-318C/T polymorphism of the CTLA-4 gene is an independent risk factor for RBC alloimmunization among sickle cell disease patients

International Journal of Immunogenetics

Volumn 44, Issue 5, 2017, Pages 219-224

  Oliveira, V B ^a   Dezan, M R ^a   Gomes, F C A ^a   Menosi Gualandro, S F ^b   Krieger, J E ^b   Pereira, A C ^b   Marsiglia, J D ^b   Levi, J E ^a   Rocha, V ^b   Mendrone Junior, A ^a   Sabino, E C ^b   Dinardo, C L ^a  

^a FUNDAÇÃO PRÓ SANGUE HEMOCENTRO DE SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

alloimmunization; CTLA 4; polymorphism; sickle cell

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; ALLOANTIBODY; CTLA4 PROTEIN, HUMAN;

ADULT; ALLOIMMUNIZATION; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DNA POLYMORPHISM; ERYTHROCYTE TRANSFUSION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SICKLE CELL ANEMIA; ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; BLOOD; ERYTHROCYTE; GENETIC PREDISPOSITION; GENETICS; IMMUNIZATION; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE;

ADULT; ANEMIA, SICKLE CELL; ANTIGEN-PRESENTING CELLS; AUTOIMMUNE DISEASES; CTLA-4 ANTIGEN; ERYTHROCYTES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMMUNIZATION; ISOANTIBODIES; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; T-LYMPHOCYTES;

EID: 85028956906     PISSN: 17443121     EISSN: 1744313X     Source Type: Journal    
DOI: 10.1111/iji.12334     Document Type: Article

References (24)

1. Bour-Jordan, H., Grogan, J. L., Tang, Q., Auger, J. A., Locksley, R. M., & Bluestone, J. A. (2003). CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nature Immunology, 4, 182–188.
2. Dezan, M. R., Oliveira, V. B., Bianchi, J. V. S., Rodrigues, V., Solano, J. H., Gomes, F. C., … Dinardo, C. L. (2016). Effectiveness of a red cell antigen-matching transfusion protocol in sickle cell disease patients. ISBT Science Series, 11, 132–139.
3. Dezan, M. R., Ribeiro, I. H., Oliveira, V. B., Vieira, J. B., Gomes, F. C., Franco, L. A., … Dinardo, C. L. (2017). RHD and RHCE genotyping by next-generation sequencing is an effective strategy to identify molecular variants within sickle cell disease patients. Blood Cells, Molecules, & Diseases, 65, 8–15.
4. Dinardo, C. L., Ito, G. M., Sampaio, L. R., & Mendrone Junior, A. (2013). Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients. Revista brasileira de hematologia e hemoterapia, 35, 414–416.
5. Fasano, R. M., Booth, G. S., Miles, M., Du, L., Koyama, T., Meier, E. R., & Luban, N. L. (2015). Red blood cell alloimmunization is influenced by recipient inflammatory state at time of transfusion in patients with sickle cell disease. British Journal of Haematology, 168, 291–300.
6. Gilson, C. R., Patel, S. R., & Zimring, J. C. (2012). CTLA4-Ig prevents alloantibody production and BMT rejection in response to platelet transfusions in mice. Transfusion, 52, 2209–2219.
7. Hendrickson, J. E., Desmarets, M., Deshpande, S. S., Chadwick, T. E., Hillyer, C. D., Roback, J. D., & Zimring, J. C. (2006). Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells. Transfusion, 46, 1526–1536.
8. Hendrickson, J. E., Hod, E. A., Perry, J. R., Ghosh, S., Chappa, P., Adisa, O., … Zimring, J. C. (2012). Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease. Transfusion, 52, 231–240.
9. Higgins, J. M., & Sloan, S. R. (2008). Stochastic modeling of human RBC alloimmunization: Evidence for a distinct population of immunologic responders. Blood, 112, 2546–2553.
10. Kumar, N., Kaur, G., Kanga, U., Mehra, N. K., Neolia, S. C., Tandon, N., & Zucman, S. C. (2015). CTLA4+49g allele associates with early onset of type 1 diabetes in north Indians. International Journal of Immunogenetics, 42, 445–452.
11. Nickel, R. S., Hendrickson, J. E., Fasano, R. M., Meyer, E. K., Winkler, A. M., Yee, M. M., … Stowell, S. R. (2016). Impact of red blood cell alloimmunization on sickle cell disease mortality: A case series. Transfusion, 56, 107–114.
12. Noizat-Pirenne, F., Tournamille, C., Bierling, P., Roudot-Thoraval, F., Le Pennec, P. Y., Rouger, P., & Ansart-Pirenne, H. (2006). Relative immunogenicity of Fya and K antigens in a Caucasian population, based on HLA class II restriction analysis. Transfusion, 46, 1328–1333.
13. Park, Y. J., Chung, H. K., Park, D. J., Kim, W. B., Kim, S. W., Koh, J. J., & Cho, B. Y. (2000). Polymorphism in the promoter and exon 1 of the cytotoxic T lymphocyte antigen-4 gene associated with autoimmune thyroid disease in Koreans. Thyroid, 10, 453–459.
14. Rodriguez, S., Gaunt, T. R., & Day, I. N. (2009). Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. American Journal of Epidemiology, 169, 505–514.
15. Rosse, W. F., Gallagher, D., Kinney, T. R., Castro, O., Dosik, H., Moohr, J., … Levy, P. S. (1990). Transfusion and alloimmunization in sickle cell disease. The cooperative study of sickle cell disease. Blood, 76, 1431–1437.
16. Ryder, A. B., Hendrickson, J. E., & Tormey, C. A. (2016). Chronic inflammatory autoimmune disorders are a risk factor for red blood cell alloimmunization. British Journal of Haematology, 174, 483–485.
17. Sippert, E. A., Visentainer, J. E., Alves, H. V., Rodrigues, C., Gilli, S. C., Addas-Carvalho, M., … Castilho, L. (2016). Red blood cell alloimmunization in patients with sickle cell disease: Correlation with HLA and cytokine gene polymorphisms. Transfusion, 57, 379–389.
18. Svahn, J., Capasso, M., Lanciotti, M., Marrone, A., Haupt, R., Bacigalupo, A., … Iolascon, A. (2005). The polymorphisms -318C>T in the promoter and 49A>G in exon 1 of CTLA4 and the risk of aplastic anemia in a Caucasian population. Bone Marrow Transplantation, 35(Suppl 1), S89–S92.
19. Ting, W. H., Chien, M. N., Lo, F. S., Wang, C. H., Huang, C. Y., Lin, C. L., … Lee, Y. J. (2016). Association of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene polymorphisms with autoimmune thyroid disease in children and adults: Case-control study. PLoS One, 11, e0154394.
20. Ueda, H., Howson, J. M., Esposito, L., Heward, J., Snook, H., Chamberlain, G., … Gough, S. C. (2003). Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature, 423, 506–511.
21. Verduin, E. P., Brand, A., van de Watering, L. M., Roelen, D. L., Kanhai, H. H., Doxiadis, I. I., … Schonewille, H. (2016). The HLA-DRB1*15 phenotype is associated with multiple red blood cell and HLA antibody responsiveness. Transfusion, 56, 1849–1856.
22. Vichinsky, E. P. (2012). The prevention and management of alloimmunization in sickle cell disease: The benefit of extended phenotypic matching of red blood cells. Immunohematology, 28, 20–23.
23. Vingert, B., Tamagne, M., Desmarets, M., Pakdaman, S., Elayeb, R., Habibi, A., … Cohen, J. L. (2014). Partial dysfunction of Treg activation in sickle cell disease. American Journal of Hematology, 89, 261–266.
24. Yu, J., Heck, S., & Yazdanbakhsh, K. (2007). Prevention of red cell alloimmunization by CD25 regulatory T cells in mouse models. American Journal of Hematology, 82, 691–696.