-
1
-
-
0014941813
-
A theory of self-nonself discrimination
-
Bretscher P, Cohn M. A theory of self-nonself discrimination. Science. 1970; 169:1042-1049.
-
(1970)
Science
, vol.169
, pp. 1042-1049
-
-
Bretscher, P1
Cohn, M.2
-
3
-
-
0034517387
-
Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor
-
Gao GF, Jakobsen BK. Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol Today. 2000; 21:630-636.
-
(2000)
Immunol Today
, vol.21
, pp. 630-636
-
-
Gao, GF1
Jakobsen, BK.2
-
4
-
-
0036667342
-
Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands
-
Gao GF, Rao Z, Bell JI. Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands. Trends Immunol. 2002; 23:408-413.
-
(2002)
Trends Immunol
, vol.23
, pp. 408-413
-
-
Gao, GF1
Rao, Z2
Bell, JI.3
-
5
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995; 182:459-465.
-
(1995)
J Exp Med
, vol.182
, pp. 459-465
-
-
Krummel, MF1
Allison, JP.2
-
6
-
-
84938350452
-
Combination cancer immunotherapy and new immunomodulatory targets
-
Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Disco. 2015; 14:561-584.
-
(2015)
Nat Rev Drug Disco
, vol.14
, pp. 561-584
-
-
Mahoney, KM1
Rennert, PD2
Freeman, GJ.3
-
7
-
-
85007531455
-
New hope for cancer treatment: cancer immunotherapy
-
[Article in Chinese]
-
Tan S, Gao GF. [New hope for cancer treatment: cancer immunotherapy]. [Article in Chinese]. Chin Sci Bull. 2015; 60:3155-3157.
-
(2015)
Chin Sci Bull
, vol.60
, pp. 3155-3157
-
-
Tan, S1
Gao, GF.2
-
8
-
-
84994335532
-
Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies
-
Tan S, Chen D, Liu K, He M, Song H, Shi Y, Liu J, Zhang CW, Qi J, Yan J, Gao S, Gao GF. Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies. Protein Cell. 2016; 7:866-877.
-
(2016)
Protein Cell
, vol.7
, pp. 866-877
-
-
Tan, S1
Chen, D2
Liu, K3
He, M4
Song, H5
Shi, Y6
Liu, J7
Zhang, CW8
Qi, J9
Yan, J10
Gao, S11
Gao, GF.12
-
9
-
-
0031054242
-
CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics
-
van der Merwe PA, Bodian DL, Daenke S, Linsley P, Davis SJ. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J Exp Med. 1997; 185:393-403.
-
(1997)
J Exp Med
, vol.185
, pp. 393-403
-
-
van der Merwe, PA1
Bodian, DL2
Daenke, S3
Linsley, P4
Davis, SJ.5
-
10
-
-
0035967157
-
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
-
Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature. 2001; 410:604-608.
-
(2001)
Nature
, vol.410
, pp. 604-608
-
-
Schwartz, JC1
Zhang, X2
Fedorov, AA3
Nathenson, SG4
Almo, SC.5
-
11
-
-
0035967146
-
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
-
Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature. 2001; 410:608-611.
-
(2001)
Nature
, vol.410
, pp. 608-611
-
-
Stamper, CC1
Zhang, Y2
Tobin, JF3
Erbe, DV4
Ikemizu, S5
Davis, SJ6
Stahl, ML7
Seehra, J8
Somers, WS9
Mosyak, L.10
-
12
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996; 271:1734-1736.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, DR1
Krummel, MF2
Allison, JP.3
-
13
-
-
85007480811
-
Immune targets and neoantigens for cancer immunotherapy and precision medicine
-
Wang RF, Wang HY. Immune targets and neoantigens for cancer immunotherapy and precision medicine. Cell Res. 2017; 27:11-37.
-
(2017)
Cell Res
, vol.27
, pp. 11-37
-
-
Wang, RF1
Wang, HY.2
-
14
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, Ferrucci PF, Hill A, Wagstaff J, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015; 373:23-34.
-
(2015)
N Engl J Med
, vol.373
, pp. 23-34
-
-
Larkin, J1
Chiarion-Sileni, V2
Gonzalez, R3
Grob, JJ4
Cowey, CL5
Lao, CD6
Schadendorf, D7
Dummer, R8
Smylie, M9
Rutkowski, P10
Ferrucci, PF11
Hill, A12
Wagstaff, J13
-
15
-
-
84942430653
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Valsecchi ME. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015; 373:1270.
-
(2015)
N Engl J Med
, vol.373
, pp. 1270
-
-
Valsecchi, ME.1
-
16
-
-
84994057015
-
Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
-
Lee JY, Lee HT, Shin W, Chae J, Choi J, Kim SH, Lim H, Heo TW, Park KY, Lee YJ, Ryu SE, Son JY, Lee JU, Heo YS. Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy. Nat Commun. 2016; 7:13354.
-
(2016)
Nat Commun
, vol.7
, pp. 13354
-
-
Lee, JY1
Lee, HT2
Shin, W3
Chae, J4
Choi, J5
Kim, SH6
Lim, H7
Heo, TW8
Park, KY9
Lee, YJ10
Ryu, SE11
Son, JY12
Lee, JU13
Heo, YS.14
-
17
-
-
84903517715
-
Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies
-
Furness AJ, Vargas FA, Peggs KS, Quezada SA. Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies. Trends Immunol. 2014; 35:290-298.
-
(2014)
Trends Immunol
, vol.35
, pp. 290-298
-
-
Furness, AJ1
Vargas, FA2
Peggs, KS3
Quezada, SA.4
-
18
-
-
84874605864
-
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
Ribas A, Kefford R, Marshall MA, Punt CJ, Haanen JB, Marmol M, Garbe C, Gogas H, Schachter J, Linette G, Lorigan P, Kendra KL, Maio M, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol. 2013; 31:616-622.
-
(2013)
J Clin Oncol
, vol.31
, pp. 616-622
-
-
Ribas, A1
Kefford, R2
Marshall, MA3
Punt, CJ4
Haanen, JB5
Marmol, M6
Garbe, C7
Gogas, H8
Schachter, J9
Linette, G10
Lorigan, P11
Kendra, KL12
Maio, M13
-
19
-
-
84984856715
-
Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy
-
Liu K, Tan S, Chai Y, Chen D, Song H, Zhang CW, Shi Y, Liu J, Tan W, Lyu J, Gao S, Yan J, Qi J, Gao GF. Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy. Cell Res. 2017; 27:151-153.
-
(2017)
Cell Res
, vol.27
, pp. 151-153
-
-
Liu, K1
Tan, S2
Chai, Y3
Chen, D4
Song, H5
Zhang, CW6
Shi, Y7
Liu, J8
Tan, W9
Lyu, J10
Gao, S11
Yan, J12
Qi, J13
Gao, GF.14
-
20
-
-
84975226255
-
Structural basis for blocking PD-1mediated immune suppression by therapeutic antibody pembrolizumab
-
Na Z, Yeo SP, Bharath SR, Bowler MW, Balikci E, Wang CI, Song H. Structural basis for blocking PD-1mediated immune suppression by therapeutic antibody pembrolizumab. Cell Res. 2017; 27:147-150.
-
(2017)
Cell Res
, vol.27
, pp. 147-150
-
-
Na, Z1
Yeo, SP2
Bharath, SR3
Bowler, MW4
Balikci, E5
Wang, CI6
Song, H.7
-
21
-
-
85011708128
-
Seeing is believing: anti-PD-1/ PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy
-
Tan S, Zhang CW, Gao GF. Seeing is believing: anti-PD-1/ PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy. Signal Transd Targeted Ther. 2016; 1: e16029. doi: 10.1038/sigtrans.2016.1029.
-
(2016)
Signal Transd Targeted Ther
, vol.1
, pp. e16029
-
-
Tan, S1
Zhang, CW2
Gao, GF.3
-
22
-
-
84994874924
-
Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy
-
Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbe C, Ferraresi V, Smylie M, et al. Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy. N Engl J Med. 2016; 375:1845-1855.
-
(2016)
N Engl J Med
, vol.375
, pp. 1845-1855
-
-
Eggermont, AM1
Chiarion-Sileni, V2
Grob, JJ3
Dummer, R4
Wolchok, JD5
Schmidt, H6
Hamid, O7
Robert, C8
Ascierto, PA9
Richards, JM10
Lebbe, C11
Ferraresi, V12
Smylie, M13
-
23
-
-
84971543833
-
Structural basis for small molecule targeting of the programmed death ligand 1 (PDL1)
-
Zak KM, Grudnik P, Guzik K, Zieba BJ, Musielak B, Domling A, Dubin G, Holak TA. Structural basis for small molecule targeting of the programmed death ligand 1 (PDL1). Oncotarget. 2016; 7:30323-30335. doi: 10.18632/ oncotarget.8730.
-
(2016)
Oncotarget
, vol.7
, pp. 30323-30335
-
-
Zak, KM1
Grudnik, P2
Guzik, K3
Zieba, BJ4
Musielak, B5
Domling, A6
Dubin, G7
Holak, TA.8
-
24
-
-
77953009791
-
The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors
-
Lee CM, Tannock IF. The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors. BMC cancer. 2010; 10:255.
-
(2010)
BMC cancer
, vol.10
, pp. 255
-
-
Lee, CM1
Tannock, IF.2
-
25
-
-
84948418552
-
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging
-
Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. Proc Natl Acad Sci USA. 2015; 112:E6506-E6514.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. E6506-E6514
-
-
Maute, RL1
Gordon, SR2
Mayer, AT3
McCracken, MN4
Natarajan, A5
Ring, NG6
Kimura, R7
Tsai, JM8
Manglik, A9
Kruse, AC10
Gambhir, SS11
Weissman, IL12
Ring, AM.13
-
26
-
-
85011632749
-
An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
-
Tan S, Zhang H, Chai Y, Song H, Tong Z, Wang Q, Qi J, Wong G, Zhu X, Liu WJ, Gao S, Wang Z, Shi Y, et al. An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nat Commun. 2017; 8:14369.
-
(2017)
Nat Commun
, vol.8
, pp. 14369
-
-
Tan, S1
Zhang, H2
Chai, Y3
Song, H4
Tong, Z5
Wang, Q6
Qi, J7
Wong, G8
Zhu, X9
Liu, WJ10
Gao, S11
Wang, Z12
Shi, Y13
-
27
-
-
84927651609
-
Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial
-
Maio M, Grob JJ, Aamdal S, Bondarenko I, Robert C, Thomas L, Garbe C, Chiarion-Sileni V, Testori A, Chen TT, Tschaika M, Wolchok JD. Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial. J Clin Oncol. 2015; 33:1191-1196.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1191-1196
-
-
Maio, M1
Grob, JJ2
Aamdal, S3
Bondarenko, I4
Robert, C5
Thomas, L6
Garbe, C7
Chiarion-Sileni, V8
Testori, A9
Chen, TT10
Tschaika, M11
Wolchok, JD.12
-
28
-
-
84960498096
-
Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study
-
Antonia S, Goldberg SB, Balmanoukian A, Chaft JE, Sanborn RE, Gupta A, Narwal R, Steele K, Gu Y, Karakunnel JJ, Rizvi NA. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study. Lancet Oncol. 2016; 17:299-308.
-
(2016)
Lancet Oncol
, vol.17
, pp. 299-308
-
-
Antonia, S1
Goldberg, SB2
Balmanoukian, A3
Chaft, JE4
Sanborn, RE5
Gupta, A6
Narwal, R7
Steele, K8
Gu, Y9
Karakunnel, JJ10
Rizvi, NA.11
-
29
-
-
84936937852
-
A phase 2 study of tremelimumab in patients with advanced uveal melanoma
-
Joshua AM, Monzon JG, Mihalcioiu C, Hogg D, Smylie M, Cheng T. A phase 2 study of tremelimumab in patients with advanced uveal melanoma. Melanoma Res. 2015; 25:342-347.
-
(2015)
Melanoma Res
, vol.25
, pp. 342-347
-
-
Joshua, AM1
Monzon, JG2
Mihalcioiu, C3
Hogg, D4
Smylie, M5
Cheng, T.6
-
30
-
-
84929192743
-
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients
-
Romano E, Kusio-Kobialka M, Foukas PG, Baumgaertner P, Meyer C, Ballabeni P, Michielin O, Weide B, Romero P, Speiser DE. Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. Proc Natl Acad Sci USA. 2015; 112:6140-6145.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 6140-6145
-
-
Romano, E1
Kusio-Kobialka, M2
Foukas, PG3
Baumgaertner, P4
Meyer, C5
Ballabeni, P6
Michielin, O7
Weide, B8
Romero, P9
Speiser, DE.10
-
31
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski Z, Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 1997; 276:307-326.
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Otwinowski, Z1
Minor, W.2
-
32
-
-
0035788107
-
Pushing the boundaries of molecular replacement with maximum likelihood
-
Read RJ. Pushing the boundaries of molecular replacement with maximum likelihood. Acta Crystallogr D Biol Crystallogr. 2001; 57:1373-1382.
-
(2001)
Acta Crystallogr D Biol Crystallogr
, vol.57
, pp. 1373-1382
-
-
Read, RJ.1
-
33
-
-
13244281317
-
Coot: model-building tools for molecular graphics
-
Emsley P, Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr. 2004; 60:2126-2132.
-
(2004)
Acta Crystallogr D Biol Crystallogr
, vol.60
, pp. 2126-2132
-
-
Emsley, P1
Cowtan, K.2
-
34
-
-
76449098262
-
PHENIX: a comprehensive Python-based system for macromolecular structure solution
-
Adams PD, Afonine PV, Bunkoczi G, Chen VB, Davis IW, Echols N, Headd JJ, Hung LW, Kapral GJ, Grosse-Kunstleve RW, McCoy AJ, Moriarty NW, Oeffner R, et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr. 2010; 66:213-221.
-
(2010)
Acta Crystallogr D Biol Crystallogr
, vol.66
, pp. 213-221
-
-
Adams, PD1
Afonine, PV2
Bunkoczi, G3
Chen, VB4
Davis, IW5
Echols, N6
Headd, JJ7
Hung, LW8
Kapral, GJ9
Grosse-Kunstleve, RW10
McCoy, AJ11
Moriarty, NW12
Oeffner, R13
|