The 'Switch' study protocol: A randomised-controlled trial of switching to an alternative tumour-necrosis factor (TNF)-inhibitor drug or abatacept or rituximab in patients with rheumatoid arthritis who have failed an initial TNF-inhibitor drug

BMC Musculoskeletal Disorders

Volumn 15, Issue 1, 2014, Pages

  Navarro Coy, Nuria C ^a,b   Brown, Sarah ^a   Bosworth, Ailsa ^c   Davies, Claire T ^a   Emery, Paul ^a,b   Everett, Colin C ^a   Fernandez, Catherine ^a   Gray, Janine C ^a   Hartley, Suzanne ^a   Hulme, Claire ^a   Keenan, Anne Maree ^a,b   McCabe, Christopher ^d   Redmond, Anthony ^a,b   Reynolds, Catherine ^a   Scott, David ^e   Sharples, Linda D ^a   Pavitt, Sue ^a   Buch, Maya H ^a,b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b CHAPEL ALLERTON HOSPITAL   (United Kingdom)

^c NATIONAL RHEUMATOID ARTHRITIS SOCIETY   (United Kingdom)

^d UNIVERSITY OF ALBERTA   (Canada)

^e UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Abatacept; Biologics; Cost effectiveness; Non responder; Randomised clinical trial; Rheumatoid arthritis; Rituximab; TNF inhibitor

Indexed keywords

ABATACEPT; ADALIMUMAB; CERTOLIZUMAB PEGOL; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; GOLIMUMAB; INFLIXIMAB; RITUXIMAB; TUMOR NECROSIS FACTOR INHIBITOR; ANTIBODY CONJUGATE; ANTIRHEUMATIC AGENT; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR;

ARTICLE; BONE DENSITY; CLASSIFICATION ALGORITHM; COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; DRUG SAFETY; DRUG TREATMENT FAILURE; HUMAN; MULTICENTER STUDY (TOPIC); PERSONALIZED MEDICINE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RHEUMATOID ARTHRITIS; TREATMENT OUTCOME; TREATMENT RESPONSE; UNITED KINGDOM; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; METHODOLOGY; MULTICENTER STUDY; PHASE 4 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT FAILURE;

ABATACEPT; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; HUMANS; IMMUNOCONJUGATES; RESEARCH DESIGN; RITUXIMAB; TREATMENT FAILURE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84926650522     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-15-452     Document Type: Article

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