-
1
-
-
0037337399
-
Treatment of Wilson disease with ammonium tetrathiomolybdate: III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy
-
Brewer G.J., Hedera P., Kluin K.J., Carlson M., Askari F., Dick R.B., et al. Treatment of Wilson disease with ammonium tetrathiomolybdate: III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy. Arch Neurol 2003, 60:379-385.
-
(2003)
Arch Neurol
, vol.60
, pp. 379-385
-
-
Brewer, G.J.1
Hedera, P.2
Kluin, K.J.3
Carlson, M.4
Askari, F.5
Dick, R.B.6
-
2
-
-
0043196697
-
Cancer therapy with tetrathiomolybdate: antiangiogenesis by lowering body copper - a review
-
Brewer G.J., Merajver S.D. Cancer therapy with tetrathiomolybdate: antiangiogenesis by lowering body copper - a review. Integr Cancer Ther 2002, 1:327-337.
-
(2002)
Integr Cancer Ther
, vol.1
, pp. 327-337
-
-
Brewer, G.J.1
Merajver, S.D.2
-
3
-
-
0034109410
-
Recognition, diagnosis, and management of Wilson's disease
-
Brewer G.J. Recognition, diagnosis, and management of Wilson's disease. Exp Biol Med (Maywood) 2000, 223:39-46.
-
(2000)
Exp Biol Med (Maywood)
, vol.223
, pp. 39-46
-
-
Brewer, G.J.1
-
4
-
-
77049283245
-
Penicillamine, a new oral therapy for Wilson's disease
-
Walshe J.M. Penicillamine, a new oral therapy for Wilson's disease. Am J Med 1956, 21:487-495.
-
(1956)
Am J Med
, vol.21
, pp. 487-495
-
-
Walshe, J.M.1
-
5
-
-
0020086199
-
Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride
-
Walshe J.M. Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride. Lancet 1982, 1:643-647.
-
(1982)
Lancet
, vol.1
, pp. 643-647
-
-
Walshe, J.M.1
-
6
-
-
0032191253
-
Treatment of Wilson's disease with zinc: XV long-term follow-up studies
-
Brewer G.J., Dick R.D., Johnson V.D., Brunberg J.A., Kluin K.J., Fink J.K. Treatment of Wilson's disease with zinc: XV long-term follow-up studies. J Lab Clin Med 1998, 132:264-278.
-
(1998)
J Lab Clin Med
, vol.132
, pp. 264-278
-
-
Brewer, G.J.1
Dick, R.D.2
Johnson, V.D.3
Brunberg, J.A.4
Kluin, K.J.5
Fink, J.K.6
-
7
-
-
0023178114
-
Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy
-
Brewer G.J., Terry C.A., Aisen A.M., Hill G.M. Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy. Arch Neurol 1987, 44:490-493.
-
(1987)
Arch Neurol
, vol.44
, pp. 490-493
-
-
Brewer, G.J.1
Terry, C.A.2
Aisen, A.M.3
Hill, G.M.4
-
8
-
-
33645733769
-
Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease
-
Brewer G.J., Askari F., Lorincz M.T., Carlson M., Schilsky M., Kluin K.J., et al. Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease. Arch Neurol 2006, 63:521-527.
-
(2006)
Arch Neurol
, vol.63
, pp. 521-527
-
-
Brewer, G.J.1
Askari, F.2
Lorincz, M.T.3
Carlson, M.4
Schilsky, M.5
Kluin, K.J.6
-
9
-
-
67649874760
-
Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine
-
Brewer G.J., Askari F., Dick R.B., Sitterly J., Fink J.K., Carlson M., et al. Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine. Transl Res 2009, 154:70-77.
-
(2009)
Transl Res
, vol.154
, pp. 70-77
-
-
Brewer, G.J.1
Askari, F.2
Dick, R.B.3
Sitterly, J.4
Fink, J.K.5
Carlson, M.6
-
10
-
-
4444338573
-
Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice
-
Askari F.K., Dick R., Mao M., Brewer G.J. Tetrathiomolybdate therapy protects against concanavalin a and carbon tetrachloride hepatic damage in mice. Exp Biol Med (Maywood) 2004, 229:857-863.
-
(2004)
Exp Biol Med (Maywood)
, vol.229
, pp. 857-863
-
-
Askari, F.K.1
Dick, R.2
Mao, M.3
Brewer, G.J.4
-
11
-
-
4644266563
-
Tetrathiomolybdate protects against liver injury from acetaminophen in mice
-
Ma S., Hou G., Dick R., Brewer G.J. Tetrathiomolybdate protects against liver injury from acetaminophen in mice. J Appl Res Clin Exp Ther 2004, 4:419-426.
-
(2004)
J Appl Res Clin Exp Ther
, vol.4
, pp. 419-426
-
-
Ma, S.1
Hou, G.2
Dick, R.3
Brewer, G.J.4
-
12
-
-
26844452252
-
Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice
-
Hou G., Dick R., Abrams G.D., Brewer G.J. Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice. J Lab Clin Med 2005, 146:299-303.
-
(2005)
J Lab Clin Med
, vol.146
, pp. 299-303
-
-
Hou, G.1
Dick, R.2
Abrams, G.D.3
Brewer, G.J.4
-
13
-
-
33646134391
-
The use of tetrathiomolybdate in treating fibrotic, inflammatory, and autoimmune diseases, including the non-obese diabetic mouse model
-
Brewer G.J., Dick R., Zeng C., Hou G. The use of tetrathiomolybdate in treating fibrotic, inflammatory, and autoimmune diseases, including the non-obese diabetic mouse model. J Inorg Biochem 2006, 100:927-930.
-
(2006)
J Inorg Biochem
, vol.100
, pp. 927-930
-
-
Brewer, G.J.1
Dick, R.2
Zeng, C.3
Hou, G.4
-
14
-
-
33846110887
-
Tetrathiomolybdate is effective in a mouse model of arthritis
-
McCubbin M.D., Hou G., Abrams G.D., Dick R., Zhang Z., Brewer G.J. Tetrathiomolybdate is effective in a mouse model of arthritis. J Rheumatol 2006, 33:2501-2506.
-
(2006)
J Rheumatol
, vol.33
, pp. 2501-2506
-
-
McCubbin, M.D.1
Hou, G.2
Abrams, G.D.3
Dick, R.4
Zhang, Z.5
Brewer, G.J.6
-
15
-
-
56349135090
-
Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis
-
Hou G., Abrams G.D., Dick R., Brewer G.J. Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis. Transl Res 2008, 152:239-244.
-
(2008)
Transl Res
, vol.152
, pp. 239-244
-
-
Hou, G.1
Abrams, G.D.2
Dick, R.3
Brewer, G.J.4
-
16
-
-
8444244570
-
Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis
-
Brewer G.J., Dick R., Ullenbruch M.R., Jin H., Phan S.H. Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis. J Inorg Biochem 2004, 98:2160-2167.
-
(2004)
J Inorg Biochem
, vol.98
, pp. 2160-2167
-
-
Brewer, G.J.1
Dick, R.2
Ullenbruch, M.R.3
Jin, H.4
Phan, S.H.5
-
17
-
-
0037342259
-
Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice
-
Brewer G.J., Ullenbruch M.R., Dick R., Olivarez L., Phan S.H. Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice. J Lab Clin Med 2003, 141:210-216.
-
(2003)
J Lab Clin Med
, vol.141
, pp. 210-216
-
-
Brewer, G.J.1
Ullenbruch, M.R.2
Dick, R.3
Olivarez, L.4
Phan, S.H.5
-
18
-
-
42449134964
-
Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis
-
Song M., Song Z., Barve S., Zhang J., Chen T., Liu M., et al. Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis. J Pharmacol Exp Ther 2008, 325:409-416.
-
(2008)
J Pharmacol Exp Ther
, vol.325
, pp. 409-416
-
-
Song, M.1
Song, Z.2
Barve, S.3
Zhang, J.4
Chen, T.5
Liu, M.6
-
19
-
-
76549123971
-
Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial
-
Askari F., Innis D., Dick R.B., Hou G., Marrero J., Greenson J., et al. Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial. Transl Res 2010, 155:123-130.
-
(2010)
Transl Res
, vol.155
, pp. 123-130
-
-
Askari, F.1
Innis, D.2
Dick, R.B.3
Hou, G.4
Marrero, J.5
Greenson, J.6
-
20
-
-
0025202925
-
Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor
-
Brem S.S., Zagzag D., Tsanaclis A.M., Gately S., Elkouby M.P., Brien S.E. Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor. Am J Pathol 1990, 137:1121-1142.
-
(1990)
Am J Pathol
, vol.137
, pp. 1121-1142
-
-
Brem, S.S.1
Zagzag, D.2
Tsanaclis, A.M.3
Gately, S.4
Elkouby, M.P.5
Brien, S.E.6
-
21
-
-
0036733754
-
Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
-
Pan Q., Kleer C.G., van Golen K.L., Irani J., Bottema K.M., Bias C., et al. Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis. Cancer Res 2002, 62:4854-4859.
-
(2002)
Cancer Res
, vol.62
, pp. 4854-4859
-
-
Pan, Q.1
Kleer, C.G.2
van Golen, K.L.3
Irani, J.4
Bottema, K.M.5
Bias, C.6
-
22
-
-
0037827092
-
Inhibition of the growth of squamous cell carcinoma by tetrathiomolybdate-induced copper suppression in a murine model
-
Cox C., Merajver S.D., Yoo S., Dick R.D., Brewer G.J., Lee J.S., et al. Inhibition of the growth of squamous cell carcinoma by tetrathiomolybdate-induced copper suppression in a murine model. Arch Otolaryngol Head Neck Surg 2003, 129:781-785.
-
(2003)
Arch Otolaryngol Head Neck Surg
, vol.129
, pp. 781-785
-
-
Cox, C.1
Merajver, S.D.2
Yoo, S.3
Dick, R.D.4
Brewer, G.J.5
Lee, J.S.6
-
23
-
-
0035073521
-
The role of copper suppression as an antiangiogenic strategy in head and neck squamous cell carcinoma
-
Cox C., Teknos T.N., Barrios M., Brewer G.J., Dick R.D., Merajver S.D. The role of copper suppression as an antiangiogenic strategy in head and neck squamous cell carcinoma. Laryngoscope 2001, 111:696-701.
-
(2001)
Laryngoscope
, vol.111
, pp. 696-701
-
-
Cox, C.1
Teknos, T.N.2
Barrios, M.3
Brewer, G.J.4
Dick, R.D.5
Merajver, S.D.6
-
24
-
-
0036118349
-
Radiotherapy and antiangiogenic TM in lung cancer
-
Khan M.K., Miller M.W., Taylor J., Gill N.K., Dick R.D., Van Golen K., et al. Radiotherapy and antiangiogenic TM in lung cancer. Neoplasia 2002, 4:164-170.
-
(2002)
Neoplasia
, vol.4
, pp. 164-170
-
-
Khan, M.K.1
Miller, M.W.2
Taylor, J.3
Gill, N.K.4
Dick, R.D.5
Van Golen, K.6
-
25
-
-
1142269357
-
Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma
-
Pan Q., Bao L.W., Kleer C.G., Brewer G.J., Merajver S.D. Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma. Mol Cancer Ther 2003, 2:617-622.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 617-622
-
-
Pan, Q.1
Bao, L.W.2
Kleer, C.G.3
Brewer, G.J.4
Merajver, S.D.5
-
26
-
-
0036708501
-
Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma
-
van Golen K.L., Bao L., Brewer G.J., Pienta K.J., Kamradt J.M., Livant D.L., et al. Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma. Neoplasia 2002, 4:373-379.
-
(2002)
Neoplasia
, vol.4
, pp. 373-379
-
-
van Golen, K.L.1
Bao, L.2
Brewer, G.J.3
Pienta, K.J.4
Kamradt, J.M.5
Livant, D.L.6
-
27
-
-
1642499579
-
An anticopper antiangiogenic approach for advanced cancer in spontaneously occurring tumors, using tetrathiomolybdate: a pilot study in a canine animal model
-
Kent M.S., Madewell B.R., Dank G., Dick R., Merajver S.D., Brewer G.J. An anticopper antiangiogenic approach for advanced cancer in spontaneously occurring tumors, using tetrathiomolybdate: a pilot study in a canine animal model. J Trace Elem Exp Med 2004, 17:9-20.
-
(2004)
J Trace Elem Exp Med
, vol.17
, pp. 9-20
-
-
Kent, M.S.1
Madewell, B.R.2
Dank, G.3
Dick, R.4
Merajver, S.D.5
Brewer, G.J.6
-
28
-
-
0033963879
-
Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: phase I study
-
Brewer G.J., Dick R.D., Grover D.K., LeClaire V., Tseng M., Wicha M., et al. Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: phase I study. Clin Cancer Res 2000, 6:1-10.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1-10
-
-
Brewer, G.J.1
Dick, R.D.2
Grover, D.K.3
LeClaire, V.4
Tseng, M.5
Wicha, M.6
-
29
-
-
0037652214
-
Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer
-
Redman B.G., Esper P., Pan Q., Dunn R.L., Hussain H.K., Chenevert T., et al. Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer. Clin Cancer Res 2003, 9:1666-1672.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1666-1672
-
-
Redman, B.G.1
Esper, P.2
Pan, Q.3
Dunn, R.L.4
Hussain, H.K.5
Chenevert, T.6
-
30
-
-
34548083741
-
Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
-
Henry N.L., Dunn R., Merjaver S., Pan Q., Pienta K.J., Brewer G., et al. Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer. Oncology 2006, 71:168-175.
-
(2006)
Oncology
, vol.71
, pp. 168-175
-
-
Henry, N.L.1
Dunn, R.2
Merjaver, S.3
Pan, Q.4
Pienta, K.J.5
Brewer, G.6
-
31
-
-
66949121496
-
A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer
-
Gartner E.M., Griffith K.A., Pan Q., Brewer G.J., Henja G.F., Merajver S.D., et al. A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer. Invest New Drugs 2009, 27:159-165.
-
(2009)
Invest New Drugs
, vol.27
, pp. 159-165
-
-
Gartner, E.M.1
Griffith, K.A.2
Pan, Q.3
Brewer, G.J.4
Henja, G.F.5
Merajver, S.D.6
-
32
-
-
47149104324
-
A phase II trial of tetrathiomolybdate after surgery for malignant mesothelioma: final results
-
discussion 90
-
Pass H.I., Brewer G.J., Dick R., Carbone M., Merajver S. A phase II trial of tetrathiomolybdate after surgery for malignant mesothelioma: final results. Ann Thorac Surg 2008, 86:383-389. discussion 90.
-
(2008)
Ann Thorac Surg
, vol.86
, pp. 383-389
-
-
Pass, H.I.1
Brewer, G.J.2
Dick, R.3
Carbone, M.4
Merajver, S.5
-
33
-
-
84879460993
-
A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naive prostate cancer
-
Lin J., Zahurak M., Beer T.M., Ryan C.J., Wilding G., Mathew P., et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naive prostate cancer. Urol Oncol 2013, 31:581-588.
-
(2013)
Urol Oncol
, vol.31
, pp. 581-588
-
-
Lin, J.1
Zahurak, M.2
Beer, T.M.3
Ryan, C.J.4
Wilding, G.5
Mathew, P.6
-
34
-
-
58149359314
-
Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors
-
Lowndes S.A., Adams A., Timms A., Fisher N., Smythe J., Watt S.M., et al. Phase I study of copper-binding agent ATN-224 in patients with advanced solid tumors. Clin Cancer Res 2008, 14:7526-7534.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7526-7534
-
-
Lowndes, S.A.1
Adams, A.2
Timms, A.3
Fisher, N.4
Smythe, J.5
Watt, S.M.6
-
35
-
-
84879551228
-
Pre-operative chemoradiation followed by post-operative adjuvant therapy with tetrathiomolybdate, a novel copper chelator, for patients with resectable esophageal cancer
-
Schneider B.J., Lee J.S., Hayman J.A., Chang A.C., Orringer M.B., Pickens A., et al. Pre-operative chemoradiation followed by post-operative adjuvant therapy with tetrathiomolybdate, a novel copper chelator, for patients with resectable esophageal cancer. Invest New Drugs 2013, 31:435-442.
-
(2013)
Invest New Drugs
, vol.31
, pp. 435-442
-
-
Schneider, B.J.1
Lee, J.S.2
Hayman, J.A.3
Chang, A.C.4
Orringer, M.B.5
Pickens, A.6
-
36
-
-
0041928194
-
Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade
-
Pan Q., Bao L.W., Merajver S.D. Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade. Mol Cancer Res 2003, 1:701-706.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 701-706
-
-
Pan, Q.1
Bao, L.W.2
Merajver, S.D.3
-
37
-
-
33748340865
-
Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1
-
Juarez J.C., Betancourt O., Pirie-Shepherd S.R., Guan X., Price M.L., Shaw D.E., et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res 2006, 12:4974-4982.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4974-4982
-
-
Juarez, J.C.1
Betancourt, O.2
Pirie-Shepherd, S.R.3
Guan, X.4
Price, M.L.5
Shaw, D.E.6
-
38
-
-
84878467452
-
Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse
-
Jain S., Cohen J., Ward M.M., Kornhauser N., Chuang E., Cigler T., et al. Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse. Ann Oncol 2013, 24:1491-1498.
-
(2013)
Ann Oncol
, vol.24
, pp. 1491-1498
-
-
Jain, S.1
Cohen, J.2
Ward, M.M.3
Kornhauser, N.4
Chuang, E.5
Cigler, T.6
|