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Volumn 15, Issue 3, 2019, Pages 133-139

Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis;Revisión sistemática y metaanálisis de la eficacia y la seguridad de leflunomida y metotrexato en el tratamiento de la artritis reumatoide

Author keywords

Leflunomide; Meta analysis; Methotrexate; Rheumatoid arthritis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; LEFLUNOMIDE; METHOTREXATE; ANTIRHEUMATIC AGENT; GAMMA GLUTAMYLTRANSFERASE; IMMUNOSUPPRESSIVE AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 85028550322     PISSN: 1699258X     EISSN: 18851398     Source Type: Journal    
DOI: 10.1016/j.reuma.2017.07.020     Document Type: Article
Times cited : (57)

References (40)
  • 3
    • 84870288967 scopus 로고    scopus 로고
    • Systematic literature review on economic implications and pharmacoeconomic issues of rheumatoid arthritis
    • Furneri, G., Mantovani, L.G., Belisari, A., Mosca, M., Cristiani, M., Bellelli, S., et al. Systematic literature review on economic implications and pharmacoeconomic issues of rheumatoid arthritis. Clin Exp Rheumatol 73 (2012), S72–S84.
    • (2012) Clin Exp Rheumatol , vol.73 , pp. S72-S84
    • Furneri, G.1    Mantovani, L.G.2    Belisari, A.3    Mosca, M.4    Cristiani, M.5    Bellelli, S.6
  • 4
    • 0035886157 scopus 로고    scopus 로고
    • Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies
    • Lard, L.R., Visser, H., Speyer, I., vander Horst-Bruinsma, I., Zwinderman, A.H., Breedveld, F.C., et al. Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies. Am J Med 111 (2001), 446–451.
    • (2001) Am J Med , vol.111 , pp. 446-451
    • Lard, L.R.1    Visser, H.2    Speyer, I.3    vander Horst-Bruinsma, I.4    Zwinderman, A.H.5    Breedveld, F.C.6
  • 5
    • 84859832981 scopus 로고    scopus 로고
    • 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • Singh, J.A., Furst, D.E., Bharat, A., Curtis, J.R., Kavanaugh, A.F., Kremer, J.M., et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken) 64 (2012), 625–629.
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , pp. 625-629
    • Singh, J.A.1    Furst, D.E.2    Bharat, A.3    Curtis, J.R.4    Kavanaugh, A.F.5    Kremer, J.M.6
  • 6
    • 77953696525 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease modifying antirheumatic drugs
    • Smolen, J., Landewé, R., Breedveld, F., Dougados, M., Emery, P., Gaujoux-Viala, C., et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease modifying antirheumatic drugs. Ann Rheum Dis 69 (2010), 964–975.
    • (2010) Ann Rheum Dis , vol.69 , pp. 964-975
    • Smolen, J.1    Landewé, R.2    Breedveld, F.3    Dougados, M.4    Emery, P.5    Gaujoux-Viala, C.6
  • 8
    • 0142124934 scopus 로고    scopus 로고
    • Methotrexate as the “anchor drug” for the treatment of early rheumatoid arthritis
    • Pincus, T., Yacizi, Y., Sokka, T., Aletaha, D., Smolen, J.S., Methotrexate as the “anchor drug” for the treatment of early rheumatoid arthritis. Clin Exp Rheumatol 21:Suppl. 31 (2003), S179–S185.
    • (2003) Clin Exp Rheumatol , vol.21 , pp. S179-S185
    • Pincus, T.1    Yacizi, Y.2    Sokka, T.3    Aletaha, D.4    Smolen, J.S.5
  • 9
    • 38149057526 scopus 로고    scopus 로고
    • Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis
    • Braun, J., Kästner, P., Flaxenberg, P., Währiwsch, J., Hanke, P., Demary, W., et al. Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis. Arthritis Rheum 58 (2008), 73–81.
    • (2008) Arthritis Rheum , vol.58 , pp. 73-81
    • Braun, J.1    Kästner, P.2    Flaxenberg, P.3    Währiwsch, J.4    Hanke, P.5    Demary, W.6
  • 10
    • 84888358290 scopus 로고    scopus 로고
    • Update on methotrexate as the anchor drug for rheumatoid arthritis
    • Pincus, T., Gibson, K.A., Castrejón, I., Update on methotrexate as the anchor drug for rheumatoid arthritis. Bull Hosp Jt Dis 71:Suppl. 1 (2013), S9–S19.
    • (2013) Bull Hosp Jt Dis , vol.71 , pp. S9-S19
    • Pincus, T.1    Gibson, K.A.2    Castrejón, I.3
  • 11
    • 0037404893 scopus 로고    scopus 로고
    • Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis
    • Hoekstra, M., van Ede, A.E., Haagsma, C.J., van derLaar, M.A., Huizinga, T.W., Kruijsen, M.W., et al. Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis. Ann Rheum Dis 62 (2003), 423–426.
    • (2003) Ann Rheum Dis , vol.62 , pp. 423-426
    • Hoekstra, M.1    van Ede, A.E.2    Haagsma, C.J.3    van derLaar, M.A.4    Huizinga, T.W.5    Kruijsen, M.W.6
  • 12
    • 12344297751 scopus 로고    scopus 로고
    • The treatment of inflammatory arthritis with methotrexate in clinical practice: treatment duration and incidence of adverse reactions
    • Kinder, A.J., Hassell, A.B., Brand, J., Brownfield, A., Grove, M., Shadforth, M.F., The treatment of inflammatory arthritis with methotrexate in clinical practice: treatment duration and incidence of adverse reactions. Rheumatology (Oxford) 44 (2005), 61–66.
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 61-66
    • Kinder, A.J.1    Hassell, A.B.2    Brand, J.3    Brownfield, A.4    Grove, M.5    Shadforth, M.F.6
  • 13
    • 67549107120 scopus 로고    scopus 로고
    • Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research
    • Salliot, C., van der Heijde, D., Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research. Ann Rheum Dis 68 (2009), 1100–1104.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1100-1104
    • Salliot, C.1    van der Heijde, D.2
  • 14
    • 0034955615 scopus 로고    scopus 로고
    • Adverse reactions to disease-modifying anti-rheumatic drugs in clinical practice
    • Grove, M.L., Hassell, A.B., Hay, E.M., Shadforth, M.F., Adverse reactions to disease-modifying anti-rheumatic drugs in clinical practice. QJM 94 (2001), 309–319.
    • (2001) QJM , vol.94 , pp. 309-319
    • Grove, M.L.1    Hassell, A.B.2    Hay, E.M.3    Shadforth, M.F.4
  • 15
    • 84863467614 scopus 로고    scopus 로고
    • My treatment approach to rheumatoid arthritis
    • Davis, J.M., Matteson, E.L., My treatment approach to rheumatoid arthritis. Mayo Clin Proc 87 (2012), 659–673.
    • (2012) Mayo Clin Proc , vol.87 , pp. 659-673
    • Davis, J.M.1    Matteson, E.L.2
  • 16
    • 20444501369 scopus 로고    scopus 로고
    • Is there a rationale to using leflunomide in early rheumatoid arthritis?
    • Dayer, J.M., Cutolo, M., Is there a rationale to using leflunomide in early rheumatoid arthritis?. Clin Exp Rheumatol 23 (2005), 404–412.
    • (2005) Clin Exp Rheumatol , vol.23 , pp. 404-412
    • Dayer, J.M.1    Cutolo, M.2
  • 17
    • 79954989937 scopus 로고    scopus 로고
    • Update 2011: leflunomide in rheumatoid arthritis – strengths and weaknesses
    • Behrens, F., Koehm, M., Burkhardt, H., Update 2011: leflunomide in rheumatoid arthritis – strengths and weaknesses. Curr Opin Rheumatol 23 (2011), 282–287.
    • (2011) Curr Opin Rheumatol , vol.23 , pp. 282-287
    • Behrens, F.1    Koehm, M.2    Burkhardt, H.3
  • 18
    • 79955043176 scopus 로고    scopus 로고
    • Methotrexate versus leflunomide in rheumatoid arthritis: what is new in 2011?
    • Singer, O., Gibofsky, A., Methotrexate versus leflunomide in rheumatoid arthritis: what is new in 2011?. Curr Opin Rheumatol 23 (2011), 288–292.
    • (2011) Curr Opin Rheumatol , vol.23 , pp. 288-292
    • Singer, O.1    Gibofsky, A.2
  • 20
    • 0027238592 scopus 로고
    • The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials
    • Felson, D.T., Anderson, J.J., Boers, M., Bombardier, C., Chernoff, M., Fried, B., et al. The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. Arthritis Rheum 36 (1993), 729–740.
    • (1993) Arthritis Rheum , vol.36 , pp. 729-740
    • Felson, D.T.1    Anderson, J.J.2    Boers, M.3    Bombardier, C.4    Chernoff, M.5    Fried, B.6
  • 21
    • 33749617467 scopus 로고    scopus 로고
    • The perception of rheumatoid arthritis core set measures by rheumatologist. Results of a survey
    • Aletaha, D., Machold, K.P., Nell, V.P.K., Smolen, J.S., The perception of rheumatoid arthritis core set measures by rheumatologist. Results of a survey. Rheumatology (Oxford) 45 (2006), 1133–1139.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1133-1139
    • Aletaha, D.1    Machold, K.P.2    Nell, V.P.K.3    Smolen, J.S.4
  • 22
    • 85100415918 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0
    • The Cochrane Collaboration Available from: [updated March 2011]
    • Higgins, J.P.T., Green, S., Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. 2011, The Cochrane Collaboration Available from: https://www.cochrane-handbook.org [updated March 2011].
    • (2011)
    • Higgins, J.P.T.1    Green, S.2
  • 23
    • 84865780053 scopus 로고    scopus 로고
    • Eficacia de leflunomida 100 mg semanales comparado con dosis bajas de metotrexate en pacientes con artritis reumatoide activa. Estudio clínico doble ciego aleatorizado
    • Jaimes-Hernández, J., Meléndez-Mercado, C.I., Eficacia de leflunomida 100 mg semanales comparado con dosis bajas de metotrexate en pacientes con artritis reumatoide activa. Estudio clínico doble ciego aleatorizado. Reumatol Clin 8 (2012), 243–249.
    • (2012) Reumatol Clin , vol.8 , pp. 243-249
    • Jaimes-Hernández, J.1    Meléndez-Mercado, C.I.2
  • 24
    • 83255164819 scopus 로고    scopus 로고
    • Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients
    • Ishaq, M., Muhammad, J.S., Hameed, K., Mirza, A.I., Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients. Mod Rheumatol 21 (2011), 375–380.
    • (2011) Mod Rheumatol , vol.21 , pp. 375-380
    • Ishaq, M.1    Muhammad, J.S.2    Hameed, K.3    Mirza, A.I.4
  • 25
    • 6744262231 scopus 로고    scopus 로고
    • A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis
    • Emery, P., Breedveld, F.C., Lemmel, E.M., Kaltwasser, J.P., Dawes, P.T., Gömör, B., et al. A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. Rheumatology (Oxford) 39 (2000), 655–665.
    • (2000) Rheumatology (Oxford) , vol.39 , pp. 655-665
    • Emery, P.1    Breedveld, F.C.2    Lemmel, E.M.3    Kaltwasser, J.P.4    Dawes, P.T.5    Gömör, B.6
  • 26
    • 18044400396 scopus 로고    scopus 로고
    • Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group
    • Cohen, S., Cannon, G.W., Schiff, M., Weaver, A., Fox, R., Olsen, N., et al. Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. Arthritis Rheum 44 (2001), 1984–1992.
    • (2001) Arthritis Rheum , vol.44 , pp. 1984-1992
    • Cohen, S.1    Cannon, G.W.2    Schiff, M.3    Weaver, A.4    Fox, R.5    Olsen, N.6
  • 27
    • 0033596065 scopus 로고    scopus 로고
    • Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate
    • Strand, V., Cohen, S., Schiff, M., Weaver, A., Fleischmann, R., Cannon, G., et al. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch Intern Med 159 (1999), 2542–2550.
    • (1999) Arch Intern Med , vol.159 , pp. 2542-2550
    • Strand, V.1    Cohen, S.2    Schiff, M.3    Weaver, A.4    Fleischmann, R.5    Cannon, G.6
  • 28
    • 0008929340 scopus 로고    scopus 로고
    • Efficacy of leflunomide vs placebo vs methotrexate in early and late rheumatoid arthritis
    • Moreland, L.W., Fleischmann, R.M., Strand, V., Efficacy of leflunomide vs placebo vs methotrexate in early and late rheumatoid arthritis. Arthritis Rheum, 41, 1998, S155.
    • (1998) Arthritis Rheum , vol.41 , pp. S155
    • Moreland, L.W.1    Fleischmann, R.M.2    Strand, V.3
  • 29
    • 0033053835 scopus 로고    scopus 로고
    • Efficacy and safety of leflunomide compared with placebo and sulfasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial
    • Smolen, J.S., Kalden, J.R., Scott, D.L., Rozman, B., Kvien, T.K., Larsen, A., et al. Efficacy and safety of leflunomide compared with placebo and sulfasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. Lancet 353 (1999), 259–266.
    • (1999) Lancet , vol.353 , pp. 259-266
    • Smolen, J.S.1    Kalden, J.R.2    Scott, D.L.3    Rozman, B.4    Kvien, T.K.5    Larsen, A.6
  • 30
    • 0033495154 scopus 로고    scopus 로고
    • Function and health-related quality of life: results from a randomized controlled trial of leflunomide versus methotrexate or placebo in patients with active rheumatoid arthritis
    • Strand, V., Tugwell, P., Bombardier, C., Maetzel, A., Crawford, B., Dorrier, C., et al. Function and health-related quality of life: results from a randomized controlled trial of leflunomide versus methotrexate or placebo in patients with active rheumatoid arthritis. Arthritis Rheum 42 (1999), 1870–1878.
    • (1999) Arthritis Rheum , vol.42 , pp. 1870-1878
    • Strand, V.1    Tugwell, P.2    Bombardier, C.3    Maetzel, A.4    Crawford, B.5    Dorrier, C.6
  • 31
    • 0034123087 scopus 로고    scopus 로고
    • Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis
    • Sharp, J.T., Strand, V., Leung, H., Hurley, F., Loew-Friedrich, I., Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 43 (2000), 495–505.
    • (2000) Arthritis Rheum , vol.43 , pp. 495-505
    • Sharp, J.T.1    Strand, V.2    Leung, H.3    Hurley, F.4    Loew-Friedrich, I.5
  • 32
    • 0034039972 scopus 로고    scopus 로고
    • Clinical improvement as reflected in measures of function and health-related quality of life following treatment with leflunomide compared with methotrexate in patients with rheumatoid arthritis: sensitivity and relative efficiency to detect a treatment effect in a twelve-month, placebo-controlled trial
    • Tugwell, P., Wells, G., Strand, V., Maetzel, A., Bombardier, C., Crawford, B., et al. Clinical improvement as reflected in measures of function and health-related quality of life following treatment with leflunomide compared with methotrexate in patients with rheumatoid arthritis: sensitivity and relative efficiency to detect a treatment effect in a twelve-month, placebo-controlled trial. Arthritis Rheum 43 (2000), 506–514.
    • (2000) Arthritis Rheum , vol.43 , pp. 506-514
    • Tugwell, P.1    Wells, G.2    Strand, V.3    Maetzel, A.4    Bombardier, C.5    Crawford, B.6
  • 33
    • 84893772728 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2013 update
    • Smolen, J.S., Landewé, R., Breedveld, F.C., Buch, M., Burmester, G., Dougados, M., et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 73 (2014), 492–509.
    • (2014) Ann Rheum Dis , vol.73 , pp. 492-509
    • Smolen, J.S.1    Landewé, R.2    Breedveld, F.C.3    Buch, M.4    Burmester, G.5    Dougados, M.6
  • 34
    • 84990308669 scopus 로고    scopus 로고
    • Measures of disease activity in rheumatoid arthritis: a clinician's guide
    • Ringold, S., Singer, N.G., Measures of disease activity in rheumatoid arthritis: a clinician's guide. Curr Rheumatol Rev 4 (2008), 259–265.
    • (2008) Curr Rheumatol Rev , vol.4 , pp. 259-265
    • Ringold, S.1    Singer, N.G.2
  • 35
    • 33644812997 scopus 로고    scopus 로고
    • The American College of Rheumatology (ACR) core set and derivative “patient only” indices to assess rheumatoid arthritis
    • Pincus, T., The American College of Rheumatology (ACR) core set and derivative “patient only” indices to assess rheumatoid arthritis. Clin Exp Rheumatol 23:Suppl. 39 (2005), S109–S113.
    • (2005) Clin Exp Rheumatol , vol.23 , pp. S109-S113
    • Pincus, T.1
  • 36
    • 0033635930 scopus 로고    scopus 로고
    • Responsiveness of the core set, response criteria, and utilities in early rheumatoid arthritis
    • Verhoeven, A.C., Boers, M., van der Linden, S., Responsiveness of the core set, response criteria, and utilities in early rheumatoid arthritis. Ann Rheum Dis 59 (2000), 966–974.
    • (2000) Ann Rheum Dis , vol.59 , pp. 966-974
    • Verhoeven, A.C.1    Boers, M.2    van der Linden, S.3
  • 37
    • 34848916744 scopus 로고    scopus 로고
    • Assessment of adherence to and persistence on disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis
    • Grijalva, C., Chung, C.P., Arbogast, P.G., Stein, C.M., Mitchel, E.F., Griffin, M.R., Assessment of adherence to and persistence on disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis. Med Care 45 (2007), S66–S76.
    • (2007) Med Care , vol.45 , pp. S66-S76
    • Grijalva, C.1    Chung, C.P.2    Arbogast, P.G.3    Stein, C.M.4    Mitchel, E.F.5    Griffin, M.R.6
  • 38
    • 0038657686 scopus 로고    scopus 로고
    • Leflunomide for the treatment of rheumatoid arthritis: a systematic review and meta-analysis
    • Osiri, M., Shea, B., Robinson, V., Suárez-Almazor, M., Strand, V., Tugwell, P., Wells, G., Leflunomide for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. J Rheumatol 30 (2003), 1182–1190.
    • (2003) J Rheumatol , vol.30 , pp. 1182-1190
    • Osiri, M.1    Shea, B.2    Robinson, V.3    Suárez-Almazor, M.4    Strand, V.5    Tugwell, P.6    Wells, G.7
  • 40
    • 0034827629 scopus 로고    scopus 로고
    • Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine
    • Scott, D.L., Smolen, J.S., Kalden, J.R., van den Putte, L.B.A., Larsen, A., Kvien, T.K., et al. Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine. Ann Rheum Dis 60 (2001), 913–923.
    • (2001) Ann Rheum Dis , vol.60 , pp. 913-923
    • Scott, D.L.1    Smolen, J.S.2    Kalden, J.R.3    van den Putte, L.B.A.4    Larsen, A.5    Kvien, T.K.6


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