Microbe profile: Candida albicans: A shape-changing, opportunistic pathogenic fungus of humans

Microbiology (United Kingdom)

Volumn 163, Issue 8, 2017, Pages 1145-1147

  Gow, Neil A R ^a   Yadav, Bhawna ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Candida albicans; Drug resistance; Immune response; Medical Mycology; Morphogenesis; Pathogenesis

Indexed keywords

ECHINOCANDIN; PYRROLE DERIVATIVE; ANTIFUNGAL AGENT;

ANTIFUNGAL RESISTANCE; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; EVOLUTION; FUNGAL GENOME; FUNGAL STRAIN; FUNGAL STRUCTURES; FUNGAL VIRULENCE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; TAXONOMY; CLASSIFICATION; CROSS INFECTION; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR EVOLUTION; OPPORTUNISTIC INFECTION;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS; CROSS INFECTION; DRUG RESISTANCE, FUNGAL; EVOLUTION, MOLECULAR; GENOME, FUNGAL; HUMANS; OPPORTUNISTIC INFECTIONS;

EID: 85028084795     PISSN: 13500872     EISSN: 14652080     Source Type: Journal    
DOI: 10.1099/mic.0.000499     Document Type: Article

References (10)

1. Noble SM, Gianetti BA, Witchley JN. Candida albicans cell-type switching and functional plasticity in the mammalian host. Nat Rev Microbiol 2017;15:96–108.
2. Brown AJ, Brown GD, Netea MG, Gow NA. Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels. Trends Microbiol 2014;22:614–622.
3. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S et al. The diploid genome sequence of Candida albicans. Proc Natl Acad Sci USA 2004;101:7329–7334.
4. Wertheimer NB, Stone N, Berman J. Ploidy dynamics and evolvability in fungi. Philos Trans R Soc Lond B Biol Sci 2016;371: 20150461.
5. Hickman MA, Zeng G, Forche A, Hirakawa MP, Abbey D et al. The ’obligate diploid’ Candida albicans forms mating-competent haploids. Nature 2013;494:55–59.
6. Hull CM, Raisner RM, Johnson AD. Evidence for mating of the "asexual" yeast Candida albicans in a mammalian host. Science 2000;289:307–310.
7. Santos MA, Tuite MF. The CUG codon is decoded in vivo as serine and not leucine in Candida albicans. Nucleic Acids Res 1995;23: 1481–1486.
8. Kullberg BJ, Arendrup MC. Invasive Candidiasis. N Engl J Med 2016;374:794–795.
9. Netea MG, Joosten LA, Van der Meer JW, Kullberg BJ, Van de Veerdonk FL et al. Immune defence against Candida fungal infections. Nat Rev Immunol 2015;15:630–642.
10. Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX et al. Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 2016;532:64–68.