Trametinib: A MEK inhibitor for management of metastatic melanoma

OncoTargets and Therapy

Volumn 8, Issue , 2015, Pages 2251-2259

  Lugowska, Iwona ^a,b   Koseła Paterczyk, Hanna ^a   Kozak, Katarzyna ^a   Rutkowski, Piotr ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

^b INSTITUTE OF MOTHER AND CHILD   (Poland)

Author keywords

BRAF mutation; Dabrafenib; MEK inhibitor; Melanoma; Trametinib

Indexed keywords

AFURESERTIB; B RAF KINASE INHIBITOR; BUPARLISIB; DABRAFENIB; EVEROLIMUS; GEMCITABINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; PACLITAXEL; TRAMETINIB; VEMURAFENIB;

ACNE; ADVANCED CANCER; ALOPECIA; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTHRALGIA; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CARDIOMYOPATHY; CENTRAL SEROUS RETINOPATHY; CHILL; CHORIORETINOPATHY; CONSTIPATION; DERMATITIS; DIARRHEA; DISEASE SEVERITY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG APPROVAL; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; ENZYME INHIBITION; EYE TOXICITY; FATIGUE; FEVER; FOOD AND DRUG ADMINISTRATION; GASTROINTESTINAL HEMORRHAGE; GENE REPRESSION; HEADACHE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HUMAN; HYPERKERATOSIS; HYPERTENSION; INTERSTITIAL LUNG DISEASE; KERATOACANTHOMA; LUNG TOXICITY; MACULOPAPULAR RASH; MAXIMUM PLASMA CONCENTRATION; MELANOMA; METASTATIC MELANOMA; MONOTHERAPY; MULTIPLE MYELOMA; NAUSEA; NON SMALL CELL LUNG CANCER; OVARY CANCER; OVERALL SURVIVAL; PANCREAS CANCER; PERIPHERAL EDEMA; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PHOTOSENSITIVITY DISORDER; PLASMA CONCENTRATION-TIME CURVE; PROGRESSION FREE SURVIVAL; PRURITUS; QUALITY OF LIFE; RASH; RETINA VEIN OCCLUSION; REVIEW; SKIN CANCER; SKIN CARCINOMA; SKIN PAPILLOMA; SKIN TOXICITY; SOLID TUMOR; THROMBOSIS; UVEITIS; VENOUS THROMBOEMBOLISM; VOMITING;

EID: 84940020969     PISSN: 11786930     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S72951     Document Type: Review

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