Mechanisms underlying increased mortality risk in patients with heart failure and reduced ejection fraction randomly assigned to adaptive servoventilation in the SERVE-HF study: results of a secondary multistate modelling analysis

The Lancet Respiratory Medicine

Volumn 4, Issue 11, 2016, Pages 873-881

  Eulenburg, Christine ^a,b   Wegscheider, Karl ^a   Woehrle, Holger ^c,d   Angermann, Christiane ^e   d'Ortho, Marie Pia ^f   Erdmann, Erland ^g   Levy, Patrick ^h   Simonds, Anita K ⁱ   Somers, Virend K ^j   Zannad, Faiez ^k   Teschler, Helmut ^l   Cowie, Martin R ^m  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c ResMed Science Center   (Germany)

^d Research Cent Ulm   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g UNIVERSITY OF COLOGNE   (Germany)

^h GRENOBLE UNIVERSITY HOSPITAL   (France)

ⁱ ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^j MAYO CLINIC   (United States)

^k UNIVERSITÉ DE LORRAINE   (France)

^l UNIVERSITY HOSPITAL ESSEN   (Germany)

^m IMPERIAL COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARDIAC GLYCOSIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT;

ADAPTIVE SERVOVENTILATION; AGED; ARTICLE; ASSISTED VENTILATION; ATTRIBUTABLE RISK; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHEYNE STOKES BREATHING; CONTROLLED STUDY; FEMALE; HEART FAILURE; HEART FAILURE AND REDUCED EJECTION FRACTION; HEART LEFT VENTRICLE EJECTION FRACTION; HOSPITAL ADMISSION; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; LIFE EVENT; MALE; MORTALITY RISK; MULTICENTER STUDY; PARALLEL DESIGN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; CAUSE OF DEATH; CENTRAL SLEEP APNEA SYNDROME; CLINICAL TRIAL; COMPLICATION; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; HOSPITALIZATION; INTERACTIVE VENTILATORY SUPPORT; MIDDLE AGED; MORTALITY; PHYSIOLOGY; PROCEDURES; PROPORTIONAL HAZARDS MODEL; STATISTICS AND NUMERICAL DATA; SUDDEN CARDIAC DEATH; TREATMENT OUTCOME;

AGED; CAUSE OF DEATH; CHEYNE-STOKES RESPIRATION; DEATH, SUDDEN, CARDIAC; FEMALE; HEART FAILURE; HOSPITALIZATION; HUMANS; INTERACTIVE VENTILATORY SUPPORT; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; SLEEP APNEA, CENTRAL; STROKE VOLUME; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84994087202     PISSN: 22132600     EISSN: 22132619     Source Type: Journal    
DOI: 10.1016/S2213-2600(16)30244-2     Document Type: Article

References (19)

1. 1 Cowie, MR, Woehrle, H, Wegscheider, K, et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med 373 (2015), 1095–1105.
2. 2 D'Elia, E, Vanoli, E, La Rovere, MT, et al. Adaptive servo ventilation reduces central sleep apnea in chronic heart failure patients: beneficial effects on autonomic modulation of heart rate. J Cardiovasc Med (Hagerstown) 14 (2013), 296–300.
3. 3 Hastings, PC, Vazir, A, Meadows, GE, et al. Adaptive servo-ventilation in heart failure patients with sleep apnea: a real world study. Int J Cardiol 139 (2010), 17–24.
4. 4 Kourouklis, SP, Vagiakis, E, Paraskevaidis, IA, et al. Effective sleep apnoea treatment improves cardiac function in patients with chronic heart failure. Int J Cardiol 168 (2013), 157–162.
5. 5 Oldenburg, O, Schmidt, A, Lamp, B, et al. Adaptive servoventilation improves cardiac function in patients with chronic heart failure and Cheyne-Stokes respiration. Eur J Heart Fail 10 (2008), 581–586.
6. 6 Takama, N, Kurabayashi, M, Effect of adaptive servo-ventilation on 1-year prognosis in heart failure patients. Circ J 76 (2012), 661–667.
7. 7 Andersen, PK, Keiding, N, Multi-state models for event history analysis. Stat Methods Med Res 11 (2002), 91–115.
8. 8 Putter, H, Fiocco, M, Geskus, RB, Tutorial in biostatistics: competing risks and multi-state models. Stat Med 26 (2007), 2389–2430.
9. 9 Cowie, MR, Woehrle, H, Wegscheider, K, et al. Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure. Eur J Heart Fail 15 (2013), 937–943.
10. 10 Djavadkhani, Y, Marshall, NS, D'Rozario, AL, et al. Ethics, consent and blinding: lessons from a placebo/sham controlled CPAP crossover trial. Thorax 70 (2015), 265–269.
11. 11 Cowie, MR, Wegscheider, K, Teschler, H, Adaptive servoventilation for central sleep apnea in Heart Failure. N Engl J Med 374 (2016), 690–691.
12. 12 Naughton, MT, Cheyne-Stokes respiration: friend or foe?. Thorax 67 (2012), 357–360.
13. 13 Andreas, S, Weidel, K, Hagenah, G, Heindl, S, Treatment of Cheyne-Stokes respiration with nasal oxygen and carbon dioxide. Eur Respir J 12 (1998), 414–419.
14. 14 Curtis, BM, O'Keefe, JH Jr, Autonomic tone as a cardiovascular risk factor: the dangers of chronic fight or flight. Mayo Clin Proc 77 (2002), 45–54.
15. 15 Nolan, J, Batin, PD, Andrews, R, et al. Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation 98 (1998), 1510–1516.
16. 16 Gomez, G, Gomez-Mateu, M, Dafni, U, Informed choice of composite end points in cardiovascular trials. Circ Cardiovasc Qual Outcomes 7 (2014), 170–178.
17. 17 Ferreira-Gonzalez, I, Alonso-Coello, P, Sola, I, et al. Composite endpoints in clinical trials. Rev Esp Cardiol 61 (2008), 283–290 (in Spanish).
18. 18 Neaton, JD, Gray, G, Zuckerman, BD, Konstam, MA, Key issues in end point selection for heart failure trials: composite end points. J Card Fail 11 (2005), 567–575.
19. 19 Freemantle, N, Calvert, M, Wood, J, Eastaugh, J, Griffin, C, Composite outcomes in randomized trials: greater precision but with greater uncertainty?. JAMA 289 (2003), 2554–2559.