Multiple sclerosis: Serum-derived exosomes express myelin proteins

Multiple Sclerosis Journal

Volumn 24, Issue 4, 2018, Pages 449-458

  Galazka, Grazyna ^a   Mycko, Marcin P ^a   Selmaj, Igor ^a   Raine, Cedric S ^b   Selmaj, Krzysztof W ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

biomarkers; exosome; immunology; Multiple sclerosis; myelin oligodendrocyte glycoprotein

Indexed keywords

MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN PROTEIN; PROTEOLIPID PROTEIN; T LYMPHOCYTE RECEPTOR;

ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; NANOPARTICLE TRACKING ANALYSIS; ORGANELLE SIZE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN CONTENT; PROTEIN EXPRESSION; RELAPSE; WESTERN BLOTTING;

EID: 85028488160     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458517696597     Document Type: Article

References (35)

1. Raine CS. The Dale E. McFarlin memorial lecture: The immunology of the multiple sclerosis lesion. Ann Neurol 1994; 36: S61–S72.
2. Hauser SL., The Charcot Lecture | beating MS: A story of B cells, with twists and turns. Mult Scler 2015; 21: 8–21.
3. Nylander A, Hafler DA., Multiple sclerosis. J Clin Invest 2012; 122: 1180–1188.
4. Hauser SL, Chan JR, Oksenberg JR., Multiple sclerosis: Prospects and promise. Ann Neurol 2013; 74: 317–327.
5. Burns J, Rosenzweig A, Zweiman B. Isolation of myelin basic protein-reactive T-cell lines from normal human blood. Cell Immunol 1983; 481: 4435–4440.
6. Cao Y, Goods BA, Raddassi K. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Sci Transl Med 2015; 7: 287ra74.
7. Goverman JM., Immune tolerance in multiple sclerosis. Immunol Rev 2011; 241: 228–240.
8. Sospedra M, Martin R., Immunology of multiple sclerosis. Ann Rev Immunol 2005; 23: 683–747.
9. Lasser C., Identification and analysis of circulating exosomal microRNA in human body fluids. Methods Mol Biol 2013; 1024: 109–128.
10. Muller L, Hong CS, Stolz DB. Isolation of biologically-active exosomes from human plasma. J Immunol Methods 2014; 411: 56–65.
11. Street JM, Barran PE, Mackay CI. Identification and proteomic profiling of exosomes in human cerebrospinal fluid. J Transl Med 2013; 89: 205–212.
12. Valadi H, Ekstrom K, Bossios A. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9: 654–659.
13. Mathivanan S, Fahner CJ, Reid GE. ExoCarta 2012: Database of exosomal proteins, RNA and lipids. Nucleic Acids Res 2012; 40: D1241–D1244.
14. Corrado C, Raimondo S, Chiesi A. Exosomes as intercellular signaling organelles involved in health and disease: Basic science and clinical applications. Int J Mol Sci 2013; 14: 5338–5366.
15. Pusic AD, Pusic KM, Kraig RP., What are exosomes and how can they be used in multiple sclerosis therapy? Expert Rev Neurother 2014; 14: 353–355.
16. Bobrie A, Colombo M, Raposo G. Exosome secretion: Molecular mechanisms and roles in immune responses. Traffic 2011; 12: 1659–1668.
17. Lublin FD, Reingold SC, Cohen JA. Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology 2014; 83: 278–286.
18. Peterson MF, Otoc N, Sethi JK. Integrated systems for exosome investigation. Methods 2015; 87: 31–45.
19. Helwa I, Cai J, Drewry MD. A Comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents. PLoS ONE 2017; 23: e0170628.
20. Cwiklinska H, Mycko MP, Luvsannorov O. Heat shock protein 70 associations with myelin basic protein and proteolipid protein in multiple sclerosis brains. Int Immunol 2003; 15(2): 241–249.
21. Haqqani AS, Delaney CE, Tremblay TL. Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells. Fluids Barriers CNS 2013; 10: 4.
22. Shi M, Liu C, Cook TJ. Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease. Acta Neuropathol 2014; 128: 639–650.
23. Fabriek BO, Zwemmer JN, Teunissen CE. In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology. J Neuroimmunol 2005; 161: 190–194.
24. Qazi KR, Gehrmann U, Domange Jordö E. Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism. Blood 2009; 113: 2673–2683.
25. Verderio C, Muzio L, Turola E. Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann Neurol 2012; 72: 610–624.
26. Sbai O, Ould-Yahoui A, Ferhat L. Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes. Glia 2010; 58: 344–366.
27. Minagar A, Jy W, Jimenez JJ. Elevated plasma endothelial microparticles in multiple sclerosis. Neurology 2001; 56: 1319–1324.
28. Jimenez J, Jy W, Mauro LM. Elevated endothelial microparticle-monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-beta 1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes. Mult Scler 2005; 11: 310–315.
29. An T, Qin S, Xu Y. Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis. J Extracell Vesicles 2015; 4: 27522.
30. Duijvesz D, Burnum-Johson KE, Gritsenko M. Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. PLos ONE 2013; 8: e82589.
31. Turchinovich A, Weiz L, Langheinz A. Characterization of extracellular circulating microRNA. Nucleic Acids Res 2011; 39: 7223–7233.
32. Xitong D, Xiaorong Z., Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases. Gene 2016; 575: 377–384.
33. Mycko MP, Cichalewska M, Cwiklinska H. miR-155-3p drives the development of autoimmune demyelination by regulation of heat shock protein 40. J Neurosci 2015; 35: 16504–16515.
34. Mycko MP, Cichalewska M, Machlanska A. MicroRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination. Proc Natl Acad Sci USA 2012; 109: E1248–E1257.
35. Gandhi R, Healy B, Gholipour T. Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. Ann Neurol 2013; 73: 729–740