Attitudes about future genetic testing for posttraumatic stress disorder and addiction among community-based veterans

Frontiers in Psychiatry

Volumn 8, Issue MAY, 2017, Pages

  Lent, Michelle R ^a   Hoffman, Stuart N ^a   Lester Kirchner, H ^a   Urosevich, Thomas G ^a   Boscarino, Joseph J ^b   Boscarino, Joseph A ^a  

^a GEISINGER MEDICAL CENTER   (United States)

^b William James College   (United States)

Author keywords

Addiction; Genetic testing; Posttraumatic stress disorder; Psychiatric genetics; Veterans

Indexed keywords

NARCOTIC ANALGESIC AGENT;

ADDICTION; ADULT; AGED; ALCOHOLISM; ARTICLE; COMMUNITY ASSESSMENT; CONCUSSION; CONSUMER ATTITUDE; DISEASE ASSOCIATION; DNA DETERMINATION; DRUG EFFECT; FEMALE; FOLLOW UP; GENETIC SCREENING; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; PAIN; POSTTRAUMATIC STRESS DISORDER; SEX RATIO; VETERAN;

EID: 85032585936     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2017.00076     Document Type: Article

References (46)

1. Burmeister M, McInnis MG, Zollner S. Psychiatric genetics: progress amid controversy. Nat Rev Genet (2008) 9(7):527-40. doi:10.1038/nrg2381
2. Lawrence RE, Appelbaum PS. Genetic testing in psychiatry: a review of attitudes and beliefs. Psychiatry (2011) 74(4):315-31. doi:10.1521/psyc.2011.74.4.315
3. Meiser B, Kasparian NA, Mitchell PB, Strong K, Simpson JM, Tabassum L, et al. Attitudes to genetic testing in families with multiple cases of bipolar disorder. Genet Test (2008) 12(2):233-43. doi:10.1089/gte.2007.0100
4. Bortolotti L, Widdows H. The right not to know: the case of psychiatric disorders. J Med Ethics (2011) 37(11):673-767. doi:10.1136/jme.2010. 041111
5. Laegsgaard MM, Kristensen AS, Mors O. Potential consumers' attitudes toward psychiatric genetic research and testing and factors influencing their intentions to test. Genet Test Mol Biomarkers (2009) 13(1):57-65. doi:10.1089/gtmb. 2008.0022
6. Austin J. Genetic testing for psychiatric disorders. Psychiatric Times (2013) 30(6):15-6.
7. Dedert EA, Elbogen EB, Hauser MA, Hertzberg JS, Wilson SM, Dennis MF, et al. Consumer perspectives on genetic testing for psychiatric disorders: the attitudes of veterans with posttraumatic stress disorder and their families. Genet Test Mol Biomarkers (2012) 16(9):1122-9. doi:10.1089/gtmb.2012. 0048
8. Lee DJ, Warner CH, Hoge CW. Advances and controversies in military posttraumatic stress disorder screening. Curr Psychiatry Rep (2014) 16(9):467. doi:10.1007/s11920-014-0467-7
9. Williams EC, Rubinsky AD, Chavez LJ, Lapham GT, Rittmueller SE, Achtmeyer CE, et al. An early evaluation of implementation of brief intervention for unhealthy alcohol use in the US Veterans Health Administration. Addiction (2014) 109(9):1472-81. doi:10.1111/add.12600
10. Kang HK, Natelson BH, Mahan CM, Lee KY, Murphy FM. Post-traumatic stress disorder and chronic fatigue syndrome-like illness among Gulf War veterans: a population-based survey of 30,000 veterans. Am J Epidemiol (2003) 157(2):141-8. doi:10.1093/aje/kwf187
11. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry (2005) 62(6):593-602. doi:10.1001/archpsyc.62.6.593
12. Kulka RA. Trauma and the Vietnam War Generation: Report of Findings from the National Vietnam Veterans Readjustment Study. New York, NY: Brunner/Mazel (1990).
13. Department of Veterans Affairs. PTSD and Substance Abuse in Veterans (2015). Available from: https://www.ptsd.va.gov/public/problems/ptsd_substance:abuse_veterans.asp
14. DeLisi LE, Bertisch H. A preliminary comparison of the hopes of researchers, clinicians, and families for the future ethical use of genetic findings on schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2006) 141B(1):110-5. doi:10.1002/ajmg.b.30249
15. Austin JC, Smith GN, Honer WG. The genomic era and perceptions of psychotic disorders: genetic risk estimation, associations with reproductive decisions and views about predictive testing. Am J Med Genet B Neuropsychiatr Genet (2006) 141B(8):926-8. doi:10.1002/ajmg.b.30372
16. Strobel B, McManus L, Leong S, Blow F, Slaymaker V, Berrettini W, et al. A cross-sectional study of attitudes about the use of genetic testing for clinical care among patients with an alcohol use disorder. Alcohol Alcohol (2013) 48:700-3. doi:10.1093/alcalc/agt130
17. Boscarino JA. Post-traumatic stress and associated disorders among Vietnam veterans: the significance of combat exposure and social support. J Trauma Stress (1995) 8(2):317-36. doi:10.1002/jts.2490080211
18. Boscarino JA, Hoffman SN, Pitcavage JM, Urosevich TG. Mental health disorders and treatment seeking among veterans in non-VA facilities: results and implications from the veterans' health study. Mil Behav Health (2015) 3(4):244-54. doi:10.1080/21635781.2015.1077179
19. Hoffman SN, Zhang X, Erlich PM, Boscarino JA. Grapheme-color synesthesia and posttraumatic stress disorder: preliminary results from the veterans health study. Psychosom Med (2012) 74(9):912-5. doi:10.1097/PSY.0b013e3182731007
20. Adams RE, Boscarino JA. Predictors of PTSD and delayed PTSD after disaster: the impact of exposure and psychosocial resources. J Nerv Ment Dis (2006) 194(7):485. doi:10.1097/01.nmd.0000228503.95503.e9
21. Boscarino JA, Adams RE, Figley CR. Mental health service use after the World Trade Center disaster: utilization trends and comparative effectiveness. J Nerv Ment Dis (2011) 199(2):91-9. doi:10.1097/NMD. 0b013e3182043b39
22. Boscarino JA, Galea S, Adams RE, Ahern J, Resnick H, Vlahov D. Mental health service and medication use in New York City after the September 11, 2001, terrorist attack. Psychiatr Serv (2004) 55(3):274-83. doi:10.1176/appi. ps.55.3.274
23. Boscarino JA, Hoffman SN, Adams RE, Figley CR, Solhkhah R. Mental health outcomes among vulnerable residents after Hurricane Sandy: implications for disaster research and planning. Am J Disaster Med (2014) 9(2):97-106. doi:10.5055/ajdm.2014.0147
24. Boscarino JA, Kirchner HL, Hoffman SN, Sartorius J. Use of the New York PTSD risk score to predict PTSD: current and future research efforts. Gen Hosp Psychiatry (2012) 34(3):317-9. doi:10.1016/j.genhosppsych.2012. 01.003
25. Galea S, Ahern J, Resnick H, Kilpatrick D, Bucuvalas M, Gold J, et al. Psychological sequelae of the September 11 terrorist attacks in New York City. N Engl J Med (2002) 346(13):982-7. doi:10.1056/NEJMsa013404
26. Boscarino JA, Kirchner HL, Hoffman SN, Sartorius J, Adams RE, Figley CR. The New York PTSD risk score for assessment of psychological trauma: male and female versions. Psychiatry Res (2012) 200(2):827-34. doi:10.1016/j. psychres.2012.04.022
27. Paulsen AS, Crowe RR, Noyes R, Pfohl B. Reliability of the telephone interview in diagnosing anxiety disorders. Arch Gen Psychiatry (1988) 45(1):62-3. doi:10.1001/archpsyc.1988.01800250076009
28. Weeks MF, Kulka RA, Lessler JT, Whitmore RW. Personal versus telephone surveys for collecting household health data at the local level. Am J Public Health (1983) 73(12):1389-94. doi:10.2105/AJPH.73.12.1389
29. King M. At risk drinking among general practice attenders: validation of the CAGE questionnaire. Psychol Med (1986) 16(1):213-7. doi:10.1017/S0033291700002658
30. Hoge CW, Castro CA, Messer SC, McGurk D, Cotting DI, Koffman RL. Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care. N Engl J Med (2004) 351(1):13-22. doi:10.1056/NEJMoa040603
31. Boscarino JA, Adams RE, Stuber J, Galea S. Disparities in mental health treatment following the World Trade Center Disaster: implications for mental health care and health services research. J Trauma Stress (2005) 18(4):287-97. doi:10.1002/jts.20039
32. Groves RM, Fowler FJ Jr, Couper MP, Lepkowski JM, Singer E, Tourangeau R. Survey Methodology (Vol. 561). New York, NY: John Wiley & Sons (2009).
33. Hosmer DW, Lemeshow S. Applied Logistic Regression. 2nd ed. New York, NY: John Wiley & Sons (2000).
34. Long JS, Freese J. Regression Models for Categorical Dependent Variables Using Stata. 3rd ed. College Station, TX: Stata Press (2014).
35. Breslau N, Lucia VC, Davis GC. Partial PTSD versus full PTSD: an empirical examination of associated impairment. Psychol Med (2004) 34(7):1205-14. doi:10.1017/S0033291704002594
36. Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med (2015) 372(9):793-5. doi:10.1056/NEJMp1500523
37. Boscarino JA, Kirchner HL, Hoffman SN, Erlich PM. Predicting PTSD using the New York risk score with genotype data: potential clinical and research opportunities. Neuropsychiatr Dis Treat (2013) 9:517-27. doi:10.2147/NDT.S42422
38. EEOC. The Genetic Information Nondiscrimination Act. (2008). Available from: http://www.eeoc.gov/laws/statutes/gina.cfm
39. Austin JC, Honer WG. The genomic era and serious mental illness: a potential application for psychiatric genetic counseling. Psychiatr Serv (2007) 58(2):254-61. doi:10.1176/ps.2007.58.2.254
40. Hippman C, Lohn Z, Ringrose A, Inglis A, Cheek J, Austin JC. "Nothing is absolute in life": understanding uncertainty in the context of psychiatric genetic counseling from the perspective of those with serious mental illness. J Genet Couns (2013) 22(5):625-32. doi:10.1007/s10897-013-9594-2
41. Austin JC, Honer WG. Psychiatric genetic counselling for parents of individuals affected with psychotic disorders: a pilot study. Early Interv Psychiatry (2008) 2(2):80-9. doi:10.1111/j.1751-7893.2008.00062.x
42. Hippman C, Ringrose A, Inglis A, Cheek J, Albert AY, Remick R, et al. A pilot randomized clinical trial evaluating the impact of genetic counseling for serious mental illnesses. J Clin Psychiatry (2016) 77(2):e190-8. doi:10.4088/JCP. 14m09710
43. Costain G, Esplen MJ, Toner B, Hodgkinson KA, Bassett AS. Evaluating genetic counseling for family members of individuals with schizophrenia in the molecular age. Schizophr Bull (2014) 40(1):88-99. doi:10.1093/schbul/sbs124
44. Erlich PM, Hoffman SN, Rukstalis M, Han JJ, Chu X, Linda Kao WH, et al. Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. Hum Genet (2010) 128(5):491-9. doi:10.1007/s00439-010-0876-6
45. Benedek DM, Wynn GH. Clinical Manual for Management of PTSD. Washington, DC: American Psychiatric Publishing, Inc. (2011).
46. Boscarino JA. Vietnam veterans, postwar experiences, and health outcomes. In: Fink G, editor. Encyclopedia of Stress. 2nd ed. New York, NY: Academic Press (2007). p. 830-8.