Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women

Clinical Nutrition

Volumn 34, Issue 3, 2015, Pages 501-507

  Salazar, Nuria ^a   Dewulf, Evelyne M ^a   Neyrinck, Audrey M ^a   Bindels, Laure B ^a   Cani, Patrice D ^a   Mahillon, Jacques ^a   de Vos, Willem M ^b,c   Thissen, Jean Paul ^a   Gueimonde, Miguel ^d   de los Reyes Gavilán, Clara G ^d   Delzenne, Nathalie M ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF HELSINKI   (Finland)

^d DEPARTMENT OF MICROBIOLOGY AND BIOCHEMISTRY OF DAIRY PRODUCTS   (Spain)

Author keywords

Bifidobacterium; Gut microbiota; ITF; Obesity; SCFA

Indexed keywords

ACETIC ACID; BACTERIAL DNA; BACTERIAL RNA; BACTERIAL TOXIN; BRANCHED CHAIN AMINO ACID; BUTYRIC ACID; FRUCTAN; GLUCOSE; HEMOGLOBIN A1C; HEXANOIC ACID; INSULIN; INULIN TYPE FRUCTAN DERIVATIVE; ISOVALERIC ACID; MALTODEXTRIN; PLACEBO; PREBIOTIC AGENT; PROPIONIC ACID; RNA 16S; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; VALERIC ACID; BIOLOGICAL MARKER; INULIN; VOLATILE FATTY ACID;

ADULT; AGED; ARTICLE; BACTERIA; BACTERIUM IDENTIFICATION; BIFIDOBACTERIUM; BIFIDOBACTERIUM ADOLESCENTIS; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM BREVE; BIFIDOBACTERIUM LONGUM; BIFIDOBACTERIUM PSEUDOCATENULATUM; BODY MASS; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATIONAL STUDY; DENATURING GRADIENT GEL ELECTROPHORESIS; DOUBLE BLIND PROCEDURE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ENDOTOXIN DETECTION; FAT MASS; FATTY ACID ANALYSIS; FATTY ACID METABOLISM; FECES LEVEL; FEMALE; GAS CHROMATOGRAPHY; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT INDEX; HUMAN; INSULIN BLOOD LEVEL; INSULINEMIA; INTESTINE FLORA; LIPOLYSIS; METABOLIC REGULATION; NONHUMAN; OBESITY; POLYMERASE CHAIN REACTION; QUALITATIVE RESEARCH; QUANTITATIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SPECIES DIFFERENCE; WOMEN'S HEALTH; ADOLESCENT; BLOOD; CHEMISTRY; DRUG EFFECTS; FECES; GENETICS; INTESTINE; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BIFIDOBACTERIUM; BIOMARKERS; BODY MASS INDEX; DNA, BACTERIAL; DOUBLE-BLIND METHOD; FATTY ACIDS, VOLATILE; FECES; FEMALE; HUMANS; INTESTINES; INULIN; MIDDLE AGED; OBESITY; PREBIOTICS; YOUNG ADULT;

EID: 84928212891     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2014.06.001     Document Type: Article

References (30)

1. Navab M., Gharavi N., Watson A.D. Inflammation and metabolic disorders. Curr Opin Clin Nutr Metab Care 2008, 11:459-464.
2. Turnbaugh P.J., Ley R.E., Mahowald M.A., Magrini V., Mardis E.R., Gordon J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031.
3. Jumpertz R., Le D.S., Turnbaugh P.J., Trinidad C., Bogardus C., Gordon J.I., et al. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr 2011, 94:58-65.
4. Conterno L., Fava F., Viola R., Tuohy K.M. Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?. Genes Nutr 2011, 6:241-260.
5. Bjursell M., Admyre T., Goransson M., Marley A.E., Smith D.M., Oscarsson J., et al. Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am J Physiol Endocrinol Metab 2011, 300:E211-E220.
6. Bellahcene M., O'Dowd J.F., Wargent E.T., Zaibi M.S., Hislop D.C., Ngala R.A., et al. Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content. Br J Nutr 2013, 109:1755-1764.
7. Schwiertz A., Taras D., Schafer K., Beijer S., Bos N.A., Donus C., et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010, 18:190-195.
8. Fava F., Gitau R., Griffin B.A., Gibson G.R., Tuohy K.M., Lovegrove J.A. The type and quantity of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome 'at-risk' population. Int J Obes (Lond) 2013, 37:216-223.
9. Teixeira T.F., Grzeskowiak L., Franceschini S.C., Bressan J., Ferreira C.L., Peluzio M.C. Higher level of faecal SCFA in women correlates with metabolic syndrome risk factors. Br J Nutr 2013, 109:914-919.
10. Munukka E., Wiklund P., Pekkala S., Volgyi E., Xu L., Cheng S., et al. Women with and without metabolic disorder differ in their gut microbiota composition. Obesity (Silver Spring) 2012, 20:1082-1087.
11. Roberfroid M., Gibson G.R., Hoyles L., McCartney A.L., Rastall R., Rowland I., et al. Prebiotic effects: metabolic and health benefits. Br J Nutr 2010, 104(Suppl.2):S1-S63.
12. Delzenne N.M., Neyrinck A.M., Backhed F., Cani P.D. Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol 2011, 7:639-646.
13. Everard A., Lazarevic V., Derrien M., Girard M., Muccioli G.G., Neyrinck A.M., et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 2011, 60:2775-2786.
14. Cani P.D., Lecourt E., Dewulf E.M., Sohet F.M., Pachikian B.D., Naslain D., et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr 2009, 90:1236-1243.
15. Parnell J.A., Reimer R.A. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr 2009, 89:1751-1759.
16. Dewulf E.M., Cani P.D., Claus S.P., Fuentes S., Puylaert P.G., Neyrinck A.M., et al. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut 2013, 62:1112-1121.
17. Satokari R.M., Vaughan E.E., Akkermans A.D., Saarela M., de Vos W.M. Bifidobacterial diversity in human feces detected by genus-specific PCR and denaturing gradient gel electrophoresis. Appl Environ Microbiol 2001, 67:504-513.
18. Ovreas L., Forney L., Daae F.L., Torsvik V. Distribution of bacterioplankton in meromictic Lake Saelenvannet, as determined by denaturing gradient gel electrophoresis of PCR-amplified gene fragments coding for 16S rRNA. Appl Environ Microbiol 1997, 63:3367-3373.
19. Gueimonde M., Tolkko S., Korpimaki T., Salminen S. New real-time quantitative PCR procedure for quantification of Bifidobacteria in human fecal samples. Appl Environ Microbiol 2004, 70:4165-4169.
20. Salazar N., Lopez P., Valdes L., Margolles A., Suarez A., Patterson A.M., et al. Microbial targets for the development of functional foods accordingly with nutritional and immune parameters altered in the elderly. JAm Coll Nutr 2013, 32:399-406.
21. Geurts L., Neyrinck A.M., Delzenne N.M., Knauf C., Cani P.D. Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. Benef Microbes 2013, 1-15.
22. Everard A., Lazarevic V., Gaia N., Johansson M., Stahlman M., Backhed F., et al. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J 2014, Apr 3. http://dx.doi.org/10.1038/ismej.2014.45.
23. Ramirez-Farias C., Slezak K., Fuller Z., Duncan A., Holtrop G., Louis P. Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii. Br J Nutr 2009, 101:541-550.
24. Joossens M., Huys G., Van Steen K., Cnockaert M., Vermeire S., Rutgeerts P., et al. High-throughput method for comparative analysis of denaturing gradient gel electrophoresis profiles from human fecal samples reveals significant increases in two bifidobacterial species after inulin-type prebiotic intake. FEMS Microbiol Ecol 2011, 75:343-349.
25. Cani P.D., Neyrinck A.M., Fava F., Knauf C., Burcelin R.G., Tuohy K.M., et al. Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007, 50:2374-2383.
26. Wu X., Ma C., Han L., Nawaz M., Gao F., Zhang X., et al. Molecular characterisation of the faecal microbiota in patients with type II diabetes. Curr Microbiol 2010, 61:69-78.
27. Backhed F., Ding H., Wang T., Hooper L.V., Koh G.Y., Nagy A., et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004, 101:15718-15723.
28. Weimer P.J., Moen G.N. Quantitative analysis of growth and volatile fatty acid production by the anaerobic ruminal bacterium Megasphaera elsdenii T81. Appl Microbiol Biotechnol 2013, 97:4075-4081.
29. Wong J.M., de Souza R., Kendall C.W., Emam A., Jenkins D.J. Colonic health: fermentation and short chain fatty acids. JClin Gastroenterol 2006, 40:235-243.
30. Samuel B.S., Shaito A., Motoike T., Rey F.E., Backhed F., Manchester J.K., et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A 2008, 105:16767-16772.