Thirst-associated preoptic neurons encode an aversive motivational drive

Science

Volumn 357, Issue 6356, 2017, Pages 1149-1155

  Allen, William E ^a   DeNardo, Laura A ^a   Chen, Michael Z ^a   Liu, Cindy D ^a   Loh, Kyle M ^b   Fenno, Lief E ^a   Ramakrishnan, Charu ^c   Deisseroth, Karl ^a,c   Luo, Liqun ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS AND CELL COMPONENTS; DEHYDRATION; GENETIC ANALYSIS; INSTRUMENTATION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVERSIVE BEHAVIOR; BRAIN NERVE CELL; CONTROLLED STUDY; DEHYDRATION; DRIVE; FLUID INTAKE; GENETIC TRANSCRIPTION; MEDIAL PREOPTIC AREA; MOTIVATION; MOUSE; NERVE CELL STIMULATION; NONHUMAN; OPERANT BEHAVIORAL TEST; OPTOGENETICS; PRIORITY JOURNAL; REWARD; TASK PERFORMANCE; THIRST; WATER DEPRIVATION; ANIMAL; CELL LINE; CYTOLOGY; DRINKING BEHAVIOR; GENE EXPRESSION PROFILING; GENETICS; NERVE CELL; PHYSIOLOGY; PREOPTIC AREA; PSYCHOLOGY; SINGLE CELL ANALYSIS;

MUS;

TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2;

ANIMALS; CELL LINE; DEHYDRATION; DRINKING BEHAVIOR; GENE EXPRESSION PROFILING; MICE; MOTIVATION; NEURONS; OPTOGENETICS; PREOPTIC AREA; SINGLE-CELL ANALYSIS; THIRST; TNF RECEPTOR-ASSOCIATED FACTOR 2;

EID: 85029501515     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aan6747     Document Type: Article

References (40)

1. C. Hull, Principles of Behavior: An Introduction to Behavior Theory (D. Appleton-Century Company, New York, 1943).
2. N. E. Miller, Science 126, 1271–1278 (1957).
3. K. Oatley, Nature 225, 797–801 (1970).
4. K. C. Berridge, Physiol. Behav. 81, 179–209 (2004).
5. D. J. Anderson, Nat. Rev. Neurosci. 17, 692–704 (2016).
6. R. C. Bolles, Theory of Motivation (Harper & Row, New York, 1967).
7. F. Toates, Motivational Systems (Cambridge Univ. Press, Cambridge, 1986).
8. J. Olds, Science 127, 315–324 (1958).
9. J. H. Jennings, G. Rizzi, A. M. Stamatakis, R. L. Ung, G. D. Stuber, Science 341, 1517–1521 (2013).
10. J. N. Betley et al., Nature 521, 180–185 (2015).
11. J. H. Jennings et al., Cell 160, 516–527 (2015).
12. E. H. Nieh et al., Cell 160, 528–541 (2015).
13. Y. Chen, Y. C. Lin, C. A. Zimmerman, R. A. Essner, Z. A. Knight, eLife 5, e18640 (2016).
14. S. M. Sternson, A.-K. Eiselt, Annu. Rev. Physiol. 79, 401–423 (2017).
15. M. L. Mangiapane, T. N. Thrasher, L. C. Keil, J. B. Simpson, W. F. Ganong, Neuroendocrinology 37, 73–77 (1983).
16. R. W. Lind, A. K. Johnson, J. Neurosci. 2, 1043–1051 (1982).
17. M. J. McKinley et al., Physiol. Behav. 81, 795–803 (2004).
18. Y. Oka, M. Ye, C. S. Zuker, Nature 520, 349–352 (2015).
19. S. B. G. Abbott, N. L. S. Machado, J. C. Geerling, C. B. Saper, J. Neurosci. 36, 8228–8237 (2016).
20. C. A. Zimmerman et al., Nature 537, 680–684 (2016).
21. M. J. McKinley et al., Acta Physiol. (Oxf.) 214, 8–32 (2015).
22. M. J. McKinley, D. K. Hards, B. J. Oldfield, Brain Res. 653, 305–314 (1994).
23. L. L. Ji, T. Fleming, M. L. Penny, G. M. Toney, J. T. Cunningham, Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R311–R321 (2005).
24. C. J. Guenthner, K. Miyamichi, H. H. Yang, H. C. Heller, L. Luo, Neuron 78, 773–784 (2013).
25. TRAP2 mice were generated by inserting the 2A-iCreERT2 construct into the Fos locus via homologous recombination. See the supplementary materials.
26. L. Ye et al., Cell 165, 1776–1788 (2016).
27. C. L. Tan et al., Cell 167, 47–59.e15 (2016).
28. M. Maruyama et al., Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R1116–R1123 (2003).
29. S. Picelli et al., Nat. Methods 10, 1096–1098 (2013).
30. J. T. Fitzsimons, Physiol. Rev. 78, 583–686 (1998).
31. E. L. Sylwestrak, P. Rajasethupathy, M. A. Wright, A. Jaffe, K. Deisseroth, Cell 164, 792–804 (2016).
32. A. Berndt et al., Proc. Natl. Acad. Sci. U.S.A. 113, 822–829 (2016).
33. E. S. Boyden, F. Zhang, E. Bamberg, G. Nagel, K. Deisseroth, Nat. Neurosci. 8, 1263–1268 (2005).
34. P. H. Janak, K. M. Tye, Nature 517, 284–292 (2015).
35. P. J. Davern, Front. Physiol. 5, 436 (2014).
36. S. D. Stocker, G. M. Toney, J. Physiol. 568, 599–615 (2005).
37. S. L. Hochstenbach, J. Ciriello, Brain Res. 713, 17–28 (1996).
38. T.-W. Chen et al., Nature 499, 295–300 (2013).
39. L. A. Gunaydin et al., Cell 157, 1535–1551 (2014).
40. L. DeNardo, L. Luo, Curr. Opin. Neurobiol. 45, 121–129 (2017).