Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study

Intensive Care Medicine

Volumn 41, Issue 11, 2015, Pages 1911-1920

  Heyland, Daren K ^a   Garland, Allan ^b   Bagshaw, Sean M ^c   Cook, Deborah ^d   Rockwood, Kenneth ^e   Stelfox, Henry T ^f   Dodek, Peter ^g   Fowler, Robert A ^h   Turgeon, Alexis F ⁱ   Burns, Karen ^j   Muscedere, John ^k   Kutsogiannis, Jim ^c   Albert, Martin ^l   Mehta, Sangeeta ^m   Jiang, Xuran ^a   Day, Andrew G ^a  

^a KINGSTON GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

^e DALHOUSIE UNIVERSITY   (Canada)

^f UNIVERSITY OF CALGARY   (Canada)

^g UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^h UNIVERSITY OF TORONTO   (Canada)

ⁱ LAVAL UNIVERSITY   (Canada)

^j ST MICHAEL'S HOSPITAL   (Canada)

^k QUEEN S UNIVERSITY   (Canada)

^l Centre de Recherche Hopital Du Sacre Coeur de Montreal   (Canada)

^m MOUNT SINAI HOSPITAL   (Canada)

more..

Author keywords

Aged 80 and older; Critical illness; Follow up study; Frailty; Outcome assessment; Physical function

Indexed keywords

VASOACTIVE AGENT;

AGED; AGING; APACHE; ARTICLE; ARTIFICIAL VENTILATION; CANADA; CHARLSON COMORBIDITY INDEX; COHORT ANALYSIS; COMORBIDITY; CONFOUNDING VARIABLE; CONTROLLED STUDY; CONVALESCENCE; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DISEASE SEVERITY; FEMALE; GERIATRIC ASSESSMENT; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; LOWER BASELINE PHYSICAL FUNCTION SCORE; LOWER FRAILTY INDEX; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; OBSERVATIONAL STUDY; PHYSICAL CAPACITY; PHYSICAL PERFORMANCE; PROSPECTIVE STUDY; QUALITY OF LIFE; REGRESSION ANALYSIS; RISK FACTOR; SCORING SYSTEM; SHORT FORM 36; SURVIVAL RATE; TREATMENT OUTCOME; VERY ELDERLY; AGE DISTRIBUTION; CLINICAL TRIAL; EPIDEMIOLOGY; FAMILY; FRAIL ELDERLY; INTERVIEW; OUTCOME ASSESSMENT; PROCEDURES; PROGNOSIS; PSYCHOLOGY; SEX RATIO; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; SURVIVAL ANALYSIS;

AGE DISTRIBUTION; AGED, 80 AND OVER; APACHE; CANADA; COMORBIDITY; CRITICAL ILLNESS; FAMILY; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HUMANS; INTERVIEWS AS TOPIC; LOGISTIC MODELS; MALE; OUTCOME ASSESSMENT (HEALTH CARE); PROGNOSIS; PROSPECTIVE STUDIES; QUALITY OF LIFE; RECOVERY OF FUNCTION; SEX DISTRIBUTION; SURVIVAL ANALYSIS;

EID: 84942504994     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-4028-2     Document Type: Article

References (44)

1. Wunsch H, Linde-Zwirble WT, Harrison DA, Barnato AE, Rowan KM, Angus DC (2009) Use of intensive care services during terminal hospitalizations in England and the United States. Am J Respir Crit Care Med 180:875–880. doi:10.1164/rccm.200902-0201OC
2. Bagshaw SM, Webb SA, Delaney A, George C, Pilcher D, Hart GK, Bellomo R (2009) Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care 13:R45. doi:10.1186/cc7768
3. Kaarlola A, Tallgren M, Pettilä V (2006) Long-term survival, quality of life, and quality-adjusted life-years among critically ill elderly patients. Crit Care Med 34:2120–2126
4. Boumendil A, Maury E, Reinhard I, Luquel L, Offenstadt G, Guidet B (2004) Prognosis of patients aged 80 years and over admitted in medical intensive care unit. Intensive Care Med 30:647–654
5. Broslawski GE, Elkins M, Algus M (1995) Functional abilities of elderly survivors of intensive care. J Am Osteopath Assoc 95:712–717
6. Boumendil A, Latouche A, Guidet B, ICE-CUB Study Group (2011) On the benefit of intensive care for very old patients. Arch Intern Med 171:1116–1117. doi:10.1001/archinternmed.2011.102
7. Garrouste-Orgeas M, Timsit JF, Montuclard L, Colvez A, Gattolliat O, Philippart F, Rigal G, Misset B, Carlet J (2006) Decision-making process, outcome, and 1 year quality of life of octogenarians referred for intensive care unit admission. Intensive Care Med 32:1045–1051
8. Hofhuis JG, van Stel HF, Schrijvers AJ, Rommes JH, Spronk PE (2011) Changes of health-related quality of life in critically ill octogenarians: a follow-up study. Chest 140:1473–1483. doi:10.1378/chest.10-0803
9. Tabah A, Philippart F, Timsit JF, Willems V, Français A, Leplège A, Carlet J, Bruel C, Misset B, Garrouste-Orgeas M (2010) Quality of life in patients aged 80 or over after ICU discharge. Crit Care 14:R2. doi:10.1186/cc8231
10. Montuclard L, Garrouste-Orgeas M, Timsit JF, Misset B, De Jonge B, Carlet J (2000) Outcome, functional autonomy, and quality of life of elderly patients with a long-term intensive care unit stay. Crit Care Med 28:3389–3395
11. Chelluri L, Pinsky MR, Donahoe MP, Grenvik A (1993) Long-term outcome of critically ill elderly patients requiring intensive care. JAMA 269:3119–3123
12. de Rooij SE, Govers AC, Korevaar JC, Giesbers AW, Levi M, de Jonge E (2008) Cognitive, functional, and quality-of-life outcomes of patients aged 80 and older who survived at least 1 year after planned or unplanned surgery or medical intensive care treatment. J Am Geriatr Soc 56:816–822. doi:10.1111/j.1532-5415.2008.01671.x
13. Merlani P, Chenaud C, Mariotti N, Ricou B (2007) Long-term outcome of elderly patients requiring intensive care admission for abdominal pathologies: survival and quality of life. Acta Anaesthesiol Scand 51:530–537
14. Chelluri L, Pinsky MR, Grenvik AN (1992) Outcome of intensive care of the “oldest-old” critically ill patients. Crit Care Med 20:757–761
15. Sjögren J, Thulin LI (2004) Quality of life in the very elderly after cardiac surgery: a comparison of SF-36 between long-term survivors and an age-matched population. Gerontology 50:407–410
16. Mahul P, Perrot D, Tempelhoff G, Gaussorgues P, Jospe R, Ducreux JC, Dumont A, Motin J, Auboyer C, Robert D (1991) Short- and long-term prognosis, functional outcome following ICU for elderly. Intensive Care Med 17:7–10
17. Udekwu P, Gurkin B, Oller D, Lapio L, Bourbina J (2001) Quality of life and functional level in elderly patients surviving surgical intensive care. J Am Coll Surg 193:245–249
18. Andersen FH, Flaatten H, Klepstad P, Romild U, Kvåle R (2015) Long-term survival and quality of life after intensive care for patients 80 years of age or older. Ann Intensive Care 5:53. doi:10.1186/s13613-015-0053-0
19. Roch A, Wiramus S, Pauly V, Forel JM, Guervilly C, Gainnier M, Papazian L (2011) Long-term outcome in medical patients aged 80 or over following admission to an intensive care unit. Crit Care 15:R36. doi:10.1186/cc9984
20. Sacanella E, Pérez-Castejón JM, Nicolás JM, Masanés F, Navarro M, Castro P, López-Soto A (2011) Functional status and quality of life 12 months after discharge from a medical ICU in healthy elderly patients: a prospective observational study. Crit Care 15:R105. doi:10.1186/cc10121
21. Khouli H, Astua A, Dombrowski W, Ahmad F, Homel P, Shapiro J, Singh J, Nallamothu R, Mahbub H, Eden E, Delfiner J (2011) Changes in health-related quality of life and factors predicting long-term outcomes in older adults admitted to intensive care units. Crit Care Med 39:731–737. doi:10.1097/CCM.0b013e318208edf8
22. Lieberman D, Nachshon L, Miloslavsky O, Dvorkin V, Shimoni A, Lieberman D (2009) How do older ventilated patients fare? A survival/functional analysis of 641 ventilations. J Crit Care 24:340–346. doi:10.1016/j.jcrc.2009.01.015
23. Heyland DK, Barwich D, Pichora D, Dodek P, Lamontagne F, You JJ, Tayler C, Porterfield P, Sinuff T, Simon J, ACCEPT (Advance Care Planning Evaluation in Elderly Patients) Study Team; Canadian Researchers at the End of Life Network (CARENET) (2013) Failure to engage hospitalized elderly patients and their families in advance care planning. JAMA Intern Med 173:778–787. doi:10.1001/jamainternmed.2013.180
24. Garrouste-Orgeas M, Tabah A, Vesin A, Philippart F, Kpodji A, Bruel C, Grégoire C, Max A, Timsit JF, Misset B (2013) The ETHICA study (part II): simulation study of determinants and variability of ICU physician decisions in patients aged 80 or over. Intensive Care Med 39:1574–1583. doi:10.1007/s00134-013-2977-x
25. Boumendil A, Angus DC, Guitonneau AL, Menn AM, Ginsburg C, Takun K, Davido A, Masmoudi R, Doumenc B, Pateron D, Garrouste-Orgeas M, Somme D, Simon T, Aegerter P, Guidet B, ICE-CUB study group (2012) Variability of intensive care admission decisions for the very elderly. PLoS ONE 7:e34387. doi:10.1371/journal.pone.0034387
26. Huynh TN, Kleerup EC, Wiley JF, Savitsky TD, Guse D, Garber BJ, Wenger NS (2013) The frequency and cost of treatment perceived to be futile in critical care. JAMA Intern Med 173:1887–1894. doi:10.1001/jamainternmed.2013.10261
27. Wright AA, Zhang B, Ray A, Mack JW, Trice E, Balboni T, Mitchell SL, Jackson VA, Block SD, Maciejewski PK, Prigerson HG (2008) Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA 300:1665–1673. doi:10.1001/jama.300.14.1665
28. Goldstein J, Hubbard RE, Moorhouse P, Andrew MK, Mitnitski A, Rockwood K (2015) The validation of a care partner-derived frailty index based upon comprehensive geriatric assessment (CP-FI-CGA) in emergency medical services and geriatric ambulatory care. Age Ageing 44:327–330. doi:10.1093/ageing/afu161
29. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K (2013) Frailty in elderly people. Lancet 381:752–762. doi:10.1016/S0140-6736(12)62167-9
30. Evans SJ, Sayers M, Mitnitski A, Rockwood K (2014) The risk of adverse outcomes in hospitalized older patients in relation to a frailty index based on a comprehensive geriatric assessment. Age Ageing 43:127–132. doi:10.1093/ageing/aft156
31. Ware JE (1996) The SF-36 health survey. In: Spilker B (ed) Quality of life and pharmacoeconomics in clinical trials, 2nd edn. Lippincott-Raven, Philadelphia, pp 337–345
32. Rogers J, Ridley S, Chrispin P, Scotton H, Lloyd D (1997) Reliability of the next of kin’s estimates of critically ill patient’s quality of life. Anaesthesia 52:1137–1143
33. Hopman WM, Towheed T, Anastassiades T, Tenenhouse A, Poliquin S, Berger C, Joseph L, Brown JP, Murray TM, Murray TM, Adachi JD, Hanley DA, Papadimitropoulos E, The Canadian Multicentre Osteoporosis Study Research Group (2000) Canadian normative data for the SF-36 health survey. CMAJ 163:265–271
34. Wyrwich KW, Metz SM, Kroenke K, Tierney WM, Babu AN, Wolinsky FD (2007) Measuring patient and clinician perspectives to evaluate change in health-related quality of life among patients with chronic obstructive pulmonary disease. J Gen Intern Med 22:161–170
35. Lloyd CB, Nietert PJ, Silvestri GA (2004) Intensive care decision making in the seriously ill and elderly. Crit Care Med 32:649–654
36. van Buuren S (2007) Multiple imputation of discrete and continuous data by fully conditional specification. Stat Methods Med Res 16:219–242
37. SAS Institute Inc (2014) SAS/STAT® 13.2 User’s Guide. SAS Institute, Cary
38. Bagshaw SM, Stelfox HT, McDermid RC, Rolfson DB, Tsuyuki RT, Baig N, Artiuch B, Ibrahim Q, Stollery DE, Rokosh E, Majumdar SR (2014) Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study. CMAJ 186:E95–E102. doi:10.1503/cmaj.130639
39. Le Maguet P, Roquilly A, Lasocki S, Asehnoune K, Carise E, Saint Martin M, Mimoz O, Le Gac G, Somme D, Cattenoz C, Feuillet F, Malledant Y, Seguin P (2014) Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study. Intensive Care Med 40:674–682. doi:10.1007/s00134-014-3253-4
40. Rockwood K, Mitnitski A, Song X, Steen B, Skoog I (2006) Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc 54:975–979
41. Taneja S, Rutenberg A, Mitnitski A, Rockwood K (2014) A dynamical network model for frailty-induced mortality. Bull Am Phys Soc 59(1):J11–J17
42. de Rooij SE, Abu-Hanna A, Levi M, de Jonge E (2007) Identification of high-risk subgroups in very elderly intensive care unit patients. Crit Care 11:R33
43. Lown DJ, Knott J, Rechnitzer T, MacIsaac C (2013) Predicting short-term and long-term mortality in elderly emergency patients admitted for intensive care. Crit Care Resusc 15:49–55
44. Turnbull AE, Krall JR, Ruhl AP, Curtis JR, Halpern SD, Lau BM, Needham DM (2014) A scenario-based, randomized trial of patient values and functional prognosis on intensivist intent to discuss withdrawing life support. Crit Care Med 42:1455–1462. doi:10.1097/CCM.0000000000000227