Zinc: An antioxidant and anti-inflammatory agent: Role of zinc in degenerative disorders of aging

Journal of Trace Elements in Medicine and Biology

Volumn 28, Issue 4, 2014, Pages 364-371

  Prasad, Ananda S ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti inflammatory agent; Antioxidant agent; Inflammatory cytokines; Oxidative stress; Zinc

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; C REACTIVE PROTEIN; CYCLOOXYGENASE 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCONATE ZINC; GLUTATHIONE TRANSFERASE; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLACEBO; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; ZINC; ZINC FINGER PROTEIN;

AGE RELATED MACULAR DEGENERATION; AGING; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ATHEROSCLEROSIS; CELLULAR IMMUNITY; CHRONIC DISEASE; CHRONIC INFLAMMATION; DEGENERATIVE DISEASE; DIABETES MELLITUS; DOWN REGULATION; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; HUMAN; LIPID PEROXIDATION; MINERAL SUPPLEMENTATION; MONOCYTE; OXIDATIVE STRESS; PARKINSON DISEASE; REVIEW; SIGNAL TRANSDUCTION; ZINC DEFICIENCY;

EID: 85028104413     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2014.07.019     Document Type: Review

References (29)

1. Prasad A.S., Halsted J.A., Nadimi M. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism, and geophagia. Am J Med 1961, 31:532-546.
2. Prasad A.S., Miale A., Farid Z., Schulert A., Sandstead H.H. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hypogonadism and dwarfism. J Lab Clin Med 1963, 61:537-549.
3. Sandstead H.H., Prasad A.S., Schulert A.R., Farid Z., Miale A., Bassily S., et al. Human zinc deficiency, endocrine manifestations and response to treatment. Am J Clin Nutr 1967, 20:422-442.
4. Prasad A.S., Miale A., Farid Z., Sandstead H.H., Schulert A.R., Darby W.J. Biochemical studies on dwarfism, hypogonadism, and anemia. AMA Arch Intern Med 1963, 111:407-428.
5. Prasad A.S., Beck F.W.J., Bao B., Fitzgerald J.T., Snell D.C., Steinberg J.D., et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin 2007, 85:837-844.
6. Bao B., Prasad A.S., Beck F.W.J., Fitzgerald J.T., Snell D., Bao G.W., et al. Zinc decreases C-reactive protein, lipid peroxidation, and implication of zinc as an atheroprotective agent. Am J Clin Nutr 2010, 91:1634-1641.
7. Prasad A.S. Biochemistry of zinc 1993, Plenum Press, New York.
8. Sandstead H.H., Penland J.G., Alcock N.W., Dayal H.H., Chen X.C., Li J.S. Effects of repletion with zinc and other micronutrients on neuropsychologic performance and growth of Chinese children. Am J Clin Nutr 1998, 68(Suppl.):470S-475S.
9. Barnes P.M., Moynahan E.J. Zinc deficiency in acrodermatitis enteropathica. Proc R Soc Med 1973, 66:327-329.
10. Sazawal S., Black R.E., Bhan M.K., Bhandari N., Sinha A., Jalla S. Zinc supplementation in young children with acute diarrhea in India. N Eng J Med 1995, 333:839-844.
11. Fisher W.C.L., Lamberti L., Roth D., Black R.E. Zinc and infectious diseases. Zinc in human health 2011, 234-253. IOS Press, Amsterdam, The Netherlands. L. Rink (Ed.).
12. Brewer G.J., Yuzbasiyan-Gurkan V. Wilson disease. Medicine 1992, 71:139-164.
13. Prasad A.S., Fitzgerald J.T., Bao B., Beck W.J., Chandrasekar P.H. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. Ann Intern Med 2000, 133:245-252.
14. Prasad A.S., Beck F.W.J., Bao B., Snell D., Fitzgerald T. Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecule in patients with common cold treated with zinc acetate. J Inf Dis 2008, 197:795-802.
15. Newsome D.A., Miceli M.V., Tats D.J., Alcock N.W., Oliver P.D. Zinc content of human retinal pigment epithelium decreases with age and macular degeneration but superoxide dismutase activity increases. J Trace Elem Exp Med 1996, 8:193-199.
16. Age-Related Eye Disease Study Research group (AREDS Report No.8) A randomized, placebo controlled, clinical trial of high-dose supplemented with vitamins C and E, beta-carotene, for age-related macular degeneration and vision loss. Arch Ophthalmol 2001, 119:1417-1436.
17. AREDS Report No.13 Association of mortality with ocular disorders and an intervention of high dose antioxidants and zinc in the age-related eye disease study. Arch Ophthalmol 2004, 122:716-726.
18. Chew E.Y., Clemons T.E., Agron E., Sperduto R.D., Sangiovanni J.P., Kurinij N., et al. Long-term effects of vitamins C and E β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35. Ophtalmology 2013, 120(8):1604-1611.
19. Prasad A.S., Beck F.W.J., Kaplan J., Chandrasekar P.H., Ortega J., Fitzgerald J.T., et al. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD). Am J Hematol 1999, 61:194-202.
20. Bao B., Prasad A.S., Beck F.W.J., Snell D., Sunega A., Sarkar F.H., et al. Zinc supplementation decreased oxidative stress, incidence of infection and generation of inflammatory cytokines in sickle cell disease patients. Transl Res 2008, 152:67-80.
21. Swe K.M.M., Abas A.B.L., Bhardwaj A., Barua A., Nair N.S. The Cochrane Collaboration Zinc supplementation for treating thalassemia and sickle cell disease. The Cochrane Library, Issue 6 2013, 1-33.
22. Hirano T., Murakami M., Fukada T., Nishida K., Yamasaki S., Suzuki T. Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule. Adv Immunol 2008, 97:149-176.
23. Haase H., Rink L. Signal transduction in monocytes: the role of zinc ions. Biometals 2007, 20:579-585.
24. Prasad A.S., Bao B., Beck F.W.J., Kucuk O., Sarkar F.H. Antioxidant effect of zinc in humans. Free Rad Biol Med 2004, 37:1182-1190.
25. Prasad A.S., Bao B., Beck F.W., Sarkar F.H. Zinc activates NF-κB in HUT-78 cells. J Lab Clin Med 2001, 138:250-255.
26. Bao B., Ahmad A., Azmi A., Li Y., Prasad A.S., Sarkar F.H. The biological significance of zinc in inflammation and aging. Inflammation advancing and nutrition 2013, 15-27. Elsevier Inc., New York. I. Rahman, D. Bagchi (Eds.).
27. Prasad A.S., Rabbani P., Abbasi A., Bowersox E., Spivey Fox M.R. Experimental zinc deficiency in humans. Ann Intern Med 1978, 89:483-490.
28. Beck F.W.J., Prasad A.S., Kaplan J., Fitzgerald J.T., Brewer G.J. Changes in cytokine production and T cell subpopulations in experimentally induced zinc deficient humans. Am J Physiol Endocrinol Metab 1977, 272:1002-1007.
29. Prasad A.S., Meftah S., Abdallah J., Kaplan J., Brewer G.J., Bach J.F., et al. Serum thymulin in human zinc deficiency. J Clin Invest 1988, 82:1202-1210.