Brief Report: Elastin Microfibril Interface 1 and Integrin-Linked Protein Kinase Are Novel Markers of Islet Regenerative Function in Human Multipotent Mesenchymal Stromal Cells

Stem Cells

Volumn 34, Issue 8, 2016, Pages 2249-2255

  Lavoie, Jessie R ^a   Creskey, Marybeth M ^a   Muradia, Gauri ^a   Bell, Gillian I ^d   Sherman, Stephen E ^d   Gao, Jun ^a   Stewart, Duncan J ^b   Cyr, Terry D ^a   Hess, David A ^d   Rosu Myles, Michael ^a,c  

^a Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Biologic marker; Diabetes mellitus; Multipotent mesenchymal stromal cells; Regeneration; Type 1

Indexed keywords

BIOLOGICAL MARKER; ELASTIN MICROFIBRIL INTERFACE 1; GLUCOSE; HEPATOMA DERIVED GROWTH FACTOR; INTEGRIN LINKED KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL REGENERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERGLYCEMIA; MESENCHYMAL STROMA CELL; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PANCREAS ISLET CELL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION; WESTERN BLOTTING;

EID: 85028247880     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2385     Document Type: Article

References (31)

1. Urban VS, Kiss J, Kovacs J et al. Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes. Stem Cells 2008;26:244–253.
2. Lee RH, Seo MJ, Reger RL et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci USA 2006;103:17438–17443.
3. Hess D, Li L, Martin M et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 2003;21:763–770.
4. Bell GI, Meschino MT, Hughes-Large JM et al. Combinatorial human progenitor cell transplantation optimizes islet regeneration through secretion of paracrine factors. Stem Cells Dev 2012;21:1863–1876.
5. Bell GI, Putman DM, Hughes-Large JM et al. Intrapancreatic delivery of human umbilical cord blood aldehyde dehydrogenase-producing cells promotes islet regeneration. Diabetologia 2012;55:1755–1760.
6. Bell GI, Broughton HC, Levac KD et al. Transplanted human bone marrow progenitor subtypes stimulate endogenous islet regeneration and revascularization. Stem Cells Dev 2012;21:97–109.
7. Phinney DG, Kopen G, Righter W et al. Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. J Cell Biochem 1999;75:424–436.
8. Siegel G, Kluba T, Hermanutz-Klein U et al. Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells. BMC Med 2013;11:146.
9. Russell KC, Phinney DG, Lacey MR et al. In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells 2010;28:788–798.
10. Siddappa R, Licht R, van Blitterswijk C et al. Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering. J Orthop Res 2007;25:1029–1041.
11. Lo Surdo J, Bauer SR Quantitative approaches to detect donor and passage differences in adipogenic potential and clonogenicity in human bone marrow-derived mesenchymal stem cells. Tissue Eng Part C Methods 2012;18:877–889.
12. Zhukareva V, Obrocka M, Houle JD et al. Secretion profile of human bone marrow stromal cells: donor variability and response to inflammatory stimuli. Cytokine 2010;50:317–321.
13. Capoccia BJ, Robson DL, Levac KD et al. Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood 2009;113:5340–5351.
14. Bell GI, Seneviratne AK, Nasri GN et al. Transplantation models to characterize the mechanisms of stem cell-induced islet regeneration. Curr Protoc Stem Cell Biol 2013;26:Unit 2B.4.
15. Lavoie JR, Ormiston ML, Perez-Iratxeta C et al. Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension. Circulation 2014;129:2125–2135.
16. Degasperi A, Birtwistle MR, Volinsky N et al. Evaluating strategies to normalise biological replicates of Western blot data. PLoS One 2014;9:e87293.
17. Liang K-Y, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986;73:13–22.
18. Pan W. Akaike's information criterion in generalized estimating equations. Biometrics 2001; 57:120–125.
19. Legate KR, Wickstrom SA, Fassler R. Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 2009;23:397–418.
20. Everett AD, Narron JV, Stoops T et al. Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor. Am J Physiol Lung Cell Mol Physiol 2004;286:L1194–1201.
21. Danussi C, Spessotto P, Petrucco A et al. Emilin1 deficiency causes structural and functional defects of lymphatic vasculature. Mol Cell Biol 2008;28:4026–4039.
22. Friedrich EB, Liu E, Sinha S et al. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol 2004;24:8134–8144.
23. Tan C, Cruet-Hennequart S, Troussard A et al. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 2004;5:79–90.
24. Danussi C, Del Bel Belluz L, Pivetta E et al. EMILIN1/alpha9beta1 integrin interaction is crucial in lymphatic valve formation and maintenance. Mol Cell Biol 2013;33:4381–4394.
25. Tabe Y, Jin L, Tsutsumi-Ishii Y et al. Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res 2007;67:684–694.
26. Mao Q, Lin C, Gao J et al. Mesenchymal stem cells overexpressing integrin-linked kinase attenuate left ventricular remodeling and improve cardiac function after myocardial infarction. Mol Cell Biochem; 2014;397:203–214.
27. Munjal C, Opoka AM, Osinska H et al. TGF-beta mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease. Dis Model Mech 2014;7:987–996.
28. Danussi C, Petrucco A, Wassermann B et al. EMILIN1-alpha4/alpha9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation. J Cell Biol 2011;195:131–145.
29. Narron JV, Stoops TD, Barringhaus K et al. Hepatoma-derived growth factor is expressed after vascular injury in the rat and stimulates smooth muscle cell migration. Pediatr Res 2006;59:778–783.
30. Everett AD, Lobe DR, Matsumura ME et al. Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development. J Clin Invest 2000;105:567–575.
31. Dedhar S, Williams B, Hannigan G. Integrin-linked kinase (ILK): A regulator of integrin and growth-factor signalling. Trends Cell Biol 1999;9:319–323.