메뉴 건너뛰기




Volumn 16, Issue 11, 2017, Pages 908-916

Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson's disease: a longitudinal cohort study and validation

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER; PLACEBO;

EID: 85029904077     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(17)30328-9     Document Type: Article
Times cited : (133)

References (43)
  • 1
    • 84940956493 scopus 로고    scopus 로고
    • Parkinson's disease
    • Kalia, LV, Lang, AE, Parkinson's disease. Lancet 386 (2015), 896–912.
    • (2015) Lancet , vol.386 , pp. 896-912
    • Kalia, L.V.1    Lang, A.E.2
  • 2
    • 84907842682 scopus 로고    scopus 로고
    • Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson's Disease 2014 conference
    • Sieber, B-A, Landis, S, Koroshetz, W, et al. Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson's Disease 2014 conference. Ann Neurol 76 (2014), 469–472.
    • (2014) Ann Neurol , vol.76 , pp. 469-472
    • Sieber, B.-A.1    Landis, S.2    Koroshetz, W.3
  • 3
    • 36248979778 scopus 로고    scopus 로고
    • Prognostic factors for the progression of Parkinson's disease: a systematic review
    • Post, B, Merkus, MP, de Haan, RJ, Speelman, JD, on behalf of the CARPA Study Group. Prognostic factors for the progression of Parkinson's disease: a systematic review. Mov Disord 22 (2007), 1839–1851.
    • (2007) Mov Disord , vol.22 , pp. 1839-1851
    • Post, B.1    Merkus, M.P.2    de Haan, R.J.3    Speelman, J.D.4
  • 4
    • 84922718224 scopus 로고    scopus 로고
    • Clinical evolution of Parkinson's disease and prognostic factors affecting motor progression: 9-year follow-up study
    • Reinoso, G, Allen, JC, Au, W-L, Seah, S-H, Tay, K-Y, Tan, LCS, Clinical evolution of Parkinson's disease and prognostic factors affecting motor progression: 9-year follow-up study. Eur J Neurol 22 (2015), 457–463.
    • (2015) Eur J Neurol , vol.22 , pp. 457-463
    • Reinoso, G.1    Allen, J.C.2    Au, W.-L.3    Seah, S.-H.4    Tay, K.-Y.5    Tan, L.C.S.6
  • 5
    • 84957428404 scopus 로고    scopus 로고
    • CSF β-amyloid 1-42 predicts progression to cognitive impairment in newly diagnosed Parkinson disease
    • Terrelonge, M, Marder, KS, Weintraub, D, Alcalay, RN, CSF β-amyloid 1-42 predicts progression to cognitive impairment in newly diagnosed Parkinson disease. J Mol Neurosci 58 (2016), 88–92.
    • (2016) J Mol Neurosci , vol.58 , pp. 88-92
    • Terrelonge, M.1    Marder, K.S.2    Weintraub, D.3    Alcalay, R.N.4
  • 6
    • 84879460078 scopus 로고    scopus 로고
    • Predicting dementia development in Parkinson's disease using Bayesian network classifiers
    • Morales, DA, Vives-Gilabert, Y, Gómez-Ansón, B, et al. Predicting dementia development in Parkinson's disease using Bayesian network classifiers. Psychiatry Res 213 (2013), 92–98.
    • (2013) Psychiatry Res , vol.213 , pp. 92-98
    • Morales, D.A.1    Vives-Gilabert, Y.2    Gómez-Ansón, B.3
  • 7
    • 85003791553 scopus 로고    scopus 로고
    • Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson's disease: a cohort study
    • Schrag, A, Siddiqui, UF, Anastasiou, Z, Weintraub, D, Schott, JM, Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson's disease: a cohort study. Lancet Neurol 16 (2017), 66–75.
    • (2017) Lancet Neurol , vol.16 , pp. 66-75
    • Schrag, A.1    Siddiqui, U.F.2    Anastasiou, Z.3    Weintraub, D.4    Schott, J.M.5
  • 8
    • 84961279264 scopus 로고    scopus 로고
    • Development and external validation of a prognostic model in newly diagnosed Parkinson disease
    • Velseboer, DC, de Bie, RMA, Wieske, L, et al. Development and external validation of a prognostic model in newly diagnosed Parkinson disease. Neurology 86 (2016), 986–993.
    • (2016) Neurology , vol.86 , pp. 986-993
    • Velseboer, D.C.1    de Bie, R.M.A.2    Wieske, L.3
  • 9
    • 85024374080 scopus 로고    scopus 로고
    • Predictors of time to initiation of symptomatic therapy in early Parkinson's disease
    • Simuni, T, Long, JD, Caspell-Garcia, C, et al. Predictors of time to initiation of symptomatic therapy in early Parkinson's disease. Ann Clin Transl Neurol 3 (2016), 482–494.
    • (2016) Ann Clin Transl Neurol , vol.3 , pp. 482-494
    • Simuni, T.1    Long, J.D.2    Caspell-Garcia, C.3
  • 10
    • 73349136256 scopus 로고    scopus 로고
    • Endpoints and analyses to discern disease-modifying drug effects in early Parkinson's disease
    • Bhattaram, VA, Siddiqui, O, Kapcala, LP, Gobburu, JVS, Endpoints and analyses to discern disease-modifying drug effects in early Parkinson's disease. AAPS J 11 (2009), 456–464.
    • (2009) AAPS J , vol.11 , pp. 456-464
    • Bhattaram, V.A.1    Siddiqui, O.2    Kapcala, L.P.3    Gobburu, J.V.S.4
  • 11
    • 0037262841 scopus 로고    scopus 로고
    • Being Bayesian about network structure: a Bayesian approach to structure discovery in Bayesian networks
    • Friedman, N, Koller, D, Being Bayesian about network structure: a Bayesian approach to structure discovery in Bayesian networks. Mach Learn 50 (2003), 95–125.
    • (2003) Mach Learn , vol.50 , pp. 95-125
    • Friedman, N.1    Koller, D.2
  • 12
    • 79953670434 scopus 로고    scopus 로고
    • Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis
    • Xing, H, McDonagh, PD, Bienkowska, J, et al. Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis. PLoS Comput Biol, 7, 2011, e1001105.
    • (2011) PLoS Comput Biol , vol.7 , pp. e1001105
    • Xing, H.1    McDonagh, P.D.2    Bienkowska, J.3
  • 13
    • 85009096641 scopus 로고    scopus 로고
    • Reverse engineering and evaluation of prediction models for progression to type 2 diabetes: an application of machine learning using electronic health records
    • Anderson, JP, Parikh, JR, Shenfeld, DK, et al. Reverse engineering and evaluation of prediction models for progression to type 2 diabetes: an application of machine learning using electronic health records. J Diabetes Sci Technol 10 (2016), 6–18.
    • (2016) J Diabetes Sci Technol , vol.10 , pp. 6-18
    • Anderson, J.P.1    Parikh, J.R.2    Shenfeld, D.K.3
  • 14
    • 84903610582 scopus 로고    scopus 로고
    • Novel predictive models for metabolic syndrome risk: a ‘big data’ analytic approach
    • Steinberg, GB, Church, BW, McCall, CJ, Scott, AB, Kalis, BP, Novel predictive models for metabolic syndrome risk: a ‘big data’ analytic approach. Am J Manag Care 20 (2014), e221–e228.
    • (2014) Am J Manag Care , vol.20 , pp. e221-e228
    • Steinberg, G.B.1    Church, B.W.2    McCall, C.J.3    Scott, A.B.4    Kalis, B.P.5
  • 15
    • 82755161902 scopus 로고    scopus 로고
    • The Parkinson Progression Marker Initiative (PPMI)
    • Marek, K, Jennings, D, Lasch, S, et al. The Parkinson Progression Marker Initiative (PPMI). Prog Neurobiol 95 (2011), 629–635.
    • (2011) Prog Neurobiol , vol.95 , pp. 629-635
    • Marek, K.1    Jennings, D.2    Lasch, S.3
  • 16
    • 61449165975 scopus 로고    scopus 로고
    • Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results
    • Goetz, CG, Tilley, BC, Shaftman, SR, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 23 (2008), 2129–2170.
    • (2008) Mov Disord , vol.23 , pp. 2129-2170
    • Goetz, C.G.1    Tilley, B.C.2    Shaftman, S.R.3
  • 17
    • 84893658916 scopus 로고    scopus 로고
    • Randomized trial of IPX066, carbidopa/levodopa extended release, in early Parkinson's disease
    • Pahwa, R, Lyons, KE, Hauser, RA, et al. Randomized trial of IPX066, carbidopa/levodopa extended release, in early Parkinson's disease. Parkinsonism Relat Disord 20 (2014), 142–148.
    • (2014) Parkinsonism Relat Disord , vol.20 , pp. 142-148
    • Pahwa, R.1    Lyons, K.E.2    Hauser, R.A.3
  • 18
    • 67651034799 scopus 로고    scopus 로고
    • Double-blind trial of levodopa/carbidopa/entacapone versus levodopa/carbidopa in early Parkinson's disease
    • Hauser, RA, Panisset, M, Abbruzzese, G, et al. Double-blind trial of levodopa/carbidopa/entacapone versus levodopa/carbidopa in early Parkinson's disease. Mov Disord 24 (2009), 541–550.
    • (2009) Mov Disord , vol.24 , pp. 541-550
    • Hauser, R.A.1    Panisset, M.2    Abbruzzese, G.3
  • 19
    • 34447252358 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease
    • Storch, A, Jost, WH, Vieregge, P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease. Arch Neurol 64 (2007), 938–944.
    • (2007) Arch Neurol , vol.64 , pp. 938-944
    • Storch, A.1    Jost, W.H.2    Vieregge, P.3
  • 20
    • 84902147760 scopus 로고    scopus 로고
    • Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience
    • Parashos, SA, Luo, S, Biglan, KM, et al. Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience. JAMA Neurol 71 (2014), 710–716.
    • (2014) JAMA Neurol , vol.71 , pp. 710-716
    • Parashos, S.A.1    Luo, S.2    Biglan, K.M.3
  • 21
    • 79951562611 scopus 로고    scopus 로고
    • lme4: mixed-effects modeling with R
    • (accessed March 17, 2014).
    • Bates, DM, lme4: mixed-effects modeling with R. http://lme4.r-forge.r-project.org/lMMwR/lrgprt.pdf, June 25, 2010 (accessed March 17, 2014).
    • (2010)
    • Bates, D.M.1
  • 22
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff, LA, Sethupathy, P, Junkins, HA, et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci USA 106 (2009), 9362–9367.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 23
    • 84939221315 scopus 로고    scopus 로고
    • DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes
    • Piñero, J, Queralt-Rosinach, N, Bravo, À, et al. DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. Database, 2015, 2015, bav028.
    • (2015) Database , vol.2015 , pp. bav028
    • Piñero, J.1    Queralt-Rosinach, N.2    Bravo, À.3
  • 24
    • 73149095252 scopus 로고    scopus 로고
    • Observed universality of phase transitions in high-dimensional geometry, with implications for modern data analysis and signal processing
    • Donoho, D, Tanner, J, Observed universality of phase transitions in high-dimensional geometry, with implications for modern data analysis and signal processing. Philos Trans A Math Phys Eng Sci 367 (2009), 4273–4293.
    • (2009) Philos Trans A Math Phys Eng Sci , vol.367 , pp. 4273-4293
    • Donoho, D.1    Tanner, J.2
  • 25
    • 70450192539 scopus 로고    scopus 로고
    • A longitudinal program for biomarker development in Parkinson's disease: a feasibility study
    • Ravina, B, Tanner, C, Dieuliis, D, et al. A longitudinal program for biomarker development in Parkinson's disease: a feasibility study. Mov Disord 24 (2009), 2081–2090.
    • (2009) Mov Disord , vol.24 , pp. 2081-2090
    • Ravina, B.1    Tanner, C.2    Dieuliis, D.3
  • 26
    • 85031725044 scopus 로고    scopus 로고
    • MDL-motivated compression of GLM ensembles increases interpretability and retains predictive power
    • (accessed Dec 21, 2016).
    • Hayete, B, Valko, M, Greenfield, A, Yan, R, MDL-motivated compression of GLM ensembles increases interpretability and retains predictive power. http://arxiv.org/abs/1611.06800, Nov 21, 2016 (accessed Dec 21, 2016).
    • (2016)
    • Hayete, B.1    Valko, M.2    Greenfield, A.3    Yan, R.4
  • 27
    • 0029883235 scopus 로고    scopus 로고
    • The response to levodopa in Parkinson's disease: imposing pharmacological law and order
    • Nutt, JG, Holford, NH, The response to levodopa in Parkinson's disease: imposing pharmacological law and order. Ann Neurol 39 (1996), 561–573.
    • (1996) Ann Neurol , vol.39 , pp. 561-573
    • Nutt, J.G.1    Holford, N.H.2
  • 28
    • 84977556275 scopus 로고    scopus 로고
    • A review of disease progression models of Parkinson's disease and applications in clinical trials
    • Venuto, CS, Potter, NB, Ray Dorsey, E, Kieburtz, K, A review of disease progression models of Parkinson's disease and applications in clinical trials. Mov Disord 31 (2016), 947–956.
    • (2016) Mov Disord , vol.31 , pp. 947-956
    • Venuto, C.S.1    Potter, N.B.2    Ray Dorsey, E.3    Kieburtz, K.4
  • 29
    • 84866629111 scopus 로고    scopus 로고
    • Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease
    • Ravina, B, Marek, K, Eberly, S, et al. Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease. Mov Disord 27 (2012), 1392–1397.
    • (2012) Mov Disord , vol.27 , pp. 1392-1397
    • Ravina, B.1    Marek, K.2    Eberly, S.3
  • 30
    • 84885699313 scopus 로고    scopus 로고
    • Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease
    • Kang, J-H, Irwin, DJ, Chen-Plotkin, AS, et al. Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. JAMA Neurol 70 (2013), 1277–1287.
    • (2013) JAMA Neurol , vol.70 , pp. 1277-1287
    • Kang, J.-H.1    Irwin, D.J.2    Chen-Plotkin, A.S.3
  • 32
    • 0346788854 scopus 로고    scopus 로고
    • LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex
    • Carim-Todd, L, Escarceller, M, Estivill, X, Sumoy, L, LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Eur J Neurosci 18 (2003), 3167–3182.
    • (2003) Eur J Neurosci , vol.18 , pp. 3167-3182
    • Carim-Todd, L.1    Escarceller, M.2    Estivill, X.3    Sumoy, L.4
  • 33
    • 0037380873 scopus 로고    scopus 로고
    • A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system
    • Laurén, J, Airaksinen, MS, Saarma, M, Timmusk, T, A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics 81 (2003), 411–421.
    • (2003) Genomics , vol.81 , pp. 411-421
    • Laurén, J.1    Airaksinen, M.S.2    Saarma, M.3    Timmusk, T.4
  • 34
    • 33751256567 scopus 로고    scopus 로고
    • The familial Parkinsonism gene LRRK2 regulates neurite process morphology
    • MacLeod, D, Dowman, J, Ha mmond, R, Leete, T, Inoue, K, Abeliovich, A, The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52 (2006), 587–593.
    • (2006) Neuron , vol.52 , pp. 587-593
    • MacLeod, D.1    Dowman, J.2    Ha mmond, R.3    Leete, T.4    Inoue, K.5    Abeliovich, A.6
  • 35
    • 35449003272 scopus 로고    scopus 로고
    • Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models
    • Inoue, H, Lin, L, Lee, X, et al. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci USA 104 (2007), 14430–14435.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14430-14435
    • Inoue, H.1    Lin, L.2    Lee, X.3
  • 36
    • 22844453047 scopus 로고    scopus 로고
    • LINGO-1 negatively regulates myelination by oligodendrocytes
    • Mi, S, Miller, RH, Lee, X, et al. LINGO-1 negatively regulates myelination by oligodendrocytes. Nat Neurosci 8 (2005), 745–751.
    • (2005) Nat Neurosci , vol.8 , pp. 745-751
    • Mi, S.1    Miller, R.H.2    Lee, X.3
  • 37
    • 6344220137 scopus 로고    scopus 로고
    • A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin
    • Li, W, Walus, L, Rabacchi, SA, et al. A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin. J Biol Chem 279 (2004), 43780–43788.
    • (2004) J Biol Chem , vol.279 , pp. 43780-43788
    • Li, W.1    Walus, L.2    Rabacchi, S.A.3
  • 38
    • 78650039010 scopus 로고    scopus 로고
    • LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease
    • Vilariño-Güell, C, Wider, C, Ross, OA, et al. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. Neurogenetics 11 (2010), 401–408.
    • (2010) Neurogenetics , vol.11 , pp. 401-408
    • Vilariño-Güell, C.1    Wider, C.2    Ross, O.A.3
  • 39
    • 84939599004 scopus 로고    scopus 로고
    • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
    • Nalls, MA, Pankratz, N, Lill, CM, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 46 (2014), 989–993.
    • (2014) Nat Genet , vol.46 , pp. 989-993
    • Nalls, M.A.1    Pankratz, N.2    Lill, C.M.3
  • 40
    • 84904113793 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases
    • Chen, T, Gai, W-P, Abbott, CA, Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases. BioMed Res Int, 2014, 2014, 209398.
    • (2014) BioMed Res Int , vol.2014 , pp. 209398
    • Chen, T.1    Gai, W.-P.2    Abbott, C.A.3
  • 41
    • 84908068702 scopus 로고    scopus 로고
    • Bayesian hierarchical model for multiple repeated measures and survival data: an application to Parkinson's disease
    • Luo, S, Wang, J, Bayesian hierarchical model for multiple repeated measures and survival data: an application to Parkinson's disease. Stat Med 33 (2014), 4279–4291.
    • (2014) Stat Med , vol.33 , pp. 4279-4291
    • Luo, S.1    Wang, J.2
  • 42
    • 74349092804 scopus 로고    scopus 로고
    • Estimating dementia-free life expectancy for Parkinson's patients using Bayesian inference and microsimulation
    • van den Hout, A, Matthews, FE, Estimating dementia-free life expectancy for Parkinson's patients using Bayesian inference and microsimulation. Biostatistics 10 (2009), 729–743.
    • (2009) Biostatistics , vol.10 , pp. 729-743
    • van den Hout, A.1    Matthews, F.E.2
  • 43
    • 83555166115 scopus 로고    scopus 로고
    • Bayesian quantitative disease-drug-trial models for Parkinson's disease to guide early drug development
    • Lee, JY, Gobburu, JVS, Bayesian quantitative disease-drug-trial models for Parkinson's disease to guide early drug development. AAPS J 13 (2011), 508–518.
    • (2011) AAPS J , vol.13 , pp. 508-518
    • Lee, J.Y.1    Gobburu, J.V.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.