Sleep-disordered breathing in acute ischemic stroke: A mechanistic link to peripheral endothelial dysfunction

Journal of the American Heart Association

Volumn 6, Issue 9, 2017, Pages

  Scherbakov, Nadja ^a   Sandek, Anja ^b   Ebner, Nicole ^b   Valentova, Miroslava ^b   Nave, Alexander Heinrich ^a   Jankowska, Ewa A ^c,d   Schefold, Jörg C ^e   von Haehling, Stephan ^b   Anker, Stefan D ^b   Fietze, Ingo ^a   Fiebach, Jochen B ^a   Haeusler, Karl Georg ^a   Doehner, Wolfram ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c WROCLAW MEDICAL UNIVERSITY   (Poland)

^d MILITARY HOSPITAL   (Poland)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

Clinical trial; Endothelial dysfunction; Sleep disorders; Sympathetic nervous system

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; CREATININE; GLUCOSE; HEMOGLOBIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; POTASSIUM; SODIUM; TRIACYLGLYCEROL; URIC ACID;

ADULT; AGED; APNEA HYPOPNEA INDEX; ARTICLE; ATRIAL FIBRILLATION; AUTONOMIC DYSFUNCTION; BRAIN ISCHEMIA; CHEYNE STOKES BREATHING; CLINICAL PROTOCOL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; FEMALE; FOLLOW UP; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; HYPEREMIA; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OBSERVATIONAL STUDY; PLETHYSMOGRAPHY; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANKIN SCALE; SEX DIFFERENCE; SLEEP DISORDERED BREATHING; SYSTOLIC BLOOD PRESSURE; VERY ELDERLY; AUTONOMIC NERVOUS SYSTEM; BREATHING; CEREBROVASCULAR ACCIDENT; CHI SQUARE DISTRIBUTION; DISABILITY; GERMANY; IMPEDANCE CARDIOGRAPHY; INNERVATION; LUNG; MANOMETRY; MULTIVARIATE ANALYSIS; ODDS RATIO; PATHOPHYSIOLOGY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PREVALENCE; PROSPECTIVE STUDY; RISK FACTOR; SLEEP; STATISTICAL MODEL; TIME FACTOR; VASCULAR ENDOTHELIUM;

AGED; AGED, 80 AND OVER; AUTONOMIC NERVOUS SYSTEM; BRAIN ISCHEMIA; CARDIOGRAPHY, IMPEDANCE; CHI-SQUARE DISTRIBUTION; DISABILITY EVALUATION; ENDOTHELIUM, VASCULAR; FEMALE; GERMANY; HUMANS; LINEAR MODELS; LOGISTIC MODELS; LUNG; MALE; MANOMETRY; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PERIPHERAL ARTERIAL DISEASE; PREVALENCE; PROSPECTIVE STUDIES; RESPIRATION; RISK FACTORS; SLEEP; SLEEP APNEA SYNDROMES; STROKE; TIME FACTORS;

EID: 85029758924     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.117.006010     Document Type: Article

References (32)

1. Hermann DM, Bassetti CL. Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery. Neurology. 2016;87:1407-1416
2. Floras JS. Sleep apnea and cardiovascular risk. J Cardiol. 2014;63:3-8
3. Stone KL, Blackwell TL, Ancoli-Israel S, Barrett-Connor E, Bauer DC, Cauley JA, Ensrud KE, Hoffman AR, Mehra R, Stefanick ML, Varosy PD, Yaffe K, Redline S; Osteoporotic Fractures in Men (MrOS) Study Research Group. Sleepdisordered breathing and risk of stroke in older community-dwelling men. Sleep. 2016;39:531-540
4. Ifergane G, Ovanyan A, Toledano R, Goldbart A, Abu-Salame I, Tal A, Stavsky M, Novack V. Obstructive sleep apnea in acute stroke: a role for systemic inflammation. Stroke. 2016;47:1207-1212
5. Birchfield RI, Sieker HO, Heyman A. Alterations in blood gases during natural sleep and narcolepsy; a correlation with the electroencephalographic stages of sleep. Neurology. 1958;8:107-112
6. Heyman A, Birchfield RI, Sieker HO. Effects of bilateral cerebral infarction on respiratory center sensitivity. Neurology. 1958;8:694-700
7. Nopmaneejumruslers C, Kaneko Y, Hajek V, Zivanovic V, Bradley TD. Cheyne-Stokes respiration in stroke: relationship to hypocapnia and occult cardiac dysfunction. Am J Respir Crit Care Med. 2005;171:1048-1052
8. Roquer J, Segura T, Serena J, Castillo J. Endothelial dysfunction, vascular disease and stroke: the ARTICO study. Cerebrovasc Dis. 2009;27(Suppl 1): 25-37
9. Dütsch M, Burger M, Dörfler C, Schwab S, Hilz MJ. Cardiovascular autonomic function in poststroke patients. Neurology. 2007;69:2249-2255
10. Korpelainen JT, Sotaniemi KA, Myllylä VV. Autonomic nervous system disorders in stroke. Clin Auton Res. 1999;9:325-333
11. Orlandi G, Fanucchi S, Strata G, Pataleo L, Landucci Pellegrini L, Prontera C, Martini A, Murri L. Transient autonomic nervous system dysfunction during hyperacute stroke. Acta Neurol Scand. 2000;102:317-321
12. Mochmann HC, Scheitz JF, Petzold GC, Haeusler KG, Audebert HJ, Laufs U, Schneider C, Landmesser U, Werner N, Endres M, Witzenbichler B, Nolte CH; TRELAS Study Group. Coronary angiographic findings in acute ischemic stroke patients with elevated cardiac troponin: the troponin elevation in acute ischemic stroke (TRELAS) study. Circulation. 2016;133:1264-1271
13. Scherbakov N, Sandek A, Martens-Lobenhoffer J, Kung T, Turhan G, Liman T, Ebinger M, von Haehling S, Bode-Böger SM, Endres M, Doehner W. Endothelial dysfunction of the peripheral vascular bed in the acute phase after ischemic stroke. Cerebrovasc Dis. 2012;33:37-46
14. Kunz AB, Kraus J, Young P, Reuss R, Wipfler P, Oschmann P, Blaes F, Dziewas R. Biomarkers of inflammation and endothelial dysfunction in stroke with and without sleep apnea. Cerebrovasc Dis. 2012;33:453-460
15. Cereda CW, Tamisier R, Manconi M, Andreotti J, Frangi J, Pifferini V, Bassetti CL. Endothelial dysfunction and arterial stiffness in ischemic stroke: the role of sleep-disordered breathing. Stroke. 2013;44:1175-1178
16. Knops M, Werner CG, Scherbakov N, Fiebach J, Dreier JP, Meisel A, Heuschmann PU, Jungehülsing GJ, von Haehling S, Dirnagl U, Anker SD, Doehner W. Investigation of changes in body composition, metabolic profile and skeletal muscle functional capacity in ischemic stroke patients: the rationale and design of the Body Size in Stroke Study (BoSSS). J Cachexia Sarcopenia Muscle. 2013;4:199-207
17. Pexman JH, Barber PA, Hill MD, Sevick RJ, Demchuk AM, Hudon ME, Hu WY, Buchan AM. Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. AJNR Am J Neuroradiol. 2001;22:1534-1542
18. Mueller A, Fietze I, Voelker R, Eddicks S, Glos M, Baumann G, Theres H. Screening for sleep-related breathing disorders by transthoracic impedance recording integrated into a Holter ECG system. J Sleep Res. 2006;15:455-462
19. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. J Am Coll Cardiol. 2008;52:686-717
20. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Køber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A; ESC Committee for Practice Guidelines. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33:1787-1847
21. Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, Karas RH, Udelson JE. Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. Am Heart J. 2003;146:168-174
22. Wang J, Yu W, Gao M, Zhang F, Gu C, Yu Y, Wei Y. Impact of obstructive sleep apnea syndrome on endothelial function, arterial stiffening, and serum inflammatory markers: an updated meta-analysis and metaregression of 18 studies. J Am Heart Assoc. 2015;4:e002454. doi: 10.1161/JAHA.115.002454
23. Itzhaki S, Lavie L, Pillar G, Tal G, Lavie P. Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia. Sleep. 2005;28:594-600
24. Nieto FJ, Herrington DM, Redline S, Benjamin EJ, Robbins JA. Sleep apnea and markers of vascular endothelial function in a large community sample of older adults. Am J Respir Crit Care Med. 2004;169:354-360
25. Schwarz EI, Puhan MA, Schlatzer C, Stradling JR, Kohler M. Effect of CPAP therapy on endothelial function in obstructive sleep apnoea: a systematic review and meta-analysis. Respirology. 2015;20:889-895
26. Good DC, Henkle JQ, Gelber D, Welsh J, Verhulst S. Sleep-disordered breathing and poor functional outcome after stroke. Stroke. 1996;27:252-259
27. Aaronson JA, van Bennekom CA, Hofman WF, van Bezeij T, van den Aardweg JG, Groet E, Kylstra WA, Schmand B. Obstructive sleep apnea is related to impaired cognitive and functional status after stroke. Sleep. 2015;38:1431-1437
28. Hilz MJ, Moeller S, Akhundova A, Marthol H, Pauli E, De Fina P, Schwab S. High NIHSS values predict impairment of cardiovascular autonomic control. Stroke. 2011;42:1528-1533
29. Eulenburg C, Wegscheider K, Woehrle H, Angermann C, d'Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H, Cowie MR. Mechanisms underlying increased mortality risk in patients with heart failure and reduced ejection fraction randomly assigned to adaptive servoventilation in the SERVE-HF study: results of a secondary multistate modelling analysis. Lancet Respir Med. 2016;4:873-881
30. Hachinski VC, Oppenheimer SM, Wilson JX, Guiraudon C, Cechetto DF. Asymmetry of sympathetic consequences of experimental stroke. Arch Neurol. 1992;49:697-702
31. Collop NA, Anderson WM, Boehlecke B, Claman D, Goldberg R, Gottlieb DJ, Hudgel D, Sateia M, Schwab R; Portable Monitoring Task Force of the American Academy of Sleep Medicine. Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable Monitoring Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med. 2007;3:737-747
32. Scharf C, Cho YK, Bloch KE, Brunckhorst C, Duru F, Balaban K, Foldvary N, Liu L, Burgess RC, Candinas R, Wilkoff BL. Diagnosis of sleep-related breathing disorders by visual analysis of transthoracic impedance signals in pacemakers. Circulation. 2004;110:2562-2567