109-1121
    • Vale, P.1    Sampayo, M.A.2
  • 89
    • 0028813783 scopus 로고
    • Dealing with seafood toxins: present approaches and future options
    • Wright, J.L.C., 1995. Dealing with seafood toxins: present approaches and future options. Food Res. Int. 28, 347–358.
    • (1995) Food Res. Int , vol.28 , pp. 347-358
    • Wright, J.L.C.1
  • 90
    • 0001062228 scopus 로고
    • Biological activities of semisynthetic analogs of dinophysistoxin-3, thje major diarrhetic shellfish toxin
    • Yanagi, T., Murata, M., Torigoe, K. and Yasumoto, T., 1989. Biological activities of semisynthetic analogs of dinophysistoxin-3, thje major diarrhetic shellfish toxin. Agric. Biol. Chem. 53, 525–529.
    • (1989) Agric. Biol. Chem , vol.53 , pp. 525-529
    • Yanagi, T.1    Murata, M.2    Torigoe, K.3    Yasumoto, T.4
  • 92
    • 0000540625 scopus 로고
    • Polyether toxin involved in seafood poisoning
    • Washington D.C., American Chemical Society
    • Yasumoto, T. and Murata, M., 1990. Polyether toxin involved in seafood poisoning. Marine toxins. S. Hall and G. Stritchartz. Washington D.C., American Chemical Society: 120–132.
    • (1990) Marine toxins , pp. 120-132
    • Yasumoto, T.1    Murata, M.2    Hall, S.3    Stritchartz, G.4
  • 94
    • 84999113210 scopus 로고
    • Occurrence of a new type of toxic shellfish poisoning in the Tohuku District
    • Yasumoto, T., Oshima, Y. and Yamaguchi, M., 1978. Occurrence of a new type of toxic shellfish poisoning in the Tohuku District. Bull. Jap. Soc. Sci. Fish. 44(11), 1249–1255.
    • (1978) Bull. Jap. Soc. Sci. Fish , vol.44 , Issue.11 , pp. 1249-1255
    • Yasumoto, T.1    Oshima, Y.2    Yamaguchi, M.3


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