Inhibition of HDAC enhances STAT acetylation, blocks NF-kB, and suppresses the renal inflammation and fibrosis in Npr1 haplotype male mice

American Journal of Physiology - Renal Physiology

Volumn 313, Issue 3, 2017, Pages F781-F795

  Kumar, Prerna ^a   Gogulamudi, Venkateswara R ^a   Periasamy, Ramu ^a   Raghavaraju, Giri ^a   Subramanian, Umadevi ^a   Pandey, Kailash N ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Natriuretic peptide receptor A; Npr1 gene disruption; Proinflammatory cytokines; Renal fibrosis; Retinoic acid; Sodium butyrate

Indexed keywords

ALBUMIN; BUTYRIC ACID; CREATININE; GUANYLATE CYCLASE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NATRIURETIC PEPTIDE RECEPTOR A; RETINOIC ACID; STAT1 PROTEIN; ANTIINFLAMMATORY AGENT; ATRIAL NATRIURETIC FACTOR RECEPTOR; AUTACOID; CYTOKINE; HDAC1 PROTEIN, MOUSE; HDAC2 PROTEIN, MOUSE; HISTONE DEACETYLASE INHIBITOR; RELA PROTEIN, MOUSE; STAT1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING ASSAY; BLOOD LEVEL; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; DISSOCIATION; DNA BINDING; GENE; HAPLOTYPE; HISTOLOGY; HYPERTENSION; IMMUNOBLOTTING; KIDNEY FIBROSIS; KIDNEY TISSUE; MALE; MOUSE; NEPHRITIS; NONHUMAN; NPR1 GENE; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN URINE LEVEL; ACETYLATION; ANIMAL; BLOOD PRESSURE; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; FIBROSIS; GENETIC PREDISPOSITION; GENETICS; KIDNEY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION;

ACETYLATION; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD PRESSURE; BUTYRIC ACID; CYTOKINES; DISEASE MODELS, ANIMAL; FIBROSIS; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITORS; INFLAMMATION MEDIATORS; KIDNEY; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEPHRITIS; PHENOTYPE; RECEPTORS, ATRIAL NATRIURETIC FACTOR; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA; TRETINOIN;

EID: 85029350217     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00166.2017     Document Type: Article

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