The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years)

Intensive Care Medicine

Volumn 43, Issue 12, 2017, Pages 1820-1828

  Flaatten, Hans ^a,b   De Lange, Dylan W ^c   Morandi, Alessandro ^d,e   Andersen, Finn H ^f,g   Artigas, Antonio ^h   Bertolini, Guido ^j   Boumendil, Ariane ^k   Cecconi, Maurizio ^l   Christensen, Steffen ⁱ   Faraldi, Loredana ^m   Fjølner, Jesper ⁱ   Jung, Christian ⁿ   Marsh, Brian ^o   Moreno, Rui ^p   Oeyen, Sandra ^q   Öhman, Christina Agwald ^r   Pinto, Bernardo Bollen ^s   Soliman, Ivo W ^c   Szczeklik, Wojciech ^t   Valentin, Andreas ^u   Watson, Ximena ^l   Zaferidis, Tilemachos ^v   Guidet, Bertrand ^w,x,y   Schmutz, René ^d   Wimmer, Franz ^d   Eller, Philipp ^d   Zotter, Klemens ^d   Swinnen, Walter ^d   De Buysscher, Pieter ^d   De Neve, Nikolaas ^d   Abraham, Paul ^d   Fleury, Yvan ^d   Schefold, Joerg C ^d   Biskup, Ewelina ^d   Taliadoros, Ioannis ^d   Piza, Petr ^d   Lauten, Alexander ^d   Sacher, Anna Lena ^d   Brenner, Thorsten ^d   Franz, Marcus ^d   Bloos, Frank ^d   Ebelt, Henning ^d   Schaller, Stefan J ^d   Fuest, Kristina ^d   Rabe, Christian ^d   Dieck, Thorben ^d   Steiner, Stephan ^d   Graf, Tobias ^d   Nia, Amir M ^d   Janosi, Rolf Alexander ^d   Meybohm, Patrick ^d   Simon, Philipp ^d   Utzolino, Stefan ^d   Rahmel, Tim ^d   Barth, Eberhard ^d   Schuster, Michael ^d   Dey, Nilanjan ^d   Sølling, Christoffer ^d   Rasmussen, Bodil Steen ^d   Rodriguez, Enver ^d   Rebollo, Sergio ^d   Aguilar, Gerardo ^d   Masdeu, Gaspar ^d   Jaimes, Marián Irazábal ^d   Prado Mira, Ángela ^d   Bodi, Maria A ^d   Barea Mendoza, Jesus A ^d   López Cuenca, Sonia ^d   Homez Guzman, Marcela ^d   Rico Feijoo, Jesús ^d   Ibarz, Mercedes ^d   Trenado Alvarez, Josep ^d   Forceville, Xavier ^d   Besch, Guillaume ^d   Mentec, Herve ^d   Michel, Philippe ^d   Mateu, Philippe ^d   Vettoretti, Lucie ^d   Bourenne, Jeremy ^d   Marin, Nathalie ^d   Guillot, Max ^d   Aissaoui, Naida ^d   Goulenok, Cyril ^d   Thieulot Rolin, Nathalie ^d   Messika, Jonathan ^d   Lamhaut, Lionel ^d   Charron, Cyril ^d   Dempsey, Ged ^d   Mathew, Shiju J ^d   Raj, Ashok S ^d   Grecu, Irina ^d   Cupitt, Jason ^d   Lawton, Tom ^d   Clark, Richard ^d   Popescu, Monica ^d   Spittle, Nick ^d   Faulkner, Maria ^d   Cowton, Amanda ^d   Elloway, Esme ^d   Williams, Patricia ^d   Reay, Michael ^d   Chukkambotla, Srikanth ^d   Kumar, Ravi ^d   Al Subaie, Nawaf ^d   Kent, Linda ^d   Tamm, Tiina ^d   Kajtor, Istvan ^d   Burns, Karen ^d   Pugh, Richard ^d   Ostermann, Marlies ^d   Kam, Elisa ^d   Bowyer, Helen ^d   Smith, Neil ^d   Templeton, Maie ^d   Henning, Jeremy ^d   Goffin, Kelly ^d   Kapoor, Ritoo ^d   Laha, Shondipon ^d   Chilton, Phil ^d   Khaliq, Waqas ^d   Crayford, Alison ^d   Coetzee, Samantha ^d   Tait, Moira ^d   Boultoukas, Evangelos ^d   Stoker, Wendy ^d   Gimenez, Marc ^d   Pope, Alan ^d   Camsooksai, Julie ^d   Pogson, David ^d   Quigley, Kate ^d   Ritzema, Jenny ^d   Hormis, Anil ^d   Boulanger, Carole ^d   Balasubramaniam, M ^d   Vamplew, Luke ^d   Burt, Karen ^d   Martin, Daniel ^d   Craig, Jayne ^d   Prowle, John ^d   Doyle, Nanci ^d   Shelton, Jonathon ^d   Scott, Carmen ^d   Donnison, Phil ^d   Shelton, Sarah ^d   Frey, Christian ^d   Ryan, Christine ^d   Spray, Dominic ^d   Barnes, Veronica ^d   Barnes, Kerry ^d   Furneval, Julie ^d   Ridgway, Stephanie ^d   Saha, Rajnish ^d   Clark, Thomas ^d   Wood, James ^d   Bolger, Clare ^d   Bassford, Christopher ^d   Lewandowski, john ^d   Zhao, Xiaobei ^d   Humphreys, Sally ^d   Dowling, Susan ^d   Richardson, Neil ^d   Burtenshaw, Andrew ^d   Stevenson, Carl ^d   Wilcock, Danielle ^d   Aidoni, Zoi ^d   Aloizos, Stavros ^d   Tasioudis, Polychronis ^d   Lampiri, Kleri ^d   Zisopoulou, Vasiliki ^d   Ifigenia, Ravani ^d   Eymorfia, Pagaki ^d   Angela, Anttoniou ^d   Katsoulas, Theodoros A ^d   Kyparissi, Aikaterini ^d   Aikaterini, Kounougeri ^d   Marinakis, George ^d   Tsimpoukas, Fotios ^d   Spyropoulou, Anastasia ^d   Zygoulis, Paris ^d   Hayes, Ivan ^d   Kelly, Yvelynne ^d   Westbrook, Andrew ^d   Fitzpatrick, Gerry ^d   Maheshwari, Darshana ^d   Motherway, Catherine ^d   Gupta, Manish ^d   Gurjar, Mohan ^d   Maji, Ismail M ^d   Negri, Giovanni ^d   Spadaro, Savino ^d   Nattino, Giuseppe ^d   Pedeferri, Matteo ^d   Boscolo, Annalisa ^d   Rossi, Simona ^d   Rossi, Maurizio ^d   Calicchio, Giuseppe ^d   Cubattoli, Lucia ^d   Di Lascio, Gabriella ^d   Barbagallo, Maria ^d   Berruto, Francesco ^d   Codazzi, Daniela ^d   Bottazzi, Andrea ^d   Fumagalli, Paolo ^d   Negro, Giancarlo ^d   Lupi, Giuseppe ^d   Savelli, Flavia ^d   Vulcano, Giuseppe A ^d   Fumagalli, Roberto ^d   Marudi, Andrea ^d   Lefons, Ugo ^d   Lembo, Rita ^d   Babini, Maria ^d   Paggioro, Alessandra ^d   Parrini, Vieri ^d   Zaccaria, Maria ^d   Clementi, Stefano ^d   Gigliuto, Carmelo ^d   Facondini, Francesca ^d   Pastorini, Simonetta ^d   Munaron, Susanna ^d   Calamai, Italo ^d   Bocchi, Anna ^d   Brizio, Elisabetta ^d   Adorni, Adele ^d   Bocci, Maria Grazia ^d   Cortegiani, Andrea ^d   Casalicchio, Tiziana ^d   Mellea, Serena ^d   Graziani, Elia ^d   Barattini, Massimo ^d   van Dijk, I ^d   van Lelyveld Haas, L E M ^d   Ramnarain, D ^d   Jansen, Tim ^d   Nooteboom, Fleur ^d   van der Voort, Peter H J ^d   Dieperink, Willem ^d   de Waard, Monique C ^d   Bormans, Laura ^d   Hahn, Michael ^d   Kemmerer, Nicolai ^d   Strietzel, Hans Frank ^d   Fehrle, Lutz ^d   Dybwik, Knut ^d   Legernaes, Terje ^d   Klepstad, Pål ^d   Olaussen, Even Braut ^d   Olsen, Knut Inge ^d   Børresen, Ole Marius ^d   Bjørsvik, Geir ^d   Maini, Sameer ^d   Czuczwar, Miroslaw ^d   Krawczyk, Pawel ^d   Ziętkiewicz, Mirosław ^d   Nowak, Łukasz R ^d   Kotfis, Katarzyna ^d   Cwyl, Katarzyna ^d   Gajdosz, Ryszard ^d   Biernawska, Jowita ^d   Grudzień, Paweł ^d   Nasiłowski, Paweł ^d   Popek, Natalia ^d   Cyrankiewicz, Waldemar ^d   Wnuk, Marek ^d   Maciejewski, Dariusz ^d   Studzińska, Dorota ^d   Zukowski, Maciej ^d   Bernas, Szymon ^d   Serwa, Marta ^d   Stefaniak, Jan ^d   Pawel, Maciejewski ^d   Szymkowiak, Malgorzata ^d   Adamik, Barbara ^d   Catorze, Nuno ^d   Castelo Branco, Miguel ^d   Barros, Inês ^d   Barros, Nelson ^d   Krystopchuk, Andriy ^d   Honrado, Teresa ^d   Sousa, Cristina ^d   Munoz, Francisco ^d   Rebelo, Marta ^d   Gomes, Rui ^d   Nunes, Jorge ^d   Dias, Celeste ^d   Fernandes, Ana Margarida ^d   Petrisor, Cristina ^d   Constantin, Bodolea ^d   Belskiy, Vladislav ^d   Boskholov, Boris ^d   Kawati, Rafael ^d   Sivik, Joakim ^d   Nauska, Jessica ^d   Smole, Daniel ^d   Parenmark, Fredric ^d   Lyrén, Johanna ^d   Rockstroh, Katalin ^d   Rydén, Sara ^d   Spångfors, Martin ^d   Strinnholm, Morten ^d   Walther, Sten ^d   De Geer, Lina ^d   Nordlund, Peter ^d   Pålsson, Staffan ^d   Zetterquist, Harald ^d   Nilsson, Annika ^d   Thiringer, Karin ^d   Jungner, Mårten ^d   Bark, Björn ^d   Nordling, Berit ^d   Sköld, Hans ^d   Brorsson, Camilla ^d   Persson, Stefan ^d   Bergström, Anna ^d   Berkius, Johan ^d   Holmström, Johanna ^d   Yapici, Nihan ^d   more..

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d Department of Rehabilitation Hospital Ancelle di Cremona ^*

^e GERIATRIC RESEARCH GROUP   (Italy)

^f Ålesund Hospital   (Norway)

^g NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^h UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

ⁱ AARHUS UNIVERSITY HOSPITAL   (Denmark)

^j MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^k INSERM   (France)

^l ST GEORGE'S UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^m OSPEDALE NIGUARDA CA GRANDA   (Italy)

ⁿ UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^o MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^p HOSPITAL DE SÃO JOSÉ   (Portugal)

^q GHENT UNIVERSITY HOSPITAL   (Belgium)

^r KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^s GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^t JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^u Kardinal Schwarzenberg Hospital   (Austria)

^v GENERAL HOSPITAL OF LARISSA   (Greece)

^w HÔPITAL SAINT ANTOINE   (France)

^x SORBONNE UNIVERSITÉ   (France)

^y INSTITUT PIERRE LOUIS D EPIDÉMIOLOGIE ET DE SANTÉ PUBLIQUE   (France)

more..

Author keywords

Elderly; Frailty; ICU; Mortality; Octogenarians; Severity of illness

Indexed keywords

VASOACTIVE AGENT;

AGED; ARTICLE; ASSISTED VENTILATION; CLINICAL ASSESSMENT; COHORT ANALYSIS; FEMALE; FOLLOW UP; FRAILTY; HUMAN; INTENSIVE CARE UNIT; ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; MORTALITY RATE; MULTICENTER STUDY; OVERALL SURVIVAL; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SHORT TERM SURVIVAL; VERY ELDERLY; CLASSIFICATION; CRITICAL ILLNESS; EPIDEMIOLOGY; EUROPE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HOSPITAL MORTALITY; LENGTH OF STAY; OUTCOME ASSESSMENT; PASSIVE EUTHANASIA; PROPORTIONAL HAZARDS MODEL; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; STATISTICS AND NUMERICAL DATA; TIME FACTOR;

AGED, 80 AND OVER; CRITICAL ILLNESS; EUROPE; EUTHANASIA, PASSIVE; FEMALE; FRAIL ELDERLY; FRAILTY; GERIATRIC ASSESSMENT; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; OUTCOME ASSESSMENT (HEALTH CARE); PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 85029721289     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-017-4940-8     Document Type: Article

References (25)

1. Nguyen YL, Angus DA, Boumendil A, Guidet B (2011) The challenge of admitting the very elderly to intensive care. Ann Intensive Care 1:29. doi:10.1186/2110-5820-1-29
2. McDermid RC, Bagshaw SM (2014) Scratching the surface: the burden of frailty in critical care. Intensive Care Med 40:740–742. doi:10.1007/s00134-014-3246-3
3. Muscedere J, Waters B, Varambally A, Bagshaw SM, Boyd JG, Maslove D et al (2017) The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. Intensive Care Med 43:1105–1122. doi:10.1007/s00134-017-4867-0
4. Heyland D, Cook D, Bagshaw SM, Garland A, Stelfox HT, Mehta S et al (2015) The very elderly admitted to ICU: a quality finish? Crit Care Med 43:1352–1360. doi:10.1097/CCM.0000000000001024
5. Flaatten H, Garrouste-Orgeas M (2015) The very old ICU patient: a never-ending story. Intensive Care Med 41:1996–1998. doi:10.1007/s00134-015-4052-2
6. Boumendil A, Angus DC, Guitonneau AL, Menn AM, Ginsburg C, Takun K, Davido A, Masmoudi R, Doumenc B, Pateron D, Garrouste-Orgeas M, Somme D, Simon T, Aegerter Ph, Guidet B (2012) Variability of intensive care admission decisions for the very elderly. PLoS One 7:e34387. doi:10.1371/journal.pone.0034387
7. Poole D, Finazzi S, Nattino G, Radrizzani D, Gristina G, Malacarne P, Livigni S, Bertolini G (2017) The prognostic importance of chronic end-stage diseases in geriatric patients admitted to 163 Italian ICUs. Minerva Anestesiol. doi:10.23736/S0375-9393.17.11919-X
8. Tabah A, Philippart F, Timsit JF, Willems V, Français A, Leplège A et al (2010) Quality of life in patients aged 80 or over after ICU discharge. Crit Care 14(1):R2. doi:10.1186/cc8231
9. Flaatten H, de Lange DW, Artigas A, Bin D, Moreno R, Christensen S et al (2017) The status of intensive care medicine research and a future agenda for very old patients in the ICU. Intensive Care Med 43:1319–1328. doi:10.1007/s00134-017-4718-z
10. Vincent JL, Moreno R, Takala J, Willatts S, de Mendonça A, Bruining H et al (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707–710
11. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I et al (2005) A global clinical measure of fitness and frailty in elderly people. CMAJ 173:489–495. doi:10.1503/cmaj.050051
12. Guidet B, Hodgson E, Feldman C, Paruk F, Lipman J, Koh Y, Vincent JL, Azoulay E, Sprung C (2014) The Durban World Congress Ethics Round Table conference report: II. Withholding or withdrawing of treatment in elderly patients admitted to the intensive care unit. J Crit Care 29:896–901. doi:10.1016/j.jcrc.2014.08.004
13. Roch A, Wiramus S, Pauly V, Forel J-M, Guervilly C, Gainnier M et al (2011) Long-term outcome in medical patients aged 80 or over following admission to an intensive care unit. Crit Care 15:R36. doi:10.1186/cc9984
14. Nielsson MS, Christiansen CF, Johansen MB, Rasmussen BS, Tønnesen E, Nørgaard M (2014) Mortality in elderly ICU patients: a cohort study. Acta Anaesthesiol Scand 58:19–26. doi:10.1111/aas.12211
15. Lown DJ, Knott J, Rechnitzer T, Maclsaac C (2013) Predicting short-term and long-term mortality in elderly emergency patients admitted for intensive care. Crit Care Resusc 15:49–55
16. Ball IM, Bagshaw SM, Burns KEA, Cook DJ, Day AG, Dodek PM et al (2016) A clinical prediction tool for hospital mortality in critically ill elderly patients. J Crit Care 35:206–212. doi:10.1016/j.jcrc.2016.05.026
17. Hall DE, Arya S, Schmid KK, Carlson MA, Lavedan P, Bailey TL et al (2017) Association of a frailty screening initiative with postoperative survival at 30, 180, and 365 days. JAMA Surg 152:233–240. doi:10.1001/jamasurg.2016.4219
18. Afilalo J, Lauck S, Kim DH, Lefèvre T, Piazza N, Lachapelle K et al (2017) Frailty in older adults undergoing aortic valve replacement: the FRAILTY-AVR study. J Am Coll Cardiol 70:689–700. doi:10.1016/j.jacc.2017.06.24
19. McDermid RC, Stelfox HT, Bagshaw SM (2011) Frailty in the critically ill: a novel concept. Crit Care 15:301. doi:10.1186/cc9297
20. Zeng A, Song X, Dong J, Mitnitski A, Liu J, Guo Z et al (2015) Mortality in relation to frailty in patients admitted to a specialized geriatric intensive care unit. J Gerontol A Biol Sci Med Sci 70:1586–1594. doi:10.1093/gerona/glv084
21. Heyland DK, Garland A, Bagshaw SM, Cook D, Rockwood K, Stelfox HT et al (2015) Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study. Intensive Care Med 41:1911–1920. doi:10.1007/s00134-015-4028-2
22. Brummel NE, Bell SP, Girard TD, Pandharipande PP, Jackson JC, Morandi A et al (2017) Frailty and subsequent disability and mortality among patients with critical illness. Am J Respir Crit Care Med 196:64–72. doi:10.1164/rccm.201605-0939OC
23. Minne L, Ludikhuize J, de Jonge E, de Rooij S, Abu-Hanna A (2011) Prognostic models for predicting mortality in elderly ICU patients: a systematic review. Intensive Care Med 37:1258–1268. doi:10.1186/cc7160
24. Boumendil A, Aegerter P, Guidet B, CUB-Rea Network (2005) Treatment intensity and outcome of patients aged 80 and older in intensive care units: a multicenter matched-cohort study. J Am Geriatr Soc 53:88–93. doi:10.1111/j.1532-5415.2005.53016.x
25. Andersen FH, Kvåle R (2012) Do elderly intensive care unit patients receive less intensive care treatment and have higher mortality? Acta Anaesthesiol Scand 56:1298–1305. doi:10.1111/j.1399-6576.2012.02782.x