Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study

BMJ (Online)

Volumn 358, Issue , 2017, Pages

  Liu, Xiaoqin ^a   Agerbo, Esben ^a,b   Ingstrup, Katja G ^a   Musliner, Katherine ^a,b   Meltzer Brody, Samantha ^c   Bergink, Veerle ^a,d   Munk Olsen, Trine ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Aarhus   (Denmark)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; AUTISM; BEHAVIOR DISORDER; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DENMARK; DISEASE SEVERITY; DRUG WITHDRAWAL; FEMALE; HAZARD RATIO; HUMAN; MALE; MENTAL DEFICIENCY; MENTAL DISEASE; MONOTHERAPY; MOOD DISORDER; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; SOMATOFORM DISORDER; TREATMENT DURATION; ADOLESCENT; DISEASE PREDISPOSITION; INFANT; MENTAL DISORDERS; NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE; PRESCHOOL CHILD; REGISTER; RISK FACTOR; TREATMENT WITHDRAWAL;

ADOLESCENT; ANTIDEPRESSIVE AGENTS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DENMARK; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MENTAL DISORDERS; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; REGISTRIES; RISK FACTORS; WITHHOLDING TREATMENT;

EID: 85029185219     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.j3668     Document Type: Article

References (51)

1. Jimenez-Solem E, Andersen JT, Petersen M, et al. Prevalence of antidepressant use during pregnancy in Denmark, a nation-wide cohort study. PLoS One 2013;8:e63034. doi:10. 1371/journal. pone. 0063034
2. Malm H, Brown AS, Gissler M, et al. Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders: A National Register-Based Study. J Am Acad Child Adolesc Psychiatry 2016;55:359-66. doi:10. 1016/j. jaac. 2016. 02. 013
3. Viktorin A, Uher R, Reichenberg A, Levine SZ, Sandin S. Autism risk following antidepressant medication during pregnancy. Psychol Med 2017;May 22:1-10. doi:10. 1017/S0033291717001301
4. Zoega H, Kieler H, Nørgaard M, et al. Use of SSRI and SNRI Antidepressants during Pregnancy: A Population-Based Study from Denmark, Iceland, Norway and Sweden. PLoS One 2015;10:e0144474. doi:10. 1371/journal. pone. 0144474
5. Petersen I, Gilbert RE, Evans SJ, Man SL, Nazareth I. Pregnancy as a major determinant for discontinuation of antidepressants: An analysis of data from The Health Improvement Network. J Clin Psychiatry 2011;72:979-85. doi:10. 4088/JCP. 10m06090blu
6. Huybrechts KF, Palmsten K, Mogun H, et al. National trends in antidepressant medication treatment among publicly insured pregnant women. Gen Hosp Psychiatry 2013;35:265-71. doi:10. 1016/j. genhosppsych. 2012. 12. 010
7. Brown HK, Ray JG, Wilton AS, Lunsky Y, Gomes T, Vigod SN. Association Between Serotonergic Antidepressant Use During Pregnancy and Autism Spectrum Disorder in Children. JAMA 2017;317:1544-52. doi:10. 1001/jama. 2017. 3415
8. Huybrechts KF, Palmsten K, Avorn J, et al. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med 2014;370:2397-407. doi:10. 1056/NEJMoa1312828
9. Hviid A, Melbye M, Pasternak B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med 2013;369:2406-15. doi:10. 1056/NEJMoa1301449
10. Stephansson O, Kieler H, Haglund B, et al. Selective serotonin reuptake inhibitors during pregnancy and risk of stillbirth and infant mortality. JAMA 2013;309:48-54. doi:10. 1001/jama. 2012. 153812
11. Viktorin A, Lichtenstein P, Lundholm C, et al. Selective serotonin re-uptake inhibitor use during pregnancy: Association with offspring birth size and gestational age. Int J Epidemiol 2016;45:170-7. doi:10. 1093/ije/dyv351
12. Clements CC, Castro VM, Blumenthal SR, et al. Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system. Mol Psychiatry 2015;20:727-34. doi:10. 1038/mp. 2014. 90
13. Boukhris T, Sheehy O, Mottron L, Bérard A. Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children. JAMA Pediatr 2016;170:117-24. doi:10. 1001/ jamapediatrics. 2015. 3356
14. Gidaya NB, Lee BK, Burstyn I, Yudell M, Mortensen EL, Newschaffer CJ. In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder. J Autism Dev Disord 2014;44: 2558-67. doi:10. 1007/s10803-014-2128-4
15. Rai D, Lee BK, Dalman C, Golding J, Lewis G, Magnusson C. Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ 2013;346:f2059. doi:10. 1136/bmj. f2059
16. Croen LA, Grether JK, Yoshida CK, Odouli R, Hendrick V. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry 2011;68:1104-12. doi:10. 1001/archgenpsychiatry. 2011. 73
17. Brown AS, Gyllenberg D, Malm H, et al. Association of Selective Serotonin Reuptake Inhibitor Exposure During Pregnancy With Speech, Scholastic, and Motor Disorders in Offspring. JAMA Psychiatry 2016;73:1163-70. doi:10. 1001/ jamapsychiatry. 2016. 2594
18. Sørensen MJ, Grønborg TK, Christensen J, et al. Antidepressant exposure in pregnancy and risk of autism spectrum disorders. Clin Epidemiol 2013;5:449-59. doi:10. 2147/CLEP. S53009
19. Sujan AC, Rickert ME, Öberg AS, et al. Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring. JAMA 2017;317:1553-62. doi:10. 1001/jama. 2017. 3413
20. Laugesen K, Olsen MS, Telén Andersen AB, Frøslev T, Sørensen HT. In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: A nationwide Danish cohort study. BMJ Open 2013;3:e003507. doi:10. 1136/ bmjopen-2013-003507
21. Figueroa R. Use of antidepressants during pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring. J Dev Behav Pediatr 2010;31:641-8. doi:10. 1097/ DBP. 0b013e3181e5ac93
22. Maciag D, Simpson KL, Coppinger D, et al. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 2006;31:47-57.
23. Glover ME, Pugh PC, Jackson NL, et al. Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats. Neuroscience 2015;284:775-97. doi:10. 1016/j. neuroscience. 2014. 10. 044
24. Videman M, Tokariev A, Saikkonen H, et al. Newborn Brain Function Is Affected by Fetal Exposure to Maternal Serotonin Reuptake Inhibitors. Cereb Cortex 2017;27:3208-16.
25. Sprowles JL, Hufgard JR, Gutierrez A, et al. Perinatal exposure to the selective serotonin reuptake inhibitor citalopram alters spatial learning and memory, anxiety, depression, and startle in Sprague-Dawley rats. Int J Dev Neurosci 2016;54:39-52. doi:10. 1016/j. ijdevneu. 2016. 08. 007
26. Oberlander TF, Gingrich JA, Ansorge MS. Sustained neurobehavioral effects of exposure to SSRI antidepressants during development: molecular to clinical evidence. Clin Pharmacol Ther 2009;86:672-7. doi:10. 1038/clpt. 2009. 201
27. Ciraulo DA, Shader RI, Greenblatt DJ. Clinical pharmacology and therapeutics of antidepressants. In: Ciraulo DA, Shader RI, eds. Pharmacotherapy of depression. Springer, 2011:34doi:10. 1007/978-1-60327-435-7-2.
28. Pedersen CB. The Danish Civil Registration System. Scand J Public Health 2011;39(Suppl):22-5. doi:10. 1177/1403494810387965
29. Knudsen LB, Olsen J. The Danish Medical Birth Registry. Dan Med Bull 1998;45:320-3.
30. Andersen TF, Madsen M, Jørgensen J, Mellemkjoer L, Olsen JH. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 1999;46:263-8.
31. Kildemoes HW, Sørensen HT, Hallas J. The Danish National Prescription Registry. Scand J Public Health 2011;39(Suppl):38-41. doi:10. 1177/1403494810394717
32. Mors O, Perto GP, Mortensen PB. The Danish Psychiatric Central Research Register. Scand J Public Health 2011;39(Suppl):54-7. doi:10. 1177/1403494810395825
33. Petersson F, Baadsgaard M, Thygesen LC. Danish registers on personal labour market affiliation. Scand J Public Health 2011;39(Suppl):95-8. doi:10. 1177/1403494811408483
34. Royston P, White IR. Multiple Imputation by Chained Equations (MICE): Implementation in Stata. J Stat Softw 2011;45:1-20. doi:10. 18637/jss. v045. i04.
35. Cole SR, Hernán MA. Adjusted survival curves with inverse probability weights. Comput Methods Programs Biomed 2004;75:45-9. doi:10. 1016/j. cmpb. 2003. 10. 004
36. Rockhill B, Newman B, Weinberg C. Use and misuse of population attributable fractions. Am J Public Health 1998;88:15-9. doi:10. 2105/AJPH. 88. 1. 15
37. Smith GD. Assessing intrauterine influences on offspring health outcomes: can epidemiological studies yield robust findings Basic Clin Pharmacol Toxicol 2008;102:245-56. doi:10. 1111/ j. 1742-7843. 2007. 00191. x
38. Dean K, Stevens H, Mortensen PB, Murray RM, Walsh E, Pedersen CB. Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder. Arch Gen Psychiatry 2010;67:822-9. doi:10. 1001/archgenpsychiatry. 2010. 86
39. McLearn KT, Minkovitz CS, Strobino DM, Marks E, Hou W. Maternal depressive symptoms at 2 to 4 months post partum and early parenting practices. Arch Pediatr Adolesc Med 2006;160:279-84. doi:10. 1001/archpedi. 160. 3. 279
40. O'Connor TG, Ben-Shlomo Y, Heron J, Golding J, Adams D, Glover V. Prenatal anxiety predicts individual differences in cortisol in preadolescent children. Biol Psychiatry 2005;58:211-7. doi:10. 1016/j. biopsych. 2005. 03. 032
41. Ornoy A. Neurobehavioral risks of SSRIs in pregnancy: Comparing human and animal data. Reprod Toxicol 2017;S0890-6238(17)30135-1.
42. Nulman I, Rovet J, Stewart DE, et al. Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: A prospective, controlled study. Am J Psychiatry 2002;159:1889-95. doi:10. 1176/appi. Ajp. 159. 11. 1889
43. Vigod SN, Wilson CA, Howard LM. Depression in pregnancy. BMJ 2016;352:i1547. doi:10. 1136/bmj. i1547
44. Dansk Selskab for Almen Medicin. Klinisk vejledning for almen praksis: Unipolar depression diagnostik og behandling. 2010. http:// www. dsam. dk/files/9/depression-med-links. pdf.
45. Frisell T, Öberg S, Kuja-Halkola R, Sjölander A. Sibling comparison designs: bias from non-shared confounders and measurement error. Epidemiology 2012;23:713-20. doi:10. 1097/EDE. 0b013e31825fa230
46. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 2004;306:879-81. doi:10. 1126/science. 1101678
47. Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry 2004;49:726-35. doi:10. 1177/070674370404901103
48. Yonkers KA, Wisner KL, Stewart DE, et al. The management of depression during pregnancy: A report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists. Obstet Gynecol 2009;114:703-13. doi:10. 1097/ AOG. 0b013e3181ba0632
49. Olesen C, Søndergaard C, Thrane N, Nielsen GL, de Jong-van den Berg L, Olsen J; EuroMAP Group. Do pregnant women report use of dispensed medications Epidemiology 2001;12:497-501. doi:10. 1097/00001648-200109000-00006
50. Lahon K, Shetty HM, Paramel A, et al. A retrospective drug utilization study of antidepressants in the psychiatric unit of a tertiary care hospital. J Clin Diagn Res 2011;5:1069-75.
51. Pedersen CB, Mors O, Bertelsen A, et al. A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry 2014;71:573-81. doi:10. 1001/ jamapsychiatry. 2014. 16