Equity in international health research collaborations in Africa: Perceptions and expectations of African researchers

PLoS ONE

Volumn 12, Issue 10, 2017, Pages

  Munung, Nchangwi Syntia ^a   Mayosi, Bongani M ^a,b   De Vries, Jantina ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICA; CAPACITY BUILDING; EXPECTATION; GENOMICS; GOLD STANDARD; HUMAN; MEDICAL RESEARCH; PERCEPTION; PUBLIC HEALTH; SCIENTIST; BIOBANK; COOPERATION; DECISION MAKING; ECONOMICS; EDUCATION; INTERVIEW; METHODOLOGY; PERSONNEL; PSYCHOLOGY; QUALITATIVE RESEARCH;

AFRICA; BIOLOGICAL SPECIMEN BANKS; BIOMEDICAL RESEARCH; CAPACITY BUILDING; COOPERATIVE BEHAVIOR; DECISION MAKING; GENOMICS; HUMANS; INTERVIEWS AS TOPIC; QUALITATIVE RESEARCH; RESEARCH DESIGN; RESEARCH PERSONNEL;

EID: 85031328788     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0186237     Document Type: Article

References (72)

1. COHRED. Health Research: Essential Link to Equity in Development. Oxford: Oxford University Press; 1990. 157 p.
2. GFHR. 10/90 Report on Health Research 2001–2002. Geneva, Switzerland: Global Forum for Health Research, 2002.
3. Collins F, Beaudet A, Draghia-Akli R, Gruss P, Savill J, Syrota A, et al. A database on global health research in Africa. The Lancet Global Health. 2013; 1(2):e64–e5. https://doi.org/10.1016/S2214-109X(13)70012-3 PMID: 25104151
4. Samb B, Evans T, Dybul M, Atun R, Moatti JP, Nishtar S, et al. An assessment of interactions between global health initiatives and country health systems. Lancet (London, England). 2009; 373(9681):2137–69. Epub 2009/06/23. https://doi.org/10.1016/s0140-6736(09)60919-3 PMID: 19541040.
5. Abayomi A, Christoffels A, Grewal R, Karam LA, Rossouw C, Staunton C, et al. Challenges of Biobanking in South Africa to Facilitate Indigenous Research in an Environment Burdened with Human Immunodeficiency Virus, Tuberculosis, and Emerging Noncommunicable Diseases. Biopreservation and Biobanking. 2013; 11(6):347–54. https://doi.org/10.1089/bio.2013.0049 PMC4076990. PMID: 24835364
6. Sirugo G, Schim van der Loeff M, Sam O, Nyan O, Pinder M, Hill AV, et al. A national DNA bank in The Gambia, West Africa, and genomic research in developing countries. Nature genetics. 2004; 36 (8):785–6. Epub 2004/07/31. https://doi.org/10.1038/ng0804-785 PMID: 15284842.
7. Dhai A. Establishing national biobanks in South Africa: The urgent need for an ethico-regulatory framework 2013.
8. Chen H, Pang T. A call for global governance of biobanks. Bulletin of the World Health Organization. 2015; 93(2):113–7. https://doi.org/10.2471/BLT.14.138420 PMC4339960. PMID: 25883404
9. H3Africa Consortium. Enabling the genomic revolution in Africa. Science. 2014; 344(6190):1346–8. https://doi.org/10.1126/science.1251546 PMID: 24948725
10. de Vries J, Pepper M. Genomic sovereignty and the African promise: mining the African genome for the benefit of Africa. J Med Ethics. 2012; 38(8):474–8. Epub 2012/04/12. https://doi.org/10.1136/medethics-2011-100448 PMID: 22493187.
11. Ramsay M. Africa: Continent of genome contrasts with implications for biomedical research and health. FEBS Letters. 2012; 586(18):2813–9. https://doi.org/10.1016/j.febslet.2012.07.061 PMID: 22858376
12. Benatar SR. Commentary: justice and medical research: a global perspective. Bioethics. 2001; 15 (4):333–40. Epub 2001/11/08. PMID: 11697389.
13. Bhutta ZA. Ethics in international health research: a perspective from the developing world. Bulletin of the World Health Organization. 2002; 80(2):114–20. Epub 2002/04/16. PMID: 11953789; PubMed Central PMCID: PMCPMC2567726.
14. Costello A, Zumla A. Moving to Research Partnerships in Developing Countries. BMJ 2000; 321:827–9. PMID: 11009530
15. Edejer TT. North-South research partnerships: the ethics of carrying out research in developing countries. Bmj. 1999; 319(7207):438–41. PMID: 10445930.
16. Robison VA. Some ethical issues in international collaborative research in developing countries. International dental journal. 1998; 48(6):552–6. Epub 1999/01/09. PMID: 9881288.
17. Caballero B. Ethical issues for collaborative research in developing countries. The American Journal of Clinical Nutrition. 2002; 76(4):717–20. PMID: 12324282
18. Benatar SR, Singer PA. A new look at international research ethics. BMJ: British Medical Journal. 2000; 321(7264):824–6. PMC1118625. PMID: 11009528
19. Tucker TJ, Makgoba MW. Public-Private Partnerships and Scientific Imperialism. Science. 2008; 320 (5879):1016. https://doi.org/10.1126/science.1156720 PMID: 18497279
20. Chu KM, Jayaraman S, Kyamanywa P, Ntakiyiruta G. Building research capacity in Africa: equity and global health collaborations. PLoS Med. 2014; 11(3):e1001612. Epub 2014/03/13. https://doi.org/10.1371/journal.pmed.1001612 PMID: 24618823; PubMed Central PMCID: PMCPMC3949667.
21. Musolino N, Lazdins J, Toohey J, C IJ. COHRED Fairness Index for international collaborative partnerships. Lancet (London, England). 2015; 385(9975):1293–4. Epub 2015/04/22. https://doi.org/10.1016/s0140-6736(15)60680-8 PMID: 25890912.
22. Wonkam A, Kenfack MA, Muna WF, Ouwe-Missi-Oukem-Boyer O. Ethics of human genetic studies in sub-saharan Africa: the case of Cameroon through a bibliometric analysis. Dev World Bioeth. 2011; 11 (3):120–7. Epub 2011/07/26. https://doi.org/10.1111/j.1471-8847.2011.00305.x PMID: 21781234.
23. Adoga MP, Fatumo SA, Agwale SM. H3Africa: a tipping point for a revolution in bioinformatics, genomics and health research in Africa. Source Code for Biology and Medicine. 2014; 9(1):1–3. https://doi.org/10.1186/1751-0473-9-1
24. Mulder NJ, Adebiyi E, Alami R, Benkahla A, Brandful J, Doumbia S, et al. H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa. Genome research. 2016; 26(2):271–7. Epub 2015/12/03. https://doi.org/10.1101/gr.196295.115 PMID: 26627985; PubMed Central PMCID: PMCPMC4728379.
25. Mensah GA, Peprah EK, Sampson UKA, Cooper RS. H3Africa comes of age. Cardiovascular Journal of Africa. 2015; 26(2):s3–s5. PMC4476302.
26. Patton MQ. Qualitative Evaluation and Research Methods. 2nd ed. Newbury Park, California: Sage; 1990.
27. Bowen GA. Naturalistic inquiry and the saturation concept: a research note. Qualitative Research. 2008; 8(1):137–52. https://doi.org/10.1177/1468794107085301
28. Strauss A, Corbin JM. Basics of Qualitative Research: Techniques and Procedures for Developing Grounded Theory. 2nd Edition ed. London: SAGE Publications; 1998.
29. Fusch PI, Ness LR. Are we there yet? Data saturation in qualitative research. The Qualitative Report. 2015; 20(9):1408.
30. QSR International Pty Ltd. NVivo qualitative data analysis software. 10 ed2012.
31. Fereday J, Mair-Cochrane E. Demonstrating rigor using thematic analysis: a hybrid approach of inductive and deductive coding and theme development. International Journal of Qualitative Methods 2006; 5 (1):80–92.
32. Braun V, Clarke V. Using thematic analysis in psychology. Qualitative Research in Psychology. 2006; 3 (2):77–101. https://doi.org/10.1191/1478088706qp063oa
33. Ritchie J, Lewis J, Lewis PSPJ, Nicholls CMN, Ormston R. Qualitative Research Practice: A Guide for Social Science Students and Researchers: SAGE Publications; 2013.
34. Corbin J, Strauss A. Basics of Qualitative Research:Techniques and Procedures for Developing Grounded Theory. 3rd Edition ed. Thousand Oaks, CA, US: Sage Publications Inc; 2008. 379 p.
35. Glaser B, Strauss A. The discovery of grounded theory: Strategies for qualitative research. New York:: Aldine Publishing Company; 1967.
36. Crane JT. Scrambling for Africa: AIDS, Expertise, and the Rise of American Global Health Science: Cornell University Press; 2013.
37. Tangwa GB. Giving voice to African thought in medical research ethics. Theoretical Medicine and Bioethics. 2017; 38(2):101–10. https://doi.org/10.1007/s11017-017-9402-3 PMID: 28343255
38. Okwaro MF, Geissler PW. In/dependent Collaborations: Perceptions and Experiences of African Scientists in Transnational HIV Research. Medical Anthropology Quarterly. 2015; 29(4):492–511. https://doi.org/10.1111/maq.12206 PMID: 25800667
39. Binka F. Editorial: north-south research collaborations: a move towards a true partnership? Tropical medicine & international health: TM & IH. 2005; 10(3):207–9. Epub 2005/02/26. https://doi.org/10.1111/j.1365-3156.2004.01373.x PMID: 15730502.
40. Lansang MA, Dennis R. Building capacity in health research in the developing world. Bulletin of the World Health Organization. 2004; 82(10):764–70. PMC2623028. PMID: 15643798
41. Larkan F, Uduma O, Lawal SA, van Bavel B. Developing a framework for successful research partnerships in global health. Globalization and Health. 2016; 12:17. https://doi.org/10.1186/s12992-016-0152-1 PMC4859962. PMID: 27154550
42. Okeke IN. African biomedical scientists and the promises of “big science”. Canadian Journal of African Studies / Revue canadienne des études africaines. 2016; 50(3):455–78. https://doi.org/10.1080/00083968.2016.1266677
43. White MT. A Right to Benefit from International Research: A New Approach to Capacity Building in Less-Developed Countries. Accountability in Research. 2007; 14(2):73–92. https://doi.org/10.1080/08989620701290341 PMID: 17844784
44. Pratt B, Hyder AA. Governance of global health research consortia: Sharing sovereignty and resources within Future Health Systems. Social Science & Medicine. 2017; 174:113–21. https://doi.org/10.1016/j.socscimed.2016.11.039.
45. Collins FS, Green ED, Guttmacher AE, Guyer MS. A vision for the future of genomics research. Nature. 2003; 422(6934):835–47. Epub 2003/04/16. https://doi.org/10.1038/nature01626 PMID: 12695777.
46. Folarin OA, Happi AN, Happi CT. Empowering African genomics for infectious disease control. Genome Biology. 2014; 15(11):1–3. https://doi.org/10.1186/s13059-014-0515-y PMID: 25417758
47. Pratt B, Loff B. A Framework to Link International Clinical Research to the Promotion of Justice in Global Health. Bioethics. 2014; 28(8):387–96. https://doi.org/10.1111/bioe.12009 PMID: 23278523
48. Adewole I, Martin DN, Williams MJ, Adebamowo C, Bhatia K, Berling C, et al. Building capacity for sustainable research programmes for cancer in Africa. Nature reviews Clinical oncology. 2014; 11(5):251–9. Epub 2014/03/13. https://doi.org/10.1038/nrclinonc.2014.37 PMID: 24614139; PubMed Central PMCID: PMCPMC4403794.
49. Adeleye OA, Ogundiran TO. Knowledge of and Training in Research Ethics in an African Health Research Community. AJOB Primary Research. 2013; 4(2):44–50. https://doi.org/10.1080/21507716.2012.720638
50. Kass NE, Hyder AA, Ajuwon A, Appiah-Poku J, Barsdorf N, Elsayed DE, et al. The structure and function of research ethics committees in Africa: a case study. PLoS medicine. 2007; 4(1):e3. Epub 2007/01/27. https://doi.org/10.1371/journal.pmed.0040003 PMID: 17253898; PubMed Central PMCID: PMCPmc1779815.
51. Nyika A, Kilama W, Chilengi R, Tangwa G, Tindana P, Ndebele P, et al. Composition, training needs and independence of ethics review committees across Africa: are the gate-keepers rising to the emerging challenges? J Med Ethics. 2009; 35(3):189–93. Epub 2009/03/03. https://doi.org/10.1136/jme.2008.025189 PMID: 19251972; PubMed Central PMCID: PMCPmc2643018.
52. Nyika A, Kilama W, Tangwa GB, Chilengi R, Tindana P. Capacity building of ethics review committees across Africa based on the results of a comprehensive needs assessment survey. Dev World Bioeth. 2009; 9(3):149–56. Epub 2009/12/22. https://doi.org/10.1111/j.1471-8847.2008.00243.x PMID: 20021494.
53. de Vries J, Bull SJ, Doumbo O, Ibrahim M, Mercereau-Puijalon O, Kwiatkowski D, et al. Ethical issues in human genomics research in developing countries. BMC Medical Ethics. 2011; 12(1):1–10. https://doi.org/10.1186/1472-6939-12-5 PMID: 21418562
54. Haga SB, Beskow LM. Ethical, legal, and social implications of biobanks for genetics research. Advances in genetics. 2008; 60:505–44. Epub 2008/03/25. https://doi.org/10.1016/S0065-2660(07)00418-X PMID: 18358331.
55. Nyika A. Ethical and practical challenges surrounding genetic and genomic research in developing countries. Acta Tropica. 2009; 112, Supplement 1:S21–S31. http://dx.doi.org/10.1016/j.actatropica.2009.07.034.
56. Parker M, Kwiatkowski DP. The ethics of sustainable genomic research in Africa. Genome Biology. 2016; 17(1):44. https://doi.org/10.1186/s13059-016-0914-3 PMID: 26956719
57. Ramsay M, de Vries J, Soodyall H, Norris SA, Sankoh O. Ethical issues in genomic research on the African continent: experiences and challenges to ethics review committees. Human Genomics. 2014; 8 (1):15. https://doi.org/10.1186/s40246-014-0015-x PMC4420849. PMID: 25145346
58. Tindana P, de Vries J. Broad Consent for Genomic Research and Biobanking: Perspectives from Low- and Middle-Income Countries. Annual review of genomics and human genetics. 2016; 17:375–93. Epub 2016/02/26. https://doi.org/10.1146/annurev-genom-083115-022456 PMID: 26905784.
59. Van Rinsum HJ, Tangwa GB. Colony of genes, genes of the colony: diversity, difference and divide. Third World Quarterly. 2004; 25(6):1031–43. https://doi.org/10.1080/0143659042000256878
60. de Vries J, Abayomi A, Littler K, Madden E, McCurdy S, Oukem-Boyer OOM, et al. Addressing ethical issues in H3Africa research–the views of research ethics committee members. The HUGO Journal. 2015; 9(1):1.
61. Costello A, Zumla A. Moving to research partnerships in developing countries. Bmj. 2000; 321 (7264):827–9. Epub 2000/09/29. PMID: 11009530; PubMed Central PMCID: PMCPMC1118627.
62. Yuille M, van Ommen G-J, Bréchot C, Cambon-Thomsen A, Dagher G, Landegren U, et al. Biobanking for europe. Briefings in bioinformatics. 2007; 9(1):14–24. https://doi.org/10.1093/bib/bbm050 PMID: 17959611
63. Makoni M. AFRICA: Universities benefit from used lab equipment: University World News; 2009 [updated 13 December 2009]. Issue No:43:[Available from: http://www.universityworldnews.com/article.php?story=2009121108334254.
64. Zofou D, Abimbola S, Norice NT, Samje M, Zoumana IT, Oyediran OA, et al. The needs of Biomedical Science Training in Africa: Perspectives from the experience of young scientists 2011.
65. Isoun TT. Building Scientific Capacity and Expanding Research Opportunities Through Regional Linkages in Africa: The Federal Government of Nigeria Perspective. Workshop on Developing A New Program To Support Regional Networks For Scientific Research And Training In Sub-Sahara Africa; 4–5 June 2007; Nairobi, Kenya 2007.
66. de Vries J, Slabbert M, Pepper MS. Ethical, legal and social issues in the context of the planning stages of the Southern African Human Genome Programme. Medicine and law. 2012; 31(1):119–52. Epub 2012/08/23. PMID: 22908741.
67. Langat SK. Reuse of samples: ethical issues encountered by two institutional ethics review committees in Kenya. Bioethics. 2005; 19(5–6):537–49. Epub 2006/01/24. PMID: 16425489.
68. Whitworth JAG, Kokwaro G, Kinyanjui S, Snewin VA, Tanner M, Walport M, et al. Strengthening capacity for health research in Africa. The Lancet. 2008; 372(9649):1590–3. http://dx.doi.org/10.1016/S01406736(08)61660-8.
69. Park P. Funding Research in Africa 2014 [cited 2017 30 June]. Available from: http://www.the-scientist.com/?articles.view/articleNo/41427/title/Funding-Research-in-Africa/.
70. GFHR. The Bamako call to action: research for health. The Lancet. 2008; 372(9653):1855. https://doi.org/10.1016/S0140-6736(08)61789-4.
71. Sitthi-amorn C, Somrongthong R. Strengthening health research capacity in developing countries: a critical element for achieving health equity. BMJ: British Medical Journal. 2000; 321(7264):813. PMID: 11009525
72. Dandara C, Huzair F, Borda-Rodriguez A, Chirikure S, Okpechi I, Warnich L, et al. H3Africa and the African Life Sciences Ecosystem: Building Sustainable Innovation. OMICS: a Journal of Integrative Biology. 2014; 18(12):733–9. https://doi.org/10.1089/omi.2014.0145 PMC4253142. PMID: 25454511