-
1
-
-
45149100665
-
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
-
Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Dohner H, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008;111:5446–56.
-
(2008)
Blood
, vol.111
, pp. 5446-5456
-
-
Hallek, M.1
Cheson, B.D.2
Catovsky, D.3
Caligaris-Cappio, F.4
Dighiero, G.5
Dohner, H.6
-
2
-
-
84874568508
-
ESMO Guidelines consensus conference on malignant lymphoma 2011 part 1: Diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL)
-
Ghielmini M, Vitolo U, Kimby E, Montoto S, Walewski J, Pfreundschuh M, et al. ESMO Guidelines consensus conference on malignant lymphoma 2011 part 1: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL). Ann Oncol 2013;24: 561–76.
-
(2013)
Ann Oncol
, vol.24
, pp. 561-576
-
-
Ghielmini, M.1
Vitolo, U.2
Kimby, E.3
Montoto, S.4
Walewski, J.5
Pfreundschuh, M.6
-
3
-
-
84927919560
-
-
Fort Washington (PA): National Comprehensive Cancer Network
-
National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology Non-Hodgkin Lymphoma Version 4.2014. Fort Washington (PA): National Comprehensive Cancer Network; 2014. Available from: https://www.nccn.org/about/nhl.pdf.
-
(2014)
Clinical Practice Guidelines in Oncology Non-hodgkin Lymphoma Version 4.2014
-
-
-
4
-
-
23044510136
-
Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
-
Keating MJ, O'Brien S, Albitar M, Lerner S, Plunkett W, Giles F, et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 2005;23:4079–88.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4079-4088
-
-
Keating, M.J.1
O'Brien, S.2
Albitar, M.3
Lerner, S.4
Plunkett, W.5
Giles, F.6
-
5
-
-
77957664665
-
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
-
Hallek M, Fischer K, Fingerle-Rowson G, Fink AM, Busch R, Mayer J, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376:1164–74.
-
(2010)
Lancet
, vol.376
, pp. 1164-1174
-
-
Hallek, M.1
Fischer, K.2
Fingerle-Rowson, G.3
Fink, A.M.4
Busch, R.5
Mayer, J.6
-
6
-
-
84969523604
-
First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): An international, open-label, randomised, phase 3, non-inferiority trial
-
Eichhorst B, Fink AM, Bahlo J, Busch R, Kovacs G, Maurer C, et al. First-line chemoimmunotherapy with bendamustine and rituximab versus fludarabine, cyclophosphamide, and rituximab in patients with advanced chronic lymphocytic leukaemia (CLL10): an international, open-label, randomised, phase 3, non-inferiority trial. Lancet Oncol 2016;17:928–42.
-
(2016)
Lancet Oncol
, vol.17
, pp. 928-942
-
-
Eichhorst, B.1
Fink, A.M.2
Bahlo, J.3
Busch, R.4
Kovacs, G.5
Maurer, C.6
-
7
-
-
84894552888
-
Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
-
Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med 2014;370:1101–10.
-
(2014)
N Engl J Med
, vol.370
, pp. 1101-1110
-
-
Goede, V.1
Fischer, K.2
Busch, R.3
Engelke, A.4
Eichhorst, B.5
Wendtner, C.M.6
-
8
-
-
84929505415
-
Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): A randomised, multicentre, open-label phase 3 trial
-
Hillmen P, Robak T, Janssens A, Babu KG, Kloczko J, Grosicki S, et al. Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): a randomised, multicentre, open-label phase 3 trial. Lancet 2015; 385:1873–83.
-
(2015)
Lancet
, vol.385
, pp. 1873-1883
-
-
Hillmen, P.1
Robak, T.2
Janssens, A.3
Babu, K.G.4
Kloczko, J.5
Grosicki, S.6
-
9
-
-
0034727833
-
Genomic aberrations and survival in chronic lymphocytic leukemia
-
Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000;343:1910–6.
-
(2000)
N Engl J Med
, vol.343
, pp. 1910-1916
-
-
Dohner, H.1
Stilgenbauer, S.2
Benner, A.3
Leupolt, E.4
Krober, A.5
Bullinger, L.6
-
10
-
-
84903971364
-
Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia
-
Pflug N, Bahlo J, Shanafelt TD, Eichhorst BF, Bergmann MA, Elter T, et al. Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia. Blood 2014;124:49–62.
-
(2014)
Blood
, vol.124
, pp. 49-62
-
-
Pflug, N.1
Bahlo, J.2
Shanafelt, T.D.3
Eichhorst, B.F.4
Bergmann, M.A.5
Elter, T.6
-
11
-
-
84901408966
-
Gene mutations and treatment outcome in chronic lymphocytic leukemia: Results from the CLL8 trial
-
Stilgenbauer S, Schnaiter A, Paschka P, Zenz T, Rossi M, Dohner K, et al. Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial. Blood 2014;123:3247–54.
-
(2014)
Blood
, vol.123
, pp. 3247-3254
-
-
Stilgenbauer, S.1
Schnaiter, A.2
Paschka, P.3
Zenz, T.4
Rossi, M.5
Dohner, K.6
-
12
-
-
84966746552
-
An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): A meta-analysis of individual patient data
-
International CLL-IPI Working Group. An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient data. Lancet Oncol 2016;17:779–90.
-
(2016)
Lancet Oncol
, vol.17
, pp. 779-790
-
-
-
13
-
-
84994637755
-
Chemoimmunotherapy versus targeted treatment in chronic lymphocytic leukemia: When, how long, how much, and in which combination?
-
Brown JR, Hallek MJ, Pagel JM. Chemoimmunotherapy versus targeted treatment in chronic lymphocytic leukemia: when, how long, how much, and in which combination? Am Soc Clin Oncol Educ Book 2016;35: e387–98.
-
(2016)
Am Soc Clin Oncol Educ Book
, vol.35
, pp. e387-e398
-
-
Brown, J.R.1
Hallek, M.J.2
Pagel, J.M.3
-
14
-
-
54049141334
-
Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: Results from a detailed genetic characterization with long-term follow-up
-
Zenz T, Krober A, Scherer K, Habe S, Buhler A, Benner A, et al. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood 2008;112:3322–9.
-
(2008)
Blood
, vol.112
, pp. 3322-3329
-
-
Zenz, T.1
Krober, A.2
Scherer, K.3
Habe, S.4
Buhler, A.5
Benner, A.6
-
15
-
-
84958181962
-
Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemia
-
Thompson PA, Tam CS, O'Brien SM, Wierda WG, Stingo F, Plunkett W, et al. Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemia. Blood 2016;127:303–9.
-
(2016)
Blood
, vol.127
, pp. 303-309
-
-
Thompson, P.A.1
Tam, C.S.2
O'Brien, S.M.3
Wierda, W.G.4
Stingo, F.5
Plunkett, W.6
-
16
-
-
84904252369
-
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia
-
Byrd JC, Brown JR, O'Brien S, Barrientos JC, Kay NE, Reddy NM, et al. Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med 2014;371:213–23.
-
(2014)
N Engl J Med
, vol.371
, pp. 213-223
-
-
Byrd, J.C.1
Brown, J.R.2
O'Brien, S.3
Barrientos, J.C.4
Kay, N.E.5
Reddy, N.M.6
-
17
-
-
84879748062
-
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
-
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum KA, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013;369:32–42.
-
(2013)
N Engl J Med
, vol.369
, pp. 32-42
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
Flinn, I.W.4
Burger, J.A.5
Blum, K.A.6
-
18
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
Furman RR, Sharman JP, Coutre SE, Cheson BD, Pagel JM, Hillmen P, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014;370:997–1007.
-
(2014)
N Engl J Med
, vol.370
, pp. 997-1007
-
-
Furman, R.R.1
Sharman, J.P.2
Coutre, S.E.3
Cheson, B.D.4
Pagel, J.M.5
Hillmen, P.6
-
19
-
-
84926679275
-
BCR pathway inhibition as therapy for chronic lymphocytic leukemiaandlymphoplasmacyticlymphoma
-
Wiestner A. BCR pathway inhibition as therapy for chronic lymphocytic leukemiaandlymphoplasmacyticlymphoma.HematologyAmSocHema-tol Educ Program 2014;2014:125–34.
-
(2014)
Hematologyamsochema-tol Educ Program
, vol.2014
, pp. 125-134
-
-
Wiestner, A.1
-
20
-
-
84893484587
-
Molecular pathways: Targeting the microenvironment in chronic lymphocytic leukemia–focus on the B-cell receptor
-
ten Hacken E, Burger JA. Molecular pathways: targeting the microenvironment in chronic lymphocytic leukemia–focus on the B-cell receptor. Clin Cancer Res 2014;20:548–56.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 548-556
-
-
Ten Hacken, E.1
Burger, J.A.2
-
21
-
-
0026696155
-
Growth- And differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells
-
Schena M, Larsson LG, Gottardi D, Gaidano G, Carlsson M, Nilsson K, et al. Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood 1992;79:2981–9.
-
(1992)
Blood
, vol.79
, pp. 2981-2989
-
-
Schena, M.1
Larsson, L.G.2
Gottardi, D.3
Gaidano, G.4
Carlsson, M.5
Nilsson, K.6
-
22
-
-
0027239823
-
Bcl-2 gene hypo-methylation and high-level expression in B-cell chronic lymphocytic leukemia
-
Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC. bcl-2 gene hypo-methylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 1993;82:1820–8.
-
(1993)
Blood
, vol.82
, pp. 1820-1828
-
-
Hanada, M.1
Delia, D.2
Aiello, A.3
Stadtmauer, E.4
Reed, J.C.5
-
23
-
-
0029964075
-
Bcl-2 rearrangements with breakpoints in both vcr and mbr in non-Hodgkin's lymphomas and chronic lymphocytic leukaemia
-
Merup M, Spasokoukotskaja T, Einhorn S, Smith CI, Gahrton G, Juliusson G. Bcl-2 rearrangements with breakpoints in both vcr and mbr in non-Hodgkin's lymphomas and chronic lymphocytic leukaemia. Br J Haematol 1996;92:647–52.
-
(1996)
Br J Haematol
, vol.92
, pp. 647-652
-
-
Merup, M.1
Spasokoukotskaja, T.2
Einhorn, S.3
Smith, C.I.4
Gahrton, G.5
Juliusson, G.6
-
24
-
-
0029871942
-
Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome
-
Robertson LE, Plunkett W, McConnell K, Keating MJ, McDonnell TJ. Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia 1996; 10:456–9.
-
(1996)
Leukemia
, vol.10
, pp. 456-459
-
-
Robertson, L.E.1
Plunkett, W.2
McConnell, K.3
Keating, M.J.4
McDonnell, T.J.5
-
25
-
-
18744396337
-
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
-
Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002;99:15524–9.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15524-15529
-
-
Calin, G.A.1
Dumitru, C.D.2
Shimizu, M.3
Bichi, R.4
Zupo, S.5
Noch, E.6
-
26
-
-
84873540049
-
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
-
Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 2013;19:202–8.
-
(2013)
Nat Med
, vol.19
, pp. 202-208
-
-
Souers, A.J.1
Leverson, J.D.2
Boghaert, E.R.3
Ackler, S.L.4
Catron, N.D.5
Chen, J.6
-
27
-
-
84883767136
-
ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets
-
Vogler M, Dinsdale D, Dyer MJ, Cohen GM. ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets. Br J Haematol 2013;163: 139–42.
-
(2013)
Br J Haematol
, vol.163
, pp. 139-142
-
-
Vogler, M.1
Dinsdale, D.2
Dyer, M.J.3
Cohen, G.M.4
-
28
-
-
84902076004
-
Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199
-
Khaw SL, Merino D, Anderson MA, Glaser SP, Bouillet P, Roberts AW, et al. Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199. Leukemia 2014;28:1207–15.
-
(2014)
Leukemia
, vol.28
, pp. 1207-1215
-
-
Khaw, S.L.1
Merino, D.2
Anderson, M.A.3
Glaser, S.P.4
Bouillet, P.5
Roberts, A.W.6
-
29
-
-
0023786047
-
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
-
Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988;335:440–2.
-
(1988)
Nature
, vol.335
, pp. 440-442
-
-
Vaux, D.L.1
Cory, S.2
Adams, J.M.3
-
30
-
-
0036716281
-
The Bcl2 family: Regulators of the cellular life-or-death switch
-
Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647–56.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
31
-
-
0024521441
-
Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
-
McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP, et al. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989;57:79–88.
-
(1989)
Cell
, vol.57
, pp. 79-88
-
-
McDonnell, T.J.1
Deane, N.2
Platt, F.M.3
Nunez, G.4
Jaeger, U.5
McKearn, J.P.6
-
32
-
-
0025251664
-
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
-
Strasser A, Harris AW, Bath ML, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990;348:331–3.
-
(1990)
Nature
, vol.348
, pp. 331-333
-
-
Strasser, A.1
Harris, A.W.2
Bath, M.L.3
Cory, S.4
-
33
-
-
0035049735
-
Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo
-
Schmitt CA, Lowe SW. Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo. Blood Cells Mol Dis 2001; 27:206–16.
-
(2001)
Blood Cells Mol Dis
, vol.27
, pp. 206-216
-
-
Schmitt, C.A.1
Lowe, S.W.2
-
34
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005;17: 393–403.
-
(2005)
Mol Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
-
35
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005;435:677–81.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
-
36
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 2008;68:3421–8.
-
(2008)
Cancer Res
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
Anderson, M.G.4
Chen, J.5
Jin, S.6
-
37
-
-
84863116430
-
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease
-
Roberts AW, Seymour JF, Brown JR, Wierda WG, Kipps TJ, Khaw SL, et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol 2012;30:488–96.
-
(2012)
J Clin Oncol
, vol.30
, pp. 488-496
-
-
Roberts, A.W.1
Seymour, J.F.2
Brown, J.R.3
Wierda, W.G.4
Kipps, T.J.5
Khaw, S.L.6
-
38
-
-
33947227522
-
Programmed anuclear cell death delimits platelet life span
-
Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, et al. Programmed anuclear cell death delimits platelet life span. Cell 2007;128:1173–86.
-
(2007)
Cell
, vol.128
, pp. 1173-1186
-
-
Mason, K.D.1
Carpinelli, M.R.2
Fletcher, J.I.3
Collinge, J.E.4
Hilton, A.A.5
Ellis, S.6
-
39
-
-
33845994359
-
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
-
Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 2007; 117:112–21.
-
(2007)
J Clin Invest
, vol.117
, pp. 112-121
-
-
Del Gaizo Moore, V.1
Brown, J.R.2
Certo, M.3
Love, T.M.4
Novina, C.D.5
Letai, A.6
-
40
-
-
38549145044
-
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
-
Letai AG. Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer 2008;8:121–32.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 121-132
-
-
Letai, A.G.1
-
41
-
-
84862489317
-
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
-
Merino D, Khaw SL, Glaser SP, Anderson DJ, Belmont LD, Wong C, et al. Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood 2012;119: 5807–16.
-
(2012)
Blood
, vol.119
, pp. 5807-5816
-
-
Merino, D.1
Khaw, S.L.2
Glaser, S.P.3
Anderson, D.J.4
Belmont, L.D.5
Wong, C.6
-
42
-
-
84955491187
-
Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia
-
Roberts AW, Davids MS, Pagel JM, Kahl BS, Puvvada SD, Gerecitano JF, et al. Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. N Engl J Med 2016;374:311–22.
-
(2016)
N Engl J Med
, vol.374
, pp. 311-322
-
-
Roberts, A.W.1
Davids, M.S.2
Pagel, J.M.3
Kahl, B.S.4
Puvvada, S.D.5
Gerecitano, J.F.6
-
43
-
-
85002931885
-
Pharmacokinetics of venetoclax, a novel BCL-2 inhibitor, in patients with relapsed or refractory chronic lymphocytic leukemia or non-Hodgkin's lymphoma
-
Salem AH, Agarwal SK, Dunbar M, Enschede SL, Humerickhouse RA, Wong SL. Pharmacokinetics of venetoclax, a novel BCL-2 inhibitor, in patients with relapsed or refractory chronic lymphocytic leukemia or non-Hodgkin's lymphoma. J Clin Pharmacol 2017;57:484–92.
-
(2017)
J Clin Pharmacol
, vol.57
, pp. 484-492
-
-
Salem, A.H.1
Agarwal, S.K.2
Dunbar, M.3
Enschede, S.L.4
Humerickhouse, R.A.5
Wong, S.L.6
-
44
-
-
85038581173
-
-
Silver Spring (MD): U.S. Food and Drug Administration
-
U.S. Food and Drug Administration. Venclexta (venetoclax tablets) prescribing information. Silver Spring (MD): U.S. Food and Drug Administration. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208573s000lbl.pdf.
-
Venclexta (venetoclax Tablets) Prescribing Information
-
-
-
45
-
-
84990249282
-
Effect of low and high fat meals on the pharmacokinetics of venetoclax, a selective first-in-class Bcl-2 inhibitor
-
Salem AH, Agarwal S, Dunbar M, Nuthalapati S, Chien D, Freise KJ, et al. Effect of low and high fat meals on the pharmacokinetics of venetoclax, a selective first-in-class Bcl-2 inhibitor. J Clin Pharmacol 2016;56:1355–61.
-
(2016)
J Clin Pharmacol
, vol.56
, pp. 1355-1361
-
-
Salem, A.H.1
Agarwal, S.2
Dunbar, M.3
Nuthalapati, S.4
Chien, D.5
Freise, K.J.6
-
46
-
-
84990250477
-
Evaluation of Rifampin's transporter inhibitory and CYP3A inductive effects on the pharmacokinetics of venetoclax, a Bcl-2 inhibitor: Results of a single- And multiple-dose study
-
Agarwal SK, Hu B, Chien D, Wong SL, Salem AH. Evaluation of Rifampin's transporter inhibitory and CYP3A inductive effects on the pharmacokinetics of venetoclax, a Bcl-2 inhibitor: results of a single- and multiple-dose study. J Clin Pharmacol 2016;56:1335–43.
-
(2016)
J Clin Pharmacol
, vol.56
, pp. 1335-1343
-
-
Agarwal, S.K.1
Hu, B.2
Chien, D.3
Wong, S.L.4
Salem, A.H.5
-
47
-
-
84988442696
-
Impact of venetoclax exposure on clinical efficacy and safety in patients with relapsed or refractory chronic lymphocytic leukemia
-
Freise KJ, Jones AK, Eckert D, Mensing S, Wong SL, Humerickhouse RA, et al. Impact of venetoclax exposure on clinical efficacy and safety in patients with relapsed or refractory chronic lymphocytic leukemia. Clin Pharmacokinet 2017;56:515–23.
-
(2017)
Clin Pharmacokinet
, vol.56
, pp. 515-523
-
-
Freise, K.J.1
Jones, A.K.2
Eckert, D.3
Mensing, S.4
Wong, S.L.5
Humerickhouse, R.A.6
-
48
-
-
85015799271
-
Phase I first-in-human study of venetoclax in patients with relapsed or refractory non-Hodgkin lymphoma
-
Jan 17. [Epub ahead of print]
-
Davids MS, Roberts AW, Seymour JF, Pagel JM, Kahl BS, Wierda WG, et al. Phase I first-in-human study of venetoclax in patients with relapsed or refractory non-Hodgkin lymphoma. J Clin Oncol 2017 Jan 17. [Epub ahead of print].
-
(2017)
J Clin Oncol
-
-
Davids, M.S.1
Roberts, A.W.2
Seymour, J.F.3
Pagel, J.M.4
Kahl, B.S.5
Wierda, W.G.6
-
49
-
-
84977263866
-
The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism
-
Anderson MA, Deng J, Seymour JF, Tam C, Kim SY, Fein J, et al. The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism. Blood 2016;127: 3215–24.
-
(2016)
Blood
, vol.127
, pp. 3215-3224
-
-
Anderson, M.A.1
Deng, J.2
Seymour, J.F.3
Tam, C.4
Kim, S.Y.5
Fein, J.6
-
50
-
-
84970032000
-
Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: A multicentre, open-label, phase 2 study
-
Stilgenbauer S, Eichhorst B, Schetelig J, Coutre S, Seymour JF, Munir T, et al. Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study. Lancet Oncol 2016;17:768–78.
-
(2016)
Lancet Oncol
, vol.17
, pp. 768-778
-
-
Stilgenbauer, S.1
Eichhorst, B.2
Schetelig, J.3
Coutre, S.4
Seymour, J.F.5
Munir, T.6
-
51
-
-
84925263674
-
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
-
Leverson JD, Phillips DC, Mitten MJ, Boghaert ER, Diaz D, Tahir SK, et al. Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy. Sci Transl Med 2015;7:279ra40.
-
(2015)
Sci Transl Med
, vol.7
, pp. 279ra40
-
-
Leverson, J.D.1
Phillips, D.C.2
Mitten, M.J.3
Boghaert, E.R.4
Diaz, D.5
Tahir, S.K.6
-
52
-
-
84927732048
-
Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib
-
Byrd JC, Furman RR, Coutre SE, Burger JA, Blum KA, Coleman M, et al. Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib. Blood 2015;125: 2497–506.
-
(2015)
Blood
, vol.125
, pp. 2497-2506
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
Burger, J.A.4
Blum, K.A.5
Coleman, M.6
-
53
-
-
84992395380
-
Ibrutinib for patients with relapsed or refractory chronic lymphocytic leukaemia with 17p deletion (RESONATE-17): A phase 2, open-label, multicentre study
-
O'Brien S, Jones JA, Coutre SE, Mato AR, Hillmen P, Tam C, et al. Ibrutinib for patients with relapsed or refractory chronic lymphocytic leukaemia with 17p deletion (RESONATE-17): a phase 2, open-label, multicentre study. Lancet Oncol 2016;17:1409–18.
-
(2016)
Lancet Oncol
, vol.17
, pp. 1409-1418
-
-
O'Brien, S.1
Jones, J.A.2
Coutre, S.E.3
Mato, A.R.4
Hillmen, P.5
Tam, C.6
-
54
-
-
84955481177
-
Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia
-
Byrd JC, Harrington B, O'Brien S, Jones JA, Schuh A, Devereux S, et al. Acalabrutinib (ACP-196) in relapsed chronic lymphocytic leukemia. N Engl J Med 2016;374:323–32.
-
(2016)
N Engl J Med
, vol.374
, pp. 323-332
-
-
Byrd, J.C.1
Harrington, B.2
O'Brien, S.3
Jones, J.A.4
Schuh, A.5
Devereux, S.6
-
55
-
-
85016866002
-
Favorable patient survival after failure of venetoclax (ABT-199/GDC-0199) therapy for relapsed or refractory chronic lymphocytic leukemia (CLL)
-
Tam C, Anderson MA, Ritchie DS, Januszewicz EH, Carney D, Roberts AW, et al. Favorable patient survival after failure of venetoclax (ABT-199/GDC-0199) therapy for relapsed or refractory chronic lymphocytic leukemia (CLL). Blood 2015;126:2939.
-
(2015)
Blood
, vol.126
, pp. 2939
-
-
Tam, C.1
Anderson, M.A.2
Ritchie, D.S.3
Januszewicz, E.H.4
Carney, D.5
Roberts, A.W.6
-
56
-
-
85028069678
-
Venetoclax is active in CLL patients who have relapsed after or are refractory to ibrutinib or idelalisib
-
Coutre S, Wierda W, Choi M, Davids MS, Cheson BD, Furman RR, et al. Venetoclax is active in CLL patients who have relapsed after or are refractory to ibrutinib or idelalisib. Haematologica 2016;101:231–2.
-
(2016)
Haematologica
, vol.101
, pp. 231-232
-
-
Coutre, S.1
Wierda, W.2
Choi, M.3
Davids, M.S.4
Cheson, B.D.5
Furman, R.R.6
-
57
-
-
84865736998
-
Targeting the B-cell lymphoma/leukemia 2 family in cancer
-
Davids MS, Letai A. Targeting the B-cell lymphoma/leukemia 2 family in cancer. J Clin Oncol 2012;30:3127–35.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3127-3135
-
-
Davids, M.S.1
Letai, A.2
-
58
-
-
56649120608
-
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
-
Mason KD, Vandenberg CJ, Scott CL, Wei AH, Cory S, Huang DC, et al. In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. Proc Natl Acad Sci U S A 2008;105:17961–6.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17961-17966
-
-
Mason, K.D.1
Vandenberg, C.J.2
Scott, C.L.3
Wei, A.H.4
Cory, S.5
Huang, D.C.6
-
59
-
-
84938981686
-
Phase 1 study of the safety, pharmacokinetics, and antitumour activity of the BCL2 inhibitor navitoclax in combination with rituximab in patients with relapsed or refractory CD20þ lymphoid malignancies
-
Roberts AW, Advani RH, Kahl BS, Persky D, Sweetenham JW, Carney DA, et al. Phase 1 study of the safety, pharmacokinetics, and antitumour activity of the BCL2 inhibitor navitoclax in combination with rituximab in patients with relapsed or refractory CD20þ lymphoid malignancies. Br J Haematol 2015;170:669–78.
-
(2015)
Br J Haematol
, vol.170
, pp. 669-678
-
-
Roberts, A.W.1
Advani, R.H.2
Kahl, B.S.3
Persky, D.4
Sweetenham, J.W.5
Carney, D.A.6
-
60
-
-
84942899779
-
Pharmacological and protein profiling suggests venetoclax (ABT-199) as optimal partner with ibrutinib in chronic lymphocytic leukemia
-
Cervantes-Gomez F, Lamothe B, Woyach JA, Wierda WG, Keating MJ, Balakrishnan K, et al. Pharmacological and protein profiling suggests venetoclax (ABT-199) as optimal partner with ibrutinib in chronic lymphocytic leukemia. Clin Cancer Res 2015;21:3705–15.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 3705-3715
-
-
Cervantes-Gomez, F.1
Lamothe, B.2
Woyach, J.A.3
Wierda, W.G.4
Keating, M.J.5
Balakrishnan, K.6
-
61
-
-
85009505605
-
Venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukaemia: A phase 1b study
-
Seymour JF, Ma S, Brander DM, Choi MY, Barrientos JC, Davids MS, et al. Venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukaemia: a phase 1b study. Lancet Oncol 2017;18:230–40.
-
(2017)
Lancet Oncol
, vol.18
, pp. 230-240
-
-
Seymour, J.F.1
Ma, S.2
Brander, D.M.3
Choi, M.Y.4
Barrientos, J.C.5
Davids, M.S.6
-
62
-
-
77950502126
-
Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
-
Wierda WG, Kipps TJ, Mayer J, Stilgenbauer S, Williams CD, Hellmann A, et al. Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol 2010; 28:1749–55.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1749-1755
-
-
Wierda, W.G.1
Kipps, T.J.2
Mayer, J.3
Stilgenbauer, S.4
Williams, C.D.5
Hellmann, A.6
-
63
-
-
0037092951
-
Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
-
Keating MJ, Flinn I, Jain V, Binet JL, Hillmen P, Byrd J, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood 2002;99:3554–61.
-
(2002)
Blood
, vol.99
, pp. 3554-3561
-
-
Keating, M.J.1
Flinn, I.2
Jain, V.3
Binet, J.L.4
Hillmen, P.5
Byrd, J.6
-
64
-
-
84907698941
-
Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: Final data from the phase 1/2 GAUGUIN study
-
Cartron G, de Guibert S, Dilhuydy MS, Morschhauser F, Leblond V, Dupuis J, et al. Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN study. Blood 2014;124:2196–202.
-
(2014)
Blood
, vol.124
, pp. 2196-2202
-
-
Cartron, G.1
De Guibert, S.2
Dilhuydy, M.S.3
Morschhauser, F.4
Leblond, V.5
Dupuis, J.6
-
65
-
-
84906855910
-
Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: A single-arm, phase 2 study
-
Burger JA, Keating MJ, Wierda WG, Hartmann E, Hoellenriegel J, Rosin NY, et al. Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 study. Lancet Oncol 2014;15:1090–9.
-
(2014)
Lancet Oncol
, vol.15
, pp. 1090-1099
-
-
Burger, J.A.1
Keating, M.J.2
Wierda, W.G.3
Hartmann, E.4
Hoellenriegel, J.5
Rosin, N.Y.6
-
66
-
-
84940063235
-
Safety and activity of BTK inhibitor ibrutinib combined with ofatumumab in chronic lymphocytic leukemia: A phase 1b/2 study
-
Jaglowski SM, Jones JA, Nagar V, Flynn JM, Andritsos LA, Maddocks KJ, et al. Safety and activity of BTK inhibitor ibrutinib combined with ofatumumab in chronic lymphocytic leukemia: a phase 1b/2 study. Blood 2015;126: 842–50.
-
(2015)
Blood
, vol.126
, pp. 842-850
-
-
Jaglowski, S.M.1
Jones, J.A.2
Nagar, V.3
Flynn, J.M.4
Andritsos, L.A.5
Maddocks, K.J.6
-
67
-
-
77952573871
-
Alemtuzumab by continuous intravenous infusion followed by subcutaneous injection plus rituximab in the treatment of patients with chronic lymphocytic leukemia recurrence
-
Faderl S, Ferrajoli A, Wierda W, O'Brien S, Lerner S, Keating MJ. Alemtuzumab by continuous intravenous infusion followed by subcutaneous injection plus rituximab in the treatment of patients with chronic lymphocytic leukemia recurrence. Cancer 2010;116: 2360–5.
-
(2010)
Cancer
, vol.116
, pp. 2360-2365
-
-
Faderl, S.1
Ferrajoli, A.2
Wierda, W.3
O'Brien, S.4
Lerner, S.5
Keating, M.J.6
-
68
-
-
84878448458
-
A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma
-
Brown JR, Messmer B, Werner L, Davids MS, Mikler E, Supko JG, et al. A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma. Haematologica 2013;98:964–70.
-
(2013)
Haematologica
, vol.98
, pp. 964-970
-
-
Brown, J.R.1
Messmer, B.2
Werner, L.3
Davids, M.S.4
Mikler, E.5
Supko, J.G.6
-
69
-
-
84895833178
-
Bendamustine in combination with ofatumumab in relapsed or refractory chronic lymphocytic leukemia: A GIMEMA Multicenter Phase II Trial
-
Cortelezzi A, Sciume M, Liberati AM, Vincenti D, Cuneo A, Reda G, et al. Bendamustine in combination with ofatumumab in relapsed or refractory chronic lymphocytic leukemia: a GIMEMA Multicenter Phase II Trial. Leukemia 2014;28:642–8.
-
(2014)
Leukemia
, vol.28
, pp. 642-648
-
-
Cortelezzi, A.1
Sciume, M.2
Liberati, A.M.3
Vincenti, D.4
Cuneo, A.5
Reda, G.6
-
70
-
-
80053020928
-
Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: A multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group
-
Fischer K, Cramer P, Busch R, Stilgenbauer S, Bahlo J, Schweighofer CD, et al. Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 2011;29:3559–66.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3559-3566
-
-
Fischer, K.1
Cramer, P.2
Busch, R.3
Stilgenbauer, S.4
Bahlo, J.5
Schweighofer, C.D.6
-
71
-
-
84959366494
-
Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): A randomised, double-blind, phase 3 study
-
Chanan-Khan A, Cramer P, Demirkan F, Fraser G, Silva RS, Grosicki S, et al. Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study. Lancet Oncol 2016;17:200–11.
-
(2016)
Lancet Oncol
, vol.17
, pp. 200-211
-
-
Chanan-Khan, A.1
Cramer, P.2
Demirkan, F.3
Fraser, G.4
Silva, R.S.5
Grosicki, S.6
-
72
-
-
79953072637
-
Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL
-
Badoux XC, Keating MJ, Wang X, O'Brien SM, Ferrajoli A, Faderl S, et al. Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL. Blood 2011; 117:3016–24.
-
(2011)
Blood
, vol.117
, pp. 3016-3024
-
-
Badoux, X.C.1
Keating, M.J.2
Wang, X.3
O'Brien, S.M.4
Ferrajoli, A.5
Faderl, S.6
-
73
-
-
85016426772
-
A phase I-II trial of fludarabine, bendamustine and rituximab (FBR) in previously treated patients with CLL
-
Jain N, Balakrishnan K, Ferrajoli A, O'Brien SM, Burger JA, Kadia TM, et al. A phase I-II trial of fludarabine, bendamustine and rituximab (FBR) in previously treated patients with CLL. Oncotarget 2017;8: 22104–12.
-
(2017)
Oncotarget
, vol.8
, pp. 22104-22112
-
-
Jain, N.1
Balakrishnan, K.2
Ferrajoli, A.3
O'Brien, S.M.4
Burger, J.A.5
Kadia, T.M.6
-
74
-
-
69849107362
-
Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: Clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
-
Stilgenbauer S, Zenz T, Winkler D, Buhler A, Schlenk RF, Groner S, et al. Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 2009;27:3994–4001.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3994-4001
-
-
Stilgenbauer, S.1
Zenz, T.2
Winkler, D.3
Buhler, A.4
Schlenk, R.F.5
Groner, S.6
-
75
-
-
84924378555
-
Second interim analysis of a phase 3 study of idelalisib (ZYDELIG (R)) plus rituximab (R) for relapsed chronic lymphocytic leukemia (CLL): Efficacy analysis in patient subpopulations with Del(17p) and other adverse prognostic factors
-
Sharman JP, Coutre SE, Furman RR, Cheson BD, Pagel JM, Hillmen P, et al. Second interim analysis of a phase 3 study of idelalisib (ZYDELIG (R)) plus rituximab (R) for relapsed chronic lymphocytic leukemia (CLL): efficacy analysis in patient subpopulations with Del(17p) and other adverse prognostic factors. Blood 2014;124:4.
-
(2014)
Blood
, vol.124
, pp. 4
-
-
Sharman, J.P.1
Coutre, S.E.2
Furman, R.R.3
Cheson, B.D.4
Pagel, J.M.5
Hillmen, P.6
-
76
-
-
84863769805
-
Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: Final results of the national cancer research institute CLL206 trial
-
Pettitt AR, Jackson R, Carruthers S, Dodd J, Dodd S, Oates M, et al. Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: final results of the national cancer research institute CLL206 trial. J Clin Oncol 2012;30:1647–55.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1647-1655
-
-
Pettitt, A.R.1
Jackson, R.2
Carruthers, S.3
Dodd, J.4
Dodd, S.5
Oates, M.6
-
77
-
-
84902831336
-
Chemoimmunotherapy for relapsed/refractory and progressive 17p13-deleted chronic lymphocytic leukemia (CLL) combining pentostatin, alemtuzumab, and low-dose rituximab is effective and tolerable and limits loss of CD20 expression by circulating CLL cells
-
Zent CS, Taylor RP, Lindorfer MA, Beum PV, LaPlant B, Wu W, et al. Chemoimmunotherapy for relapsed/refractory and progressive 17p13-deleted chronic lymphocytic leukemia (CLL) combining pentostatin, alemtuzumab, and low-dose rituximab is effective and tolerable and limits loss of CD20 expression by circulating CLL cells. Am J Hematol 2014;89:757–65.
-
(2014)
Am J Hematol
, vol.89
, pp. 757-765
-
-
Zent, C.S.1
Taylor, R.P.2
Lindorfer, M.A.3
Beum, P.V.4
LaPlant, B.5
Wu, W.6
-
78
-
-
80052188111
-
Cyclophosphamide, fludarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia
-
Badoux XC, Keating MJ, Wang X, O'Brien SM, Ferrajoli A, Faderl S, et al. Cyclophosphamide, fludarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia. Blood 2011;118:2085–93.
-
(2011)
Blood
, vol.118
, pp. 2085-2093
-
-
Badoux, X.C.1
Keating, M.J.2
Wang, X.3
O'Brien, S.M.4
Ferrajoli, A.5
Faderl, S.6
|