Carbapenem-resistant Enterobacteriaceae colonization (CRE) and subsequent risk of infection and 90-day mortality in critically ill patients, an observational study

PLoS ONE

Volumn 12, Issue 10, 2017, Pages

  McConville, Thomas Howe ^a   Sullivan, Sean Berger ^a   Gomez Simmonds, Angela ^a   Whittier, Susan ^a   Uhlemann, Anne Catrin ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; CEPHALOSPORIN; CARBAPENEM DERIVATIVE; CEPHALOSPORIN DERIVATIVE;

ADULT; AGED; ALL CAUSE MORTALITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTION; FECES; FEMALE; HOSPITAL ADMISSION; HUMAN; INFECTION RISK; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; RECTUM; CLASSIFICATION; COMPARATIVE STUDY; CRITICAL ILLNESS; CROSS INFECTION; DRUG EFFECTS; ENTEROBACTERIACEAE INFECTIONS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MORTALITY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARBAPENEMS; CEPHALOSPORINS; COHORT STUDIES; CRITICAL ILLNESS; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; RECTUM;

EID: 85031129071     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0186195     Document Type: Article

References (33)

1. CDC. Antibiotic resistance threats in the United States, 2013. http://wwwcdcgov/drugresistance/threat-report-2013/. 2013. http://www.cdc.gov/drugresistance/threat-report-2013/.
2. Falagas ME, Tansarli GS, Karageorgopoulos DE, Vardakas KZ. Deaths attributable to carbapenem-resistant Enterobacteriaceae infections. Emerg Infect Dis. 2014; 20(7):1170–5. https://doi.org/10.3201/eid2007.121004 PMID: 24959688; PubMed Central PMCID: PMCPMC4073868.
3. Gomez-Simmonds A, Greenman M, Sullivan SB, Tanner JP, Sowash MG, Whittier S, et al. Population structure of Klebsiella pneumoniae causing bloodstream infections at a New York City tertiary care hospital: Diversification of multidrug-resistant isolates. J Clin Microbiol. 2015; 53(7):2060–7. https://doi.org/10.1128/JCM.03455-14 PMID: 25878348
4. Debby BD, Ganor O, Yasmin M, David L, Nathan K, Ilana T, et al. Epidemiology of carbapenem resistant Klebsiella pneumoniae colonization in an intensive care unit. Eur J Clin Microbiol Infect Dis. 2012; 31(8):1811–7. https://doi.org/10.1007/s10096-011-1506-5 PMID: 22246509.
5. Papadimitriou-Olivgeris M, Marangos M, Fligou F, Christofidou M, Bartzavali C, Anastassiou ED, et al. Risk factors for KPC-producing Klebsiella pneumoniae enteric colonization upon ICU admission. J Antimicrob Chemother. 2012; 67(12):2976–81. Epub 2012/08/29. https://doi.org/10.1093/jac/dks316 PMID: 22927316.
6. Tischendorf J, de Avila RA, Safdar N. Risk of infection following colonization with carbapenem-resistant Enterobactericeae: A systematic review. Am J Infect Control. 2016. Epub 2016/02/24. https://doi.org/10.1016/j.ajic.2015.12.005 PMID: 26899297.
7. Taglietti F, Di Bella S, Galati V, Topino S, Iappelli M, Petrosillo N. Carbapenemase-producing Klebsiella pneumoniae-related mortality among solid organ-transplanted patients: do we know enough? Transpl Infect Dis. 2013; 15(4):E164–5. Epub 2013/04/23. https://doi.org/10.1111/tid.12085 PMID: 23601113.
8. Kalpoe JS, Sonnenberg E, Factor SH, del Rio Martin J, Schiano T, Patel G, et al. Mortality associated with carbapenem-resistant Klebsiella pneumoniae infections in liver transplant recipients. Liver Transpl. 2012; 18(4):468–74. Epub 2012/04/03. https://doi.org/10.1002/lt.23374 PMID: 22467548.
9. Falagas ME, Rafailidis PI, Kofteridis D, Virtzili S, Chelvatzoglou FC, Papaioannou V, et al. Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case control study. J Antimicrob Chemother. 2007; 60(5):1124–30. Epub 2007/09/22. https://doi.org/10.1093/jac/dkm356 PMID: 17884829.
10. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev. 2012; 25(4):682–707. Epub 2012/10/05. https://doi.org/10.1128/CMR.05035-11 PMID: 23034326; PubMed Central PMCID: PMC3485753.
11. Gomez-Simmonds A, Hu Y, Sullivan SB, Wang Z, Whittier S, Uhlemann AC. Evidence from a New York City hospital of rising incidence of genetically diverse carbapenem-resistant Enterobacter cloacae and dominance of ST171, 2007–14. J Antimicrob Chemother. 2016. https://doi.org/10.1093/jac/dkw132 PMID: 27118776; PubMed Central PMCID: PMCPMC4954924.
12. Calfee D, Jenkins SG. Use of active surveillance cultures to detect asymptomatic colonization with carbapenem-resistant Klebsiella pneumoniae in intensive care unit patients. Infect Control Hosp Epidemiol. 2008; 29(10):966–8. Epub 2008/08/30. https://doi.org/10.1086/590661 PMID: 18754738.
13. Vidal-Navarro L, Pfeiffer C, Bouziges N, Sotto A, Lavigne JP. Faecal carriage of multidrug-resistant Gram-negative bacilli during a non-outbreak situation in a French university hospital. J Antimicrob Chemother. 2010; 65(11):2455–8. Epub 2010/09/04. https://doi.org/10.1093/jac/dkq333 PMID: 20813808.
14. Wiener-Well Y, Rudensky B, Yinnon AM, Kopuit P, Schlesinger Y, Broide E, et al. Carriage rate of carbapenem-resistant Klebsiella pneumoniae in hospitalised patients during a national outbreak. J Hosp Infect. 2010; 74(4):344–9. https://doi.org/10.1016/j.jhin.2009.07.022 PMID: 19783067.
15. Banach DB, Francois J, Blash S, Patel G, Jenkins SG, LaBombardi V, et al. Active surveillance for carbapenem-resistant Enterobacteriaceae using stool specimens submitted for testing for Clostridium diffi-cile. Infect Control Hosp Epidemiol. 2014; 35(1):82–4. Epub 2013/12/18. https://doi.org/10.1086/ 674391 PMID: 24334803; PubMed Central PMCID: PMC3984911.
16. Bhargava A, Hayakawa K, Silverman E, Haider S, Alluri KC, Datla S, et al. Risk factors for colonization due to carbapenem-resistant Enterobacteriaceae among patients exposed to long-term acute care and acute care facilities. Infect Control Hosp Epidemiol. 2014; 35(4):398–405. https://doi.org/10.1086/ 675614 PMID: 24602945.
17. Zhao ZC, Xu XH, Liu MB, Wu J, Lin J, Li B. Fecal carriage of carbapenem-resistant Enterobacteriaceae in a Chinese university hospital. Am J Infect Control. 2014; 42(5):e61–4. Epub 2014/04/30. https://doi.org/10.1016/j.ajic.2014.01.024 PMID: 24773806.
18. Dickstein Y, Edelman R, Dror T, Hussein K, Bar-Lavie Y, Paul M. Carbapenem-resistant Enterobacteriaceae colonization and infection in critically ill patients: a retrospective matched cohort comparison with non-carriers. J Hosp Infect. 2016. https://doi.org/10.1016/j.jhin.2016.05.018 PMID: 27392978.
19. Dautzenberg MJ, Wekesa AN, Gniadkowski M, Antoniadou A, Giamarellou H, Petrikkos GL, et al. The association between colonization with carbapenemase-producing enterobacteriaceae and overall ICU mortality: an observational cohort study. Crit Care Med. 2015; 43(6):1170–7. https://doi.org/10.1097/CCM.0000000000001028 PMID: 25882764; PubMed Central PMCID: PMCPMC4431676.
20. CDC. Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities. MMWR Morb Mortal Wkly Rep. 2009; 58(10):256–60. PMID: 19300408.
21. Detsis M, Karanika S, Mylonakis E. ICU Acquisition Rate, Risk Factors, and Clinical Significance of Digestive Tract Colonization With Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae: A Systematic Review and Meta-Analysis. Crit Care Med. 2017; 45(4):705–14. https://doi.org/10.1097/CCM.0000000000002253 PMID: 28157141.
22. CLSI. Performance standards for antimicrobial susceptibility testing. Clinical and Laboratory Standards Institute. Twenty-fifth informational supplement, Clinical and Laboratory Standards Institute, Wayne, PA, 2015, M100–S252015.
23. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40(5):373–83. PMID: 3558716.
24. CDC/NHSN. CDC/NHSN Surveillance Definitions for Specific Type of Infections. http://wwwcdcgov/ nhsn/pdfs/pscmanual/17pscnosinfdef_currentpdf. 2014.
25. Borer A, Saidel-Odes L, Eskira S, Nativ R, Riesenberg K, Livshiz-Riven I, et al. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K pneumoniae. Am J Infect Control. 2012; 40(5):421–5. Epub 2011/09/13. https://doi.org/10.1016/j.ajic.2011.05.022 PMID: 21906844.
26. Pisney LM, Barron MA, Kassner E, Havens D, Madinger NE. Carbapenem-resistant Enterobacteriaceae rectal screening during an outbreak of New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae at an acute care hospital. Infect Control Hosp Epidemiol. 2014; 35(4):434–6. https://doi.org/10.1086/675597 PMID: 24602952.
27. Lowe CF, Kus JV, Salt N, Callery S, Louie L, Khan MA, et al. Nosocomial transmission of New Delhi metallo-beta-lactamase-1-producing Klebsiella pneumoniae in Toronto, Canada. Infect Control Hosp Epidemiol. 2013; 34(1):49–55. https://doi.org/10.1086/668778 PMID: 23221192.
28. Schechner V, Kotlovsky T, Kazma M, Mishali H, Schwartz D, Navon-Venezia S, et al. Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected? Clin Microbiol Infect. 2013; 19(5):451–6. https://doi.org/10.1111/j.14690691.2012.03888.x PMID: 22563800.
29. Lubbert C, Becker-Rux D, Rodloff AC, Laudi S, Busch T, Bartels M, et al. Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case-control analysis. Infection. 2014; 42(2):309–16. Epub 2013/11/13. https://doi.org/10.1007/s15010-013-0547-3 PMID: 24217959.
30. Epstein L, Hunter JC, Arwady MA, Tsai V, Stein L, Gribogiannis M, et al. New Delhi metallo-beta-lacta-mase-producing carbapenem-resistant Escherichia coli associated with exposure to duodenoscopes. JAMA. 2014; 312(14):1447–55. Epub 2014/10/08. https://doi.org/10.1001/jama.2014.12720 PMID: 25291580.
31. Rutala WA, Weber DJ. Gastrointestinal endoscopes: a need to shift from disinfection to sterilization? JAMA. 2014; 312(14):1405–6. Epub 2014/10/08. https://doi.org/10.1001/jama.2014.12559 PMID: 25291575.
32. Machuca I, Gutierrez-Gutierrez B, Perez Cortes S, Gracia-Ahufinger I, Serrano J, Madrigal MD, et al. Oral decontamination with aminoglycosides is associated with lower risk of mortality and infections in high-risk patients colonized with colistin-resistant, KPC-producing Klebsiella pneumoniae. J Antimicrob Chemother. 2016; 71(11):3242–9. https://doi.org/10.1093/jac/dkw272 PMID: 27494911.
33. Kronman MP, Zerr DM, Qin X, Englund J, Cornell C, Sanders JE, et al. Intestinal decontamination of multidrug-resistant Klebsiella pneumoniae after recurrent infections in an immunocompromised host. Diagn Microbiol Infect Dis. 2014; 80(1):87–9. https://doi.org/10.1016/j.diagmicrobio.2014.06.006 PMID: 25041704; PubMed Central PMCID: PMCPMC4162817.