Vildagliptin stimulates endothelial cell network formation and ischemia-induced revascularization via an endothelial nitric-oxide synthase-dependent mechanism

Journal of Biological Chemistry

Volumn 289, Issue 39, 2014, Pages 27235-27245

  Ishii, Masakazu ^a,c   Shibata, Rei ^a   Kondo, Kazuhisa ^a   Kambara, Takahiro ^a   Shimizu, Yuuki ^a   Tanigawa, Tohru ^b   Bando, Yasuko K ^a   Nishimura, Masahiro ^c   Ouchi, Noriyuki ^a   Murohara, Toyoaki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; BLOOD VESSELS; CELL SIGNALING; CYTOLOGY; HEMODYNAMICS; MAMMALS; MUSCLE; NITRIC OXIDE; PHOSPHORYLATION;

CARDIO-VASCULAR DISEASE; DIPEPTIDYL PEPTIDASE; ENDOTHELIAL NITRIC-OXIDE SYNTHASE (ENOS); GLUCAGON-LIKE PEPTIDE-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; NITRIC-OXIDE SYNTHASE; PROTECTIVE EFFECTS; STIMULATORY EFFECTS;

ENDOTHELIAL CELLS;

ADIPOCYTOKINE; ADIPONECTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; VILDAGLIPTIN; ADAMANTANE; ADIPOQ PROTEIN, HUMAN; ADIPOQ PROTEIN, MOUSE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; NITRILE; NOS3 PROTEIN, HUMAN; NOS3 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYRROLIDINE DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CAPILLARY DENSITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; GLUCOSE BLOOD LEVEL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIA; LEG ISCHEMIA; MOUSE; MUSCLE ISCHEMIA; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVASCULARIZATION; UMBILICAL VEIN ENDOTHELIAL CELL; WILD TYPE; 3T3 CELL LINE; ADIPOCYTE; ANALOGS AND DERIVATIVES; ANIMAL; CELL DIFFERENTIATION; HINDLIMB; KNOCKOUT MOUSE; METABOLISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; VASCULARIZATION;

3T3-L1 CELLS; ADAMANTANE; ADIPOCYTES; ADIPONECTIN; ANIMALS; CELL DIFFERENTIATION; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; GLUCAGON-LIKE PEPTIDE 1; HINDLIMB; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; ISCHEMIA; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; NITRILES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINES; SIGNAL TRANSDUCTION;

EID: 84907588641     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.557835     Document Type: Article

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