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Volumn 2017, Issue , 2017, Pages

New Antihyperglycemic Drugs and Heart Failure: Synopsis of Basic and Clinical Data

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HYPERGLYCEMIC AGENT; METFORMIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; ROSIGLITAZONE; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 85028684244     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2017/1253425     Document Type: Review
Times cited : (10)

References (91)
  • 1
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk ofmyocardial infarction and death fromcardiovascular causes
    • S. E. Nissen and K. Wolski, "Effect of rosiglitazone on the risk ofmyocardial infarction and death fromcardiovascular causes, " The New England Journal ofMedicine, vol. 356, no. 24, pp. 2457-2471, 2007.
    • (2007) The New England Journal OfMedicine , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 2
    • 84857634931 scopus 로고    scopus 로고
    • Impact of FDA guidance for developing diabetes drugs on trial design: From policy to practice
    • M. A. Bethel and H. Sourij, "Impact of FDA guidance for developing diabetes drugs on trial design: From policy to practice, " Current Cardiology Reports, vol. 14, no. 1, pp. 59-69, 2012.
    • (2012) Current Cardiology Reports , vol.14 , Issue.1 , pp. 59-69
    • Bethel, M.A.1    Sourij, H.2
  • 3
    • 84901768284 scopus 로고    scopus 로고
    • Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes
    • R. R. Holman, H. Sourij, and R. M. Califf, "Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes, " The Lancet, vol. 383, no. 9933, pp. 2008-2017, 2014.
    • (2014) The Lancet , vol.383 , Issue.9933 , pp. 2008-2017
    • Holman, R.R.1    Sourij, H.2    Califf, R.M.3
  • 4
    • 43449083224 scopus 로고    scopus 로고
    • Prevention of heart failure: A scientific statement from the American Heart Association Councils on epidemiology and prevention, clinical cardiology, cardiovascular nursing, and high blood pressure research; Quality of Care and Outcomes Research Interdisciplinary Working Group; And Functional Genomics and Translational Biology Interdisciplinary Working Group
    • D. D. Schocken, E. J. Benjamin, G. C. Fonarowet al., "Prevention of heart failure: A scientific statement from the American Heart Association Councils on epidemiology and prevention, clinical cardiology, cardiovascular nursing, and high blood pressure research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group, " Circulation, vol. 117, no. 19, pp. 2544-2565, 2008.
    • (2008) Circulation , vol.117 , Issue.19 , pp. 2544-2565
    • Schocken, D.D.1    Benjamin, E.J.2    Fonarow, G.C.3
  • 5
    • 1442299811 scopus 로고    scopus 로고
    • Heart failure prevalence, incidence, and mortality in the elderly with diabetes
    • A. G. Bertoni, W. G. Hundley, M. W. Massing, D. E. Bonds, G. L. Burke, and D. C. Goff Jr., "Heart failure prevalence, incidence, and mortality in the elderly with diabetes, " Diabetes Care, vol. 27, no. 3, pp. 699-703, 2004.
    • (2004) Diabetes Care , vol.27 , Issue.3 , pp. 699-703
    • Bertoni, A.G.1    Hundley, W.G.2    Massing, M.W.3    Bonds, D.E.4    Burke, G.L.5    Goff, D.C.6
  • 6
    • 84962045933 scopus 로고    scopus 로고
    • Prevalence and coprevalence of comorbidities among patientswith type 2 diabetes mellitus
    • K. Iglay, H. Hannachi, P. J. Howie et al., "Prevalence and coprevalence of comorbidities among patientswith type 2 diabetes mellitus, " Current Medical Research and Opinion, vol. 32, no. 7, pp. 1243-1252, 2016.
    • (2016) Current Medical Research and Opinion , vol.32 , Issue.7 , pp. 1243-1252
    • Iglay, K.1    Hannachi, H.2    Howie, P.J.3
  • 7
    • 0043025552 scopus 로고    scopus 로고
    • Heart failure: The frequent, forgotten, and often fatal complication of diabetes
    • D. S. H. Bell, "Heart failure: The frequent, forgotten, and often fatal complication of diabetes, " Diabetes Care, vol. 26, no. 8, pp. 2433-2441, 2003.
    • (2003) Diabetes Care , vol.26 , Issue.8 , pp. 2433-2441
    • Bell, D.S.H.1
  • 8
    • 0016251063 scopus 로고
    • Role of diabetes in congestive heart failure: The Framinghamstudy
    • W. B. Kannel, M. Hjortland, and W. P. Castelli, "Role of diabetes in congestive heart failure: The Framinghamstudy, " The American Journal of Cardiology, vol. 34, no. 1, pp. 29-34, 1974.
    • (1974) The American Journal of Cardiology , vol.34 , Issue.1 , pp. 29-34
    • Kannel, W.B.1    Hjortland, M.2    Castelli, W.P.3
  • 10
    • 0017759141 scopus 로고
    • Evidence for cardiomyopathy in familial diabetes mellitus
    • T. J. Regan, M. M. Lyons, S. S. Ahmed et al., "Evidence for cardiomyopathy in familial diabetes mellitus, " Journal ofClinical Investigation, vol. 60, no. 4, pp. 884-899, 1977.
    • (1977) Journal OfClinical Investigation , vol.60 , Issue.4 , pp. 884-899
    • Regan, T.J.1    Lyons, M.M.2    Ahmed, S.S.3
  • 11
    • 33746920337 scopus 로고    scopus 로고
    • Advanced glycation end products: Sparking the development of diabetic vascular injury
    • A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, "Advanced glycation end products: sparking the development of diabetic vascular injury, " Circulation, vol. 114, no. 6, pp. 597-605, 2006.
    • (2006) Circulation , vol.114 , Issue.6 , pp. 597-605
    • Goldin, A.1    Beckman, J.A.2    Schmidt, A.M.3    Creager, M.A.4
  • 12
    • 0021671376 scopus 로고
    • Pathomorphologic aspects of muscular tissue in diabetes mellitus
    • V. W. Fischer, H. B. Barner, and L. S. Larose, "Pathomorphologic aspects of muscular tissue in diabetes mellitus, " Human Pathology, vol. 15, no. 12, pp. 1127-1136, 1984.
    • (1984) Human Pathology , vol.15 , Issue.12 , pp. 1127-1136
    • Fischer, V.W.1    Barner, H.B.2    Larose, L.S.3
  • 13
    • 0025148503 scopus 로고
    • Acomparisonof the pathological spectrum of hypertensive, diabetic, and hypertensivediabetic heart disease
    • K. H. VanHoeven andS. M. Factor, "Acomparisonof the pathological spectrum of hypertensive, diabetic, and hypertensivediabetic heart disease, " Circulation, vol. 82, no. 3, pp. 848-855, 1990.
    • (1990) Circulation , vol.82 , Issue.3 , pp. 848-855
    • VanHoeven, K.H.1    Factor, S.M.2
  • 14
    • 0021847795 scopus 로고
    • Quantitative approach to the histopathology of the biopsied right ventricular myocardium in patients with diabetes mellitus
    • S.-I. Nunoda, A. Genda, N. Sugihara, A. Nakayama, S. Mizuno, and R. Takeda, "Quantitative approach to the histopathology of the biopsied right ventricular myocardium in patients with diabetes mellitus, " Heart and Vessels, vol. 1, no. 1, pp. 43-47, 1985.
    • (1985) Heart and Vessels , vol.1 , Issue.1 , pp. 43-47
    • Nunoda, S.-I.1    Genda, A.2    Sugihara, N.3    Nakayama, A.4    Mizuno, S.5    Takeda, R.6
  • 15
    • 10044268430 scopus 로고    scopus 로고
    • Altered cardiac calcium handling in diabetes
    • D. D. Belke and W. H. Dillmann, "Altered cardiac calcium handling in diabetes, " Current Hypertension Reports, vol. 6, no. 6, pp. 424-429, 2004.
    • (2004) Current Hypertension Reports , vol.6 , Issue.6 , pp. 424-429
    • Belke, D.D.1    Dillmann, W.H.2
  • 17
    • 3342967512 scopus 로고    scopus 로고
    • Is the failing heart energy starvedOnusing chemical energy to support cardiac function
    • J. S. Ingwall and R. G. Weiss, "Is the failing heart energy starvedOnusing chemical energy to support cardiac function, " Circulation Research, vol. 95, no. 2, pp. 135-145, 2004.
    • (2004) Circulation Research , vol.95 , Issue.2 , pp. 135-145
    • Ingwall, J.S.1    Weiss, R.G.2
  • 18
    • 19644366915 scopus 로고    scopus 로고
    • Insulin causes [Ca2+]idependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium
    • D. Von Lewinski, S. Bruns, S. Walther, H. Kögler, and B. Pieske, "Insulin causes [Ca2+]idependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium, " Circulation, vol. 111, no. 20, pp. 2588-2595, 2005.
    • (2005) Circulation , vol.111 , Issue.20 , pp. 2588-2595
    • Von Lewinski, D.1    Bruns, S.2    Walther, S.3    Kögler, H.4    Pieske, B.5
  • 19
    • 75149186052 scopus 로고    scopus 로고
    • Functional effects of glucose transporters in human ventricular myocardium
    • D. VonLewinski, R. Gasser, P. P. Rainer et al., "Functional effects of glucose transporters in human ventricular myocardium, " European Journal of Heart Failure, vol. 12, no. 2, pp. 106-113, 2010.
    • (2010) European Journal of Heart Failure , vol.12 , Issue.2 , pp. 106-113
    • VonLewinski, D.1    Gasser, R.2    Rainer, P.P.3
  • 20
    • 77952803960 scopus 로고    scopus 로고
    • Glucosetransporter-mediated positive inotropic effects in human myocardium of diabetic and nondiabetic patients
    • D. von Lewinski, P. P. Rainer, R. Gasser et al., "Glucosetransporter-mediated positive inotropic effects in human myocardium of diabetic and nondiabetic patients, " Metabolism: Clinical and Experimental, vol. 59, no. 7, pp. 1020-1028, 2010.
    • (2010) Metabolism: Clinical and Experimental , vol.59 , Issue.7 , pp. 1020-1028
    • Von Lewinski, D.1    Rainer, P.P.2    Gasser, R.3
  • 21
    • 0008340411 scopus 로고    scopus 로고
    • Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: An open study
    • H.-P. Hermann, B. Pieske, E. Schwarzmüller, J. Keul, H. Just, and G. Hasenfuss, "Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: An open study, " Lancet, vol. 353, no. 9161, pp. 1321-1323, 1999.
    • (1999) Lancet , vol.353 , Issue.9161 , pp. 1321-1323
    • Hermann, H.-P.1    Pieske, B.2    Schwarzmüller, E.3    Keul, J.4    Just, H.5    Hasenfuss, G.6
  • 22
    • 0037080690 scopus 로고    scopus 로고
    • Influence of pyruvate on contractile performance and Ca2+ cycling in isolated failing human myocardium
    • G. Hasenfuss, L. S. Maier, H.-P. Hermann et al., "Influence of pyruvate on contractile performance and Ca2+ cycling in isolated failing human myocardium, " Circulation, vol. 105, no. 2, pp. 194-199, 2002.
    • (2002) Circulation , vol.105 , Issue.2 , pp. 194-199
    • Hasenfuss, G.1    Maier, L.S.2    Hermann, H.-P.3
  • 23
    • 33745894642 scopus 로고    scopus 로고
    • Diabetes in heart failure: Prevalence and impact on outcome in the population
    • A. M. From, C. L. Leibson, F. Bursi et al., "Diabetes in heart failure: prevalence and impact on outcome in the population, " The American Journal of Medicine, vol. 119, no. 7, pp. 591-599, 2006.
    • (2006) The American Journal of Medicine , vol.119 , Issue.7 , pp. 591-599
    • From, A.M.1    Leibson, C.L.2    Bursi, F.3
  • 24
    • 0035810983 scopus 로고    scopus 로고
    • Glycemic control and heart failure among adult patients with diabetes
    • C. Iribarren, A. J. Karter, A. S. Go et al., "Glycemic control and heart failure among adult patients with diabetes, " Circulation, vol. 103, no. 22, pp. 2668-2673, 2001.
    • (2001) Circulation , vol.103 , Issue.22 , pp. 2668-2673
    • Iribarren, C.1    Karter, A.J.2    Go, A.S.3
  • 25
    • 84939457713 scopus 로고    scopus 로고
    • Heart failure, saxagliptin, and diabetes mellitus: Observations from the SAVOR-TIMI 53 randomized trial
    • B. M. Scirica, E. Braunwald, I. Raz et al., "Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial, " Circulation, vol. 132, no. 15, pp. e121-e122, 2015.
    • (2015) Circulation , vol.132 , Issue.15 , pp. e121-e122
    • Scirica, B.M.1    Braunwald, E.2    Raz, I.3
  • 26
    • 84978087025 scopus 로고    scopus 로고
    • Effects of Dipeptidyl Peptidase 4 Inhibitors and Sodium-Glucose Linked coTransporter-2 Inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis
    • G. Savarese, C. D'Amore, M. Federici et al., "Effects of Dipeptidyl Peptidase 4 Inhibitors and Sodium-Glucose Linked coTransporter-2 Inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis, " International Journal of Cardiology, vol. 220, pp. 595-601, 2016.
    • (2016) International Journal of Cardiology , vol.220 , pp. 595-601
    • Savarese, G.1    D'Amore, C.2    Federici, M.3
  • 28
    • 85014665993 scopus 로고    scopus 로고
    • Perspectives on cardiovascular effects of incretin-based drugs: From bedside to bench, return trip
    • M. Luconi, G. Cantini, A. Ceriello, and E. Mannucci, "Perspectives on cardiovascular effects of incretin-based drugs: From bedside to bench, return trip, " International Journal of Cardiology, vol. 241, pp. 302-310, 2017.
    • (2017) International Journal of Cardiology , vol.241 , pp. 302-310
    • Luconi, M.1    Cantini, G.2    Ceriello, A.3    Mannucci, E.4
  • 30
    • 84929057224 scopus 로고    scopus 로고
    • The nonglycemic actions of dipeptidyl peptidase-4 inhibitors
    • N.-H. Kim, T. Yu, and D. H. Lee, "The nonglycemic actions of dipeptidyl peptidase-4 inhibitors, " BioMed Research International, vol. 2014, Article ID 368703, 10 pages, 2014.
    • (2014) BioMed Research International , vol.2014
    • Kim, N.-H.1    Yu, T.2    Lee, D.H.3
  • 31
    • 84930625640 scopus 로고    scopus 로고
    • DPP4 in cardiometabolic disease: Recent insights from the laboratory and clinical trials of DPP4 inhibition
    • J. Zhong, A. Maiseyeu, S. N. Davis, and S. Rajagopalan, "DPP4 in cardiometabolic disease: recent insights from the laboratory and clinical trials of DPP4 inhibition, " Circulation Research, vol. 116, no. 8, pp. 1491-1504, 2015.
    • (2015) Circulation Research , vol.116 , Issue.8 , pp. 1491-1504
    • Zhong, J.1    Maiseyeu, A.2    Davis, S.N.3    Rajagopalan, S.4
  • 32
    • 84879258494 scopus 로고    scopus 로고
    • Cardiovascular pleiotropic actions of DPP-4 inhibitors: A step at the cutting edge in understanding their additional therapeutic potentials
    • P. Balakumar and S. A. Dhanaraj, "Cardiovascular pleiotropic actions of DPP-4 inhibitors: A step at the cutting edge in understanding their additional therapeutic potentials, " Cellular Signalling, vol. 25, no. 9, pp. 1799-1803, 2013.
    • (2013) Cellular Signalling , vol.25 , Issue.9 , pp. 1799-1803
    • Balakumar, P.1    Dhanaraj, S.A.2
  • 33
    • 84961161310 scopus 로고    scopus 로고
    • Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase
    • A. Solini, C. Rossi, E. Duranti, S. Taddei, A. Natali, and A. Virdis, "Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase, " Vascular Pharmacology, vol. 76, pp. 62-71, 2015.
    • (2015) Vascular Pharmacology , vol.76 , pp. 62-71
    • Solini, A.1    Rossi, C.2    Duranti, E.3    Taddei, S.4    Natali, A.5    Virdis, A.6
  • 35
    • 84870053428 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition with saxagliptin enhanced nitric oxide release and reduced blood pressure and sICAM-1 levels in hypertensive rats
    • R. P. Mason, R. F. Jacob, R. Kubant, A. Ciszewski, J. J. Corbalan, and T. Malinski, "Dipeptidyl peptidase-4 inhibition with saxagliptin enhanced nitric oxide release and reduced blood pressure and sICAM-1 levels in hypertensive rats, " Journal of Cardiovascular Pharmacology, vol. 60, no. 5, pp. 467-473, 2012.
    • (2012) Journal of Cardiovascular Pharmacology , vol.60 , Issue.5 , pp. 467-473
    • Mason, R.P.1    Jacob, R.F.2    Kubant, R.3    Ciszewski, A.4    Corbalan, J.J.5    Malinski, T.6
  • 36
    • 84954026149 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition improves cardiac function in experimental myocardial infarction: Role of stromal cell-derived factor-1
    • K. A. Connelly, A. Advani, Y. Zhang et al., "Dipeptidyl peptidase-4 inhibition improves cardiac function in experimental myocardial infarction: role of stromal cell-derived factor-1, " Journal of Diabetes, vol. 8, no. 1, pp. 63-75, 2016.
    • (2016) Journal of Diabetes , vol.8 , Issue.1 , pp. 63-75
    • Connelly, K.A.1    Advani, A.2    Zhang, Y.3
  • 37
    • 84995554939 scopus 로고    scopus 로고
    • Saxagliptin and tadalafil differentially alter cyclic guanosine monophosphate (cGMP) signaling and left ventricular function in aorticbanded mini-swine
    • J. A. Hiemstra, D. I. Lee, K. Chakir et al., "Saxagliptin and tadalafil differentially alter cyclic guanosine monophosphate (cGMP) signaling and left ventricular function in aorticbanded mini-swine, " Journal of the AmericanHeart Association, vol. 5, no. 4, Article IDe003277, 2016.
    • (2016) Journal of the AmericanHeart Association , vol.5 , Issue.4
    • Hiemstra, J.A.1    Lee, D.I.2    Chakir, K.3
  • 38
    • 78650625483 scopus 로고    scopus 로고
    • Role of myocardial viscoelasticity in disturbances of electrical andmechanical activity in calciumoverloaded cardiomyocytes: Mathematicalmodeling
    • L. B. Katsnelson, T. Sulman, O. Solovyova, and V. S. Markhasin, "Role of myocardial viscoelasticity in disturbances of electrical andmechanical activity in calciumoverloaded cardiomyocytes: mathematicalmodeling, " Journal ofTheoretical Biology, vol. 272, pp. 83-95, 2011.
    • (2011) Journal OfTheoretical Biology , vol.272 , pp. 83-95
    • Katsnelson, L.B.1    Sulman, T.2    Solovyova, O.3    Markhasin, V.S.4
  • 39
    • 84978878024 scopus 로고    scopus 로고
    • Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-B/IB system through the activation of AMP-activated protein kinase
    • S.-T. Tang, H. Su, Q. Zhang et al., "Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-B/IB system through the activation of AMP-activated protein kinase, " International Journal ofMolecularMedicine, vol. 37, no. 6, pp. 1558-1566, 2016.
    • (2016) International Journal OfMolecularMedicine , vol.37 , Issue.6 , pp. 1558-1566
    • Tang, S.-T.1    Su, H.2    Zhang, Q.3
  • 40
    • 84883781630 scopus 로고    scopus 로고
    • DPP-4 inhibition attenuates cardiac dysfunction and adverse remodeling following myocardial infarction in rats with experimental diabetes
    • K. A. Connelly, Y. Zhang, A. Advani et al., "DPP-4 inhibition attenuates cardiac dysfunction and adverse remodeling following myocardial infarction in rats with experimental diabetes, " CardiovascularTherapeutics, vol. 31, no. 5, pp. 259-267, 2013.
    • (2013) CardiovascularTherapeutics , vol.31 , Issue.5 , pp. 259-267
    • Connelly, K.A.1    Zhang, Y.2    Advani, A.3
  • 41
    • 84961827085 scopus 로고    scopus 로고
    • Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats
    • T.-M. Lee, W.-T. Chen, and N.-C. Chang, "Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats, " Bioscience Reports, vol. 36, no. 2, Article ID e00307, 2016.
    • (2016) Bioscience Reports , vol.36 , Issue.2
    • Lee, T.-M.1    Chen, W.-T.2    Chang, N.-C.3
  • 42
    • 84944749153 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition attenuates arrhythmias via a protein kinase adependent pathway in infarcted hearts
    • T.-M. Lee, W.-T. Chen, andN.-C. Chang, "Dipeptidyl peptidase-4 inhibition attenuates arrhythmias via a protein kinase adependent pathway in infarcted hearts, " Circulation Journal, vol. 79, no. 11, pp. 2461-2470, 2015.
    • (2015) Circulation Journal , vol.79 , Issue.11 , pp. 2461-2470
    • Lee, T.-M.1    Chen, W.-T.2    Chang, N.-C.3
  • 43
    • 84887202275 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor-sitagliptin modulates calcium dysregulation, inflammation, and PPARs in hypertensive cardiomyocytes
    • T.-I. Lee, Y.-H. Kao, Y.-C. Chen, J.-H. Huang, M.-I. Hsu, and Y.-J. Chen, "The dipeptidyl peptidase-4 inhibitor-sitagliptin modulates calcium dysregulation, inflammation, and PPARs in hypertensive cardiomyocytes, " International Journal of Cardiology, vol. 168, no. 6, pp. 5390-5395, 2013.
    • (2013) International Journal of Cardiology , vol.168 , Issue.6 , pp. 5390-5395
    • Lee, T.-I.1    Kao, Y.-H.2    Chen, Y.-C.3    Huang, J.-H.4    Hsu, M.-I.5    Chen, Y.-J.6
  • 44
    • 85016393901 scopus 로고    scopus 로고
    • Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction
    • G. Esposito, D. Cappetta, R. Russo et al., "Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction, " British Journal of Pharmacology, 2017.
    • (2017) British Journal of Pharmacology
    • Esposito, G.1    Cappetta, D.2    Russo, R.3
  • 45
    • 84958863679 scopus 로고    scopus 로고
    • DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats
    • M. A. Alam, M. R. Hasan Chowdhury, P. Jain, M. A. T. Sagor, and H. M. Reza, "DPP-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2K1C) rats, " Diabetology and Metabolic Syndrome, vol. 7, no. 1, article no. 95, 2015.
    • (2015) Diabetology and Metabolic Syndrome , vol.7 , Issue.1
    • Alam, M.A.1    Hasan Chowdhury, M.R.2    Jain, P.3    Sagor, M.A.T.4    Reza, H.M.5
  • 46
    • 84927933303 scopus 로고    scopus 로고
    • Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4
    • N. Hamdani, A.-S. Hervent, L. Vandekerckhove et al., "Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4, " Cardiovascular Research, vol. 104, no. 3, pp. 423-431, 2014.
    • (2014) Cardiovascular Research , vol.104 , Issue.3 , pp. 423-431
    • Hamdani, N.1    Hervent, A.-S.2    Vandekerckhove, L.3
  • 47
    • 84955239325 scopus 로고    scopus 로고
    • Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly Activated by Cyclic AMP 1/Ras-Related Protein 1 Axis
    • M. Aoyama, H. Kawase, Y. K. Bando, A. Monji, and T. Murohara, "Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly Activated by Cyclic AMP 1/Ras-Related Protein 1 Axis, " Circulation: Heart Failure, vol. 9, no. 1, 2016.
    • (2016) Circulation: Heart Failure , vol.9 , Issue.1
    • Aoyama, M.1    Kawase, H.2    Bando, Y.K.3    Monji, A.4    Murohara, T.5
  • 48
    • 85013728733 scopus 로고    scopus 로고
    • Dipeptidylpeptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice
    • K. Akita, K. Isoda, K. Shimada, and H. Daida, "Dipeptidylpeptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice, " Journal of the American Heart Association, vol. 4, no. 3, Article ID e001469, 2015.
    • (2015) Journal of the American Heart Association , vol.4 , Issue.3
    • Akita, K.1    Isoda, K.2    Shimada, K.3    Daida, H.4
  • 49
    • 84983606976 scopus 로고    scopus 로고
    • Inhibition of DPP-4 by alogliptin improves coronary flow reserve and left ventricular systolic function evaluated by phase contrast cine magnetic resonance imaging in patientswith type 2 diabetes and coronary artery disease
    • S. Kato, K. Fukui, H. Kirigaya et al., "Inhibition of DPP-4 by alogliptin improves coronary flow reserve and left ventricular systolic function evaluated by phase contrast cine magnetic resonance imaging in patientswith type 2 diabetes and coronary artery disease, " International Journal of Cardiology, vol. 223, pp. 770-775, 2016.
    • (2016) International Journal of Cardiology , vol.223 , pp. 770-775
    • Kato, S.1    Fukui, K.2    Kirigaya, H.3
  • 50
    • 80053358548 scopus 로고    scopus 로고
    • Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure
    • M. Yin, H. H. W. Silljé, M. Meissner, W. H. Van Gilst, and R. A. De Boer, "Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure, " Cardiovascular Diabetology, vol. 10, article no. 85, 2011.
    • (2011) Cardiovascular Diabetology , vol.10
    • Yin, M.1    Silljé, H.H.W.2    Meissner, M.3    Van Gilst, W.H.4    De Boer, R.A.5
  • 51
    • 84894488315 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor reduces infarct size and preserves cardiac function via mitochondrial protection in ischaemia-reperfusion rat heart
    • K. Chinda, J. Sanit, S. Chattipakorn, and N. Chattipakorn, "Dipeptidyl peptidase-4 inhibitor reduces infarct size and preserves cardiac function via mitochondrial protection in ischaemia-reperfusion rat heart, " Diabetes and Vascular Disease Research, vol. 11, no. 2, pp. 75-83, 2014.
    • (2014) Diabetes and Vascular Disease Research , vol.11 , Issue.2 , pp. 75-83
    • Chinda, K.1    Sanit, J.2    Chattipakorn, S.3    Chattipakorn, N.4
  • 52
    • 84893704052 scopus 로고    scopus 로고
    • Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats
    • T. Miyoshi, K. Nakamura, M. Yoshida et al., "Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats, " Cardiovascular Diabetology, vol. 13, no. 1, article 43, 2014.
    • (2014) Cardiovascular Diabetology , vol.13 , Issue.1
    • Miyoshi, T.1    Nakamura, K.2    Yoshida, M.3
  • 53
    • 84907588641 scopus 로고    scopus 로고
    • Vildagliptin stimulates endothelial cell network formation and ischemia-induced revascularization via an endothelial nitric-oxide synthasedependent mechanism
    • M. Ishii, R. Shibata, K. Kondo et al., "Vildagliptin stimulates endothelial cell network formation and ischemia-induced revascularization via an endothelial nitric-oxide synthasedependent mechanism, " Journal of Biological Chemistry, vol. 289, no. 39, pp. 27235-27245, 2014.
    • (2014) Journal of Biological Chemistry , vol.289 , Issue.39 , pp. 27235-27245
    • Ishii, M.1    Shibata, R.2    Kondo, K.3
  • 54
    • 84879030222 scopus 로고    scopus 로고
    • Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats
    • N. Apaijai, H. Pintana, S. C. Chattipakorn, andN. Chattipakorn, "Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats, " British Journal of Pharmacology, vol. 169, no. 5, pp. 1048-1057, 2013.
    • (2013) British Journal of Pharmacology , vol.169 , Issue.5 , pp. 1048-1057
    • Apaijai, N.1    Pintana, H.2    Chattipakorn, S.C.3    Chattipakorn, N.4
  • 55
    • 84879324265 scopus 로고    scopus 로고
    • Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male zucker obese rats
    • A. R. Aroor, J. R. Sowers, S. B. Bender et al., "Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male zucker obese rats, " Endocrinology, vol. 154, no. 7, pp. 2501-2513, 2013.
    • (2013) Endocrinology , vol.154 , Issue.7 , pp. 2501-2513
    • Aroor, A.R.1    Sowers, J.R.2    Bender, S.B.3
  • 56
    • 84983751884 scopus 로고    scopus 로고
    • Vascular effects of linagliptin in non-obese diabetic mice are glucose-independent and involve positive modulation of the endothelial nitric oxide synthase (eNOS)/caveolin-1 (CAV-1) pathway
    • V. Vellecco, E. Mitidieri, A. Gargiulo et al., "Vascular effects of linagliptin in non-obese diabetic mice are glucose-independent and involve positive modulation of the endothelial nitric oxide synthase (eNOS)/caveolin-1 (CAV-1) pathway, " Diabetes, Obesity and Metabolism, vol. 18, no. 12, pp. 1236-1243, 2016.
    • (2016) Diabetes, Obesity and Metabolism , vol.18 , Issue.12 , pp. 1236-1243
    • Vellecco, V.1    Mitidieri, E.2    Gargiulo, A.3
  • 57
    • 84989888013 scopus 로고    scopus 로고
    • Effects of linagliptin and liraglutide on glucose-and angiotensin II-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro
    • X.-W. Wang, F.-X. Zhang, F. Yang et al., "Effects of linagliptin and liraglutide on glucose-and angiotensin II-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro, " Acta Pharmacologica Sinica, vol. 37, no. 10, pp. 1349-1358, 2016.
    • (2016) Acta Pharmacologica Sinica , vol.37 , Issue.10 , pp. 1349-1358
    • Wang, X.-W.1    Zhang, F.-X.2    Yang, F.3
  • 58
    • 84948740668 scopus 로고    scopus 로고
    • Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
    • M. A. Pfeffer, B. Claggett, R. Diaz et al., "Lixisenatide in patients with type 2 diabetes and acute coronary syndrome, " The New England Journal of Medicine, vol. 373, no. 23, pp. 2247-2257, 2015.
    • (2015) The New England Journal of Medicine , vol.373 , Issue.23 , pp. 2247-2257
    • Pfeffer, M.A.1    Claggett, B.2    Diaz, R.3
  • 59
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • S. P. Marso, G. H. Daniels, K. B. Frandsen et al., "Liraglutide and cardiovascular outcomes in type 2 diabetes, " New England Journal of Medicine, vol. 375, no. 4, pp. 311-322, 2016.
    • (2016) New England Journal of Medicine , vol.375 , Issue.4 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Frandsen, K.B.3
  • 60
    • 84994813253 scopus 로고    scopus 로고
    • Semaglutide and cardiovascular outcomes in patients with type 2 diabetes
    • S. P. Marso, S. C. Bain, A. Consoli et al., "Semaglutide and cardiovascular outcomes in patients with type 2 diabetes, " New England Journal of Medicine, vol. 375, no. 19, pp. 1834-1844, 2016.
    • (2016) New England Journal of Medicine , vol.375 , Issue.19 , pp. 1834-1844
    • Marso, S.P.1    Bain, S.C.2    Consoli, A.3
  • 61
    • 84977480444 scopus 로고    scopus 로고
    • Rationale and design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) trial
    • R. R. Holman, M. A. Bethel, J. George et al., "Rationale and design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) trial, " American Heart Journal, vol. 174, pp. 103-110, 2016.
    • (2016) American Heart Journal , vol.174 , pp. 103-110
    • Holman, R.R.1    Bethel, M.A.2    George, J.3
  • 62
    • 0023008693 scopus 로고
    • Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
    • S. Mojsov, G. Heinrich, I. B. Wilson, M. Ravazzola, L. Orci, and J. F. Habener, "Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing, " Journal of Biological Chemistry, vol. 261, no. 25, pp. 11880-11889, 1986.
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.25 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3    Ravazzola, M.4    Orci, L.5    Habener, J.F.6
  • 63
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • T. J. Kieffer, C. H. S. McIntosh, and R. A. Pederson, "Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV, " Endocrinology, vol. 136, no. 8, pp. 3585-3596, 1995.
    • (1995) Endocrinology , vol.136 , Issue.8 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.S.2    Pederson, R.A.3
  • 64
    • 0031789874 scopus 로고    scopus 로고
    • Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: Implications for basal intracellular cyclic adenosine 3, 5-monophosphate levels and-cell glucose competence
    • V. Serre, W. Dolci, E. Schaerer et al., "Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: Implications for basal intracellular cyclic adenosine 3, 5-monophosphate levels and-cell glucose competence, " Endocrinology, vol. 139, no. 11, pp. 4448-4454, 1998.
    • (1998) Endocrinology , vol.139 , Issue.11 , pp. 4448-4454
    • Serre, V.1    Dolci, W.2    Schaerer, E.3
  • 65
    • 84870054636 scopus 로고    scopus 로고
    • GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
    • J. J. Meier, "GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus, " Nature Reviews Endocrinology, vol. 8, no. 12, pp. 728-742, 2012.
    • (2012) Nature Reviews Endocrinology , vol.8 , Issue.12 , pp. 728-742
    • Meier, J.J.1
  • 66
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • D. J. Drucker and M. A. Nauck, "The incretin system: glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes, " The Lancet, vol. 368, no. 9548, pp. 1696-1705, 2006.
    • (2006) The Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 67
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • L. A. Nikolaidis, S. Mankad, G. G. Sokos et al., "Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion, " Circulation, vol. 109, no. 8, pp. 962-965, 2004.
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3
  • 68
    • 77954948794 scopus 로고    scopus 로고
    • Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes
    • J. Koska, E. A. Schwartz, M. P. Mullin, D. C. Schwenke, and P. D. Reaven, "Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes, " Diabetes Care, vol. 33, no. 5, pp. 1028-1030, 2010.
    • (2010) Diabetes Care , vol.33 , Issue.5 , pp. 1028-1030
    • Koska, J.1    Schwartz, E.A.2    Mullin, M.P.3    Schwenke, D.C.4    Reaven, P.D.5
  • 69
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    • J. Lonborg, N. Vejlstrup, H. Kelbæk et al., "Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction, " European Heart Journal, vol. 33, no. 12, pp. 1491-1499, 2012.
    • (2012) European Heart Journal , vol.33 , Issue.12 , pp. 1491-1499
    • Lonborg, J.1    Vejlstrup, N.2    Kelbæk, H.3
  • 70
    • 84920778263 scopus 로고    scopus 로고
    • Selective targeting of glucagon-like peptide-1 signalling as a novel therapeutic approach for cardiovascular disease in diabetes
    • M. Tate, A. Chong, E. Robinson, B. D. Green, and D. J. Grieve, "Selective targeting of glucagon-like peptide-1 signalling as a novel therapeutic approach for cardiovascular disease in diabetes, " British Journal of Pharmacology, vol. 172, no. 3, pp. 721-736, 2015.
    • (2015) British Journal of Pharmacology , vol.172 , Issue.3 , pp. 721-736
    • Tate, M.1    Chong, A.2    Robinson, E.3    Green, B.D.4    Grieve, D.J.5
  • 71
    • 84877317750 scopus 로고    scopus 로고
    • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    • M. Kim, M. J. Platt, T. Shibasaki et al., "GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure, " Nature Medicine, vol. 19, no. 5, pp. 567-575, 2013.
    • (2013) Nature Medicine , vol.19 , Issue.5 , pp. 567-575
    • Kim, M.1    Platt, M.J.2    Shibasaki, T.3
  • 72
    • 84897883235 scopus 로고    scopus 로고
    • Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model
    • P. Richards, H. E. Parker, A. E. Adriaenssens et al., "Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model, " Diabetes, vol. 63, no. 4, pp. 1224-1233, 2014.
    • (2014) Diabetes , vol.63 , Issue.4 , pp. 1224-1233
    • Richards, P.1    Parker, H.E.2    Adriaenssens, A.E.3
  • 73
    • 84875299548 scopus 로고    scopus 로고
    • Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies
    • P. Wohlfart, W. Linz, T. Hübschle et al., "Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies, " Journal of Translational Medicine, vol. 11, no. 1, article no. 84, 2013.
    • (2013) Journal of Translational Medicine , vol.11 , Issue.1
    • Wohlfart, P.1    Linz, W.2    Hübschle, T.3
  • 74
    • 84952655093 scopus 로고    scopus 로고
    • Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in humanmyocardium
    • M. Wallner, E. Kolesnik, K. Ablasser et al., "Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in humanmyocardium, " Journal of Molecular and Cellular Cardiology, vol. 89, pp. 365-375, 2015.
    • (2015) Journal of Molecular and Cellular Cardiology , vol.89 , pp. 365-375
    • Wallner, M.1    Kolesnik, E.2    Ablasser, K.3
  • 75
    • 33751241720 scopus 로고    scopus 로고
    • Epac proteins: Multi-purpose cAMP targets
    • J. L. Bos, "Epac proteins: multi-purpose cAMP targets, " Trends in Biochemical Sciences, vol. 31, no. 12, pp. 680-686, 2006.
    • (2006) Trends in Biochemical Sciences , vol.31 , Issue.12 , pp. 680-686
    • Bos, J.L.1
  • 77
    • 0029057061 scopus 로고
    • Phosphorylation and desensitization of the human 1-adrenergic receptor: Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase
    • N. J. Freedman, S. B. Liggett, D. E. Drachman, G. Pei, M. G. Caron, and R. J. Lefkowitz, "Phosphorylation and desensitization of the human 1-adrenergic receptor: Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase, " Journal of Biological Chemistry, vol. 270, no. 30, pp. 17953-17961, 1995.
    • (1995) Journal of Biological Chemistry , vol.270 , Issue.30 , pp. 17953-17961
    • Freedman, N.J.1    Liggett, S.B.2    Drachman, D.E.3    Pei, G.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 78
    • 77953291767 scopus 로고    scopus 로고
    • Troglitazone stimulates-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor
    • D. G. Tilley, A. D. Nguyen, and H. A. Rockman, "Troglitazone stimulates-arrestin-dependent cardiomyocyte contractility via the angiotensin II type 1A receptor, " Biochemical and Biophysical Research Communications, vol. 396, no. 4, pp. 921-926, 2010.
    • (2010) Biochemical and Biophysical Research Communications , vol.396 , Issue.4 , pp. 921-926
    • Tilley, D.G.1    Nguyen, A.D.2    Rockman, H.A.3
  • 79
    • 79960355012 scopus 로고    scopus 로고
    • G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function
    • D. G. Tilley, "G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function, " Circulation Research, vol. 109, no. 2, pp. 217-230, 2011.
    • (2011) Circulation Research , vol.109 , Issue.2 , pp. 217-230
    • Tilley, D.G.1
  • 80
    • 77951872871 scopus 로고    scopus 로고
    • Arrestindependent activation of Ca2+/calmodulin kinase II after 1-adrenergic receptor stimulation
    • S. Mangmool, A. K. Shukla, and H. A. Rockman, "-Arrestindependent activation of Ca2+/calmodulin kinase II after 1-adrenergic receptor stimulation, " Journal of Cell Biology, vol. 189, no. 3, pp. 573-587, 2010.
    • (2010) Journal of Cell Biology , vol.189 , Issue.3 , pp. 573-587
    • Mangmool, S.1    Shukla, A.K.2    Rockman, H.A.3
  • 81
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • B. Zinman, C. Wanner, J. M. Lachin et al., "Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes, " TheNew England Journal ofMedicine, vol. 373, no. 22, pp. 2117-2128, 2015.
    • (2015) TheNew England Journal OfMedicine , vol.373 , Issue.22 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 83
    • 84964507777 scopus 로고    scopus 로고
    • SGLT2 Inhibition and cardiovascular events: Why did EMPA-REG Outcomes surprise and what were the likely mechanisms
    • N. Sattar, J. McLaren, S. L. Kristensen, D. Preiss, and J. J. McMurray, "SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms" Diabetologia, vol. 59, no. 7, pp. 1333-1339, 2016.
    • (2016) Diabetologia , vol.59 , Issue.7 , pp. 1333-1339
    • Sattar, N.1    McLaren, J.2    Kristensen, S.L.3    Preiss, D.4    McMurray, J.J.5
  • 84
    • 84975853831 scopus 로고    scopus 로고
    • CV protection in the EMPA-REG OUTCOME trial: A thrifty substrate hypothesis
    • E. Ferrannini, M. Mark, and E. Mayoux, "CV protection in the EMPA-REG OUTCOME trial: A thrifty substrate hypothesis, " Diabetes Care, vol. 39, no. 7, pp. 1108-1114, 2016.
    • (2016) Diabetes Care , vol.39 , Issue.7 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 85
    • 79952721660 scopus 로고    scopus 로고
    • Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members
    • J. Chen, S. Williams, S. Ho et al., "Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members, " DiabetesTherapy, vol. 1, no. 2, pp. 57-92, 2010.
    • (2010) DiabetesTherapy , vol.1 , Issue.2 , pp. 57-92
    • Chen, J.1    Williams, S.2    Ho, S.3
  • 86
    • 84987624200 scopus 로고    scopus 로고
    • The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels
    • S. A. Hawley, R. J. Ford, B. K. Smith et al., "The Na+/glucose cotransporter inhibitor canagliflozin activates AMPK by inhibiting mitochondrial function and increasing cellular AMP levels, " Diabetes, vol. 65, no. 9, pp. 2784-2794, 2016.
    • (2016) Diabetes , vol.65 , Issue.9 , pp. 2784-2794
    • Hawley, S.A.1    Ford, R.J.2    Smith, B.K.3
  • 87
    • 84991712516 scopus 로고    scopus 로고
    • Empagliflozin decreasesmyocardial cytoplasmic Na+ through inhibition of the cardiacNa+/H+ exchanger in rats and rabbits
    • A. Baartscheer, C. A. Schumacher, R. C. I. Wüst et al., "Empagliflozin decreasesmyocardial cytoplasmic Na+ through inhibition of the cardiacNa+/H+ exchanger in rats and rabbits, " Diabetologia, vol. 60, no. 3, pp. 568-573, 2017.
    • (2017) Diabetologia , vol.60 , Issue.3 , pp. 568-573
    • Baartscheer, A.1    Schumacher, C.A.2    Wüst, R.C.I.3
  • 88
    • 85010216514 scopus 로고    scopus 로고
    • Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodentmodel of diabetes
    • J. Habibi, A. R. Aroor, J. R. Sowers et al., "Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodentmodel of diabetes, " Cardiovascular Diabetology, vol. 16, no. 1, 2017.
    • (2017) Cardiovascular Diabetology , vol.16 , Issue.1
    • Habibi, J.1    Aroor, A.R.2    Sowers, J.R.3
  • 89
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group, "Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34), " The Lancet, vol. 352, no. 9131, pp. 854-865, 1998.
    • (1998) The Lancet , vol.352 , Issue.9131 , pp. 854-865
  • 90
    • 78851470539 scopus 로고    scopus 로고
    • Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials
    • C. Lamanna, M. Monami, N. Marchionni, and E. Mannucci, "Effect of metformin on cardiovascular events and mortality: A meta-analysis of randomized clinical trials, " Diabetes, Obesity& Metabolism, vol. 13, no. 3, pp. 221-228, 2011.
    • (2011) Diabetes, Obesity& Metabolism , vol.13 , Issue.3 , pp. 221-228
    • Lamanna, C.1    Monami, M.2    Marchionni, N.3    Mannucci, E.4
  • 91
    • 84983667048 scopus 로고    scopus 로고
    • Randomized trials to evaluate cardiovascular safety of antihyperglycemic medications
    • P. G. Steg and R. Roussel, "Randomized trials to evaluate cardiovascular safety of antihyperglycemic medications, " Circulation, vol. 134, no. 8, pp. 571-573, 2016.
    • (2016) Circulation , vol.134 , Issue.8 , pp. 571-573
    • Steg, P.G.1    Roussel, R.2


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