Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine

Cell Host and Microbe

Volumn 22, Issue 1, 2017, Pages 99-110.e7

  Zaitseva, Elena ^a   Zaitsev, Eugene ^a   Melikov, Kamran ^a   Arakelyan, Anush ^a   Marin, Mariana ^b   Villasmil, Rafael ^c   Margolis, Leonid B ^a   Melikyan, Gregory B ^b   Chernomordik, Leonid V ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL EYE INSTITUTE   (United States)

Author keywords

cell activation; cell signaling; gp120 CD4 coreceptor; hemifusion; HIV entry; lipid scramblase; membrane fusion; phosphatidylserine exposure; TMEM16F activity; viral entry

Indexed keywords

CALCIUM ION; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN; LACTADHERIN; LYSOPHOSPHATIDYLCHOLINE; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLSERINE; PLERIXAFOR; SHORT HAIRPIN RNA; AMIDE; ANO6 PROTEIN, HUMAN; ANOCTAMIN; CALCIUM; CCR5 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; HETEROCYCLIC COMPOUND; MONOCLONAL ANTIBODY; PHOSPHOLIPID TRANSFER PROTEIN; QUATERNARY AMMONIUM DERIVATIVE; VIRUS ENVELOPE PROTEIN;

ARTICLE; CELL FUSION; CELL MEMBRANE; CELL SURFACE; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INOCULATION; MEMBRANE FUSION; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; TARGET CELL; VIRION; VIRUS ATTACHMENT; VIRUS CONCENTRATION; VIRUS ENTRY; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; HEK293 CELL LINE; HELA CELL LINE; HOST PATHOGEN INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; METABOLISM; PATHOGENICITY; PHYSIOLOGY; VIROLOGY; VIRUS ACTIVATION;

AMIDES; ANOCTAMINS; ANTIBODIES, MONOCLONAL; CALCIUM; CD4 ANTIGENS; CELL LINE; CELL MEMBRANE; HEK293 CELLS; HELA CELLS; HETEROCYCLIC COMPOUNDS; HIV INFECTIONS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MEMBRANE FUSION; PHOSPHATIDYLSERINES; PHOSPHOLIPID TRANSFER PROTEINS; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, CCR5; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; VIRAL ENVELOPE PROTEINS; VIRUS ACTIVATION; VIRUS ATTACHMENT; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 85030456275     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2017.06.012     Document Type: Article

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