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Volumn 2017, Issue 9, 2017, Pages

Certolizumab pegol (CDP870) for rheumatoid arthritis in adults

Author keywords

[No Author keywords available]

Indexed keywords

CERTOLIZUMAB PEGOL; ANTIRHEUMATIC AGENT; IMMUNOGLOBULIN F(AB) FRAGMENT; METHOTREXATE;

EID: 85029164720     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD007649.pub4     Document Type: Review
Times cited : (7)

References (160)
  • 1
    • 85029172026 scopus 로고    scopus 로고
    • Baseline parameters identified in early, methotrexate-naive rheumatoid arthritis patients with better outcomes with certolizumab pegol+methotrexate compared to placebo+methotrexate: Post-hoc analyses of c-opera, a randomized, controlled, phase 3 study
    • Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2015 Rome Italy. 10 - 13 June 2015. 2971475
    • Atsumi T, Yamamoto K, Takeuchi T, Yamanaka H, Ishiguro N, Tanaka Y, et al. Baseline parameters identified in early, methotrexate-naive rheumatoid arthritis patients with better outcomes with certolizumab pegol+methotrexate compared to placebo+methotrexate: Post-hoc analyses of c-opera, a randomized, controlled, phase 3 study. Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2015 Rome Italy. 10 - 13 June 2015. 2015; Vol. 74:716-7. 2971475
    • (2015) , vol.74 , pp. 716-717
    • Atsumi, T.1    Yamamoto, K.2    Takeuchi, T.3    Yamanaka, H.4    Ishiguro, N.5    Tanaka, Y.6
  • 2
    • 85029151350 scopus 로고    scopus 로고
    • Clinical benefit of 1-year certolizumab pegol treatment in MTX-naïve, early rheumatoid arthritis patients is maintained after discontinuation up to 1 year
    • Arthritis and Rheumatology.Conference: American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, ACR/ARHP 2015 San Francisco, CA United States. 6 - 11 November 2015. 2971476
    • Atsumi T, Yamamoto K, Takeuchi T, Yamanaka H, Ishiguro N, Tanaka Y, et al. Clinical benefit of 1-year certolizumab pegol treatment in MTX-naïve, early rheumatoid arthritis patients is maintained after discontinuation up to 1 year. Arthritis and Rheumatology.Conference: American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, ACR/ARHP 2015 San Francisco, CA United States. 6 - 11 November 2015. 2015; Vol. 67. 2971476
    • (2015) , vol.67
    • Atsumi, T.1    Yamamoto, K.2    Takeuchi, T.3    Yamanaka, H.4    Ishiguro, N.5    Tanaka, Y.6
  • 3
    • 84954360828 scopus 로고    scopus 로고
    • The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression
    • 2971479
    • Atsumi T, Yamamoto K, Takeuchi T, Yamanaka H, Ishiguro N, Tanaka Y, et al. The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression. Annals of the Rheumatic Diseases 2016;75(1):75-83. 2971479
    • (2016) Annals of the Rheumatic Diseases , vol.75 , Issue.1 , pp. 75-83
    • Atsumi, T.1    Yamamoto, K.2    Takeuchi, T.3    Yamanaka, H.4    Ishiguro, N.5    Tanaka, Y.6
  • 4
    • 85029172513 scopus 로고    scopus 로고
    • The first early rheumatoid arthritis, certolizumab pegol, multicenter, double-blind, randomized, parallel-group study: C-Opera, in patients fulfilling the 2010 ACR/EULAR classification criteria, demonstrates inhibition of joint damage progression
    • Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2014 Paris France. 11 - 14 June 2014. 2971477
    • Atsumi T, Yamamoto K, Takeuchi T, Yamanaka H, Ishiguro N, Tanaka Y, et al. The first early rheumatoid arthritis, certolizumab pegol, multicenter, double-blind, randomized, parallel-group study: C-Opera, in patients fulfilling the 2010 ACR/EULAR classification criteria, demonstrates inhibition of joint damage progression. Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2014 Paris France. 11 - 14 June 2014. 2014; Vol. 73. 2971477
    • (2014) , vol.73
    • Atsumi, T.1    Yamamoto, K.2    Takeuchi, T.3    Yamanaka, H.4    Ishiguro, N.5    Tanaka, Y.6
  • 5
    • 85029161875 scopus 로고    scopus 로고
    • The first, multicenter, double-blind, randomized, parallel-group study of certolizumab pegol in early rheumatoid arthritis demonstrates inhibition of joint damage progression
    • Arthritis and Rheumatology.Conference: 2014 ACR/ARHP Annual Meeting Boston, MA United States. 14 - 19 November 2014. 2971478
    • Atsumi T, Yamamoto K, Takeuchi T, Yamanaka H, Ishiguro N, Tanaka Y, et al. The first, multicenter, double-blind, randomized, parallel-group study of certolizumab pegol in early rheumatoid arthritis demonstrates inhibition of joint damage progression. Arthritis and Rheumatology.Conference: 2014 ACR/ARHP Annual Meeting Boston, MA United States. 14 - 19 November 2014. 2014; Vol. 66:S1078-9. 2971478
    • (2014) , vol.66 , pp. S1078-S1079
    • Atsumi, T.1    Yamamoto, K.2    Takeuchi, T.3    Yamanaka, H.4    Ishiguro, N.5    Tanaka, Y.6
  • 6
    • 85029172823 scopus 로고    scopus 로고
    • CDP870 a novel, humanised tumour necrosis factor alpha inhibitor improves HRQOL. Late breaking abstract
    • European League Against Rheumatism Annual Conference. 2971442
    • Emery P, Smolen J, Choy E, et al. CDP870 a novel, humanised tumour necrosis factor alpha inhibitor improves HRQOL. Late breaking abstract. European League Against Rheumatism Annual Conference. 2002. 2971442
    • (2002)
    • Emery, P.1    Smolen, J.2    Choy, E.3
  • 7
    • 85029151881 scopus 로고    scopus 로고
    • Assesment report for Cimzia. Procedure No EMEA/H/C/001037
    • London, 2009 (accessed 3rd July 2017):-. [Procedure No.EMEA/H/C/001037]2971441
    • European Medicines Agency. Assesment report for Cimzia. Procedure No EMEA/H/C/001037. www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/001037/WC500069735.pdf. London, 2009 (accessed 3rd July 2017):1-47. [Procedure No.EMEA/H/C/001037]2971441
  • 8
    • 33645612360 scopus 로고    scopus 로고
    • CDP870, A novel pegylated, humanized TNF-alpha inhibitor, is effective in treating the signs and symptoms of rheumatoid arthritis (RA)
    • Abstract to Rheumatology annual scientific meeting. 2971443
    • Keystone E, Choy E, Kalden J, Klareskog, Sany J, Smolen J, et al. CDP870, A novel pegylated, humanized TNF-alpha inhibitor, is effective in treating the signs and symptoms of rheumatoid arthritis (RA). Abstract to Rheumatology annual scientific meeting [abstract # LB-3]. 2001. 2971443
    • (2001)
    • Keystone, E.1    Choy, E.2    Kalden, J.3    Klareskog, S.J.4    Smolen, J.5
  • 9
    • 0036796777 scopus 로고    scopus 로고
    • Efficacy of a novel pegylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial
    • 2971451
    • Choy EH, Hazleman B, Smith M, Moss K, Lisi L, Scott DG, et al. Efficacy of a novel pegylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial. Rheumatology (Oxford) 2002;41(10):1133-7. 2971451
    • (2002) Rheumatology (Oxford) , vol.41 , Issue.10 , pp. 1133-1137
    • Choy, E.H.1    Hazleman, B.2    Smith, M.3    Moss, K.4    Lisi, L.5    Scott, D.G.6
  • 10
    • 84863854575 scopus 로고    scopus 로고
    • Certolizumab pegol plus MTX administered every 4 weeks is effective in patients with RA who are partial responders to MTX
    • 2971445
    • Choy E, McKenna F, Vencovsky J, Valente R, Goel N, Vanlunen B, et al. Certolizumab pegol plus MTX administered every 4 weeks is effective in patients with RA who are partial responders to MTX. Rheumatology (Oxford) 2012;51(7):1226-34. 2971445
    • (2012) Rheumatology (Oxford) , vol.51 , Issue.7 , pp. 1226-1234
    • Choy, E.1    McKenna, F.2    Vencovsky, J.3    Valente, R.4    Goel, N.5    Vanlunen, B.6
  • 11
    • 85029183216 scopus 로고    scopus 로고
    • Clinical Study Summary Study No.: CDP870-014
    • 2008 (accessed 3rd July 2017). 2971446
    • UCB. Clinical Study Summary Study No.: CDP870-014. www.ucb.com/_up/ucb_com_patients/documents/C87032_CSS_20080608.pdf 2008 (accessed 3rd July 2017). 2971446
  • 12
    • 85029177002 scopus 로고    scopus 로고
    • Improvements in workplace and household productivity following 52 weeks of treatment with certolizumab pegol in combination with methotrexate in DMARD-naive patients with severe, active and progressive rheumatoid arthritis: Results from the c-early randomized, double-blind, controlled phase 3 study
    • Value in Health.Conference: ISPOR 18th Annual European Congress Milan, Italy.Conference. 7 - 11 November 2015. 2971484
    • Emery P, Bingham C, Burmester GR, Bykerk VP, Furst D, Mariette X, et al. Improvements in workplace and household productivity following 52 weeks of treatment with certolizumab pegol in combination with methotrexate in DMARD-naive patients with severe, active and progressive rheumatoid arthritis: Results from the c-early randomized, double-blind, controlled phase 3 study. Value in Health.Conference: ISPOR 18th Annual European Congress Milan, Italy.Conference. 7 - 11 November 2015. 2015; Vol. 18:7. 2971484
    • (2015) , vol.18 , pp. 7
    • Emery, P.1    Bingham, C.2    Burmester, G.R.3    Bykerk, V.P.4    Furst, D.5    Mariette, X.6
  • 13
    • 85009072248 scopus 로고    scopus 로고
    • Improvements in patient-reported outcomes and workplace and household productivity following 52 weeks of treatment with certolizumab pegol in combination with methotrexate in DMARD-naive early rheumatoid arthritis patients: Results from the C-early randomized, double-blind, controlled phase 3 study
    • Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2015 Rome Italy. 10 - 13 June 2015. 2971485
    • Emery P, Bingham CO, Burmester G-R, Bykerk VP, Furst DE, Mariette X, et al. Improvements in patient-reported outcomes and workplace and household productivity following 52 weeks of treatment with certolizumab pegol in combination with methotrexate in DMARD-naive early rheumatoid arthritis patients: Results from the C-early randomized, double-blind, controlled phase 3 study. Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2015 Rome Italy. 10 - 13 June 2015. 2015; Vol. 74:712-3. 2971485
    • (2015) , vol.74 , pp. 712-713
    • Emery, P.1    Bingham, C.O.2    Burmester, G.-R.3    Bykerk, V.P.4    Furst, D.E.5    Mariette, X.6
  • 14
    • 85009072248 scopus 로고    scopus 로고
    • SAT0165 Improvements in patient-reported outcomes and workplace and household productivity following 52 weeks of treatment with certolizumab pegol in combination with methotrexate in dmard-naïve early rheumatoid arthritis patients: results from the C-Early randomized, double-blind, controlled phase 3 study
    • 2971483
    • Emery P, Bingham CO, Burmester G-R, Bykerk VP, Furst DE, Mariette X, et al. SAT0165 Improvements in patient-reported outcomes and workplace and household productivity following 52 weeks of treatment with certolizumab pegol in combination with methotrexate in dmard-naïve early rheumatoid arthritis patients: results from the C-Early randomized, double-blind, controlled phase 3 study. Annals of the Rheumatic Diseases 2015;74(Suppl 2):712-3. 2971483
    • (2015) Annals of the Rheumatic Diseases , vol.74 , pp. 712-713
    • Emery, P.1    Bingham, C.O.2    Burmester, G.-R.3    Bykerk, V.P.4    Furst, D.E.5    Mariette, X.6
  • 15
    • 85009072248 scopus 로고    scopus 로고
    • sSAT0164 The first study of certolizumab pegol in combination with methotrexate in dmard-naïve early rheumatoid arthritis patients led to Sustained clinical response and inhibition of radiographic progression at 52 weeks: The C-Early randomized, double-blind, controlled phase 3 study
    • 2971482
    • Emery P, Bingham CO, Burmester G-R, Bykerk VP, Furst DE, Mariette X, et al. sSAT0164 The first study of certolizumab pegol in combination with methotrexate in dmard-naïve early rheumatoid arthritis patients led to Sustained clinical response and inhibition of radiographic progression at 52 weeks: The C-Early randomized, double-blind, controlled phase 3 study. Annals of the Rheumatic Diseases 2015;74(Suppl 2):712. 2971482
    • (2015) Annals of the Rheumatic Diseases , vol.74 , pp. 712
    • Emery, P.1    Bingham, C.O.2    Burmester, G.-R.3    Bykerk, V.P.4    Furst, D.E.5    Mariette, X.6
  • 16
    • 85029153160 scopus 로고    scopus 로고
    • Early response as a predictor of long-term remission in DMARD-naive patients with severe, active and progressive rheumatoid arthritis treated with certolizumab pegol in combination with methotrexate
    • Arthritis and Rheumatology.Conference: American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, ACR/ARHP 2015 San Francisco, CA United States. 6 - 11 November 2015. 2971486
    • Weinblatt M, Bingham C, Burmester G, Bykerk V, Furst DE, Mariette X, et al. Early response as a predictor of long-term remission in DMARD-naive patients with severe, active and progressive rheumatoid arthritis treated with certolizumab pegol in combination with methotrexate. Arthritis and Rheumatology.Conference: American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, ACR/ARHP 2015 San Francisco, CA United States. 6 - 11 November 2015. 2015; Vol. 67. 2971486
    • (2015) , vol.67
    • Weinblatt, M.1    Bingham, C.2    Burmester, G.3    Bykerk, V.4    Furst, D.E.5    Mariette, X.6
  • 17
    • 85029149069 scopus 로고    scopus 로고
    • Certolizumab pegol in combination with methotrexate in DMARD-naive patients with active, severe, progressive rheumatoid arthritis: Results from a randomized, double-blind, controlled phase 3 study
    • Arthritis and Rheumatology.Conference: American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, ACR/ARHP 2015 San Francisco, CA United States. 6 - 11 November 2015. 2971487
    • Weinblatt M, Bingham C, Burmester G, Bykerk VP, Furst DE, Mariette X, et al. Certolizumab pegol in combination with methotrexate in DMARD-naive patients with active, severe, progressive rheumatoid arthritis: Results from a randomized, double-blind, controlled phase 3 study. Arthritis and Rheumatology.Conference: American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, ACR/ARHP 2015 San Francisco, CA United States. 6 - 11 November 2015. 2015; Vol. 67. 2971487
    • (2015) , vol.67
    • Weinblatt, M.1    Bingham, C.2    Burmester, G.3    Bykerk, V.P.4    Furst, D.E.5    Mariette, X.6
  • 18
    • 51549094075 scopus 로고    scopus 로고
    • Efficacy and safety of certolizumab pegol monotherapy in patients with rheumatoid arthritis failing previous DMARD therapy
    • 2971453
    • Fleischmann D, Mason D, Cohen S. Efficacy and safety of certolizumab pegol monotherapy in patients with rheumatoid arthritis failing previous DMARD therapy. Annals of the Rheumatic Diseases 2007;66 Suppl II:169. 2971453
    • (2007) Annals of the Rheumatic Diseases , Issue.66 , pp. 169
    • Fleischmann, D.1    Mason, D.2    Cohen, S.3
  • 19
    • 85029167496 scopus 로고    scopus 로고
    • Certolizumab pegol monotherapy 400mg every 4 weeks improves physical functioning and reduces pain in patients with rheumatoid arthritis Who have previously failed DMARD therapy
    • Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13-16 June. 2971454
    • Fleischmann R, Keininger DL, Tahiri-Fitzgerald E, Mease P. Certolizumab pegol monotherapy 400mg every 4 weeks improves physical functioning and reduces pain in patients with rheumatoid arthritis Who have previously failed DMARD therapy. Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13-16 June [Abstract #0148]. 2007. 2971454
    • (2007)
    • Fleischmann, R.1    Keininger, D.L.2    Tahiri-Fitzgerald, E.3    Mease, P.4
  • 20
    • 67449123606 scopus 로고    scopus 로고
    • Efficacy and safety of certolizumab pegol monotherapy every 4 weeks in patients with rheumatoid arthritis failing previous disease modifying antirheumatic therapy: the FAST4WARD study
    • 2971455
    • Fleischmann R, Vencovsky J, Van Vollenhoven RF, Borenstein D, Box J, Coteur G, et al. Efficacy and safety of certolizumab pegol monotherapy every 4 weeks in patients with rheumatoid arthritis failing previous disease modifying antirheumatic therapy: the FAST4WARD study. Annals of the Rheumatic Diseases 2009;68(6):805-11. 2971455
    • (2009) Annals of the Rheumatic Diseases , vol.68 , Issue.6 , pp. 805-811
    • Fleischmann, R.1    Vencovsky, J.2    Van Vollenhoven, R.F.3    Borenstein, D.4    Box, J.5    Coteur, G.6
  • 21
    • 85029165388 scopus 로고    scopus 로고
    • Certolizumab pegol 400 mg every 4 weeks as monotherapy rapidly reduces disease activity in active rheumatoid arthritis
    • Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; November 6 - 11; Boston, Massachusetts. 2971456
    • Keystone E, Mason D, Fleischmann R. Certolizumab pegol 400 mg every 4 weeks as monotherapy rapidly reduces disease activity in active rheumatoid arthritis. Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; November 6 - 11; Boston, Massachusetts. [Abstract #277]. 2007. 2971456
    • (2007)
    • Keystone, E.1    Mason, D.2    Fleischmann, R.3
  • 22
    • 85029166625 scopus 로고    scopus 로고
    • Certolizumab pegol monotherapy improves productivity in patients with active rheumatoid arthritis: results from a phase III randomized controlled trial
    • Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June. 2971457
    • Strand V, Brown M, Purcaru O, Richard L. Certolizumab pegol monotherapy improves productivity in patients with active rheumatoid arthritis: results from a phase III randomized controlled trial. Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June [Abstract #0478]. 2007. 2971457
    • (2007)
    • Strand, V.1    Brown, M.2    Purcaru, O.3    Richard, L.4
  • 23
    • 85029166272 scopus 로고    scopus 로고
    • Certolizumab pegol monotherapy 400mg every 4 weeks improves health-related quality of life and relieves fatigue in patients with rheumatoid arthritis who have previously failed DMARD therapy
    • Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June. 2971458
    • Strand V, Keininger D, Tahiri-Fitzgerald E, Fleischmann R. Certolizumab pegol monotherapy 400mg every 4 weeks improves health-related quality of life and relieves fatigue in patients with rheumatoid arthritis who have previously failed DMARD therapy. Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June [Abstract #0205]. 2007. 2971458
    • (2007)
    • Strand, V.1    Keininger, D.2    Tahiri-Fitzgerald, E.3    Fleischmann, R.4
  • 24
    • 79961122554 scopus 로고    scopus 로고
    • Dose escalation of certolizumab pegol from 200 mg to 400 mg every other week provides no additional efficacy in rheumatoid arthritis: an analysis of individual patient-level data
    • 2971489
    • Curtis JR, Chen L, Luijtens K, Navarro-Millan I, Goel N, Gervitz L, et al. Dose escalation of certolizumab pegol from 200 mg to 400 mg every other week provides no additional efficacy in rheumatoid arthritis: an analysis of individual patient-level data. Arthritis and Rheumatism 2011;63(8):2203-8. 2971489
    • (2011) Arthritis and Rheumatism , vol.63 , Issue.8 , pp. 2203-2208
    • Curtis, J.R.1    Chen, L.2    Luijtens, K.3    Navarro-Millan, I.4    Goel, N.5    Gervitz, L.6
  • 25
    • 84861127529 scopus 로고    scopus 로고
    • Predicting future response to certolizumab pegol in rheumatoid arthritis patients: features at 12 weeks associated with low disease activity at 1 year
    • 2971490
    • Curtis JR, Luijtens K, Kavanaugh A. Predicting future response to certolizumab pegol in rheumatoid arthritis patients: features at 12 weeks associated with low disease activity at 1 year. Arthritis Care Research (Hoboken) 2012;64(5):658-67. 2971490
    • (2012) Arthritis Care Research (Hoboken) , vol.64 , Issue.5 , pp. 658-667
    • Curtis, J.R.1    Luijtens, K.2    Kavanaugh, A.3
  • 26
    • 85029163725 scopus 로고    scopus 로고
    • Analysis of pooled data from two randomized controlled trials and their open-label extensions: Long-term safety in rheumatoid arthritis before and after certolizumab pegol dose increase/decrease
    • Conference: 2014 ACR/ARHP Annual Meeting Boston, MA United States 14 - 19 N0vember 2014.:. 6669726
    • Haraoui B, Bykerk VP, Van Vollenhoven R, De Longueville M, Luijtens K, Ralston P, et al. Analysis of pooled data from two randomized controlled trials and their open-label extensions: Long-term safety in rheumatoid arthritis before and after certolizumab pegol dose increase/decrease. Arthritis and Rheumatology.Conference: 2014 ACR/ARHP Annual Meeting Boston, MA United States 14 - 19 N0vember 2014. 2014; Vol. 66:S199. 6669726
    • (2014) Arthritis and Rheumatology , vol.66 , pp. S199
    • Haraoui, B.1    Bykerk, V.P.2    Van Vollenhoven, R.3    De Longueville, M.4    Luijtens, K.5    Ralston, P.6
  • 27
    • 55849112632 scopus 로고    scopus 로고
    • Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: findings of a fifty-two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • 2971491
    • Keystone E, Heijde D, Mason D Jr, Landewé R, Vollenhoven RV, Combe B, et al. Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: findings of a fifty-two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Arthritis and Rheumatism 2008;58(11):3319-29. 2971491
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.11 , pp. 3319-3329
    • Keystone, E.1    Heijde, D.2    Mason, D.3    Landewé, R.4    Vollenhoven, R.V.5    Combe, B.6
  • 28
    • 84882503404 scopus 로고    scopus 로고
    • 5-Year results from the RAPID 1 trial and open-label extension: long-term safety and efficacy of certolizumab pegol in combination with methotrexate in the treatment of rheumatoid arthritis
    • [Epub ahead of print]]6669727
    • Keystone E, Landewé R, Van Vollenhoven R, Combe B, Strand V, Mease P, et al. 5-Year results from the RAPID 1 trial and open-label extension: long-term safety and efficacy of certolizumab pegol in combination with methotrexate in the treatment of rheumatoid arthritis. Annals of the Rheumatic Diseases 2013;72(12):A228-9. [10.1136/annrheumdis-2013-203695. [Epub ahead of print]]6669727
    • (2013) Annals of the Rheumatic Diseases , vol.72 , Issue.12 , pp. A228-A229
    • Keystone, E.1    Landewé, R.2    Van Vollenhoven, R.3    Combe, B.4    Strand, V.5    Mease, P.6
  • 29
    • 85029157236 scopus 로고    scopus 로고
    • Long-term safety and efficacy of certolizumab pegol in combination with methotrexate in the treatment of rheumatoid arthritis: 5-year results from a 52-week randomized controlled trial and open-label extension study
    • CRA 2014 Whistler, BC Canada. 24 February - 1 March 2014.:. 6669728
    • Keystone E, Landewé R, Van Vollenhoven R, Combe B, Strand V, Mease P, et al. Long-term safety and efficacy of certolizumab pegol in combination with methotrexate in the treatment of rheumatoid arthritis: 5-year results from a 52-week randomized controlled trial and open-label extension study. Journal of Rheumatology Conference: 69th Annual Meeting of the Canadian Rheumatology Association, CRA 2014 Whistler, BC Canada. 24 February - 1 March 2014. 2014; Vol. 41:7. 6669728
    • (2014) Journal of Rheumatology Conference: 69th Annual Meeting of the Canadian Rheumatology Association , vol.41 , pp. 7
    • Keystone, E.1    Landewé, R.2    Van Vollenhoven, R.3    Combe, B.4    Strand, V.5    Mease, P.6
  • 30
    • 85019195043 scopus 로고    scopus 로고
    • Long-term safety and efficacy of certolizumab pegol in combination with methotrexate in the treatment of rheumatoid arthritis: 5-year results from the RAPID 1 trial and open-label extension
    • PUBMED: 23918037]6669729
    • Keystone E, Landewé R, Van Vollenhoven R, Combe B, Strand V, Mease P, et al. Long-term safety and efficacy of certolizumab pegol in combination with methotrexate in the treatment of rheumatoid arthritis: 5-year results from the RAPID 1 trial and open-label extension. Annals of the Rheumatic Diseases 2013;65:S988-9. [PUBMED: 23918037]6669729
    • (2013) Annals of the Rheumatic Diseases , vol.65 , pp. S988-S989
    • Keystone, E.1    Landewé, R.2    Van Vollenhoven, R.3    Combe, B.4    Strand, V.5    Mease, P.6
  • 31
    • 53649093366 scopus 로고    scopus 로고
    • The anti-TNF certolizumab pegol in combination with methotrexate is significantly more effective than methotrexate alone in the treatment of patients with active rheumatoid arthritis: 1-year results from the RAPID 1 study
    • Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; 6 - 11 November 2007; Boston, Massachusetts. 2971492
    • Keystone E, Mason D, Combe B. The anti-TNF certolizumab pegol in combination with methotrexate is significantly more effective than methotrexate alone in the treatment of patients with active rheumatoid arthritis: 1-year results from the RAPID 1 study. Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; 6 - 11 November 2007; Boston, Massachusetts [Abstract #700]. 2007. 2971492
    • (2007)
    • Keystone, E.1    Mason, D.2    Combe, B.3
  • 32
    • 84865327391 scopus 로고    scopus 로고
    • Sustained efficacy of certolizumab pegol added to methotrexate in the treatment of rheumatoid arthritis: 2-year results from the RAPID 1 trial
    • 6669730
    • Keystone EC, Combe B, Smolen J, Strand V, Goel N, van Vollenhoven R, et al. Sustained efficacy of certolizumab pegol added to methotrexate in the treatment of rheumatoid arthritis: 2-year results from the RAPID 1 trial. Rheumatology (Oxford) 2012;51:1628-38. 6669730
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 1628-1638
    • Keystone, E.C.1    Combe, B.2    Smolen, J.3    Strand, V.4    Goel, N.5    van Vollenhoven, R.6
  • 33
    • 85029163749 scopus 로고    scopus 로고
    • A study of the safety and effectiveness of lyophilized certolizumab pegol in the treatment of signs and symptoms of rheumatoid arthritis and in prevention of joint damage in patients with active rheumatoid arthritis
    • (first received 9th September 2005). 6669731
    • NCT00175877. A study of the safety and effectiveness of lyophilized certolizumab pegol in the treatment of signs and symptoms of rheumatoid arthritis and in prevention of joint damage in patients with active rheumatoid arthritis. clinicaltrials.gov/ct2/show/NCT00175877 (first received 9th September 2005). 6669731
  • 34
    • 72249101218 scopus 로고    scopus 로고
    • Certolizumab pegol results in clinically meaningful improvements in physical function and health-related quality of life in patients with active rheumatoid arthritis despite treatment with methotrexate
    • Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; 6 - 11 November 2007; Boston, Massachusetts. 2971493
    • Strand V, Keininger DL, Tahiri-Fizgerald E. Certolizumab pegol results in clinically meaningful improvements in physical function and health-related quality of life in patients with active rheumatoid arthritis despite treatment with methotrexate. Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; 6 - 11 November 2007; Boston, Massachusetts. [Abstract #946]. 2007. 2971493
    • (2007)
    • Strand, V.1    Keininger, D.L.2    Tahiri-Fizgerald, E.3
  • 35
    • 75749102955 scopus 로고    scopus 로고
    • Rapid and sustained improvements in health-related quality of life, fatigue, and other patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol plus methotrexate over 1 year: results from the RAPID 1 randomized controlled trial
    • 2971494
    • Strand V, Mease P, Burmester G, Nikaï E, Coteur G, Vollenhoven R, et al. Rapid and sustained improvements in health-related quality of life, fatigue, and other patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol plus methotrexate over 1 year: results from the RAPID 1 randomized controlled trial. Arthritis Research & Therapy 2009; Vol. 11, issue 6:R170. 2971494
    • (2009) Arthritis Research & Therapy , vol.11 , Issue.6 , pp. R170
    • Strand, V.1    Mease, P.2    Burmester, G.3    Nikaï, E.4    Coteur, G.5    Vollenhoven, R.6
  • 36
    • 85029171292 scopus 로고    scopus 로고
    • Preliminary results suggest certolizumab pegol plus methotrexate is effective in reducing signs and symptoms of rheumatoid arthritis in patients refractory to methotrexate. Results from the RAPID 1 Study. Abstract number: OPO016
    • EULAR 2007. 2971495
    • UCB. Preliminary results suggest certolizumab pegol plus methotrexate is effective in reducing signs and symptoms of rheumatoid arthritis in patients refractory to methotrexate. Results from the RAPID 1 Study. Abstract number: OPO016. EULAR 2007. 2007. 2971495
    • (2007)
  • 37
    • 84863517729 scopus 로고    scopus 로고
    • Timing and magnitude of initial change in disease activity score 28 predicts the likelihood of achieving low disease activity at 1 year in rheumatoid arthritis patients treated with certolizumab pegol: a post-hoc analysis of the RAPID 1 trial
    • 2971496
    • Van der Heijde D, Keystone EC, Curtis JR, Landewé RB, Schiff MH, Khanna D, et al. Timing and magnitude of initial change in disease activity score 28 predicts the likelihood of achieving low disease activity at 1 year in rheumatoid arthritis patients treated with certolizumab pegol: a post-hoc analysis of the RAPID 1 trial. Journal of Rheumatology 2012;39(7):1326-33. 2971496
    • (2012) Journal of Rheumatology , vol.39 , Issue.7 , pp. 1326-1333
    • Van der Heijde, D.1    Keystone, E.C.2    Curtis, J.R.3    Landewé, R.B.4    Schiff, M.H.5    Khanna, D.6
  • 38
    • 79955015841 scopus 로고    scopus 로고
    • Inhibition of radiographic progression by lyophilized certolizumab pegol added to methotrexate in comparison with methotrexate alone in patients with rheumatoid arthritis: the RAPID 1 trial
    • Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; November 6-11; Boston, Massachusetts. 2971497
    • Van der Heijde D, Strand V, Keystone E, Landewé R. Inhibition of radiographic progression by lyophilized certolizumab pegol added to methotrexate in comparison with methotrexate alone in patients with rheumatoid arthritis: the RAPID 1 trial. Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; November 6-11; Boston, Massachusetts. [Abstract #940]. 2007. 2971497
    • (2007)
    • Van der Heijde, D.1    Strand, V.2    Keystone, E.3    Landewé, R.4
  • 39
    • 77950805136 scopus 로고    scopus 로고
    • Inhibition of progression of structural damage by week 16 with certolizumab pegol: Results from the RAPID trials
    • 2971498
    • Van der Heijde D, Weinblatt M, Landewé R, Goel N, Wells A, Fleischmann R. Inhibition of progression of structural damage by week 16 with certolizumab pegol: Results from the RAPID trials. Arthritis and Rheumatism 2008;58(9 Suppl):529-30. 2971498
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.9 , pp. 529-530
    • Van der Heijde, D.1    Weinblatt, M.2    Landewé, R.3    Goel, N.4    Wells, A.5    Fleischmann, R.6
  • 40
    • 85029181117 scopus 로고    scopus 로고
    • A study of CDP870 as add-on medication to methotrexate (MTX) in patients with rheumatoid arthritis
    • (firs treceived 9th October 2009). 2971469
    • NCT00993317. A study of CDP870 as add-on medication to methotrexate (MTX) in patients with rheumatoid arthritis. clinicaltrials.gov/ct2/show/study/NCT00993317 (firs treceived 9th October 2009). 2971469
  • 41
    • 85029163725 scopus 로고    scopus 로고
    • Analysis of pooled data from two randomized controlled trials and their open-label extensions: Long-term safety in rheumatoid arthritis before and after certolizumab pegol dose increase/decrease
    • Arthritis and Rheumatology.Conference: 2014 ACR/ARHP Annual Meeting Boston, MA United States 14 - 19 N0vember 2014. 6669732
    • Haraoui B, Bykerk VP, Van Vollenhoven R, De Longueville M, Luijtens K, Ralston P, et al. Analysis of pooled data from two randomized controlled trials and their open-label extensions: Long-term safety in rheumatoid arthritis before and after certolizumab pegol dose increase/decrease. Arthritis and Rheumatology.Conference: 2014 ACR/ARHP Annual Meeting Boston, MA United States 14 - 19 N0vember 2014. 2014; Vol. 66:S199. 6669732
    • (2014) , vol.66 , pp. S199
    • Haraoui, B.1    Bykerk, V.P.2    Van Vollenhoven, R.3    De Longueville, M.4    Luijtens, K.5    Ralston, P.6
  • 42
    • 70449514894 scopus 로고    scopus 로고
    • Effect of certolizumab pegol with methotrexate on home and work place productivity and social activities in patients with active rheumatoid arthritis
    • 2971500
    • Kavanaugh A, Smolen JS, Emery P, Purcaru O, Keystone E, Richard L, et al. Effect of certolizumab pegol with methotrexate on home and work place productivity and social activities in patients with active rheumatoid arthritis. Arthritis and Rheumatism 2009;61(11):1592-600. 2971500
    • (2009) Arthritis and Rheumatism , vol.61 , Issue.11 , pp. 1592-1600
    • Kavanaugh, A.1    Smolen, J.S.2    Emery, P.3    Purcaru, O.4    Keystone, E.5    Richard, L.6
  • 43
    • 53649095950 scopus 로고    scopus 로고
    • Liquid formulation certolizumab pegol with methotrexate decreases progression of structural joint damage in rheumatoid arthritis patients: the RAPID 2 study
    • Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; 6 - 11 November 2007; Boston, Massachusetts. 2971501
    • Landewé R, Strand V, Smolen J, Van der Heijde D. Liquid formulation certolizumab pegol with methotrexate decreases progression of structural joint damage in rheumatoid arthritis patients: the RAPID 2 study. Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; 6 - 11 November 2007; Boston, Massachusetts. [Abstract #696]. 2007. 2971501
    • (2007)
    • Landewé, R.1    Strand, V.2    Smolen, J.3    Van der Heijde, D.4
  • 44
    • 85029170471 scopus 로고    scopus 로고
    • Efficacy and rapid response of certolizumab pegol liquid formulation in combination with methotrexate (MTX) in patients with active rheumatoid arthritis despite MTX therapy: results from the RAPID 2 study
    • Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; 6 - 11 November 2007; Boston, Massachusetts. 2971502
    • Mease P, Mason D, Kavanaugh A, Smolen J. Efficacy and rapid response of certolizumab pegol liquid formulation in combination with methotrexate (MTX) in patients with active rheumatoid arthritis despite MTX therapy: results from the RAPID 2 study. Program and abstracts of the American College of Rheumatology (ACR) 71st Annual Meeting; 6 - 11 November 2007; Boston, Massachusetts. [Abstract #941]. 2007. 2971502
    • (2007)
    • Mease, P.1    Mason, D.2    Kavanaugh, A.3    Smolen, J.4
  • 45
    • 79955020599 scopus 로고    scopus 로고
    • Certolizumab pegol added onto methotrexate improves physical functioning and reduces pain in patients with rheumatoid arthritis who have an incomplete response to methotrexate: data from rapid 2
    • Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June. 2971503
    • Schiff M, Keininger DL, Tahiri-Fitzgerald E. Certolizumab pegol added onto methotrexate improves physical functioning and reduces pain in patients with rheumatoid arthritis who have an incomplete response to methotrexate: data from rapid 2. Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June [Abstract #0200]. 2007. 2971503
    • (2007)
    • Schiff, M.1    Keininger, D.L.2    Tahiri-Fitzgerald, E.3
  • 46
    • 67449120376 scopus 로고    scopus 로고
    • Efficacy and safety of certolizumab pegol in combination with methotrexate (mtx) in patients with active rheumatoid arthritis despite MTX therapy: results from the Rapid 2 study
    • Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June. 2971504
    • Smolen J, Brzezicki J, Mason D, Kavanaugh A. Efficacy and safety of certolizumab pegol in combination with methotrexate (mtx) in patients with active rheumatoid arthritis despite MTX therapy: results from the Rapid 2 study. Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June [Abstract #0202]. 2007. 2971504
    • (2007)
    • Smolen, J.1    Brzezicki, J.2    Mason, D.3    Kavanaugh, A.4
  • 47
    • 67449124634 scopus 로고    scopus 로고
    • Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial
    • 2971505
    • Smolen JS, Landewe RB, Mease PJ, BrzezickiJ, Mason D, Luijtens K, et al. Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial. Annals of the Rheumatic Diseases 2009;68:797-804. 2971505
    • (2009) Annals of the Rheumatic Diseases , vol.68 , pp. 797-804
    • Smolen, J.S.1    Landewe, R.B.2    Mease, P.J.3    Brzezicki, J.4    Mason, D.5    Luijtens, K.6
  • 48
    • 84940971178 scopus 로고    scopus 로고
    • Certolizumab pegol plus methotrexate 5-year results from the rheumatoid arthritis prevention of structural damage (RAPID) 2 randomized controlled trial and long-term extension in rheumatoid arthritis patients
    • 6669733
    • Smolen JS, Van Vollenhoven R, Kavanaugh A, Strand V, Vencovsky J, Schiff M, et al. Certolizumab pegol plus methotrexate 5-year results from the rheumatoid arthritis prevention of structural damage (RAPID) 2 randomized controlled trial and long-term extension in rheumatoid arthritis patients. Arthritis Research & Therapy 2015;17:245. 6669733
    • (2015) Arthritis Research & Therapy , vol.17 , pp. 245
    • Smolen, J.S.1    Van Vollenhoven, R.2    Kavanaugh, A.3    Strand, V.4    Vencovsky, J.5    Schiff, M.6
  • 49
    • 72249101218 scopus 로고    scopus 로고
    • Certolizumab pegol results in clinically meaningful improvements in physical function and health-related quality of life in patients with active rheumatoid arthritis despite treatment with methotrexate
    • Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June 2007. 2971506
    • Strand V, Keininger DL, Tahiri-Fizgerald E. Certolizumab pegol results in clinically meaningful improvements in physical function and health-related quality of life in patients with active rheumatoid arthritis despite treatment with methotrexate. Program and abstracts of the European League Against Rheumatism (EULAR) Annual Meeting; Barcelona, Spain 13 - 16 June 2007 [Abstract #0335]. 2007. 2971506
    • (2007)
    • Strand, V.1    Keininger, D.L.2    Tahiri-Fizgerald, E.3
  • 50
    • 79955810283 scopus 로고    scopus 로고
    • Certolizumab pegol plus methotrexate provides broad relief from the burden of rheumatoid arthritis: analysis of patient-reported outcomes from the RAPID 2 trial
    • 2971507
    • Strand V, Smolen JS, Van Vollenhoven RF, Mease P, Burmester GR, Hiepe F, et al. Certolizumab pegol plus methotrexate provides broad relief from the burden of rheumatoid arthritis: analysis of patient-reported outcomes from the RAPID 2 trial. Annals of the Rheumatic Diseases 2011;70(6):996-1002. 2971507
    • (2011) Annals of the Rheumatic Diseases , vol.70 , Issue.6 , pp. 996-1002
    • Strand, V.1    Smolen, J.S.2    Van Vollenhoven, R.F.3    Mease, P.4    Burmester, G.R.5    Hiepe, F.6
  • 51
    • 85029166652 scopus 로고    scopus 로고
    • Rheumatoid arthritis (RA) moderate to low disease activity study (CERTAIN)
    • (first received 5th May 2008). 2971448
    • NCT00674362. Rheumatoid arthritis (RA) moderate to low disease activity study (CERTAIN). clinicaltrials.gov/ct2/show/NCT00674362 (first received 5th May 2008). 2971448
  • 52
    • 84885804471 scopus 로고    scopus 로고
    • Maintenance of remission in rheumatoid arthritis patients with low-moderate disease activity following withdrawal of certolizumab PEGOL treatment: Week 52 results from the certain study
    • 6669734
    • Smolen JS, Emery P, Ferraccioli G, Samborski W, Berenbaum F, Davies O, et al. Maintenance of remission in rheumatoid arthritis patients with low-moderate disease activity following withdrawal of certolizumab PEGOL treatment: Week 52 results from the certain study. Annals of the Rheumatic Disease 2013;71 Suppl 3:361. 6669734
    • (2013) Annals of the Rheumatic Disease , Issue.71 , pp. 361
    • Smolen, J.S.1    Emery, P.2    Ferraccioli, G.3    Samborski, W.4    Berenbaum, F.5    Davies, O.6
  • 53
    • 84926623879 scopus 로고    scopus 로고
    • Certolizumab pegol in rheumatoid arthritis patients with low to moderate activity: the CERTAIN double-blind, randomised, placebo-controlled trial
    • 6669735
    • Smolen JS, Emery P, Ferraccioli GF, Samborski W, Berenbaum F, Davies OR, et al. Certolizumab pegol in rheumatoid arthritis patients with low to moderate activity: the CERTAIN double-blind, randomised, placebo-controlled trial. Annals of the Rheumatic Diseases 2015; Vol. 74, issue 5:843-50. [DOI: 10.1136/annrheumdis-2013-204632]6669735
    • (2015) Annals of the Rheumatic Diseases , vol.74 , Issue.5 , pp. 843-850
    • Smolen, J.S.1    Emery, P.2    Ferraccioli, G.F.3    Samborski, W.4    Berenbaum, F.5    Davies, O.R.6
  • 54
    • 84940971178 scopus 로고    scopus 로고
    • Certolizumab pegol plus methotrexate 5-year results from the rheumatoid arthritis prevention of structural damage (RAPID) 2 randomized controlled trial and long-term extension in rheumatoid arthritis patients
    • 6669736
    • Smolen JS, Van Vollenhoven R, Kavanaugh A, Strand V, Vencovsky J, Schiff M, et al. Certolizumab pegol plus methotrexate 5-year results from the rheumatoid arthritis prevention of structural damage (RAPID) 2 randomized controlled trial and long-term extension in rheumatoid arthritis patients. Arthritis Research & Therapy 2015;17:245. 6669736
    • (2015) Arthritis Research & Therapy , vol.17 , pp. 245
    • Smolen, J.S.1    Van Vollenhoven, R.2    Kavanaugh, A.3    Strand, V.4    Vencovsky, J.5    Schiff, M.6
  • 55
    • 84948777260 scopus 로고    scopus 로고
    • Impact of certolizumab pegol on patient-reported outcomes in rheumatoid arthritis and correlation with clinical measures of disease activity
    • 2971509
    • Pope J, Bingham CO 3rd, Fleischmann RM, Dougados M, Massarotti EM, Wollenhaupt J, et al. Impact of certolizumab pegol on patient-reported outcomes in rheumatoid arthritis and correlation with clinical measures of disease activity. Arthritis Research & Therapy 2015;17:343. 2971509
    • (2015) Arthritis Research & Therapy , vol.17 , pp. 343
    • Pope, J.1    Bingham, C.O.2    Fleischmann, R.M.3    Dougados, M.4    Massarotti, E.M.5    Wollenhaupt, J.6
  • 56
    • 84870317631 scopus 로고    scopus 로고
    • Efficacy and safety of certolizumab pegol in a broad population of patients with active rheumatoid arthritis: results from the REALISTIC phase IIIb study
    • 2971510
    • Weinblatt ME, Fleischmann R, Huizinga TW, Emery P, Pope J, Massarotti EM, et al. Efficacy and safety of certolizumab pegol in a broad population of patients with active rheumatoid arthritis: results from the REALISTIC phase IIIb study. Rheumatology (Oxford) 2012;51:2204-14. 2971510
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 2204-2214
    • Weinblatt, M.E.1    Fleischmann, R.2    Huizinga, T.W.3    Emery, P.4    Pope, J.5    Massarotti, E.M.6
  • 57
    • 84946829699 scopus 로고    scopus 로고
    • Twenty-eight-week results from the REALISTIC phase IIIb randomized trial: efficacy, safety and predictability of response to certolizumab pegol in a diverse rheumatoid arthritis population
    • 6669737
    • Weinblatt ME, Fleischmann R, Van Vollenhoven RF, Emery P, Huizinga TW, Cutolo M, et al. Twenty-eight-week results from the REALISTIC phase IIIb randomized trial: efficacy, safety and predictability of response to certolizumab pegol in a diverse rheumatoid arthritis population. Arthritis Research & Therapy 2015;17:325. [DOI: 10.1186/s13075-015-0841-9]6669737
    • (2015) Arthritis Research & Therapy , vol.17 , pp. 325
    • Weinblatt, M.E.1    Fleischmann, R.2    Van Vollenhoven, R.F.3    Emery, P.4    Huizinga, T.W.5    Cutolo, M.6
  • 58
    • 85029158124 scopus 로고    scopus 로고
    • Efficacy confirmation trial of CDP870 without coadministration of methotrexate (MTX) in Japanese rheumatoid arthritis (RA)
    • (first received 14 November 2008). 2971460
    • NCT00791921. Efficacy confirmation trial of CDP870 without coadministration of methotrexate (MTX) in Japanese rheumatoid arthritis (RA). clinicaltrials.gov/show/NCT00791921 (first received 14 November 2008). 2971460
  • 59
    • 85029152697 scopus 로고    scopus 로고
    • Long-term treatment study of certolizumab pegol without coadministration of methotrexate in Japanese rheumatoid arthritis (RA) patients
    • (first received 23rd February 2009). 6669738
    • NCT00850343. Long-term treatment study of certolizumab pegol without coadministration of methotrexate in Japanese rheumatoid arthritis (RA) patients. clinicaltrials.gov/ct2/show/NCT00850343?term=NCT00850343&rank=1 (first received 23rd February 2009). 6669738
  • 61
    • 84906303711 scopus 로고    scopus 로고
    • Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients who could not receive methotrexate: 52-week results from an open-label extension of the HIKARI study
    • 6669740
    • Tanaka Y, Yamamoto K, Takeuchi T, Yamanaka H, Ishiguro N, Eguchi K, et al. Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients who could not receive methotrexate: 52-week results from an open-label extension of the HIKARI study. Modern Rheumatology 2013; Vol. 24, issue 5:725-33. [DOI: 10.3109/14397595.2013.865822]6669740
    • (2013) Modern Rheumatology , vol.24 , Issue.5 , pp. 725-733
    • Tanaka, Y.1    Yamamoto, K.2    Takeuchi, T.3    Yamanaka, H.4    Ishiguro, N.5    Eguchi, K.6
  • 62
    • 84897972127 scopus 로고    scopus 로고
    • Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: The HIKARI randomized, placebo-controlled trial
    • 6669741
    • Yamamoto, Kazuhiko, Takeuchi, Tsutomu, Yamanaka, Hisashi, et al. Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: The HIKARI randomized, placebo-controlled trial. Modern Rheumatology 2014;24:552-560. 6669741
    • (2014) Modern Rheumatology , vol.24 , pp. 552-560
    • Yamamoto, K.1    Takeuchi, T.2    Yamanaka, H.3
  • 63
    • 84890547440 scopus 로고    scopus 로고
    • AB0469. Improved physical function, pain, and health related quality of life with certolizumab pegol in Japanese rheumatoid arthritis patients without methotrexate co-administration:results from the Hikari study
    • 2971461
    • Yamanaka H, Yamamoto K, Takeuchi T, Ishiguro N, Tanaka Y, Eguchi K, et al. AB0469. Improved physical function, pain, and health related quality of life with certolizumab pegol in Japanese rheumatoid arthritis patients without methotrexate co-administration:results from the Hikari study. Annals of the Rheumaic Diseases 2013;71 Suppl 3:664. 2971461
    • (2013) Annals of the Rheumaic Diseases , Issue.71 , pp. 664
    • Yamanaka, H.1    Yamamoto, K.2    Takeuchi, T.3    Ishiguro, N.4    Tanaka, Y.5    Eguchi, K.6
  • 64
    • 85029153072 scopus 로고    scopus 로고
    • Certolizumab pegol improved physical function and heath related quality of life in patients with active rheumatoid arthritis who could not be treated with methotrexate: results form HIKARI study
    • 2971462
    • Yamanaka H, Yamamoto K, Takeuchi T, Ishiguro N, Tanaka Y, Eguchi K, et al. Certolizumab pegol improved physical function and heath related quality of life in patients with active rheumatoid arthritis who could not be treated with methotrexate: results form HIKARI study. Modern Rheumatology 2012;22 Suppl ll:S83. 2971462
    • (2012) Modern Rheumatology , Issue.22 , pp. S83
    • Yamanaka, H.1    Yamamoto, K.2    Takeuchi, T.3    Ishiguro, N.4    Tanaka, Y.5    Eguchi, K.6
  • 65
    • 85029144543 scopus 로고    scopus 로고
    • Efficacy confirmation trial of CDP870 as add-on medication to methotrexate (MTX) in Japanese rheumatoid arthritis (RA)
    • (first received 14th November 2008). 2971464
    • NCT00791999. Efficacy confirmation trial of CDP870 as add-on medication to methotrexate (MTX) in Japanese rheumatoid arthritis (RA). clinicaltrials.gov/ct2/show/study/NCT00791999?term=NCT00791999&rank=1 (first received 14th November 2008). 2971464
  • 66
    • 85029160519 scopus 로고    scopus 로고
    • Better clinical responses seen early with the loading dose of certolizumab pegol are maintained until one year
    • Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2014 Paris France. 11 - 14 June 2014. 6669742
    • Takeuchi T, Yamamoto K, Yamanaka H, Ishiguro N, Tanaka Y, Eguchi K, et al. Better clinical responses seen early with the loading dose of certolizumab pegol are maintained until one year. Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2014 Paris France. 11 - 14 June 2014. 2014; Vol. 73. 6669742
    • (2014) , vol.73
    • Takeuchi, T.1    Yamamoto, K.2    Yamanaka, H.3    Ishiguro, N.4    Tanaka, Y.5    Eguchi, K.6
  • 67
    • 84906318255 scopus 로고    scopus 로고
    • Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: 52-week results from an open-label extension of the J-RAPID study
    • 6669743
    • Tanaka Y, Yamamoto K, Takeuchi T, Yamanaka H, Ishiguro N, Eguchi K, et al. Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: 52-week results from an open-label extension of the J-RAPID study. Modern Rheumatology 2014;24(5):734-43. 6669743
    • (2014) Modern Rheumatology , vol.24 , Issue.5 , pp. 734-743
    • Tanaka, Y.1    Yamamoto, K.2    Takeuchi, T.3    Yamanaka, H.4    Ishiguro, N.5    Eguchi, K.6
  • 68
    • 84906324352 scopus 로고    scopus 로고
    • Efficacy and safety of certolizumab pegol plus methotrexate in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: the J-RAPID randomized, placebo-controlled trial
    • 2971465
    • Yamamoto K, Takeuchi T, Yamanaka H, Ishiguro N, Tanaka Y, Eguchi K, et al. Efficacy and safety of certolizumab pegol plus methotrexate in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: the J-RAPID randomized, placebo-controlled trial. Modern Rheumatology 2014;24(5):715-24. [DOI: 10.3109/14397595.2013.864224]2971465
    • (2014) Modern Rheumatology , vol.24 , Issue.5 , pp. 715-724
    • Yamamoto, K.1    Takeuchi, T.2    Yamanaka, H.3    Ishiguro, N.4    Tanaka, Y.5    Eguchi, K.6
  • 69
    • 84890547440 scopus 로고    scopus 로고
    • AB0469 Improved physical function, pain, and health related quality of life with certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: Results from the JRapid study
    • 2971466
    • Yamanaka H, Yamamoto K, Takeuchi T, Ishiguro N, Tanaka Y, Eguchi K, et al. AB0469 Improved physical function, pain, and health related quality of life with certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: Results from the JRapid study. Annals of the Rheumatic Diseases 2013;71 Suppl 3:664. [DOI: 10.1136/annrheumdis-2012-eular.468]2971466
    • (2013) Annals of the Rheumatic Diseases , Issue.71 , pp. 664
    • Yamanaka, H.1    Yamamoto, K.2    Takeuchi, T.3    Ishiguro, N.4    Tanaka, Y.5    Eguchi, K.6
  • 70
    • 85029153072 scopus 로고    scopus 로고
    • Certolizumab pegol improved physical function and heath related quality of life in patients with active Rheumatoid Arthritis despite treatment with methotrexate: results form the JRAPID study
    • 2971467
    • Yamanaka H, Yamamoto K, Takeuchi T, Ishiguro N, Tanaka Y, Eguchi K, et al. Certolizumab pegol improved physical function and heath related quality of life in patients with active Rheumatoid Arthritis despite treatment with methotrexate: results form the JRAPID study. Modern Rheumatology 2012;22 Suppl ll:S83. 2971467
    • (2012) Modern Rheumatology , Issue.22 , pp. S83
    • Yamanaka, H.1    Yamamoto, K.2    Takeuchi, T.3    Ishiguro, N.4    Tanaka, Y.5    Eguchi, K.6
  • 72
    • 84933074076 scopus 로고    scopus 로고
    • MRI assessment of early response to certolizumab pegol in rheumatoid arthritis: a randomised, double-blind, placebo-controlled phase IIIb study applying MRI at weeks 0, 1, 2, 4, 8 and 16
    • 2971473
    • Østergaard M, Jacobsson LTH, Schaufelberger C, Hansen MS, Bijlsma JWJ, Dudek A, et al. MRI assessment of early response to certolizumab pegol in rheumatoid arthritis: a randomised, double-blind, placebo-controlled phase IIIb study applying MRI at weeks 0, 1, 2, 4, 8 and 16. Annals of the Rheumatic Diseases 2015;74(6):1156-63. 2971473
    • (2015) Annals of the Rheumatic Diseases , vol.74 , Issue.6 , pp. 1156-1163
    • Østergaard, M.1    Jacobsson, L.T.H.2    Schaufelberger, C.3    Hansen, M.S.4    Bijlsma, J.W.J.5    Dudek, A.6
  • 73
    • 85029163502 scopus 로고    scopus 로고
    • Long term tolerability and efficacy of a 4-week-administration of certolizumab pegol as monotherapy and combination therapy in rheumatoid arthritis; 5-year-data of an open extension study
    • 2971514
    • Alten R, Fleischmann R, van Vollenhoven R, Vencovsky J, Davies O, Stach C, et al. Long term tolerability and efficacy of a 4-week-administration of certolizumab pegol as monotherapy and combination therapy in rheumatoid arthritis; 5-year-data of an open extension study. Zeitschrift Für Rheumatologie 2013;72:111. 2971514
    • (2013) Zeitschrift Für Rheumatologie , vol.72 , pp. 111
    • Alten, R.1    Fleischmann, R.2    van Vollenhoven, R.3    Vencovsky, J.4    Davies, O.5    Stach, C.6
  • 75
    • 85029159708 scopus 로고    scopus 로고
    • Randomization to patient-reported RAPID3 versus physician-based CDAI tools for prediction of treatment response and assessment of patient-reported outcomes in rheumatoid arthritis patients receiving certolizumab pegol: Results from the predict study
    • Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2014 Paris France. 11 -14 June 2014. 2971544
    • Curtis JR, Churchill M, Kivitz A, Samad A, Gauer L, Coteur G, et al. Randomization to patient-reported RAPID3 versus physician-based CDAI tools for prediction of treatment response and assessment of patient-reported outcomes in rheumatoid arthritis patients receiving certolizumab pegol: Results from the predict study. Annals of the Rheumatic Diseases.Conference: Annual European Congress of Rheumatology of the European League Against Rheumatism, EULAR 2014 Paris France. 11 -14 June 2014. 2014; Vol. 73. 2971544
    • (2014) , vol.73
    • Curtis, J.R.1    Churchill, M.2    Kivitz, A.3    Samad, A.4    Gauer, L.5    Coteur, G.6
  • 76
    • 84948425085 scopus 로고    scopus 로고
    • A randomized trial comparing disease activity measures for the assessment and prediction of response in rheumatoid arthritis patients initiating certolizumab pegol
    • 2971546
    • Curtis JR, Churchill M, Kivitz A, Samad A, Gauer L, Gervitz L, et al. A randomized trial comparing disease activity measures for the assessment and prediction of response in rheumatoid arthritis patients initiating certolizumab pegol. Arthritis & Rheumatology 2015;67(12):3104-12. 2971546
    • (2015) Arthritis & Rheumatology , vol.67 , Issue.12 , pp. 3104-3112
    • Curtis, J.R.1    Churchill, M.2    Kivitz, A.3    Samad, A.4    Gauer, L.5    Gervitz, L.6
  • 77
    • 85029141874 scopus 로고    scopus 로고
    • Improvement in disease activity and the long-term risk of serious infectious events in rheumatoid arthritis patients treated with certolizumab pegol
    • Arthritis and Rheumatology.Conference: American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, ACR/ARHP 2015 San Francisco, CA United States. 6 - 11 November 2015. 2971548
    • Curtis JR, De Longueville M, O'Brien C, Haraoui B. Improvement in disease activity and the long-term risk of serious infectious events in rheumatoid arthritis patients treated with certolizumab pegol. Arthritis and Rheumatology.Conference: American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting, ACR/ARHP 2015 San Francisco, CA United States. 6 - 11 November 2015. 2015; Vol. 67. 2971548
    • (2015) , vol.67
    • Curtis, J.R.1    De Longueville, M.2    O'Brien, C.3    Haraoui, B.4
  • 79
    • 85029181433 scopus 로고    scopus 로고
    • Dosing flexibility study in patients with rheumatoid arthritis (DoseFlex)
    • (first received 21st December 2007). 2971552
    • NCT00580840. Dosing flexibility study in patients with rheumatoid arthritis (DoseFlex). clinicaltrials.gov/ct2/show/results/NCT00580840 (first received 21st December 2007). 2971552
  • 80
    • 85029188314 scopus 로고    scopus 로고
    • Long-term safety and efficacy of 4-weekly certolizumab pegol monotherapy and combination therapy in rheumatoid arthritis: 5-year results from an open-label extension study
    • 2971561
    • Fleischmann R, Van Vollenhoven R, Vencovsky J, Alten R, Davies O, Stach C, et al. Long-term safety and efficacy of 4-weekly certolizumab pegol monotherapy and combination therapy in rheumatoid arthritis: 5-year results from an open-label extension study. Annals of the Rheumatic Diseases 2013;72:435. 2971561
    • (2013) Annals of the Rheumatic Diseases , vol.72 , pp. 435
    • Fleischmann, R.1    Van Vollenhoven, R.2    Vencovsky, J.3    Alten, R.4    Davies, O.5    Stach, C.6
  • 81
    • 84900800432 scopus 로고    scopus 로고
    • Long-term benefits over more than 4 years of certolizumab pegol combination therapy on workplace and household productivity, and participation in social activities in rheumatoid arthritis: Results from the open-label extension study
    • 2971587
    • Kavanaugh A, Smolen JS, Emery P, Keystone E, Strand V, Purcaru O, et al. Long-term benefits over more than 4 years of certolizumab pegol combination therapy on workplace and household productivity, and participation in social activities in rheumatoid arthritis: Results from the open-label extension study. Value in Health 2013;16:A570. 2971587
    • (2013) Value in Health , vol.16 , pp. A570
    • Kavanaugh, A.1    Smolen, J.S.2    Emery, P.3    Keystone, E.4    Strand, V.5    Purcaru, O.6
  • 82
    • 85029173568 scopus 로고    scopus 로고
    • PMS66 - Effect of certolizumab pegol on workplace And household productivity In United States patients with rheumatoid arthritis with or without prior anti-Tnf exposure: results from the Predict study
    • 2971589
    • Kavanaugh A, Mease PJ, Strand V, Purcaru O, Curtis JR. PMS66 - Effect of certolizumab pegol on workplace And household productivity In United States patients with rheumatoid arthritis with or without prior anti-Tnf exposure: results from the Predict study. Value in Health 2014;17(3):A53. 2971589
    • (2014) Value in Health , vol.17 , Issue.3 , pp. A53
    • Kavanaugh, A.1    Mease, P.J.2    Strand, V.3    Purcaru, O.4    Curtis, J.R.5
  • 83
    • 84897452311 scopus 로고    scopus 로고
    • Vaccine responses in patients with rheumatoid arthritis treated with certolizumab pegol: results from a single-blind randomized phase IV trial
    • 2971599
    • Kivitz AJ, Schechtman J, Texter M, Fichtner A, De Longueville M, Chartash EK. Vaccine responses in patients with rheumatoid arthritis treated with certolizumab pegol: results from a single-blind randomized phase IV trial. Journal of Rheumatology 2014;41(4):648-57. 2971599
    • (2014) Journal of Rheumatology , vol.41 , Issue.4 , pp. 648-657
    • Kivitz, A.J.1    Schechtman, J.2    Texter, M.3    Fichtner, A.4    De Longueville, M.5    Chartash, E.K.6
  • 84
    • 85029187355 scopus 로고    scopus 로고
    • A study of the safety and effectiveness of liquid certolizumab pegol in the treatment of signs and symptoms of rheumatoid arthritis and in prevention of joint damage in patients with active rheumatoid arthritis
    • (first received 8th September 2005). 2971623
    • NCT00160641. A study of the safety and effectiveness of liquid certolizumab pegol in the treatment of signs and symptoms of rheumatoid arthritis and in prevention of joint damage in patients with active rheumatoid arthritis. clinicaltrials.gov/ct2/show/NCT00160641?term=NCT00160641&rank=1 (first received 8th September 2005). 2971623
  • 85
    • 85029152514 scopus 로고    scopus 로고
    • Open label long-term safety study of certolizumab pegol (CZP) for patients with rheumatoid arthritis
    • (first received 6th September 2005). 2971625
    • NCT00160693. Open label long-term safety study of certolizumab pegol (CZP) for patients with rheumatoid arthritis. clinicaltrials.gov/ct2/show/NCT00160693 (first received 6th September 2005). 2971625
  • 86
    • 85029165589 scopus 로고    scopus 로고
    • Open label extension for patients coming from the dosing flexibility study in patients with rheumatoid arthritis (RA) (Dose Flex II)
    • (first received 5th June 2008). 2971631
    • NCT00753454. Open label extension for patients coming from the dosing flexibility study in patients with rheumatoid arthritis (RA) (Dose Flex II). clinicaltrials.gov/ct2/show/NCT00753454?term=NCT00753454&rank=1 (first received 5th June 2008). 2971631
  • 87
    • 85029166457 scopus 로고    scopus 로고
    • Follow-up of rheumatoid arthritis (RA) moderate to low disease activity study (CERTAIN 2)
    • (first received 5th January 2009). 2971633
    • NCT00843778. Follow-up of rheumatoid arthritis (RA) moderate to low disease activity study (CERTAIN 2). clinicaltrials.gov/ct2/show/NCT00843778?term=NCT00843778&rank=1 (first received 5th January 2009). 2971633
  • 88
    • 85029178828 scopus 로고    scopus 로고
    • Long-term treatment study of certolizumab pegol (CDP870) as add-on medication to methotrexate in Japanese rheumatoid arthritis (RA) Patients
    • (first received 23rd February 2009). 2971639
    • NCT00851318. Long-term treatment study of certolizumab pegol (CDP870) as add-on medication to methotrexate in Japanese rheumatoid arthritis (RA) Patients. clinicaltrials.gov/ct2/show/NCT00851318?term=certolizumab+and+arthritis&lup_s=01%2F01%2F2013&lup_e=03%2F01%2F2016&rank=11 (first received 23rd February 2009). 2971639
  • 89
    • 85029184095 scopus 로고    scopus 로고
    • Assessing the use of certolizumab pegol in adult subjects with rheumatoid arthritis on the antibody response when receiving influenza virus and pneumococcal vaccines
    • (first received 9th October 2009). 2971641
    • NCT00993668. Assessing the use of certolizumab pegol in adult subjects with rheumatoid arthritis on the antibody response when receiving influenza virus and pneumococcal vaccines. clinicaltrials.gov/ct2/show/results/NCT00993668?term=NCT00993668&rank=1 (first received 9th October 2009). 2971641
  • 90
    • 85029179699 scopus 로고    scopus 로고
    • Open-label, extension study of CDP870 in patients with rheumatoid arthritis
    • (first received 17th March 2010). 2971649
    • NCT01197066. Open-label, extension study of CDP870 in patients with rheumatoid arthritis. clinicaltrials.gov/ct2/show/NCT01197066? (first received 17th March 2010). 2971649
  • 91
    • 85029162898 scopus 로고    scopus 로고
    • A comparison of two assessment tools in predicting treatment success of cimzia in rheumatoid arthritis subjects (PREDICT)
    • (first received 6th December 2010). 6669744
    • NCT01255761. A comparison of two assessment tools in predicting treatment success of cimzia in rheumatoid arthritis subjects (PREDICT). clinicaltrials.gov/ct2/show/NCT01255761?term=NCT01255761&rank=1 (first received 6th December 2010). 6669744
  • 92
    • 85029172647 scopus 로고    scopus 로고
    • A 12 week study to assess changes in joint inflammation using ultrasonography in patients with rheumatoid arthritis (RA)
    • (first received 7th February 2011). 2971655
    • NCT01292265. A 12 week study to assess changes in joint inflammation using ultrasonography in patients with rheumatoid arthritis (RA). clinicaltrials.gov/ct2/show/NCT01292265?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=25 (first received 7th February 2011). 2971655
  • 93
    • 85029178027 scopus 로고    scopus 로고
    • Rheumatoid arthritis treatment and biopsy study assessing certolizumab pegol (Cimzia)
    • (first received 14th June 2011). 2971657
    • NCT01374971. Rheumatoid arthritis treatment and biopsy study assessing certolizumab pegol (Cimzia). clinicaltrials.gov/ct2/show/results/NCT01374971?term=NCT01374971&rank=1 (first received 14th June 2011). 2971657
  • 94
    • 85029178818 scopus 로고    scopus 로고
    • Open label study to assess the predictability of early response to certolizumab pegol in patients with rheumatoid arthritis (SPEED)
    • (first received 27th September 2011). 2971659
    • NCT01443364. Open label study to assess the predictability of early response to certolizumab pegol in patients with rheumatoid arthritis (SPEED). clinicaltrials.gov/ct2/show/NCT01443364?term=certolizumab+and+arthritis&lup_s=01%2F01%2F2013&lup_e=03%2F01%2F2016&rank=13 (first received 27th September 2011). 2971659
  • 95
    • 85029184362 scopus 로고    scopus 로고
    • Health-related quality of life and patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol
    • (first received 1st February 2012). 2971661
    • NCT01526434. Health-related quality of life and patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol. clinicaltrials.gov/ct2/show/NCT01526434?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=28 (first received 1st February 2012). 2971661
  • 96
    • 85029179777 scopus 로고    scopus 로고
    • An open-label extension study of certolizumab pegol in Chinese patients with rheumatoid arthritis who enrolled in RA0044 (RAPID-C OLE)
    • (first received 15th December 2014). 2971669
    • NCT02319642. An open-label extension study of certolizumab pegol in Chinese patients with rheumatoid arthritis who enrolled in RA0044 (RAPID-C OLE). clinicaltrials.gov/ct2/show/NCT02319642?term=certolizumab+and+arthritis&lup_s=01%2F01%2F2013&lup_e=03%2F01%2F2016&rank=4 (first received 15th December 2014). 2971669
  • 97
    • 85029188747 scopus 로고    scopus 로고
    • Long-term treatment study of CDP870 self-injection in patients with active rheumatoid arthritis who are participating in the long-term treatment studies (Study 275-08-002 or Study 275-08-004) of CDP870
    • (first received 23rd October 2015). 2971671
    • NCT02586246. Long-term treatment study of CDP870 self-injection in patients with active rheumatoid arthritis who are participating in the long-term treatment studies (Study 275-08-002 or Study 275-08-004) of CDP870. clinicaltrials.gov/ct2/show/NCT02586246?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=24 (first received 23rd October 2015). 2971671
  • 98
    • 85029167769 scopus 로고    scopus 로고
    • SWITCH clinical trial for patients with rheumatoid arthritis who have failed an initial TNF-blocking drug (SWITCH)
    • (first received 11th February 2011). 6669745
    • NCT01295151. SWITCH clinical trial for patients with rheumatoid arthritis who have failed an initial TNF-blocking drug (SWITCH). clinicaltrials.gov/ct2/show/NCT01295151 (first received 11th February 2011). 6669745
  • 99
    • 84926650522 scopus 로고    scopus 로고
    • The 'Switch' study protocol: a randomised-controlled trial of switching to an alternative tumour-necrosis factor (TNF)-inhibitor drug or abatacept or rituximab in patients with rheumatoid arthritis who have failed an initial TNF-inhibitor drug
    • 6669746
    • Navarro C, Nuria C, Brown S, Bosworth A, et al. The 'Switch' study protocol: a randomised-controlled trial of switching to an alternative tumour-necrosis factor (TNF)-inhibitor drug or abatacept or rituximab in patients with rheumatoid arthritis who have failed an initial TNF-inhibitor drug. BMC Musculoskeletal Disorders 2014; Vol. 15:452. [DOI: 10.1186/1471-2474-15-452]6669746
    • (2014) BMC Musculoskeletal Disorders , vol.15 , pp. 452
    • Navarro, C.1    Nuria, C.2    Brown, S.3    Bosworth, A.4
  • 100
    • 85029163692 scopus 로고    scopus 로고
    • Cimzia treatment in rheumatoid arthritis: randomizing to stop versus continue disease-modifying anti-rheumatic drug(s)
    • (first received 7th December 2011). 2971723
    • NCT01489384. Cimzia treatment in rheumatoid arthritis: randomizing to stop versus continue disease-modifying anti-rheumatic drug(s). clinicaltrials.gov/ct2/show/NCT01489384?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=45 (first received 7th December 2011). 2971723
  • 101
    • 85029150204 scopus 로고    scopus 로고
    • Active conventional therapy compared to three different biologic treatments in early rheumatoid arthritis with subsequent dose reduction
    • (first received 8th December 2011). 2971725
    • NCT01491815. Active conventional therapy compared to three different biologic treatments in early rheumatoid arthritis with subsequent dose reduction. clinicaltrials.gov/ct2/show/NCT01491815?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=51 (first received 8th December 2011). 2971725
  • 102
    • 85029179629 scopus 로고    scopus 로고
    • Study to assess the short- and long-term efficacy of certolizumab pegol plus methotrexate compared to adalimumab plus methotrexate in subjects with moderate to severe rheumatoid arthritis (RA) inadequately responding to methotrexate
    • (first received 22nd December 2011). 2971727
    • NCT01500278. Study to assess the short- and long-term efficacy of certolizumab pegol plus methotrexate compared to adalimumab plus methotrexate in subjects with moderate to severe rheumatoid arthritis (RA) inadequately responding to methotrexate. clinicaltrials.gov/ct2/show/NCT01500278?term=certolizumab+and+arthritis&lup_s=01%2F01%2F2013&lup_e=03%2F01%2F2016&rank=17 (first received 22nd December 2011). 2971727
  • 103
    • 85029155379 scopus 로고    scopus 로고
    • Ultrasound and withdrawal of biological DMARDs in rheumatoid arthritis
    • (first received 16th May 2012). 2971729
    • NCT01602302. Ultrasound and withdrawal of biological DMARDs in rheumatoid arthritis. clinicaltrials.gov/ct2/show/NCT01602302?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=48 (first received 16th May 2012). 2971729
  • 104
    • 85029154479 scopus 로고    scopus 로고
    • A study of certolizumab pegol as additional therapy in Chinese patients with active rheumatoid arthritis (RAPID-C)
    • (first received 28th May 2014). 2971731
    • NCT02151851. A study of certolizumab pegol as additional therapy in Chinese patients with active rheumatoid arthritis (RAPID-C). clinicaltrials.gov/ct2/show/NCT02151851?term=certolizumab+and+arthritis&lup_s=01%2F01%2F2013&lup_e=03%2F01%2F2016&rank=18 (first received 28th May 2014). 2971731
  • 105
    • 85029187569 scopus 로고    scopus 로고
    • RICE: Remission by Intra-articular Injection Plus Certolizumab
    • (first received 30th October 2014). 2971733
    • NCT02293590. RICE: Remission by Intra-articular Injection Plus Certolizumab. clinicaltrials.gov/ct2/show/NCT02293590?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=50 (first received 30th October 2014). 2971733
  • 106
    • 85029155342 scopus 로고    scopus 로고
    • Multiple dose study of UCB4940 as add-on to certolizumab pegol in subjects with rheumatoid arthritis
    • (first received 27th April 2015). 2971735
    • NCT02430909. Multiple dose study of UCB4940 as add-on to certolizumab pegol in subjects with rheumatoid arthritis. clinicaltrials.gov/ct2/show/NCT02430909?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=34 (first received 27th April 2015). 2971735
  • 107
    • 85029162596 scopus 로고    scopus 로고
    • Dose reduction for early rheumatoid arthritis patients with low disease activity
    • (first received 29th May 2015). 2971737
    • NCT02466581. Dose reduction for early rheumatoid arthritis patients with low disease activity. clinicaltrials.gov/ct2/show/NCT02466581?term=certolizumab+and+arthritis&lup_s=01%2F01%2F0201&lup_e=03%2F01%2F2016&rank=42 (first received 29th May 2015). 2971737
  • 109
  • 110
    • 10744230594 scopus 로고    scopus 로고
    • Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials
    • Bhandari M, Busse JW, Jackowski D, Montori VM, Schünemann H, Sprague S, et al. Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials. Canadian Medical Association Journal 2004;170(4):477-80.
    • (2004) Canadian Medical Association Journal , vol.170 , Issue.4 , pp. 477-480
    • Bhandari, M.1    Busse, J.W.2    Jackowski, D.3    Montori, V.M.4    Schünemann, H.5    Sprague, S.6
  • 112
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006;295(19):2275-85.
    • (2006) JAMA , vol.295 , Issue.19 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 113
    • 55849095891 scopus 로고    scopus 로고
    • Evidence that cytokines play a role in rheumatoid arthritis
    • Brennan FM, McInnes IB. Evidence that cytokines play a role in rheumatoid arthritis. The Journal of Clinical Investigation 2008;118(11):3537-45.
    • (2008) The Journal of Clinical Investigation , vol.118 , Issue.11 , pp. 3537-3545
    • Brennan, F.M.1    McInnes, I.B.2
  • 114
    • 84917738589 scopus 로고    scopus 로고
    • Update on the safety profile of certolizumab pegol in rheumatoid arthritis: an integrated analysis from clinical trials
    • Bykerk VP, Cush J, Winthrop K, Calabrese L, Lortholary O, de Longueville M, et al. Update on the safety profile of certolizumab pegol in rheumatoid arthritis: an integrated analysis from clinical trials. Annals of the Rheumatic Diseases 2015;74(1):96-103. [DOI: 10.1136/annrheumdis-2013-203660]
    • (2015) Annals of the Rheumatic Diseases , vol.74 , Issue.1 , pp. 96-103
    • Bykerk, V.P.1    Cush, J.2    Winthrop, K.3    Calabrese, L.4    Lortholary, O.5    de Longueville, M.6
  • 115
    • 33845482745 scopus 로고    scopus 로고
    • A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness
    • Chen YF, Jobanputra P, Barton P, Jowett S, Bryan S, Clark W, et al. A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness. Health Technology Assessment 2006; Vol. 10, issue 42:1-235.
    • (2006) Health Technology Assessment , vol.10 , Issue.42 , pp. 1-235
    • Chen, Y.F.1    Jobanputra, P.2    Barton, P.3    Jowett, S.4    Bryan, S.5    Clark, W.6
  • 116
    • 84902261143 scopus 로고    scopus 로고
    • The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study
    • Cross M, Smith E, Hoy D, Carmona L, Wolfe F, Vos T, et al. The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study. Annals of the Rheumatic Diseases 2014;73(7):1316-22.
    • (2014) Annals of the Rheumatic Diseases , vol.73 , Issue.7 , pp. 1316-1322
    • Cross, M.1    Smith, E.2    Hoy, D.3    Carmona, L.4    Wolfe, F.5    Vos, T.6
  • 117
    • 0036191292 scopus 로고    scopus 로고
    • Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period
    • Doran MF, Pond GR, Crowson CS, O'Fallon WM, Gabriel SE. Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis and Rheumatism 2002;46:625-31.
    • (2002) Arthritis and Rheumatism , vol.46 , pp. 625-631
    • Doran, M.F.1    Pond, G.R.2    Crowson, C.S.3    O'Fallon, W.M.4    Gabriel, S.E.5
  • 119
    • 85029151881 scopus 로고    scopus 로고
    • Assesment report for Cimzia. Procedure No EMEA/H/C/001037
    • London, 2009 (accessed 4th July 2017):-. [Procedure No.EMEA/H/C/001037]
    • European Medical Agency. Assesment report for Cimzia. Procedure No EMEA/H/C/001037. www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/001037/WC500069735.pdf. London, 2009 (accessed 4th July 2017):1-47. [Procedure No.EMEA/H/C/001037]
  • 120
    • 84959512635 scopus 로고    scopus 로고
    • Does evidence-based practice improve patient outcomes? An analysis of a natural experiment in a Spanish hospital
    • Emparanza JI, Cabello JB, Burls AJE. Does evidence-based practice improve patient outcomes? An analysis of a natural experiment in a Spanish hospital. Journal of Evaluation in Clinical Practice 2015;21(6):1059-65.
    • (2015) Journal of Evaluation in Clinical Practice , vol.21 , Issue.6 , pp. 1059-1065
    • Emparanza, J.I.1    Cabello, J.B.2    Burls, A.J.E.3
  • 121
    • 85029152881 scopus 로고    scopus 로고
    • Postmarket Drug Safety Information for Patients and Providers - Information for Healthcare Professionals: Cimzia (certolizumab pegol), Enbrel (etanercept), Humira (adalimumab), and Remicade (infliximab)
    • (accessed 7 Jul 2014)
    • Center for Drug Evaluation and Research. Postmarket Drug Safety Information for Patients and Providers - Information for Healthcare Professionals: Cimzia (certolizumab pegol), Enbrel (etanercept), Humira (adalimumab), and Remicade (infliximab). www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm124185.htm (accessed 7 Jul 2014).
  • 122
    • 79953752083 scopus 로고    scopus 로고
    • American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials
    • Felson DT, Smolen JS, Wells G, Zhang B, Van Tuyl LHD, Funovits J, et al. American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis and Rheumatism 2011;63(3):573-86.
    • (2011) Arthritis and Rheumatism , vol.63 , Issue.3 , pp. 573-586
    • Felson, D.T.1    Smolen, J.S.2    Wells, G.3    Zhang, B.4    Van Tuyl, L.H.D.5    Funovits, J.6
  • 124
    • 77956812620 scopus 로고    scopus 로고
    • Physical function improvements and relief from fatigue and pain are associated with increased productivity at work and at home in rheumatoid arthritis patients treated with certolizumab pegol
    • Hazes JM, Taylor P, Strand V, Purcaru O, Coteur G, Mease P. Physical function improvements and relief from fatigue and pain are associated with increased productivity at work and at home in rheumatoid arthritis patients treated with certolizumab pegol. Rheumatology (Oxford) 2010;49(10):1900-10.
    • (2010) Rheumatology (Oxford) , vol.49 , Issue.10 , pp. 1900-1910
    • Hazes, J.M.1    Taylor, P.2    Strand, V.3    Purcaru, O.4    Coteur, G.5    Mease, P.6
  • 125
    • 84872417999 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011
    • Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.handbook.cochrane.org.
    • Higgins, J.P.1    Green, S.2
  • 126
    • 84873115118 scopus 로고    scopus 로고
    • A randomised efficacy and discontinuation study of etanercept versus adalimumab (RED SEA) for rheumatoid arthritis: a pragmatic, unblinded, non inferiority study of first TNF inhibitor use: outcomes over 2 years
    • Jobanputra P, Maggs F, Deeming A, Carruthers D, Rankin E, Jordan AC, et al. A randomised efficacy and discontinuation study of etanercept versus adalimumab (RED SEA) for rheumatoid arthritis: a pragmatic, unblinded, non inferiority study of first TNF inhibitor use: outcomes over 2 years. BMJ Open 2012;2(6):e001395.
    • (2012) BMJ Open , vol.2 , Issue.6
    • Jobanputra, P.1    Maggs, F.2    Deeming, A.3    Carruthers, D.4    Rankin, E.5    Jordan, A.C.6
  • 127
    • 84865327391 scopus 로고    scopus 로고
    • Sustained efficacy of certolizumab pegol added to methotrexate in the treatment of rheumatoid arthritis: 2-year results from the RAPID 1 trial
    • Keystone EC, Combe B, Smolen J, Strand V, Goel N, van Vollenhoven R, et al. Sustained efficacy of certolizumab pegol added to methotrexate in the treatment of rheumatoid arthritis: 2-year results from the RAPID 1 trial. Rheumatology (Oxford) 2012;51(9):1628-38.
    • (2012) Rheumatology (Oxford) , vol.51 , Issue.9 , pp. 1628-1638
    • Keystone, E.C.1    Combe, B.2    Smolen, J.3    Strand, V.4    Goel, N.5    van Vollenhoven, R.6
  • 128
    • 84963853701 scopus 로고    scopus 로고
    • Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology
    • Kharlamova N, Jiang X, Sherina N, Potempa B, Israelsson L, Quirke AM, et al. Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology. Arthritis & Rheumatology 2016;68(3):604-13.
    • (2016) Arthritis & Rheumatology , vol.68 , Issue.3 , pp. 604-613
    • Kharlamova, N.1    Jiang, X.2    Sherina, N.3    Potempa, B.4    Israelsson, L.5    Quirke, A.M.6
  • 129
    • 0025612201 scopus 로고
    • Estimating rates of change in randomized clinical trials
    • Laird NM, Wang F. Estimating rates of change in randomized clinical trials. Controlled Clinical Trials 1990;11(6):405-19.
    • (1990) Controlled Clinical Trials , vol.11 , Issue.6 , pp. 405-419
    • Laird, N.M.1    Wang, F.2
  • 130
    • 0023887476 scopus 로고
    • An assessment of clinically useful measures of the consequences of treatment
    • Laupacis A, Sackett DL, Roberts RS. An assessment of clinically useful measures of the consequences of treatment. New England Journal of Medicine 1988;318(26):1728-33.
    • (1988) New England Journal of Medicine , vol.318 , Issue.26 , pp. 1728-1733
    • Laupacis, A.1    Sackett, D.L.2    Roberts, R.S.3
  • 133
    • 84875930018 scopus 로고    scopus 로고
    • Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile
    • Lundberg K, Bengtsson C, Kharlamova N, Reed E, Jiang X, Kallberg H, et al. Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile. Annals of the Rheumatic Diseases 2013;72(5):652-8.
    • (2013) Annals of the Rheumatic Diseases , vol.72 , Issue.5 , pp. 652-658
    • Lundberg, K.1    Bengtsson, C.2    Kharlamova, N.3    Reed, E.4    Jiang, X.5    Kallberg, H.6
  • 134
    • 0034121235 scopus 로고    scopus 로고
    • Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins
    • MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis and Rheumatism 2000;43(1):30-7.
    • (2000) Arthritis and Rheumatism , vol.43 , Issue.1 , pp. 30-37
    • MacGregor, A.J.1    Snieder, H.2    Rigby, A.S.3    Koskenvuo, M.4    Kaprio, J.5    Aho, K.6
  • 135
    • 70350764945 scopus 로고    scopus 로고
    • Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies
    • Meune C, Touze E, Trinquart L, Allanmore Y. Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies. Rheumatology 2009;48:1309-13.
    • (2009) Rheumatology , vol.48 , pp. 1309-1313
    • Meune, C.1    Touze, E.2    Trinquart, L.3    Allanmore, Y.4
  • 136
    • 84875885446 scopus 로고    scopus 로고
    • Newest clinical trial results with antitumor necrosis factor and non antitumor necrosis factor biologics for rheumatoid arthritis
    • Navarro-Millán I, Curtis JR. Newest clinical trial results with antitumor necrosis factor and non antitumor necrosis factor biologics for rheumatoid arthritis. Current Opinion in Rheumatology 2013;25(3):384-90.
    • (2013) Current Opinion in Rheumatology , vol.25 , Issue.3 , pp. 384-390
    • Navarro-Millán, I.1    Curtis, J.R.2
  • 138
    • 85029158108 scopus 로고    scopus 로고
    • Certolizumab pegol (CIMZIA©) for the treatment of rheumatoid arthritis. Single technology appraisal (STA) manufacturer submission to NICE
    • UCB. Certolizumab pegol (CIMZIA©) for the treatment of rheumatoid arthritis. Single technology appraisal (STA) manufacturer submission to NICE. NICE 2009:1-180.
    • (2009) NICE , pp. 1-180
  • 139
    • 84894288992 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014;506(7488):376-81.
    • (2014) Nature , vol.506 , Issue.7488 , pp. 376-381
    • Okada, Y.1    Wu, D.2    Trynka, G.3    Raj, T.4    Terao, C.5    Ikari, K.6
  • 140
    • 19944433899 scopus 로고    scopus 로고
    • Early suppression of disease activity is essential for maintenance of work capacity in patients with recent-onset rheumatoid arthritis: five-year experience from the FIN-RACo trial
    • Puolakka K, Kautiainen H, Möttönen T, Hannonen P, Korpela M, Hakala M, et al. FIN-RACo Trial Group. Early suppression of disease activity is essential for maintenance of work capacity in patients with recent-onset rheumatoid arthritis: five-year experience from the FIN-RACo trial. Arthritis and Rheumatology 2005;52(1):36-4.
    • (2005) Arthritis and Rheumatology , vol.52 , Issue.1 , pp. 36-44
    • Puolakka, K.1    Kautiainen, H.2    Möttönen, T.3    Hannonen, P.4    Korpela, M.5    Hakala, M.6
  • 141
    • 84922387653 scopus 로고    scopus 로고
    • The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis
    • Roubille C, Richer V, Starnino T, McCourt C, McFarlane A, Fleming P, et al. The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis. Annals of the Rheumatic Diseases 2015;74(3):480-9.
    • (2015) Annals of the Rheumatic Diseases , vol.74 , Issue.3 , pp. 480-489
    • Roubille, C.1    Richer, V.2    Starnino, T.3    McCourt, C.4    McFarlane, A.5    Fleming, P.6
  • 145
    • 84859832981 scopus 로고    scopus 로고
    • 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care and Research 2012;64:625-39.
    • (2012) Arthritis Care and Research , vol.64 , pp. 625-639
    • Singh, J.A.1    Furst, D.E.2    Bharat, A.3    Curtis, J.R.4    Kavanaugh, A.F.5    Kremer, J.M.6
  • 146
    • 84937630522 scopus 로고    scopus 로고
    • Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis
    • Singh JA, Cameron C, Noorbaloochi S, Cullis T, Tucker M, Christensen R, et al. Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis. Lancet 2015;386(9990):258-65.
    • (2015) Lancet , vol.386 , Issue.9990 , pp. 258-265
    • Singh, J.A.1    Cameron, C.2    Noorbaloochi, S.3    Cullis, T.4    Tucker, M.5    Christensen, R.6
  • 148
    • 84893772728 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
    • Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Annals of the Rheumatic Diseases 2014;73(3):492-509.
    • (2014) Annals of the Rheumatic Diseases , vol.73 , Issue.3 , pp. 492-509
    • Smolen, J.S.1    Landewé, R.2    Breedveld, F.C.3    Buch, M.4    Burmester, G.5    Dougados, M.6
  • 149
    • 0037231721 scopus 로고    scopus 로고
    • Functional disability in rheumatoid arthritis patients compared with a community population in Finland
    • PUBMED: 12528104]
    • Sokka T, Krishnan E, Hakkinen A, Hannonen P. Functional disability in rheumatoid arthritis patients compared with a community population in Finland. Arthritis and Rheumatism 2003;48(1):59-63. [PUBMED: 12528104]
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.1 , pp. 59-63
    • Sokka, T.1    Krishnan, E.2    Hakkinen, A.3    Hannonen, P.4
  • 150
    • 0033619529 scopus 로고    scopus 로고
    • Explaining heterogeneity in meta-analysis: a comparison of methods
    • Thompson SG, Sharp SJ. Explaining heterogeneity in meta-analysis: a comparison of methods. Statistics in Medicine 1999;18(20):2693-708.
    • (1999) Statistics in Medicine , vol.18 , Issue.20 , pp. 2693-2708
    • Thompson, S.G.1    Sharp, S.J.2
  • 151
    • 84875907505 scopus 로고    scopus 로고
    • Extra-articular rheumatoid arthritis
    • Turesson C. Extra-articular rheumatoid arthritis. Current Opinion in Rheumatology 2013;23(3):360-6.
    • (2013) Current Opinion in Rheumatology , vol.23 , Issue.3 , pp. 360-366
    • Turesson, C.1
  • 152
    • 33646093759 scopus 로고    scopus 로고
    • Developing optimal search strategies for detecting clinically sound treatment studies in EMBASE
    • Wong SS, Wilczynski NL, Haynes RB. Developing optimal search strategies for detecting clinically sound treatment studies in EMBASE. Journal of the Medical Library Association 2006;94(1):41-7.
    • (2006) Journal of the Medical Library Association , vol.94 , Issue.1 , pp. 41-47
    • Wong, S.S.1    Wilczynski, N.L.2    Haynes, R.B.3
  • 153
    • 33646745148 scopus 로고    scopus 로고
    • Optimal CINAHL search strategies for identifying therapy studies and review articles
    • Wong SS, Wilczynski NL, Haynes RB. Optimal CINAHL search strategies for identifying therapy studies and review articles. Journal of Nursing Scholarship 2006;38(2):194-9.
    • (2006) Journal of Nursing Scholarship , vol.38 , Issue.2 , pp. 194-199
    • Wong, S.S.1    Wilczynski, N.L.2    Haynes, R.B.3
  • 154
    • 0141727782 scopus 로고    scopus 로고
    • West Midlands Rheumatology Services and Training Committee. The prevalence of patients with rheumatoid arthritis in the West Midlands fulfilling the BSR criteria for anti-tumour necrosis factor therapy: an out-patient study
    • Yee CS, Filer A, Pace A, Douglas K, Situnayake D, Rowe IF. West Midlands Rheumatology Services and Training Committee. The prevalence of patients with rheumatoid arthritis in the West Midlands fulfilling the BSR criteria for anti-tumour necrosis factor therapy: an out-patient study. Rheumatology (Oxford) 2003;42:856-9.
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 856-859
    • Yee, C.S.1    Filer, A.2    Pace, A.3    Douglas, K.4    Situnayake, D.5    Rowe, I.F.6
  • 155
    • 6744245548 scopus 로고    scopus 로고
    • How does functional disability in early rheumatoid arthritis affect patients and their lives? Results of 5 years of follow-up in 732 patients from the early RA study (ERAS)
    • Young A, Dixey J, Cox N, Davies P, Devlin J, Emery P, et al. How does functional disability in early rheumatoid arthritis affect patients and their lives? Results of 5 years of follow-up in 732 patients from the early RA study (ERAS). Rheumatology 2000;39(6):603-11.
    • (2000) Rheumatology , vol.39 , Issue.6 , pp. 603-611
    • Young, A.1    Dixey, J.2    Cox, N.3    Davies, P.4    Devlin, J.5    Emery, P.6
  • 156
    • 0025737883 scopus 로고
    • Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials
    • Yusuf S, Wittes J, Probstfield J, Tyroler HA. Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials. JAMA 1991;266(1):93-8.
    • (1991) JAMA , vol.266 , Issue.1 , pp. 93-98
    • Yusuf, S.1    Wittes, J.2    Probstfield, J.3    Tyroler, H.A.4
  • 157
    • 84918513170 scopus 로고    scopus 로고
    • The efficacy and safety of certolizumab pegol (CZP) in the treatment of active rheumatoid arthritis (RA): a meta-analysis from nine randomized controlled trials
    • Zhou Q, Zhou Y, Chen H, Wang Z, Tang Z, Liu J. The efficacy and safety of certolizumab pegol (CZP) in the treatment of active rheumatoid arthritis (RA): a meta-analysis from nine randomized controlled trials. International Journal of Clinical and Experimental Medicine 2014;7(11):3870-80.
    • (2014) International Journal of Clinical and Experimental Medicine , vol.7 , Issue.11 , pp. 3870-3880
    • Zhou, Q.1    Zhou, Y.2    Chen, H.3    Wang, Z.4    Tang, Z.5    Liu, J.6


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