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Volumn 27, Issue 5, 2017, Pages 403-410

Current status and future direction in the management of malignant melanoma

Author keywords

BRAF; CTLA 4; MEK inhibitor; Melanoma; Nanoparticle; Photodynamic therapy; Programmed cell death 1 receptor

Indexed keywords

AXITINIB; B RAF KINASE INHIBITOR; BEVACIZUMAB; CANCER VACCINE; DACARBAZINE; IPILIMUMAB; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; NANOPARTICLE; PEGINTERFERON ALPHA; PEMBROLIZUMAB; PROTEIN TYROSINE KINASE INHIBITOR; RNA VACCINE;

EID: 85032373537     PISSN: 09608931     EISSN: 14735636     Source Type: Journal    
DOI: 10.1097/CMR.0000000000000379     Document Type: Review
Times cited : (50)

References (88)
  • 1
    • 0003964361 scopus 로고    scopus 로고
    • American Cancer Society. [Accessed 13 October]
    • American Cancer Society. Cancer Facts and Figures 2016. Available at: http://www.cancer.org/acs/groups/content/@research/documents/document/acspc-047079.pdf. [Accessed 13 October 2016].
    • (2016) Cancer Facts and Figures 2016
  • 2
    • 84907499926 scopus 로고    scopus 로고
    • Treating advanced melanoma: Current insights and opportunities
    • Tronnier M, Mitteldorf C. Treating advanced melanoma: current insights and opportunities. Cancer Manag Res 2014; 6: 349-356.
    • (2014) Cancer Manag Res , vol.6 , pp. 349-356
    • Tronnier, M.1    Mitteldorf, C.2
  • 3
    • 84897014639 scopus 로고    scopus 로고
    • Current and future roles of targeted therapy and immunotherapy in advanced melanoma
    • Olszanski AJ. Current and future roles of targeted therapy and immunotherapy in advanced melanoma. J Manag Care Spec Pharm 2014; 20: 346-356.
    • (2014) J Manag Care Spec Pharm , vol.20 , pp. 346-356
    • Olszanski, A.J.1
  • 5
    • 0033565416 scopus 로고    scopus 로고
    • Classification of cutaneous malignant melanoma: A reassessment of histopathologic criteria for the distinction of different types
    • Weyers W, Euler M, Diaz-Cascajo C, Schill WB, Bonczkowitz M. Classification of cutaneous malignant melanoma: a reassessment of histopathologic criteria for the distinction of different types. Cancer 1999; 86: 288-299.
    • (1999) Cancer , vol.86 , pp. 288-299
    • Weyers, W.1    Euler, M.2    Diaz-Cascajo, C.3    Schill, W.B.4    Bonczkowitz, M.5
  • 6
    • 84976328992 scopus 로고    scopus 로고
    • Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline: Update 2016
    • Garbe C, Peris K, Hauschild A, Saiag P, Middleton M, Bastholt L, et al. Diagnosis and treatment of melanoma. European consensus-based interdisciplinary guideline: update 2016. Eur J Cancer 2016; 63: 201-217.
    • (2016) Eur J Cancer , vol.63 , pp. 201-217
    • Garbe, C.1    Peris, K.2    Hauschild, A.3    Saiag, P.4    Middleton, M.5    Bastholt, L.6
  • 8
    • 37549072095 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. Accessed 13 March
    • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Available at: https://www.nccn.org/professionals/physician-gls/f-guidelines.asp. [Accessed 13 March 2017].
    • (2017) NCCN Clinical Practice Guidelines in Oncology
  • 9
    • 84933516644 scopus 로고    scopus 로고
    • Recent advances in targeted nanoparticles drug delivery to melanoma
    • Li J, Wang Y, Liang R, An X, Wang K, Shen G, et al. Recent advances in targeted nanoparticles drug delivery to melanoma. Nanomedicine 2015; 11: 769-794.
    • (2015) Nanomedicine , vol.11 , pp. 769-794
    • Li, J.1    Wang, Y.2    Liang, R.3    An, X.4    Wang, K.5    Shen, G.6
  • 10
    • 84878299289 scopus 로고    scopus 로고
    • Efficacy of combined axitinib with dacarbazine in a b16f1 melanoma xenograft model
    • Zhang XH, Qiao EQ, Gao Z, Yuan HQ, Cai PF, Li XM, et al. Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model. Oncol Lett 2013; 6: 69-74.
    • (2013) Oncol Lett , vol.6 , pp. 69-74
    • Zhang, X.H.1    Qiao, E.Q.2    Gao, Z.3    Yuan, H.Q.4    Cai, P.F.5    Li, X.M.6
  • 11
    • 79952613370 scopus 로고    scopus 로고
    • Systematic review of medical treatment in melanoma: Current status and future prospects
    • Garbe C, Eigentler TK, Keilholz U, Hauschild A, Kirkwood JM. Systematic review of medical treatment in melanoma: current status and future prospects. Oncologist 2011; 16: 5-24.
    • (2011) Oncologist , vol.16 , pp. 5-24
    • Garbe, C.1    Eigentler, T.K.2    Keilholz, U.3    Hauschild, A.4    Kirkwood, J.M.5
  • 12
    • 0032858487 scopus 로고    scopus 로고
    • Phase III multicenter randomized trial of the dartmouth regimen versus dacarbazine in patients with metastatic melanoma
    • Chapman PB, Einhorn LH, Meyers ML, Saxman S, Destro AN, Panageas KS, et al. Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol 1999; 17: 2745-2751.
    • (1999) J Clin Oncol , vol.17 , pp. 2745-2751
    • Chapman, P.B.1    Einhorn, L.H.2    Meyers, M.L.3    Saxman, S.4    Destro, A.N.5    Panageas, K.S.6
  • 13
    • 1842562211 scopus 로고    scopus 로고
    • Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: A phase III study
    • Avril MF, Aamdal S, Grob JJ, Hauschild A, Mohr P, Bonerandi JJ, et al. Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study. J Clin Oncol 2004; 22: 1118-1125.
    • (2004) J Clin Oncol , vol.22 , pp. 1118-1125
    • Avril, M.F.1    Aamdal, S.2    Grob, J.J.3    Hauschild, A.4    Mohr, P.5    Bonerandi, J.J.6
  • 14
    • 70350100345 scopus 로고    scopus 로고
    • Involvement of abc transporters in melanogenesis and the development of multidrug resistance of melanoma
    • Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM. Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res 2009; 22: 740-749.
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 740-749
    • Chen, K.G.1    Valencia, J.C.2    Gillet, J.P.3    Hearing, V.J.4    Gottesman, M.M.5
  • 15
    • 0346727156 scopus 로고    scopus 로고
    • Drug resistance in human melanoma: Mechanisms and therapeutic opportunities
    • Rockmann H, Schadendorf D. Drug resistance in human melanoma: mechanisms and therapeutic opportunities. Onkologie 2003; 26: 581-587.
    • (2003) Onkologie , vol.26 , pp. 581-587
    • Rockmann, H.1    Schadendorf, D.2
  • 16
    • 77953520970 scopus 로고    scopus 로고
    • DNA repair pathways and human metastatic malignant melanoma
    • Sarasin A, Dessen P. DNA repair pathways and human metastatic malignant melanoma. Curr Mol Med 2010; 10: 413-418.
    • (2010) Curr Mol Med , vol.10 , pp. 413-418
    • Sarasin, A.1    Dessen, P.2
  • 17
    • 0037352253 scopus 로고    scopus 로고
    • Adjuvant therapy of cutaneous melanoma: The interferon debate
    • Kefford RF. Adjuvant therapy of cutaneous melanoma: the interferon debate. Ann Oncol 2003; 14: 358-365.
    • (2003) Ann Oncol , vol.14 , pp. 358-365
    • Kefford, R.F.1
  • 18
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: The eastern cooperative oncology group trial est 1684
    • Kirkwood JM, Strawderman MH, Ernstoff MS, Smith TJ, Borden EC, Blum RH. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol 1996; 14: 7-17.
    • (1996) J Clin Oncol , vol.14 , pp. 7-17
    • Kirkwood, J.M.1    Strawderman, M.H.2    Ernstoff, M.S.3    Smith, T.J.4    Borden, E.C.5    Blum, R.H.6
  • 19
    • 0041409703 scopus 로고    scopus 로고
    • Does adjuvant interferon-Alpha for high-risk melanoma provide a worthwhile benefits a meta-Analysis of the randomised trials
    • Wheatley K, Ives N, Hancock B, Gore M, Eggermont A, Suciu S. Does adjuvant interferon-Alpha for high-risk melanoma provide a worthwhile benefits A meta-Analysis of the randomised trials. Cancer Treat Rev 2003; 29: 241-252.
    • (2003) Cancer Treat Rev , vol.29 , pp. 241-252
    • Wheatley, K.1    Ives, N.2    Hancock, B.3    Gore, M.4    Eggermont, A.5    Suciu, S.6
  • 20
    • 84879551963 scopus 로고    scopus 로고
    • Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b (eortc 18991 side study
    • Busse A, Rapion J, Fusi A, Suciu S, Nonnenmacher A, Santinami M, et al. Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b (EORTC 18991 side study). Cancer Immunol Immunother 2013; 62: 1223-1233.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1223-1233
    • Busse, A.1    Rapion, J.2    Fusi, A.3    Suciu, S.4    Nonnenmacher, A.5    Santinami, M.6
  • 21
    • 84655168007 scopus 로고    scopus 로고
    • Ulceration and stage are predictive of interferon efficacy in melanoma: Results of the phase III adjuvant trials eortc 18952 and eortc 18991
    • Eggermont AM, Suciu S, Testori A, Kruit WH, Marsden J, Punt CJ, et al. Ulceration and stage are predictive of interferon efficacy in melanoma: results of the phase III adjuvant trials EORTC 18952 and EORTC 18991. Eur J Cancer 2012; 48: 218-225.
    • (2012) Eur J Cancer , vol.48 , pp. 218-225
    • Eggermont, A.M.1    Suciu, S.2    Testori, A.3    Kruit, W.H.4    Marsden, J.5    Punt, C.J.6
  • 23
    • 0344440995 scopus 로고    scopus 로고
    • Phase II trial of intralesional therapy with interleukin-2 in soft-Tissue melanoma metastases
    • Radny P, Caroli UM, Bauer J, Paul T, Schlegel C, Eigentler TK, et al. Phase II trial of intralesional therapy with interleukin-2 in soft-Tissue melanoma metastases. Br J Cancer 2003; 89: 1620-1626.
    • (2003) Br J Cancer , vol.89 , pp. 1620-1626
    • Radny, P.1    Caroli, U.M.2    Bauer, J.3    Paul, T.4    Schlegel, C.5    Eigentler, T.K.6
  • 24
    • 84859984869 scopus 로고    scopus 로고
    • Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma
    • Guan H, Singh NP, Singh UP, Nagarkatti PS, Nagarkatti M. Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma. PLoS One 2012; 7: e35650.
    • (2012) PLoS One , vol.7 , pp. e35650
    • Guan, H.1    Singh, N.P.2    Singh, U.P.3    Nagarkatti, P.S.4    Nagarkatti, M.5
  • 26
    • 51049113834 scopus 로고    scopus 로고
    • Braf v600e disrupts azd6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and raf proteins
    • Friday BB, Yu C, Dy GK, Smith PD, Wang L, Thibodeau SN, et al. BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins. Cancer Res 2008; 68: 6145-6153.
    • (2008) Cancer Res , vol.68 , pp. 6145-6153
    • Friday, B.B.1    Yu, C.2    Dy, G.K.3    Smith, P.D.4    Wang, L.5    Thibodeau, S.N.6
  • 27
    • 77949732073 scopus 로고    scopus 로고
    • Raf inhibitors transactivate raf dimers and erk signalling in cells with wild-Type braf
    • Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-Type BRAF. Nature 2010; 464: 427-430.
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 28
    • 84896714827 scopus 로고    scopus 로고
    • Safety and efficacy of vemurafenib in braf(v600e) and braf(v600k) mutation-positive melanoma (brim-3): Extended follow-up of a phase 3, randomised, open-label study
    • McArthur GA, Chapman PB, Robert C, Larkin J, Haanen JB, Dummer R, et al. Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol 2014; 15: 323-332.
    • (2014) Lancet Oncol , vol.15 , pp. 323-332
    • McArthur, G.A.1    Chapman, P.B.2    Robert, C.3    Larkin, J.4    Haanen, J.B.5    Dummer, R.6
  • 31
    • 84868120907 scopus 로고    scopus 로고
    • Dabrafenib in patients with val600glu or val600lys braf-mutant melanoma metastatic to the brain (break-mb): A multicentre, open-label, phase 2 trial
    • Long GV, Trefzer U, Davies MA, Kefford RF, Ascierto PA, Chapman PB, et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol 2012; 13: 1087-1095.
    • (2012) Lancet Oncol , vol.13 , pp. 1087-1095
    • Long, G.V.1    Trefzer, U.2    Davies, M.A.3    Kefford, R.F.4    Ascierto, P.A.5    Chapman, P.B.6
  • 32
    • 84891648456 scopus 로고    scopus 로고
    • Phase II trial (break-2) of the braf inhibitor dabrafenib (gsk2118436) in patients with metastatic melanoma
    • Ascierto PA, Minor D, Ribas A, Lebbe C, O'Hagan A, Arya N, et al. Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma. J Clin Oncol 2013; 31: 3205-3211.
    • (2013) J Clin Oncol , vol.31 , pp. 3205-3211
    • Ascierto, P.A.1    Minor, D.2    Ribas, A.3    Lebbe, C.4    O'Hagan, A.5    Arya, N.6
  • 33
    • 84861083983 scopus 로고    scopus 로고
    • Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
    • Falchook GS, Long GV, Kurzrock R, Kim KB, Arkenau TH, Brown MP, et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet 2012; 379: 1893-1901.
    • (2012) Lancet , vol.379 , pp. 1893-1901
    • Falchook, G.S.1    Long, G.V.2    Kurzrock, R.3    Kim, K.B.4    Arkenau, T.H.5    Brown, M.P.6
  • 35
    • 84930165164 scopus 로고    scopus 로고
    • Trametinib: A novel signal transduction inhibitor for the treatment of metastatic cutaneous melanoma
    • Chung C, Reilly S. Trametinib: a novel signal transduction inhibitor for the treatment of metastatic cutaneous melanoma. Am J Health Syst Pharm 2015; 72: 101-110.
    • (2015) Am J Health Syst Pharm , vol.72 , pp. 101-110
    • Chung, C.1    Reilly, S.2
  • 36
    • 34248591612 scopus 로고    scopus 로고
    • Targeting the raf-mek-erk mitogen-Activated protein kinase cascade for the treatment of cancer
    • Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-Activated protein kinase cascade for the treatment of cancer. Oncogene 2007; 26: 3291-3310.
    • (2007) Oncogene , vol.26 , pp. 3291-3310
    • Roberts, P.J.1    Der, C.J.2
  • 39
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in braf-mutated metastatic melanoma: A multicentre, openlabel, phase 3 randomised controlled trial
    • Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, openlabel, phase 3 randomised controlled trial. Lancet 2012; 380: 358-365.
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3    Jouary, T.4    Gutzmer, R.5    Millward, M.6
  • 40
    • 84871390702 scopus 로고    scopus 로고
    • Intratumoral molecular heterogeneity in a braf-mutant, braf inhibitorresistant melanoma: A case illustrating the challenges for personalized medicine
    • Wilmott JS, Tembe V, Howle JR, Sharma R, Thompson JF, Rizos H, et al. Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitorresistant melanoma: a case illustrating the challenges for personalized medicine. Mol Cancer Ther 2012; 11: 2704-2708.
    • (2012) Mol Cancer Ther , vol.11 , pp. 2704-2708
    • Wilmott, J.S.1    Tembe, V.2    Howle, J.R.3    Sharma, R.4    Thompson, J.F.5    Rizos, H.6
  • 41
    • 84879496934 scopus 로고    scopus 로고
    • Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma
    • Trunzer K, Pavlick AC, Schuchter L, Gonzalez R, McArthur GA, Hutson TE, et al. Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. J Clin Oncol 2013; 31: 1767-1774.
    • (2013) J Clin Oncol , vol.31 , pp. 1767-1774
    • Trunzer, K.1    Pavlick, A.C.2    Schuchter, L.3    Gonzalez, R.4    McArthur, G.A.5    Hutson, T.E.6
  • 43
    • 84906075553 scopus 로고    scopus 로고
    • Mechanism and consequences of raf kinase activation by small-molecule inhibitors
    • Holderfield M, Nagel TE, Stuart DD. Mechanism and consequences of RAF kinase activation by small-molecule inhibitors. Br J Cancer 2014; 111: 640-645.
    • (2014) Br J Cancer , vol.111 , pp. 640-645
    • Holderfield, M.1    Nagel, T.E.2    Stuart, D.D.3
  • 44
    • 84869067183 scopus 로고    scopus 로고
    • Relief of profound feedback inhibition of mitogenic signaling by raf inhibitors attenuates their activity in brafv600e melanomas
    • Lito P, Pratilas CA, Joseph EW, Tadi M, Halilovic E, Zubrowski M, et al. Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas. Cancer Cell 2012; 22: 668-682.
    • (2012) Cancer Cell , vol.22 , pp. 668-682
    • Lito, P.1    Pratilas, C.A.2    Joseph, E.W.3    Tadi, M.4    Halilovic, E.5    Zubrowski, M.6
  • 45
    • 63149194964 scopus 로고    scopus 로고
    • V600e-braf is associated with disabled feedback inhibition of raf-mek signaling and elevated transcriptional output of the pathway
    • Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, et al. V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc Natl Acad Sci USA 2009; 106: 4519-4524.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4519-4524
    • Pratilas, C.A.1    Taylor, B.S.2    Ye, Q.3    Viale, A.4    Sander, C.5    Solit, D.B.6
  • 46
    • 84861852381 scopus 로고    scopus 로고
    • Receptor tyrosine kinases in cancer escape from braf inhibitors
    • Lo RS. Receptor tyrosine kinases in cancer escape from BRAF inhibitors. Cell Res 2012; 22: 945-947.
    • (2012) Cell Res , vol.22 , pp. 945-947
    • Lo, R.S.1
  • 47
  • 48
    • 85045540390 scopus 로고    scopus 로고
    • National Cancer Institute. Accessed 13 March
    • National Cancer Institute. FDA Approval for Trametinib. Available at: https://www.cancer.gov/about-cancer/treatment/drugs/fda-Trametinib. [Accessed 13 March 2017].
    • (2017) FDA Approval for Trametinib
  • 49
    • 84862494584 scopus 로고    scopus 로고
    • Assessment of association between braf-v600e mutation status in melanomas and clinical response to ipilimumab
    • Shahabi V, Whitney G, Hamid O, Schmidt H, Chasalow SD, Alaparthy S, et al. Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab. Cancer Immunol Immunother 2012; 61: 733-737.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 733-737
    • Shahabi, V.1    Whitney, G.2    Hamid, O.3    Schmidt, H.4    Chasalow, S.D.5    Alaparthy, S.6
  • 50
    • 58749105795 scopus 로고    scopus 로고
    • Overcoming immunologic tolerance to melanoma: Targeting ctla-4 with ipilimumab (mdx-010
    • Weber J. Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with ipilimumab (MDX-010). Oncologist 2008; 13 (Suppl 4): 16-25.
    • (2008) Oncologist , vol.13 , pp. 16-25
    • Weber, J.1
  • 51
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011; 364: 2517-2526.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O'Day, S.4    Weber, J.5    Garbe, C.6
  • 52
    • 84880310548 scopus 로고    scopus 로고
    • Fouryear survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials
    • Wolchok JD,Weber JS, Maio M, Neyns B, Harmankaya K, Chin K, et al. Fouryear survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials. Ann Oncol 2013; 24: 2174-2180.
    • (2013) Ann Oncol , vol.24 , pp. 2174-2180
    • Wolchok, J.D.1    Weber, J.S.2    Maio, M.3    Neyns, B.4    Harmankaya, K.5    Chin, K.6
  • 54
    • 84957839638 scopus 로고    scopus 로고
    • Ctla-4 and pd-1 pathways: Similarities, differences, and implications of their inhibition
    • Buchbinder EI, Desai A. CTLA-4 and PD-1 pathways: similarities, differences, and implications of their inhibition. Am J Clin Oncol 2016; 39: 98-106.
    • (2016) Am J Clin Oncol , vol.39 , pp. 98-106
    • Buchbinder, E.I.1    Desai, A.2
  • 56
    • 85045541469 scopus 로고    scopus 로고
    • Food Drug Administration. Accessed 13 March U.S.
    • U.S. Food & Drug Administration. Pembrolizumab. Available at: https://www. fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm412861.htm. [Accessed 13 March 2017].
    • (2017) Pembrolizumab
  • 57
    • 84924055386 scopus 로고    scopus 로고
    • Immunotherapies and novel combinations: The focus of advances in the treatment of melanoma
    • Ascierto PA. Immunotherapies and novel combinations: the focus of advances in the treatment of melanoma. Cancer Immunol Immunother 2015; 64: 271-274.
    • (2015) Cancer Immunol Immunother , vol.64 , pp. 271-274
    • Ascierto, P.A.1
  • 58
    • 84939967609 scopus 로고    scopus 로고
    • The role of anti-pd-1/pd-l1 agents in melanoma: Progress to date
    • Tsai KK, Daud AI. The role of anti-PD-1/PD-L1 agents in melanoma: progress to date. Drugs 2015; 75: 563-575.
    • (2015) Drugs , vol.75 , pp. 563-575
    • Tsai, K.K.1    Daud, A.I.2
  • 61
    • 40149090144 scopus 로고    scopus 로고
    • Statistical profiles of malignant melanoma and other skin cancers in Japan: 2007 update
    • Ishihara K, Saida T, Otsuka F, Yamazaki N. Statistical profiles of malignant melanoma and other skin cancers in Japan: 2007 update. Int J Clin Oncol 2008; 13: 33-41.
    • (2008) Int J Clin Oncol , vol.13 , pp. 33-41
    • Ishihara, K.1    Saida, T.2    Otsuka, F.3    Yamazaki, N.4
  • 62
    • 84881512367 scopus 로고    scopus 로고
    • Imatinib for melanomas harboring mutationally activated or amplified kit arising on mucosal, acral, and chronically sundamaged skin
    • Hodi FS, Corless CL, Giobbie-Hurder A, Fletcher JA, Zhu M, Marino-Enriquez A, et al. Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sundamaged skin. J Clin Oncol 2013; 31: 3182-3190.
    • (2013) J Clin Oncol , vol.31 , pp. 3182-3190
    • Hodi, F.S.1    Corless, C.L.2    Giobbie-Hurder, A.3    Fletcher, J.A.4    Zhu, M.5    Marino-Enriquez, A.6
  • 63
    • 79960708519 scopus 로고    scopus 로고
    • Phase II, open-label, single-Arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-kit mutation or amplification
    • Guo J, Si L, Kong Y, Flaherty KT, Xu X, Zhu Y, et al. Phase II, open-label, single-Arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol 2011; 29: 2904-2909.
    • (2011) J Clin Oncol , vol.29 , pp. 2904-2909
    • Guo, J.1    Si, L.2    Kong, Y.3    Flaherty, K.T.4    Xu, X.5    Zhu, Y.6
  • 66
    • 84864722943 scopus 로고    scopus 로고
    • Nras mutation status is an independent prognostic factor in metastatic melanoma
    • Jakob JA, Bassett RL Jr, Ng CS, Curry JL, Joseph RW, Alvarado GC, et al. NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer 2012; 118: 4014-4023.
    • (2012) Cancer , vol.118 , pp. 4014-4023
    • Jakob, J.A.1    Bassett, R.L.2    Ng, C.S.3    Curry, J.L.4    Joseph, R.W.5    Alvarado, G.C.6
  • 67
    • 84875235432 scopus 로고    scopus 로고
    • Mek162 for patients with advanced melanoma harbouring nras or val600 braf mutations: A non-randomised, open-label phase 2 study
    • Ascierto PA, Schadendorf D, Berking C, Agarwala SS, van Herpen CM, Queirolo P, et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol 2013; 14: 249-256.
    • (2013) Lancet Oncol , vol.14 , pp. 249-256
    • Ascierto, P.A.1    Schadendorf, D.2    Berking, C.3    Agarwala, S.S.4    Van Herpen, C.M.5    Queirolo, P.6
  • 68
    • 84890284472 scopus 로고    scopus 로고
    • Antitumor activity of the selective pan-raf inhibitor tak-632 in braf inhibitor-resistant melanoma
    • Nakamura A, Arita T, Tsuchiya S, Donelan J, Chouitar J, Carideo E, et al. Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma. Cancer Res 2013; 73: 7043-7055.
    • (2013) Cancer Res , vol.73 , pp. 7043-7055
    • Nakamura, A.1    Arita, T.2    Tsuchiya, S.3    Donelan, J.4    Chouitar, J.5    Carideo, E.6
  • 69
    • 84870289371 scopus 로고    scopus 로고
    • Oncogenic nras signaling differentially regulates survival and proliferation in melanoma
    • Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, Langsdorf AE, et al. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med 2012; 18: 1503-1510.
    • (2012) Nat Med , vol.18 , pp. 1503-1510
    • Kwong, L.N.1    Costello, J.C.2    Liu, H.3    Jiang, S.4    Helms, T.L.5    Langsdorf, A.E.6
  • 70
    • 84862502742 scopus 로고    scopus 로고
    • Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: Predictive importance of induced early hypertension
    • Schuster C, Eikesdal HP, Puntervoll H, Geisler J, Geisler S, Heinrich D, et al. Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension. PLoS One 2012; 7: e38364.
    • (2012) PLoS One , vol.7 , pp. e38364
    • Schuster, C.1    Eikesdal, H.P.2    Puntervoll, H.3    Geisler, J.4    Geisler, S.5    Heinrich, D.6
  • 71
    • 84868024200 scopus 로고    scopus 로고
    • Nanoparticles improve biological functions of phthalocyanine photosensitizers used for photodynamic therapy
    • Jia X, Jia L. Nanoparticles improve biological functions of phthalocyanine photosensitizers used for photodynamic therapy. Curr Drug Metab 2012; 13: 1119-1122.
    • (2012) Curr Drug Metab , vol.13 , pp. 1119-1122
    • Jia, X.1    Jia, L.2
  • 72
    • 84858652159 scopus 로고    scopus 로고
    • Targeted polymeric therapeutic nanoparticles: Design, development and clinical translation
    • Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev 2012; 41: 2971-3010.
    • (2012) Chem Soc Rev , vol.41 , pp. 2971-3010
    • Kamaly, N.1    Xiao, Z.2    Valencia, P.M.3    Radovic-Moreno, A.F.4    Farokhzad, O.C.5
  • 73
    • 84874032148 scopus 로고    scopus 로고
    • Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy
    • Kenjo E, Asai T, Yonenaga N, Ando H, Ishii T, Hatanaka K, et al. Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy. Biol Pharm Bull 2013; 36: 287-291.
    • (2013) Biol Pharm Bull , vol.36 , pp. 287-291
    • Kenjo, E.1    Asai, T.2    Yonenaga, N.3    Ando, H.4    Ishii, T.5    Hatanaka, K.6
  • 74
    • 84922265201 scopus 로고    scopus 로고
    • Advances in targeted therapy for unresectable melanoma: New drugs and combinations
    • Hao M, Song F, Du X, Wang G, Yang Y, Chen K, et al. Advances in targeted therapy for unresectable melanoma: new drugs and combinations. Cancer Lett 2015; 359: 1-8.
    • (2015) Cancer Lett , vol.359 , pp. 1-8
    • Hao, M.1    Song, F.2    Du, X.3    Wang, G.4    Yang, Y.5    Chen, K.6
  • 76
    • 84861128031 scopus 로고    scopus 로고
    • Lysosomal delivery of a lipophilic gemcitabine prodrug using novel acid-sensitive micelles improved its antitumor activity
    • Zhu S, Lansakara PD, Li X, Cui Z. Lysosomal delivery of a lipophilic gemcitabine prodrug using novel acid-sensitive micelles improved its antitumor activity. Bioconjug Chem 2012; 23: 966-980.
    • (2012) Bioconjug Chem , vol.23 , pp. 966-980
    • Zhu, S.1    Lansakara, P.D.2    Li, X.3    Cui, Z.4
  • 77
    • 77955768765 scopus 로고    scopus 로고
    • Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin
    • Talelli M, Iman M, Varkouhi AK, Rijcken CJ, Schiffelers RM, Etrych T, et al. Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials 2010; 31: 7797-7804.
    • (2010) Biomaterials , vol.31 , pp. 7797-7804
    • Talelli, M.1    Iman, M.2    Varkouhi, A.K.3    Rijcken, C.J.4    Schiffelers, R.M.5    Etrych, T.6
  • 78
    • 84876130374 scopus 로고    scopus 로고
    • Nanotheranostics for personalized medicine
    • Kim TH, Lee S, Chen X. Nanotheranostics for personalized medicine. Expert Rev Mol Diagn 2013; 13: 257-269.
    • (2013) Expert Rev Mol Diagn , vol.13 , pp. 257-269
    • Kim, T.H.1    Lee, S.2    Chen, X.3
  • 82
    • 84929393244 scopus 로고    scopus 로고
    • Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma
    • Monge-Fuentes V, Muehlmann LA, de Azevedo RB. Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma. Nano Rev 2014; 5. doi: 10.3402/nano.v5.24381.
    • (2014) Nano Rev , vol.5
    • Monge-Fuentes, V.1    Muehlmann, L.A.2    De Azevedo, R.B.3
  • 83
    • 38049045167 scopus 로고    scopus 로고
    • A new method for photodynamic therapy of melanotic melanoma -effects of depigmentation with violet light photodynamic therapy
    • Ma LW, Nielsen KP, Iani V, Moan J. A new method for photodynamic therapy of melanotic melanoma -effects of depigmentation with violet light photodynamic therapy. J Environ Pathol Toxicol Oncol 2007; 26: 165-172.
    • (2007) J Environ Pathol Toxicol Oncol , vol.26 , pp. 165-172
    • Ma, L.W.1    Nielsen, K.P.2    Iani, V.3    Moan, J.4
  • 84
    • 0032031146 scopus 로고    scopus 로고
    • Photoinactivation of amelanotic and melanotic melanoma cells sensitized by axially substituted si-naphthalocyanines
    • Soncin M, Busetti A, Biolo R, Jori G, Kwag G, Li YS, et al. Photoinactivation of amelanotic and melanotic melanoma cells sensitized by axially substituted Si-naphthalocyanines. J Photochem Photobiol B 1998; 42: 202-210.
    • (1998) J Photochem Photobiol B , vol.42 , pp. 202-210
    • Soncin, M.1    Busetti, A.2    Biolo, R.3    Jori, G.4    Kwag, G.5    Li, Y.S.6
  • 85
    • 84870294469 scopus 로고    scopus 로고
    • In vivo photodynamic therapy using upconversion nanoparticles as remotecontrolled nanotransducers
    • Idris NM, Gnanasammandhan MK, Zhang J, Ho PC, Mahendran R, Zhang Y. In vivo photodynamic therapy using upconversion nanoparticles as remotecontrolled nanotransducers. Nat Med 2012; 18: 1580-1585.
    • (2012) Nat Med , vol.18 , pp. 1580-1585
    • Idris, N.M.1    Gnanasammandhan, M.K.2    Zhang, J.3    Ho, P.C.4    Mahendran, R.5    Zhang, Y.6
  • 86
    • 27144557960 scopus 로고    scopus 로고
    • A tumorigenic subpopulation with stem cell properties in melanomas
    • Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 2005; 65: 9328-9337.
    • (2005) Cancer Res , vol.65 , pp. 9328-9337
    • Fang, D.1    Nguyen, T.K.2    Leishear, K.3    Finko, R.4    Kulp, A.N.5    Hotz, S.6
  • 88
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 2010; 141: 583-594.
    • (2010) Cell , vol.141 , pp. 583-594
    • Roesch, A.1    Fukunaga-Kalabis, M.2    Schmidt, E.C.3    Zabierowski, S.E.4    Brafford, P.A.5    Vultur, A.6


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