Trans-10,cis-12-Conjugated Linoleic Acid Affects Expression of Lipogenic Genes in Mammary Glands of Lactating Dairy Goats

Journal of Agricultural and Food Chemistry

Volumn 65, Issue 43, 2017, Pages 9460-9467

  Shi, Huaiping ^a   Zhang, Tianying ^a   Li, Cong ^a   Wang, Jianjue ^a   Huang, Jiangtao ^a   Li, Zhongyang ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

conjugated linoleic acid; dairy goat; lipogenesis; mammary gland; milk fat

Indexed keywords

CHAINS; DAIRIES; DAIRY PRODUCTS; DIETARY SUPPLEMENTS; GENE EXPRESSION; GENES; LINOLEIC ACID; MAMMALS; OILS AND FATS; POLYMERASE CHAIN REACTION; UNSATURATED FATTY ACIDS;

CONJUGATED LINOLEIC ACID; DIETARY SUPPLEMENTATION; LIPOGENESIS; MAMMARY GLAND; MEDIUM-CHAIN FATTY ACIDS; MILK FATS; MRNA EXPRESSION LEVEL; QUANTITATIVE POLYMERASE CHAIN REACTION;

FATTY ACIDS;

CONJUGATED LINOLEIC ACID; FATTY ACID; FATTY ACID BINDING PROTEIN 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANS-10,CIS-12-CONJUGATED LINOLEIC ACID;

ANALYSIS; ANIMAL; CHEMISTRY; DIETARY SUPPLEMENT; FEMALE; GENETICS; GOAT; LACTATION; LIPOGENESIS; METABOLISM; MILK; UDDER;

ANIMALS; DIETARY SUPPLEMENTS; FATTY ACID BINDING PROTEIN 3; FATTY ACIDS; FEMALE; GOATS; LACTATION; LINOLEIC ACIDS, CONJUGATED; LIPOGENESIS; MAMMARY GLANDS, ANIMAL; MILK; PPAR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 85032638469     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.7b02377     Document Type: Article

References (36)

1. Bauman, D. E.; Griinari, J. M. Nutritional regulation of milk fat synthesis Annu. Rev. Nutr. 2003, 23, 203-227 10.1146/annurev.nutr.23.011702.073408
2. Baumgard, L. H.; Corl, B. A.; Dwyer, D. A.; Sæbø, A.; Bauman, D. E. Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis Am. J. Physiol.: Regul., Integr. Comp. Physiol. 2000, 278, R179-R184
3. Lock, A. L.; Teles, B. M.; Perfield, J. W., 2nd; Bauman, D. E.; Sinclair, L. A. A conjugated linoleic acid supplement containing trans-10,cis-12 reduces milk fat synthesis in lactating sheep J. Dairy Sci. 2006, 89, 1525-1532 10.3168/jds.S0022-0302(06)72220-2
4. Lock, A. L.; Rovai, M.; Gipson, T. A.; de Veth, M. J.; Bauman, D. E. A conjugated linoleic acid supplement containing trans-10,cis-12-conjugated linoleic acid reduces milk fat synthesis in lactating goats J. Dairy Sci. 2008, 91, 3291-3299 10.3168/jds.2008-1071
5. Bauman, D. E.; Harvatine, K. J.; Lock, A. L. Nutrigenomics, rumen-derived bioactive fatty acids, and the regulation of milk fat synthesis Annu. Rev. Nutr. 2011, 31, 299-319 10.1146/annurev.nutr.012809.104648
6. Baumgard, L. H.; Matitashvili, E.; Corl, B. A.; Dwyer, D. A.; Bauman, D. E. trans-10,cis-12-Conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows J. Dairy Sci. 2002, 85, 2155-2163 10.3168/jds.S0022-0302(02)74294-X
7. Harvatine, K. J.; Bauman, D. E. SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA J. Nutr. 2006, 136, 2468-2474
8. Gervais, R.; McFadden, J. W.; Lengi, A. J.; Corl, B. A.; Chouinard, P. Y. Effects of intravenous infusion of trans-10,cis-12-18:2 on mammary lipid metabolism in lactating dairy cows J. Dairy Sci. 2009, 92, 5167-5177 10.3168/jds.2009-2281
9. Hussein, M.; Harvatine, K. H.; Weerasinghe, W. M.; Sinclair, L. A.; Bauman, D. E. Conjugated linoleic acid-induced milk fat depression in lactating ewes is accompanied by reduced expression of mammary genes involved in lipid synthesis J. Dairy Sci. 2013, 96, 3825-3834 10.3168/jds.2013-6576
10. Griinari, J.; Bauman, D. Milk fat depression: Concepts, mechanisms and management applications Ruminant Physiol.: Dig., Metab. Impact Nutr. Gene Expression, Immunol. Stress 2006, 389-417
11. Kadegowda, A. K.; Bionaz, M.; Piperova, L. S.; Erdman, R. A.; Loor, J. J. Peroxisome proliferator-activated receptor-γ activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents J. Dairy Sci. 2009, 92, 4276-4289 10.3168/jds.2008-1932
12. Chilliard, Y.; Ferlay, A.; Rouel, J.; Lamberet, G. A review of nutritional and physiological factors affecting goat milk lipid synthesis and lipolysis J. Dairy Sci. 2003, 86, 1751-1770 10.3168/jds.S0022-0302(03)73761-8
13. Shingfield, K. J.; Bernard, L.; Leroux, C.; Chilliard, Y. Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants Animal 2010, 4, 1140-1166 10.1017/S1751731110000510
14. Bernard, L.; Montazer Torbati, M. B.; Graulet, B.; Leroux, C.; Chilliard, Y. Long-chain fatty acids differentially alter lipogenesis in bovine and caprine mammary slices J. Dairy Res. 2013, 80, 89-95 10.1017/S0022029912000726
15. Chilliard, Y.; Toral, P. G.; Shingfield, K. J.; Rouel, J.; Leroux, C.; Bernard, L. Effects of diet and physiological factors on milk fat synthesis, milk fat composition and lipolysis in the goat: A short review Small Ruminant Res. 2014, 122, 31-37 10.1016/j.smallrumres.2014.07.014
16. Luna, P.; Juarez, M.; de la Fuente, M. A. Validation of a rapid milk fat separation method to determine the fatty acid profile by gas chromatography J. Dairy Sci. 2005, 88, 3377-3381 10.3168/jds.S0022-0302(05)73021-6
17. Kadegowda, A. K.; Bionaz, M.; Thering, B.; Piperova, L. S.; Erdman, R. A.; Loor, J. J. Identification of internal control genes for quantitative polymerase chain reaction in mammary tissue of lactating cows receiving lipid supplements J. Dairy Sci. 2009, 92, 2007-2019 10.3168/jds.2008-1655
18. Shingfield, K. J.; Rouel, J.; Chilliard, Y. Effect of calcium salts of a mixture of conjugated linoleic acids containing trans-10,cis-12 in the diet on milk fat synthesis in goats Br. J. Nutr. 2009, 101, 1006-1019 10.1017/S0007114508051696
19. Baldin, M.; Dresch, R.; Souza, J.; Fernandes, D.; Gama, M.; Harvatine, K.; Oliveira, D. CLA induced milk fat depression reduced dry matter intake and improved energy balance in dairy goats Small Ruminant Research 2014, 116, 44-50 10.1016/j.smallrumres.2013.10.001
20. Mackle, T. R.; Kay, J. K.; Auldist, M. J.; McGibbon, A. K.; Philpott, B. A.; Baumgard, L. H.; Bauman, D. E. Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows J. Dairy Sci. 2003, 86, 644-652 10.3168/jds.S0022-0302(03)73642-X
21. Odens, L. J.; Burgos, R.; Innocenti, M.; VanBaale, M. J.; Baumgard, L. H. Effects of varying doses of supplemental conjugated linoleic acid on production and energetic variables during the transition period J. Dairy Sci. 2007, 90, 293-305 10.3168/jds.S0022-0302(07)72630-9
22. Emery, R. S. Biosynthesis of milk fat J. Dairy Sci. 1973, 56, 1187-1195 10.3168/jds.S0022-0302(73)85334-2
23. Fujino, T.; Kondo, J.; Ishikawa, M.; Morikawa, K.; Yamamoto, T. T. Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate J. Biol. Chem. 2001, 276, 11420-11426 10.1074/jbc.M008782200
24. Palmquist, D. L. Milk fat: Origin of fatty acids and influence of nutritional factors thereon. In Advanced Dairy Chemistry; Fox, P. F.; McSweeney, P. L. H., Eds.; Springer: Boston, MA, 2006; Vol. 2 Lipids, pp 43-92, DOI: 10.1007/0-387-28813-9-2.
25. Bionaz, M.; Loor, J. J. Gene networks driving bovine milk fat synthesis during the lactation cycle BMC Genomics 2008, 9, 366 10.1186/1471-2164-9-366
26. Bionaz, M.; Loor, J. J. ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation J. Nutr. 2008, 138, 1019-1024
27. Invernizzi, G.; Thering, B. J.; McGuire, M. A.; Savoini, G.; Loor, J. J. Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements Funct. Integr. Genomics 2010, 10, 561-575 10.1007/s10142-010-0179-y
28. Kelsey, J. A.; Corl, B. A.; Collier, R. J.; Bauman, D. E. The effect of breed, parity, and stage of lactation on conjugated linoleic acid (CLA) in milk fat from dairy cows J. Dairy Sci. 2003, 86, 2588-2597 10.3168/jds.S0022-0302(03)73854-5
29. Bernard, L.; Rouel, J.; Leroux, C.; Ferlay, A.; Faulconnier, Y.; Legrand, P.; Chilliard, Y. Mammary lipid metabolism and milk fatty acid secretion in alpine goats fed vegetable lipids J. Dairy Sci. 2005, 88, 1478-1489 10.3168/jds.S0022-0302(05)72816-2
30. Yen, C. L.; Stone, S. J.; Koliwad, S.; Harris, C.; Farese, R. V., Jr. Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis J. Lipid Res. 2008, 49, 2283-2301 10.1194/jlr.R800018-JLR200
31. Walther, T. C.; Farese, R. V., Jr. Lipid droplets and cellular lipid metabolism Annu. Rev. Biochem. 2012, 81, 687-714 10.1146/annurev-biochem-061009-102430
32. Shi, H.; Luo, J.; Zhu, J.; Li, J.; Sun, Y.; Lin, X.; Zhang, L.; Yao, D.; Shi, H. PPAR γ Regulates Genes Involved in Triacylglycerol Synthesis and Secretion in Mammary Gland Epithelial Cells of Dairy Goats PPAR Res. 2013, 2013, 1-10 10.1155/2013/310948
33. Kang, Y.; Hengbo, S.; Jun, L.; Jun, L.; Wangsheng, Z.; Huibin, T.; Huaiping, S. PPARG modulated lipid accumulation in dairy GMEC via regulation of ADRP gene J. Cell. Biochem. 2015, 116, 192-201 10.1002/jcb.24958
34. Eberle, D.; Hegarty, B.; Bossard, P.; Ferre, P.; Foufelle, F. SREBP transcription factors: Master regulators of lipid homeostasis Biochimie 2004, 86, 839-848 10.1016/j.biochi.2004.09.018
35. Ma, L.; Corl, B. A. Transcriptional regulation of lipid synthesis in bovine mammary epithelial cells by sterol regulatory element binding protein-1 J. Dairy Sci. 2012, 95, 3743-3755 10.3168/jds.2011-5083
36. Granlund, L.; Juvet, L. K.; Pedersen, J. I.; Nebb, H. I. trans-10,cis-12-Conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARγ modulator J. Lipid Res. 2003, 44, 1441-1452 10.1194/jlr.M300120-JLR200