Coronary Artery Calcium Distribution Is an Independent Predictor of Incident Major Coronary Heart Disease Events: Results from the Framingham Heart Study

Circulation: Cardiovascular Imaging

Volumn 10, Issue 10, 2017, Pages

  Ferencik, Maros ^a,b   Pencina, Karol M ^c   Liu, Ting ^d   Ghemigian, Khristine ^a   Baltrusaitis, Kristin ^e   Massaro, Joseph M ^e   D'Agostino, Ralph B ^e   O'Donnell, Christopher J ^f   Hoffmann, Udo ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d CHINA MEDICAL UNIVERSITY   (China)

^e Boston University   (United States)

^f FRAMINGHAM HEART STUDY   (United States)

Author keywords

atherosclerosis; coronary angiography; coronary artery disease; coronary disease; epidemiology

Indexed keywords

ADULT; AGATSTON SCORE; ARTICLE; CARDIOVASCULAR DISEASE; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY CALCIUM SCORE; DIABETES MELLITUS; DISEASE FREE SURVIVAL; DYSLIPIDEMIA; FEMALE; FRAMINGHAM RISK SCORE; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; OBESITY; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SMOKING; AGED; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY DISEASE; DIAGNOSTIC IMAGING; INCIDENCE; KAPLAN MEIER METHOD; MASSACHUSETTS; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE; PROCEDURES; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; TIME FACTOR; VASCULAR CALCIFICATION;

ADULT; AGED; COMPUTED TOMOGRAPHY ANGIOGRAPHY; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY DISEASE; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; INCIDENCE; KAPLAN-MEIER ESTIMATE; MALE; MASSACHUSETTS; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; VASCULAR CALCIFICATION;

EID: 85031001930     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.117.006592     Document Type: Article

References (31)

1. Nakahara T, Dweck MR, Narula N, Pisapia D, Narula J, Strauss HW. Coronary artery calcification: From mechanism to molecular imaging. JACC Cardiovasc Imaging. 2017;10:582-593. doi: 10.1016/j. jcmg.2017.03.005.
2. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358:1336-1345. doi: 10.1056/NEJMoa072100.
3. Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC. Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA. 2004;291:210-215. doi: 10.1001/jama.291.2.210.
4. Hoffmann U, Massaro JM, D'Agostino RB, Kathiresan S, Fox CS, O'Donnell CJ. Cardiovascular event prediction and risk reclassification by coronary, aortic, and valvular calcification in the Framingham Heart Study. J Am Heart Assoc. 2016;5:e003144.
5. Sangiorgi G, Rumberger JA, Severson A, Edwards WD, Gregoire J, Fitzpatrick LA, Schwartz RS. Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: A histologic study of 723 coronary artery segments using nondecalcifying methodology. J Am Coll Cardiol. 1998;31:126-133.
6. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-832.
7. Bittencourt MS, Hulten E, Ghoshhajra B, O'Leary D, Christman MP, Montana P, Truong QA, Steigner M, Murthy VL, Rybicki FJ, Nasir K, Gowdak LH, Hainer J, Brady TJ, Di Carli MF, Hoffmann U, Abbara S, Blankstein R. Prognostic value of nonobstructive and obstructive coronary artery disease detected by coronary computed tomography angiography to identify cardiovascular events. Circ Cardiovasc Imaging. 2014;7:282-291. doi: 10.1161/CIRCIMAGING.113.001047.
8. Mancini GB, Hartigan PM, Shaw LJ, Berman DS, Hayes SW, Bates ER, Maron DJ, Teo K, Sedlis SP, Chaitman BR, Weintraub WS, Spertus JA, Kostuk WJ, Dada M, Booth DC, Boden WE. Predicting outcome in the COURAGE trial (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation): Coronary anatomy versus ischemia. JACC Cardiovasc Interv. 2014;7:195-201. doi: 10.1016/j.jcin.2013.10.017.
9. Bartel AG, Chen JT, Peter RH, Behar VS, Kong Y, Lester RG. The significance of coronary calcification detected by fluoroscopy. A report of 360 patients. Circulation. 1974;49:1247-1253.
10. Budoff MJ, Georgiou D, Brody A, Agatston AS, Kennedy J, Wolfkiel C, Stanford W, Shields P, Lewis RJ, Janowitz WR, Rich S, Brundage BH. Ultrafast computed tomography as a diagnostic modality in the detection of coronary artery disease: A multicenter study. Circulation. 1996;93:898-904.
11. Williams M, Shaw LJ, Raggi P, Morris D, Vaccarino V, Liu ST, Weinstein S.R. , Mosler TP, Tseng PH, Flores FR, Nasir K, Budoff M. Prognostic value of number and site of calcified coronary lesions compared with the total score. JACC Cardiovasc Imaging. 2008;1:61-69. doi: 10.1016/j. jcmg.2007.09.001.
12. Brown ER, Kronmal RA, Bluemke DA, Guerci AD, Carr JJ, Goldin J, Detrano R. Coronary calcium coverage score: Determination, correlates, and predictive accuracy in the Multi-Ethnic Study of Atherosclerosis. Radiology. 2008;247:669-675. doi: 10.1148/radiol.2473071469.
13. Blaha MJ, Budoff MJ, Tota-Maharaj R, Dardari ZA, Wong ND, Kronmal RA, Eng J, Post WS, Blumenthal RS, Nasir K. Improving the CAC score by addition of regional measures of calcium distribution: Multi-Ethnic Study of Atherosclerosis. JACC Cardiovasc Imaging. 2016;9:1407-1416. doi: 10.1016/j.jcmg.2016.03.001.
14. Hoffmann U, Massaro JM, Fox CS, Manders E, O'Donnell CJ. Defining normal distributions of coronary artery calcium in women and men (from the Framingham Heart Study). Am J Cardiol. 2008;102:1136-41, 1141.e1. doi: 10.1016/j.amjcard.2008.06.038.
15. Leipsic J, Abbara S, Achenbach S, Cury R, Earls JP, Mancini GJ, Nieman K, Pontone G, Raff GL. SCCT guidelines for the interpretation and reporting of coronary CT angiography: A report of the Society of Cardiovascular Computed Tomography Guidelines Committee. J Cardiovasc Comput Tomogr. 2014;8:342-358. doi: 10.1016/j.jcct.2014.07.003.
16. Kannel WB, Feinleib M, McNamara PM, Garrison RJ, Castelli WP. An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol. 1979;110:281-290.
17. Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, Benjamin EJ, D'Agostino RB Sr, Fox CS, Larson MG, Murabito JM, O'Donnell CJ, Vasan RS, Wolf PA, Levy D. The third generation cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, recruitment, and initial examination. Am J Epidemiol. 2007;165:1328-1335. doi: 10.1093/aje/kwm021.
18. D'Agostino RB Sr, Vasan RS, Pencina MJ, Wolf PA, Cobain M, Massaro JM, Kannel WB. General cardiovascular risk profile for use in primary care: The Framingham Heart Study. Circulation. 2008;117:743-753. doi: 10.1161/CIRCULATIONAHA.107.699579.
19. Goff DC Jr, Lloyd-Jones DM, Bennett G, Coady S, D'Agostino RB, Gibbons R, Greenland P, Lackland DT, Levy D, O'Donnell CJ, Robinson JG, Schwartz JS, Shero ST, Smith SC Jr, Sorlie P, Stone NJ, Wilson PW, Jordan HS, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 suppl 2):S49-S73. doi: 10.1161/01. cir.0000437741.48606.98.
20. Pencina MJ, D'Agostino RB, Pencina KM, Janssens AC, Greenland P. Interpreting incremental value of markers added to risk prediction models. Am J Epidemiol. 2012;176:473-481. doi: 10.1093/aje/kws207.
21. Schuijf JD, Wijns W, Jukema JW, Decramer I, Atsma DE, De Roos A, Stokkel MP, Dibbets-Schneider P, van der Wall EE, Bax JJ. A comparative regional analysis of coronary atherosclerosis and calcium score on multislice CT versus myocardial perfusion on SPECT. J Nucl Med. 2006;47:1749-1755.
22. Qian Z, Anderson H, Marvasty I, Akram K, Vazquez G, Rinehart S, Voros S. Lesion-A nd vessel-specific coronary artery calcium scores are superior to whole-heart Agatston and volume scores in the diagnosis of obstructive coronary artery disease. J Cardiovasc Comput Tomogr. 2010;4:391-399. doi: 10.1016/j.jcct.2010.09.001.
23. Tota-Maharaj R, Al-Mallah MH, Nasir K, Qureshi WT, Blumenthal RS, Blaha MJ. Improving the relationship between coronary artery calcium score and coronary plaque burden: Addition of regional measures of coronary artery calcium distribution. Atherosclerosis. 2015;238:126-131. doi: 10.1016/j.atherosclerosis.2014.11.008.
24. Silverman MG, Harkness JR, Blankstein R, Budoff MJ, Agatston AS, Carr JJ, Lima JA, Blumenthal RS, Nasir K, Blaha MJ. Baseline subclinical atherosclerosis burden and distribution are associated with frequency and moDe of future coronary revascularization: Multi-ethnic study of atherosclerosis. JACC Cardiovasc Imaging. 2014;7:476-486. doi: 10.1016/j. jcmg.2014.03.005.
25. Grunfeld C, Scherzer R, Varosy PD, Ambarish G, Nasir K, Budoff M. Relation of coronary artery plaque location to extent of coronary artery disease studied by computed tomographic angiography. J Cardiovasc Comput Tomogr. 2010;4:19-26. doi: 10.1016/j.jcct.2010.01.009.
26. Schmermund A, Möhlenkamp S, Baumgart D, Kriener P, Pump H, Grönemeyer D, Seibel R, Erbel R. Usefulness of topography of coronary calcium by electron-beam computed tomography in predicting the natural history of coronary atherosclerosis. Am J Cardiol. 2000;86:127-132.
27. Wang JC, Normand SL, Mauri L, Kuntz RE. Coronary artery spatial distribution of acute myocardial infarction occlusions. Circulation. 2004;110:278-284. doi: 10.1161/01.CIR.0000135468.67850.F4.
28. Parikh NI, Honeycutt EF, Roe MT, Neely M, Rosenthal EJ, Mittleman MA, Carrozza JP Jr, Ho KK. Left and codominant coronary artery circulations are associated with higher in-hospital mortality among patients undergoing percutaneous coronary intervention for acute coronary syndromes: Report From the National Cardiovascular Database Cath Percutaneous Coronary Intervention (CathPCI) Registry. Circ Cardiovasc Qual Outcomes. 2012;5:775-782. doi: 10.1161/CIRCOUTCOMES.111.964593.
29. Veltman CE, van der Hoeven BL, Hoogslag GE, Boden H, Kharbanda RK, De Graaf MA, Delgado V, van Zwet EW, Schalij MJ, Bax JJ, Scholte AJ. Influence of coronary vessel dominance on short-A nd long-term outcome in patients after ST-segment elevation myocardial infarction. Eur Heart J. 2015;36:1023-1030. doi: 10.1093/eurheartj/ehu236.
30. Veltman CE, De Graaf FR, Schuijf JD, van Werkhoven JM, Jukema JW, Kaufmann PA, Pazhenkottil AP, Kroft LJ, Boersma E, Bax JJ, Schalij MJ, van der Wall EE. Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography. Eur Heart J. 2012;33:1367-1377. doi: 10.1093/eurheartj/ehs034.
31. Gebhard C, Fuchs TA, Stehli J, Gransar H, Berman DS, Budoff MJ, Achenbach S, Al-Mallah M, Andreini D, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan KM, Chow BJ, Cury RC, Delago A, Gomez MJ, Hadamitzky M, Hausleiter J, Hindoyan N, Feuchtner G, Kim YJ, Leipsic J, Lin FY, Maffei E, Pontone G, Raff G, Shaw LJ, Villines TC, Dunning AM, Min JK, Kaufmann PA. Coronary dominance and prognosis in patients undergoing coronary computed tomographic angiography: Results from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry. Eur Heart J Cardiovasc Imaging. 2015;16:853-862. doi: 10.1093/ehjci/jeu314.