RNA Vaccination Therapy: Advances in an Emerging Field

Journal of Immunology Research

Volumn 2016, Issue , 2016, Pages

  Kreiter, Sebastian ^a   Diken, Mustafa ^a   Pascolo, Steve ^b   Nair, Smita K ^c   Thielemans, Kris M ^d   Geall, Andrew ^e  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^e Avidity NanoMedicines   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOSOME; MESSENGER RNA; NANOPARTICLE; PROTAMINE; PROTEIN; RNA VACCINE; TRANSCRIPTOME; TUMOR ANTIGEN; TUMOR VACCINE; VIRUS ANTIGEN; RECOMBINANT VACCINE; RNA;

ALLERGY; ANTIBODY RESPONSE; CANCER IMMUNIZATION; CELLULAR IMMUNITY; CYTOTOXICITY; DENDRITIC CELL; DRUG EFFICACY; DRUG MANUFACTURE; EDITORIAL; GENETIC TRANSFECTION; HUMAN; IMMUNE RESPONSE; INFECTION; NEOPLASM; NONHUMAN; PERSONALIZED MEDICINE; PROTEIN EXPRESSION; RNA IMMUNIZATION; T LYMPHOCYTE; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; VACCINATION;

HUMANS; RNA; TRANSCRIPTION, GENETIC; VACCINATION; VACCINES, SYNTHETIC;

EID: 84960976699     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2016/9703914     Document Type: Editorial

References (15)

1. J. A. Wolff, R. W. Malone,P. Williams et al., "Direct gene transfer into mousemuscle in vivo," Science, vol. 247, no. 4949, pp. 1465-1468, 1990.
2. F. Martinon, S. Krishnan, G. Lenzen et al., "Induction of virusspecific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA," European Journal of Immunology, vol. 23, no. 7, pp. 1719-1722, 1993.
3. R. M. Conry, A. F. LoBuglio, M. Wright et al., "Characterization of a messenger RNA polynucleotide vaccine vector," Cancer Research, vol. 55, no. 7, pp. 1397-1400, 1995.
4. D. Boczkowski, S. K. Nair, D. Snyder, and E. Gilboa, "Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo," The Journal of Experimental Medicine, vol. 184, no. 2, pp. 465-472, 1996.
5. A. Bonehill, A. M. T. Van Nuffel, J. Corthals et al., "Singlestep antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients," Clinical Cancer Research, vol. 15, no. 10, pp. 3366-3375, 2009.
6. D. Benteyn, C. Heirman, A. Bonehill, K. Thielemans, and K. Breckpot, "mRNA-based dendritic cell vaccines," Expert Review of Vaccines, vol. 14, no. 2, pp. 161-176, 2015.
7. I. Hoerr, R. Obst, H.-G. Rammensee, and G. Jung, "In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies," European Journal of Immunology, vol. 30, no. 1, pp. 1-7, 2000.
8. B. Weide, J.-P. Carralot, A. Reese et al., "Results of the first phase I/II clinical vaccination trial with direct injection of mRNA," Journal of Immunotherapy, vol. 31, no. 2, pp. 180-188, 2008.
9. B. Weide, S. Pascolo, B. Scheel et al., "Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients," Journal of Immunotherapy, vol. 32, no. 5, pp. 498-507, 2009.
10. S. M. Rittig, M. Haentschel, K. J. Weimer et al., "Intradermal vaccinations with RNA coding for TAA generate CD8+ and CD4+ immune responses and induce clinical benefit in vaccinated patients," Molecular Therapy, vol. 19, no. 5, pp. 990-999, 2011.
11. J. C. Castle, S. Kreiter, J. Diekmann et al., "Exploiting the mutanome for tumor vaccination," Cancer Research, vol. 72, no. 5, pp. 1081-1091, 2012.
12. S. Kreiter, M. Vormehr, N. van de Roemer et al., "Mutant MHC class II epitopes drive therapeutic immune responses to cancer," Nature, vol. 520, no. 7549, pp. 692-696, 2015.
13. B. Petsch,M. Schnee, A. B. Vogel et al., "Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection," Nature Biotechnology, vol. 30, no. 12, pp. 1210-1216, 2012.
14. M. Brazzoli, D. Magini, A. Bonci et al., "Induction of broadbased immunity and protective efficacy by self-amplifying mRNA vaccines encoding influenza virus hemagglutinin," Journal of Virology, vol. 90, no. 1, pp. 332-344, 2015.
15. R. Weiss, S. Scheiblhofer, E. Roesler, E. Weinberger, and J. Thalhamer, "MRNA vaccination as a safe approach for specific protection from type I allergy," Expert Review of Vaccines, vol. 11, no. 1, pp. 55-67, 2012.