메뉴 건너뛰기




Volumn 17, Issue 9, 2017, Pages 2381-2389

Assessment of Tocilizumab (Anti–Interleukin-6 Receptor Monoclonal) as a Potential Treatment for Chronic Antibody-Mediated Rejection and Transplant Glomerulopathy in HLA-Sensitized Renal Allograft Recipients

Author keywords

alloantibody; clinical research practice; kidney (allograft) function dysfunction; kidney transplantation nephrology; rejection: antibody mediated (ABMR); rejection: chronic; sensitization; translational research science

Indexed keywords

ALLOANTIBODY; HLA ANTIGEN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY; TOCILIZUMAB;

EID: 85028420640     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.14228     Document Type: Article
Times cited : (273)

References (37)
  • 1
    • 34047236016 scopus 로고    scopus 로고
    • Antibody-mediated renal allograft rejection: Diagnosis and pathogenesis
    • Colvin RB. Antibody-mediated renal allograft rejection: Diagnosis and pathogenesis. J Am Soc Nephrol 2007; 18: 1046–1056.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1046-1056
    • Colvin, R.B.1
  • 2
    • 84895061441 scopus 로고    scopus 로고
    • Diagnosis and management of antibody-mediated rejection: Current status and novel approaches
    • Djamali A, Kaufman DB, Ellis TM, Zhong W, Matas A, Samaniego M. Diagnosis and management of antibody-mediated rejection: Current status and novel approaches. Am J Transplant 2014; 14: 255–271.
    • (2014) Am J Transplant , vol.14 , pp. 255-271
    • Djamali, A.1    Kaufman, D.B.2    Ellis, T.M.3    Zhong, W.4    Matas, A.5    Samaniego, M.6
  • 3
    • 9644262465 scopus 로고    scopus 로고
    • Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: Report of the NIH IG02 trial
    • Jordan SC, Tyan D, Stablein D, et al. Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: Report of the NIH IG02 trial. J Am Soc Nephrol 2004; 15: 3256–3262.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3256-3262
    • Jordan, S.C.1    Tyan, D.2    Stablein, D.3
  • 5
    • 79960856720 scopus 로고    scopus 로고
    • Desensitization in HLA-incompatible kidney recipients and survival
    • Montgomery RA, Lonze BE, King KE, et al. Desensitization in HLA-incompatible kidney recipients and survival. N Engl J Med 2011; 365: 318–326.
    • (2011) N Engl J Med , vol.365 , pp. 318-326
    • Montgomery, R.A.1    Lonze, B.E.2    King, K.E.3
  • 6
    • 47549105407 scopus 로고    scopus 로고
    • Rituximab and intravenous immune globulin for desensitization during renal transplantation
    • Vo AA, Lukovsky M, Toyoda M, et al. Rituximab and intravenous immune globulin for desensitization during renal transplantation. N Engl J Med 2008; 359: 242–251.
    • (2008) N Engl J Med , vol.359 , pp. 242-251
    • Vo, A.A.1    Lukovsky, M.2    Toyoda, M.3
  • 7
    • 84877600533 scopus 로고    scopus 로고
    • Efficacy, outcomes, and cost-effectiveness of desensitization using IVIg and rituximab
    • Vo AA, Petrozzino J, Yeung K, et al. Efficacy, outcomes, and cost-effectiveness of desensitization using IVIg and rituximab. Transplantation 2013; 95: 852–858.
    • (2013) Transplantation , vol.95 , pp. 852-858
    • Vo, A.A.1    Petrozzino, J.2    Yeung, K.3
  • 8
    • 84856411838 scopus 로고    scopus 로고
    • Understanding the causes of kidney transplant failure: The dominant role of antibody-mediated rejection and nonadherence
    • Sellarés J, de Freitas DG, Mengel M, et al. Understanding the causes of kidney transplant failure: The dominant role of antibody-mediated rejection and nonadherence. Am J Transplant 2012; 12: 388–399.
    • (2012) Am J Transplant , vol.12 , pp. 388-399
    • Sellarés, J.1    de Freitas, D.G.2    Mengel, M.3
  • 9
    • 84861751725 scopus 로고    scopus 로고
    • The impact of donor-specific anti-HLA antibodies on late kidney allograft failure
    • Loupy A, Hill GS, Jordan SC. The impact of donor-specific anti-HLA antibodies on late kidney allograft failure. Nat Rev Nephrol 2012; 8: 348–357.
    • (2012) Nat Rev Nephrol , vol.8 , pp. 348-357
    • Loupy, A.1    Hill, G.S.2    Jordan, S.C.3
  • 10
    • 33847761900 scopus 로고    scopus 로고
    • Banff ‘05 meeting report: Differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy (‘CAN’)
    • Solez K, Colvin RB, Racusen LC, et al. Banff ‘05 meeting report: Differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy (‘CAN’). Am J Transplant 2007; 7: 518–526.
    • (2007) Am J Transplant , vol.7 , pp. 518-526
    • Solez, K.1    Colvin, R.B.2    Racusen, L.C.3
  • 11
    • 47249158959 scopus 로고    scopus 로고
    • The spectrum of antibody-mediated renal allograft injury: Implications for treatment
    • Gloor J, Cosio F, Lager DJ, Stegall MD. The spectrum of antibody-mediated renal allograft injury: Implications for treatment. Am J Transplant 2008; 8: 1367–1373.
    • (2008) Am J Transplant , vol.8 , pp. 1367-1373
    • Gloor, J.1    Cosio, F.2    Lager, D.J.3    Stegall, M.D.4
  • 12
    • 84872979797 scopus 로고    scopus 로고
    • Antibody-mediated vascular rejection of kidney allografts: A population-based study
    • Lefaucheur C, Loupy A, Vernerey D, et al. Antibody-mediated vascular rejection of kidney allografts: A population-based study. Lancet 2013; 381: 313–319.
    • (2013) Lancet , vol.381 , pp. 313-319
    • Lefaucheur, C.1    Loupy, A.2    Vernerey, D.3
  • 13
    • 77956231885 scopus 로고    scopus 로고
    • Advances in diagnosing and managing antibody-mediated rejection
    • quiz 45-8
    • Jordan SC, Reinsmoen N, Peng A, et al. Advances in diagnosing and managing antibody-mediated rejection. Pediatr Nephrol 2010; 25: 2035–2045; quiz 45-8.
    • (2010) Pediatr Nephrol , vol.25 , pp. 2035-2045
    • Jordan, S.C.1    Reinsmoen, N.2    Peng, A.3
  • 14
    • 84893389755 scopus 로고    scopus 로고
    • Banff 2013 meeting report: Inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions
    • Haas M, Sis B, Racusen LC, et al. Banff 2013 meeting report: Inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant 2014; 14: 272–283.
    • (2014) Am J Transplant , vol.14 , pp. 272-283
    • Haas, M.1    Sis, B.2    Racusen, L.C.3
  • 15
    • 84904617950 scopus 로고    scopus 로고
    • The biology and medical implications of interleukin-6
    • Tanaka T, Kishimoto T. The biology and medical implications of interleukin-6. Cancer Immunol Res 2014; 2: 288–294.
    • (2014) Cancer Immunol Res , vol.2 , pp. 288-294
    • Tanaka, T.1    Kishimoto, T.2
  • 17
    • 84925944179 scopus 로고    scopus 로고
    • Anti-interleukin 6 receptor antibodies attenuate antibody recall responses in a mouse model of allosensitization
    • Kim I, Wu G, Chai NN, Klein AS, Jordan S. Anti-interleukin 6 receptor antibodies attenuate antibody recall responses in a mouse model of allosensitization. Transplantation 2014; 98: 1262–1270.
    • (2014) Transplantation , vol.98 , pp. 1262-1270
    • Kim, I.1    Wu, G.2    Chai, N.N.3    Klein, A.S.4    Jordan, S.5
  • 18
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nat Immunol 2015; 16: 448–457.
    • (2015) Nat Immunol , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 19
    • 84983527075 scopus 로고    scopus 로고
    • Interleukin 6 (IL-6), a cytokine critical to mediation of inflammation, autoimmunity and allograft rejection: Therapeutic implications of IL-6 receptor blockade
    • Jordan SC, Choi J, Kim I, et al. Interleukin 6 (IL-6), a cytokine critical to mediation of inflammation, autoimmunity and allograft rejection: Therapeutic implications of IL-6 receptor blockade. Transplantation 2017; 101: 32–44.
    • (2017) Transplantation , vol.101 , pp. 32-44
    • Jordan, S.C.1    Choi, J.2    Kim, I.3
  • 20
    • 84944108633 scopus 로고    scopus 로고
    • A phase I/II trial of the interleukin-6 receptor-specific humanized monoclonal (tocilizumab) + intravenous immunoglobulin in difficult to desensitize patients
    • Vo AA, Choi J, Kim I, et al. A phase I/II trial of the interleukin-6 receptor-specific humanized monoclonal (tocilizumab) + intravenous immunoglobulin in difficult to desensitize patients. Transplantation 2015; 99: 2356–2363.
    • (2015) Transplantation , vol.99 , pp. 2356-2363
    • Vo, A.A.1    Choi, J.2    Kim, I.3
  • 21
    • 85009502202 scopus 로고    scopus 로고
    • Differences in pathologic features and graft outcomes in antibody-mediated rejection of renal allografts due to persistent/recurrent versus de novo donor-specific antibodies
    • Haas M, Mirocha J, Reinsmoen NL, et al. Differences in pathologic features and graft outcomes in antibody-mediated rejection of renal allografts due to persistent/recurrent versus de novo donor-specific antibodies. Kidney Int 2017; 91: 729–737.
    • (2017) Kidney Int , vol.91 , pp. 729-737
    • Haas, M.1    Mirocha, J.2    Reinsmoen, N.L.3
  • 22
    • 84924588068 scopus 로고    scopus 로고
    • Cutting edge: Circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production
    • Chavele KM, Merry E, Ehrenstein MR. Cutting edge: Circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production. J Immunol 2015; 194: 2482–2485.
    • (2015) J Immunol , vol.194 , pp. 2482-2485
    • Chavele, K.M.1    Merry, E.2    Ehrenstein, M.R.3
  • 23
    • 84869755800 scopus 로고    scopus 로고
    • Targeting interleukin-6: All the way to treat autoimmune and inflammatory diseases
    • Tanaka T, Kishimoto T. Targeting interleukin-6: All the way to treat autoimmune and inflammatory diseases. Int J Biol Sci 2012; 8: 1227–1236.
    • (2012) Int J Biol Sci , vol.8 , pp. 1227-1236
    • Tanaka, T.1    Kishimoto, T.2
  • 24
    • 84922469342 scopus 로고    scopus 로고
    • Therapeutic uses of anti-interleukin-6 receptor antibody
    • Kang S, Tanaka T, Kishimoto T. Therapeutic uses of anti-interleukin-6 receptor antibody. Int Immunol 2015; 27: 21–29.
    • (2015) Int Immunol , vol.27 , pp. 21-29
    • Kang, S.1    Tanaka, T.2    Kishimoto, T.3
  • 25
    • 84855962311 scopus 로고    scopus 로고
    • Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance
    • Zhao X, Boenisch O, Yeung M, et al. Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance. Am J Transplant 2012; 12: 90–101.
    • (2012) Am J Transplant , vol.12 , pp. 90-101
    • Zhao, X.1    Boenisch, O.2    Yeung, M.3
  • 26
    • 84987638132 scopus 로고    scopus 로고
    • Immunological characterization of de novo and recall alloantibody suppression by CTLA4Ig in a mouse model of allosensitization
    • Kim I, Wu G, Chai NN, Klein AS, Jordan SC. Immunological characterization of de novo and recall alloantibody suppression by CTLA4Ig in a mouse model of allosensitization. Transpl Immunol 2016; 38: 84–92.
    • (2016) Transpl Immunol , vol.38 , pp. 84-92
    • Kim, I.1    Wu, G.2    Chai, N.N.3    Klein, A.S.4    Jordan, S.C.5
  • 27
    • 84948713427 scopus 로고    scopus 로고
    • Intrarenal B cell cytokines promote transplant fibrosis and tubular atrophy
    • Tse GH, Johnston CJ, Kluth D, et al. Intrarenal B cell cytokines promote transplant fibrosis and tubular atrophy. Am J Transplant 2015; 15: 3067–3080.
    • (2015) Am J Transplant , vol.15 , pp. 3067-3080
    • Tse, G.H.1    Johnston, C.J.2    Kluth, D.3
  • 28
    • 84863803849 scopus 로고    scopus 로고
    • B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells
    • Barr TA, Shen P, Brown S, et al. B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells. J Exp Med 2012; 209: 1001–1010.
    • (2012) J Exp Med , vol.209 , pp. 1001-1010
    • Barr, T.A.1    Shen, P.2    Brown, S.3
  • 29
    • 84969932760 scopus 로고    scopus 로고
    • Graft-derived IL-6 amplifies proliferation and survival of effector T cells that drive alloimmune-mediated vascular rejection
    • von Rossum A, Rey K, Enns W, et al. Graft-derived IL-6 amplifies proliferation and survival of effector T cells that drive alloimmune-mediated vascular rejection. Transplantation 2016; 100: 2332–2341.
    • (2016) Transplantation , vol.100 , pp. 2332-2341
    • von Rossum, A.1    Rey, K.2    Enns, W.3
  • 30
    • 83755195858 scopus 로고    scopus 로고
    • Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells
    • Fogal B, Yi T, Wang C, et al. Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells. J Immunol 2011; 187: 6268–6280.
    • (2011) J Immunol , vol.187 , pp. 6268-6280
    • Fogal, B.1    Yi, T.2    Wang, C.3
  • 31
    • 84924324722 scopus 로고    scopus 로고
    • Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: Increase in regulatory T cells correlates with clinical response
    • Kikuchi J, Hashizume M, Kaneko Y, Yoshimoto K, Nishina N, Takeuchi T. Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: Increase in regulatory T cells correlates with clinical response. Arthritis Res Ther 2015; 17: 10.
    • (2015) Arthritis Res Ther , vol.17 , pp. 10
    • Kikuchi, J.1    Hashizume, M.2    Kaneko, Y.3    Yoshimoto, K.4    Nishina, N.5    Takeuchi, T.6
  • 32
    • 78751469023 scopus 로고    scopus 로고
    • Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation
    • Tawara I, Koyama M, Liu C, et al. Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation. Clin Cancer Res 2011; 17: 77–88.
    • (2011) Clin Cancer Res , vol.17 , pp. 77-88
    • Tawara, I.1    Koyama, M.2    Liu, C.3
  • 33
    • 84871042935 scopus 로고    scopus 로고
    • Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus
    • Shirota Y, Yarboro C, Fischer R, Pham TH, Lipsky P, Illei GG. Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus. Ann Rheum Dis 2013; 72: 118–128.
    • (2013) Ann Rheum Dis , vol.72 , pp. 118-128
    • Shirota, Y.1    Yarboro, C.2    Fischer, R.3    Pham, T.H.4    Lipsky, P.5    Illei, G.G.6
  • 34
    • 84962362104 scopus 로고    scopus 로고
    • Current outcomes of chronic active antibody mediated rejection - A large single center retrospective review using the updated BANFF 2013 criteria
    • Redfield RR, Ellis TM, Zhong W, et al. Current outcomes of chronic active antibody mediated rejection - A large single center retrospective review using the updated BANFF 2013 criteria. Hum Immunol 2016; 77: 346–352.
    • (2016) Hum Immunol , vol.77 , pp. 346-352
    • Redfield, R.R.1    Ellis, T.M.2    Zhong, W.3
  • 35
    • 84945465561 scopus 로고    scopus 로고
    • Rates and determinants of progression to graft failure in kidney allograft recipients with de novo donor-specific antibody
    • Wiebe C, Gibson IW, Blydt-Hansen TD, et al. Rates and determinants of progression to graft failure in kidney allograft recipients with de novo donor-specific antibody. Am J Transplant 2015; 15: 2921–2930.
    • (2015) Am J Transplant , vol.15 , pp. 2921-2930
    • Wiebe, C.1    Gibson, I.W.2    Blydt-Hansen, T.D.3
  • 36
    • 84954460944 scopus 로고    scopus 로고
    • 2013 Banff criteria for chronic active antibody-mediated rejection: Assessment in a real-life setting
    • De Serres SA, Noël R, Côté I, et al. 2013 Banff criteria for chronic active antibody-mediated rejection: Assessment in a real-life setting. Am J Transplant 2016; 16: 1516–1525.
    • (2016) Am J Transplant , vol.16 , pp. 1516-1525
    • De Serres, S.A.1    Noël, R.2    Côté, I.3
  • 37
    • 85028407588 scopus 로고    scopus 로고
    • Non-human primate lung allograft survival is prolonged by IL-6 inhibition and ATG treatment possibly through expansion of peripheral regulatory T cells
    • [Abstract]
    • Aoyama ATM, Smith R-N, et al. Non-human primate lung allograft survival is prolonged by IL-6 inhibition and ATG treatment possibly through expansion of peripheral regulatory T cells [Abstract]. Transplant Proc 2009; 41: 429–430.
    • (2009) Transplant Proc , vol.41 , pp. 429-430
    • Aoyama, A.T.M.1    Smith, R.-N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.