Tandem amplification of the staphylococcal cassette chromosome mec element can drive high-level methicillin resistance in methicillin-resistant staphylococcus aureus

Antimicrobial Agents and Chemotherapy

Volumn 61, Issue 9, 2017, Pages

  Gallagher, Laura A ^a   Coughlan, Simone ^a,b   Black, Nikki S ^a   Lalor, Pierce ^a   Waters, Elaine M ^a   Wee, Bryan ^c   Watson, Mick ^c   Downing, Tim ^b   Fitzgerald, J Ross ^c   Fleming, Gerard T A ^a   O’Gara, James P ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b DUBLIN CITY UNIVERSITY   (Ireland)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Antibiotic; Antibiotic resistance; Beta lactams; Continuous culture; MecA beta lactam; Mechanism; Resistance; SCCmec; Staphylococcus

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL DNA; BACTERIAL PROTEIN; BETA LACTAM; METICILLIN;

BACTERIAL CHROMOSOME; DRUG EFFECTS; GENETICS; METHICILLIN RESISTANCE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGY; STAPHYLOCOCCUS INFECTION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMS; CHROMOSOMES, BACTERIAL; DNA, BACTERIAL; METHICILLIN; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCAL INFECTIONS;

EID: 85028405597     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00869-17     Document Type: Article

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